Characterization of Infrared Dark Clouds -- NH3_3 Observations of an Absorption-contrast Selected IRDC Sample

Despite increasing research in massive star formation, little is known about its earliest stages. Infrared Dark Clouds (IRDCs) are cold, dense and massive enough to harbour the sites of future high-mass star formation. But up to now, mainly small samples have been observed and analysed. To understand the physical conditions during the early stages of high-mass star formation, it is necessary to learn more about the physical conditions and stability in relatively unevolved IRDCs. Thus, for characterising IRDCs studies of large samples are needed. We investigate a complete sample of 218 northern hemisphere high-contrast IRDCs using the ammonia (1,1)- and (2,2)-inversion transitions. We detected ammonia (1,1)-inversion transition lines in 109 of our IRDC candidates. Using the data we were able to study the physical conditions within the star-forming regions statistically. We compared them with the conditions in more evolved regions which have been observed in the same fashion as our sample sources. Our results show that IRDCs have, on average, rotation temperatures of 15 K, are turbulent (with line width FWHMs around 2 km s$^{-1}$), have ammonia column densities on the order of $10^{14}$ cm$^{-2}$ and molecular hydrogen column densities on the order of $10^{22}$ cm$^{-2}$. Their virial masses are between 100 and a few 1000 M$_\odot$. The comparison of bulk kinetic and potential energies indicate that the sources are close to virial equilibrium. IRDCs are on average cooler and less turbulent than a comparison sample of high-mass protostellar objects, and have lower ammonia column densities. Virial parameters indicate that the majority of IRDCs are currently stable, but are expected to collapse in the future.Comment: 21 pages, 11 figures, 7 tables. Paper accepted for publication in Astronomy & Astrophysic

Simplified Quantum Process Tomography

We propose and evaluate experimentally an approach to quantum process tomography that completely removes the scaling problem plaguing the standard approach. The key to this simplification is the incorporation of prior knowledge of the class of physical interactions involved in generating the dynamics, which reduces the problem to one of parameter estimation. This allows part of the problem to be tackled using efficient convex methods, which, when coupled with a constraint on some parameters allows globally optimal estimates for the Kraus operators to be determined from experimental data. Parameterising the maps provides further advantages: it allows the incorporation of mixed states of the environment as well as some initial correlation between the system and environment, both of which are common physical situations following excitation of the system away from thermal equilibrium. Although the approach is not universal, in cases where it is valid it returns a complete set of positive maps for the dynamical evolution of a quantum system at all times.Comment: Added references to interesting related work by Bendersky et a

Encoding a qubit into multilevel subspaces

We present a formalism for encoding the logical basis of a qubit into subspaces of multiple physical levels. The need for this multilevel encoding arises naturally in situations where the speed of quantum operations exceeds the limits imposed by the addressability of individual energy levels of the qubit physical system. A basic feature of the multilevel encoding formalism is the logical equivalence of different physical states and correspondingly, of different physical transformations. This logical equivalence is a source of a significant flexibility in designing logical operations, while the multilevel structure inherently accommodates fast and intense broadband controls thereby facilitating faster quantum operations. Another important practical advantage of multilevel encoding is the ability to maintain full quantum-computational fidelity in the presence of mixing and decoherence within encoding subspaces. The formalism is developed in detail for single-qubit operations and generalized for multiple qubits. As an illustrative example, we perform a simulation of closed-loop optimal control of single-qubit operations for a model multilevel system, and subsequently apply these operations at finite temperatures to investigate the effect of decoherence on operational fidelity.Comment: IOPart LaTeX, 2 figures, 31 pages; addition of a numerical simulatio

The crystal structure of the outer membrane protein VceC from the bacterial pathogen Vibrio cholerae at 1.8 Å resolution

Multidrug resistance in Gram-negative bacteria arises in part from the activities of tripartite drug efflux pumps. In the pathogen Vibrio cholerae, one such pump comprises the inner membrane proton antiporter VceB, the periplasmic adaptor VceA, and the outer membrane channel VceC. Here, we report the crystal structure of VceC at 1.8 Å resolution. The trimeric VceC is organized in the crystal lattice within laminar arrays that resemble membranes. A well resolved detergent molecule within this array interacts with the transmembrane -barrel domain in a fashion that may mimic proteinlipopolysaccharide contacts. Our analyses of the external surfaces of VceC and other channel proteins suggest that different classes of efflux pumps have distinct architectures. We discuss the implications of these findings for mechanisms of drug and protein export

Integrated Photonic Sensing

Loss is a critical roadblock to achieving photonic quantum-enhanced technologies. We explore a modular platform for implementing integrated photonics experiments and consider the effects of loss at different stages of these experiments, including state preparation, manipulation and measurement. We frame our discussion mainly in the context of quantum sensing and focus particularly on the use of loss-tolerant Holland-Burnett states for optical phase estimation. In particular, we discuss spontaneous four-wave mixing in standard birefringent fibre as a source of pure, heralded single photons and present methods of optimising such sources. We also outline a route to programmable circuits which allow the control of photonic interactions even in the presence of fabrication imperfections and describe a ratiometric characterisation method for beam splitters which allows the characterisation of complex circuits without the need for full process tomography. Finally, we present a framework for performing state tomography on heralded states using lossy measurement devices. This is motivated by a calculation of the effects of fabrication imperfections on precision measurement using Holland-Burnett states.Comment: 19 pages, 7 figure

Observations on the Formation of Massive Stars by Accretion

Observations of the H66a recombination line from the ionized gas in the cluster of newly formed massive stars, G10.6-0.4, show that most of the continuum emission derives from the dense gas in an ionized accretion flow that forms an ionized disk or torus around a group of stars in the center of the cluster. The inward motion observed in the accretion flow suggests that despite the equivalent luminosity and ionizing radiation of several O stars, neither radiation pressure nor thermal pressure has reversed the accretion flow. The observations indicate why the radiation pressure of the stars and the thermal pressure of the HII region are not effective in reversing the accretion flow. The observed rate of the accretion flow, 0.001 solar masses/yr, is sufficient to form massive stars within the time scale imposed by their short main sequence lifetimes. A simple model of disk accretion relates quenched HII regions, trapped hypercompact HII regions, and photo-evaporating disks in an evolutionary sequence

Urinary eicosanoid metabolites in HIV-infected women with central obesity switching to raltegravir: an analysis from the women, integrase, and fat accumulation trial.

Chronic inflammation is a hallmark of HIV infection. Eicosanoids reflect inflammation, oxidant stress, and vascular health and vary by sex and metabolic parameters. Raltegravir (RAL) is an HIV-1 integrase inhibitor that may have limited metabolic effects. We assessed urinary F2-isoprostanes (F2-IsoPs), prostaglandin E2 (PGE-M), prostacyclin (PGI-M), and thromboxane B2 (TxB2) in HIV-infected women switching to RAL-containing antiretroviral therapy (ART). Thirty-seven women (RAL = 17; PI/NNRTI = 20) with a median age of 43 years and BMI 32 kg/m(2) completed week 24. TxB2 increased in the RAL versus PI/NNRTI arm (+0.09 versus -0.02; P = 0.06). Baseline PGI-M was lower in the RAL arm (P = 0.005); no other between-arm cross-sectional differences were observed. In the PI/NNRTI arm, 24-week visceral adipose tissue change correlated with PGI-M (rho = 0.45; P = 0.04) and TxB2 (rho = 0.44; P = 0.005) changes, with a trend seen for PGE-M (rho = 0.41; P = 0.07). In an adjusted model, age ≥ 50 years (N = 8) was associated with increased PGE-M (P = 0.04). In this randomized trial, a switch to RAL did not significantly affect urinary eicosanoids over 24 weeks. In women continuing PI/NNRTI, increased visceral adipose tissue correlated with increased PGI-M and PGE-M. Older age (≥ 50) was associated with increased PGE-M. Relationships between aging, adiposity, ART, and eicosanoids during HIV-infection require further study

Optimal control of quantum gates and suppression of decoherence in a system of interacting two-level particles

Methods of optimal control are applied to a model system of interacting two-level particles (e.g., spin-half atomic nuclei or electrons or two-level atoms) to produce high-fidelity quantum gates while simultaneously negating the detrimental effect of decoherence. One set of particles functions as the quantum information processor, whose evolution is controlled by a time-dependent external field. The other particles are not directly controlled and serve as an effective environment, coupling to which is the source of decoherence. The control objective is to generate target one- and two-qubit unitary gates in the presence of strong environmentally-induced decoherence and under physically motivated restrictions on the control field. The quantum-gate fidelity, expressed in terms of a novel state-independent distance measure, is maximized with respect to the control field using combined genetic and gradient algorithms. The resulting high-fidelity gates demonstrate the feasibility of precisely guiding the quantum evolution via the optimal control, even when the system complexity is exacerbated by environmental coupling. It is found that the gate duration has an important effect on the control mechanism and resulting fidelity. An analysis of the sensitivity of the gate performance to random variations in the system parameters reveals a significant degree of robustness attained by the optimal control solutions

Fidelity of optimally controlled quantum gates with randomly coupled multiparticle environments

This work studies the feasibility of optimal control of high-fidelity quantum gates in a model of interacting two-level particles. One particle (the qubit) serves as the quantum information processor, whose evolution is controlled by a time-dependent external field. The other particles are not directly controlled and serve as an effective environment, coupling to which is the source of decoherence. The control objective is to generate target one-qubit gates in the presence of strong environmentally-induced decoherence and under physically motivated restrictions on the control field. It is found that interactions among the environmental particles have a negligible effect on the gate fidelity and require no additional adjustment of the control field. Another interesting result is that optimally controlled quantum gates are remarkably robust to random variations in qubit-environment and inter-environment coupling strengths. These findings demonstrate the utility of optimal control for management of quantum-information systems in a very precise and specific manner, especially when the dynamics complexity is exacerbated by inherently uncertain environmental coupling.Comment: tMOP LaTeX, 9 pages, 3 figures; Special issue of the Journal of Modern Optics: 37th Winter Colloquium on the Physics of Quantum Electronics, 2-6 January 200