612 research outputs found
Unbound states of 32Cl and the 31S(p,\gamma)32Cl reaction rate
The 31S(p,\gamma)32Cl reaction is expected to provide the dominant break-out
path from the SiP cycle in novae and is important for understanding enrichments
of sulfur observed in some nova ejecta. We studied the 32S(3He,t)32Cl
charge-exchange reaction to determine properties of proton-unbound levels in
32Cl that have previously contributed significant uncertainties to the
31S(p,\gamma)32Cl reaction rate. Measured triton magnetic rigidities were used
to determine excitation energies in 32Cl. Proton-branching ratios were obtained
by detecting decay protons from unbound 32Cl states in coincidence with
tritons. An improved 31S(p,\gamma)32Cl reaction rate was calculated including
robust statistical and systematic uncertainties
A Global Perspective on Trends in Nature-Based Tourism
Falling attendance at United States and Japanese national parks has led to claims of a pervasive shift away from nature-based recreation. A global analysis, however, now suggests that while visit rates are declining slightly in some richer countries, elsewhere nature tourism is booming
Attractiveness of periodic orbits in parametrically forced systemswith time-increasing friction
We consider dissipative one-dimensional systems subject to a periodic force
and study numerically how a time-varying friction affects the dynamics. As a
model system, particularly suited for numerical analysis, we investigate the
driven cubic oscillator in the presence of friction. We find that, if the
damping coefficient increases in time up to a final constant value, then the
basins of attraction of the leading resonances are larger than they would have
been if the coefficient had been fixed at that value since the beginning. From
a quantitative point of view, the scenario depends both on the final value and
the growth rate of the damping coefficient. The relevance of the results for
the spin-orbit model are discussed in some detail.Comment: 30 pages, 6 figure
Modelling frontal discontinuities in wind fields
A Bayesian procedure for the retrieval of wind vectors over the ocean using satellite borne scatterometers requires realistic prior near-surface wind field models over the oceans. We have implemented carefully chosen vector Gaussian Process models; however in some cases these models are too smooth to reproduce real atmospheric features, such as fronts. At the scale of the scatterometer observations, fronts appear as discontinuities in wind direction. Due to the nature of the retrieval problem a simple discontinuity model is not feasible, and hence we have developed a constrained discontinuity vector Gaussian Process model which ensures realistic fronts. We describe the generative model and show how to compute the data likelihood given the model. We show the results of inference using the model with Markov Chain Monte Carlo methods on both synthetic and real data
Results of a randomized, double-blind phase II clinical trial of NY-ESO-1 vaccine with ISCOMATRIX adjuvant versus ISCOMATRIX alone in participants with high-risk resected melanoma.
BACKGROUND: To compare the clinical efficacy of New York Esophageal squamous cell carcinoma-1 (NY-ESO-1) vaccine with ISCOMATRIX adjuvant versus ISCOMATRIX alone in a randomized, double-blind phase II study in participants with fully resected melanoma at high risk of recurrence. METHODS: Participants with resected stage IIc, IIIb, IIIc and IV melanoma expressing NY-ESO-1 were randomized to treatment with three doses of NY-ESO-1/ISCOMATRIX or ISCOMATRIX adjuvant administered intramuscularly at 4-week intervals, followed by a further dose at 6 months. Primary endpoint was the proportion free of relapse at 18 months in the intention-to-treat (ITT) population and two per-protocol populations. Secondary endpoints included relapse-free survival (RFS) and overall survival (OS), safety and NY-ESO-1 immunity. RESULTS: The ITT population comprised 110 participants, with 56 randomized to NY-ESO-1/ISCOMATRIX and 54 to ISCOMATRIX alone. No significant toxicities were observed. There were no differences between the study arms in relapses at 18 months or for median time to relapse; 139 vs 176 days (p=0.296), or relapse rate, 27 (48.2%) vs 26 (48.1%) (HR 0.913; 95% CI 0.402 to 2.231), respectively. RFS and OS were similar between the study arms. Vaccine recipients developed strong positive antibody responses to NY-ESO-1 (p≤0.0001) and NY-ESO-1-specific CD4+ and CD8+ responses. Biopsies following relapse did not demonstrate differences in NY-ESO-1 expression between the study populations although an exploratory study demonstrated reduced (NY-ESO-1)+/Human Leukocyte Antigen (HLA) class I+ double-positive cells in biopsies from vaccine recipients performed on relapse in 19 participants. CONCLUSIONS: The vaccine was well tolerated, however, despite inducing antigen-specific immunity, it did not affect survival endpoints. Immune escape through the downregulation of NY-ESO-1 and/or HLA class I molecules on tumor may have contributed to relapse
Searching for Long Strings in CMB Maps
Using analytical methods and Monte Carlo simulations, we analyze new
statistics designed to detect isolated step-like discontinuities which are
coherent over large areas of Cosmic Microwave Background (CMB) pixel maps. Such
coherent temperature discontinuities are predicted by the Kaiser-Stebbins
effect to form due to long cosmic strings present in our present horizon. The
background of the coherent step-like seed is assumed to be a scale invariant
Gaussian random field which could have been produced by a superposition of
seeds on smaller scales and/or by inflationary quantum fluctuations. We find
that the proposed statistics can detect the presense of a coherent
discontinuity at a sensitivity level almost an order of magnitude better
compared to more conventional statistics like the skewness or the kurtosis.Comment: 10 pages, 3 Figures, Use RevTe
Predictable and robust performance of a Bi-2223 superconducting coil for compact isochronous cyclotrons
The development of ever smaller medical particle accelerators is motivated by a desire to make proton therapy accessible to more patients. Reducing the footprint of particle accelerators and subsequently proton therapy facilities allows for cheaper and broader usage of proton therapy. By employing superconducting technologies for field shaping, the size of particle accelerators can be reduced further below what is possible with saturated iron. This article discusses experiments on a first-of-its-kind double pancake (DP), and an assembly of six DP coils, designed to be used as a so-called ‘flutter coil’ for a compact isochronous cyclotron for proton therapy, fabricated from high-temperature superconducting (HTS) Bi 2 − x Pbx Sr2Ca2Cu3Oy (Bi-2223) tape. The coils were mounted under pre-stress within a stainless-steel structure to maintain mechanical stability during the experiments. The critical current as a function of the temperature of both coils was measured in a conduction-cooled setup. A model describing the coils, based on tape data, was created and revealed that the measurements were in excellent agreement with the predictions. Additional experiments were performed to study the quench and thermal runaway behaviour of the HTS coils, determining whether such coils can be protected against fault scenarios, using realistic quench-detection levels and discharge extraction-rates. These experiments demonstrate that the coils are very robust and can be well protected against quenches and thermal-runaway events using common quench-protection measures with realistic parameters.</p
Elemental energy spectra of cosmic rays measured by CREAM-II
We present new measurements of the energy spectra of cosmic-ray (CR) nuclei
from the second flight of the balloon-borne experiment CREAM (Cosmic Ray
Energetics And Mass). The instrument (CREAM-II) was comprised of detectors
based on different techniques (Cherenkov light, specific ionization in
scintillators and silicon sensors) to provide a redundant charge identification
and a thin ionization calorimeter capable of measuring the energy of cosmic
rays up to several hundreds of TeV. The data analysis is described and the
individual energy spectra of C, O, Ne, Mg, Si and Fe are reported up to ~ 10^14
eV. The spectral shape looks nearly the same for all the primary elements and
can be expressed as a power law in energy E^{-2.66+/-0.04}. The nitrogen
absolute intensity in the energy range 100-800 GeV/n is also measured.Comment: 4 pages, 3 figures, presented at ICRC 2009, Lodz, Polan
Measurements of cosmic-ray energy spectra with the 2nd CREAM flight
During its second Antarctic flight, the CREAM (Cosmic Ray Energetics And
Mass) balloon experiment collected data for 28 days, measuring the charge and
the energy of cosmic rays (CR) with a redundant system of particle
identification and an imaging thin ionization calorimeter. Preliminary direct
measurements of the absolute intensities of individual CR nuclei are reported
in the elemental range from carbon to iron at very high energy.Comment: 4 pages, 3 figures, presented at XV International Symposium on Very
High Energy Cosmic Ray Interactions (ISVHECRI 2008
Energy spectra of cosmic-ray nuclei at high energies
We present new measurements of the energy spectra of cosmic-ray (CR) nuclei
from the second flight of the balloon-borne experiment Cosmic Ray Energetics
And Mass (CREAM). The instrument included different particle detectors to
provide redundant charge identification and measure the energy of CRs up to
several hundred TeV. The measured individual energy spectra of C, O, Ne, Mg,
Si, and Fe are presented up to eV. The spectral shape looks
nearly the same for these primary elements and it can be fitted to an power law in energy. Moreover, a new measurement of the absolute
intensity of nitrogen in the 100-800 GeV/ energy range with smaller errors
than previous observations, clearly indicates a hardening of the spectrum at
high energy. The relative abundance of N/O at the top of the atmosphere is
measured to be (stat.)(sys.) at 800
GeV/, in good agreement with a recent result from the first CREAM flight.Comment: 32 pages, 10 figures. Accepted for publication in Astrophysical
Journa
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