Ambient Fine Particulate Matter, Outdoor Temperature and Risk of Metabolic Syndrome

Ambient air pollution and temperature have been linked with cardiovascular morbidity and mortality. Metabolic syndrome and its components—abdominal obesity, elevated fasting blood glucose, low high-density lipoprotein cholesterol, hypertension and hypertriglyceridemia—predict cardiovascular disease, but the environmental causes are understudied. This study prospectively examined the long-term associations of air pollution, defined as fine-particulate matter with diameter ≤2.5µm (PM2.5), and temperature on the development of metabolic syndrome and its components. Using covariate-adjusted Cox-models, we estimated associations of annual mean PM2.5 and temperature with incident risk of metabolic dysfunctions in 587 elderly Normative Aging Study men (mean (SD), 70 (7) years) between 1993-2011. A 1-μg/m3 annual PM2.5 increase was associated with higher risk of developing metabolic syndrome (Hazard ratio [HR]=1.27, 95% Confidence Interval (CI): 1.06, 1.52), elevated fasting blood glucose (HR=1.20, 95%CI: 1.03, 1.39) and hypertriglyceridemia (HR=1.14, 95%CI:1.00, 1.30). Metabolic syndrome and high fasting blood glucose findings remained significant in PM2.5 levels below the U.S. Environmental Protection Agency’s limit (12-μg/m3). A 1-Cº annual temperature increase was associated with greater elevated fasting blood glucose risk (HR=1.33, 95%CI: 1.14, 1.56). Men living in neighborhoods with worse air quality—i.e., with higher PM2.5 levels and/or warmer than average—showed increased risk of developing metabolic dysfunction

Perpendicular-to-grain compression behaviour of screw reinforced timber and a novel application of digital image correlation

This project investigates various factors which influence the behaviour of a timber roof structure designed by Smith & Wallwork Engineers. The first part of the project focused on material of sweet chestnut, where Digital Image Correlation (DIC) was employed to obtain values for the shear modulus. DIC was able to implement the shear field test method prescribed in BS EN 408:2010, along with two new methods developed based on additional information available through DIC. These methods were accurate, fast to implement, and potentially more robust than the shear field test method. A method to estimate the true value of the Timoshenko shear coefficient was also developed. The second section of the project involved physical testing of portions of the roof structure to investigate the behaviour of screw-reinforced and unreinforced timber loaded perpendicular to grain. Together with finite element modelling, it was noticed that a key aspect of the connection's behaviour was the axial force transfer between overlapping screws via shear in the timber, and the resulting relative displacement between the screws. A simple spring model was developed to characterise the compression stiffness of the roof which can now be used in reverse to calculate the forces due to moisture expansion or contraction

The rotational stiffness of cross-laminated timber half-lap joints

Half-lap joints in cross-laminated timber are often conservatively assumed to have no rotational stiffness, preventing applications where the cross-joint stiffness could be utilised. The stiffness of a typical half-lap joint was derived from static four point bend tests, with experiments carried out through a combination of laboratory testing and finite element modelling. A simplified calculation method was developed to predict the rotational stiffness from the joint configuration and material properties. This was incorporated into a spreadsheet design tool for use by the industry partner

Daily surveillance of falls is feasible and reveals a high incidence of falls among older adults

OBJECTIVE: To ensure accurate data capture for a fall study through a system of daily contact with participants. METHODS: Fifty‐eight adults older than 60 years of age and living independently in the community in Canberra, Australia, were recruited for a prospective fall study. We adopted a system of daily contact with study participants for at least 12 months, either by email or by text, asking whether they had suffered a fall in the previous 24 h. At the final testing session, we asked participants whether they had experienced a fall during the previous twelve months. RESULTS: We found no evidence that the daily reporting regime led to excess participant attrition. Only three participants withdrew over the course of the study, and the burden of responding was not cited as a factor in any of these cases. Of the 55 participants who completed the full twelve‐month study period, 38 (69%) experienced at least one fall. We also identified inconsistencies between recall of falls occurring during the last twelve months of the study and the contemporaneously recorded data. CONCLUSIONS: Previous studies have found that increasing the reporting demands on fall study participants will lead to higher attrition. This study demonstrates that it is possible to maintain participant engagement and minimise attrition with appropriate design of reporting procedures. We confirm existing evidence regarding the unreliability of retrospective recall of falls. The study highlights the importance of comprehensive and accurate data capture and points to the possibility of under‐reporting of fall incidence

Are non-brain stem-dead cardiac donors acceptable donors?

BACKGROUND: The deleterious effects of brainstem death (BSD) on donor cardiac function and endothelial integrity have been documented previously. Domino cardiac donation (heart of a heart-lung recipient transplanted into another recipient) is a way to avoid the effects of brainstem death and may confer both short- and long-term benefits to allograft recipients. METHODS: This study evaluates short- and long-term outcome in heart recipients of BSD donors (cadaveric) as compared with domino hearts explanted from patients who underwent heart-lung transplantation. RESULTS: Patients having undergone cardiac transplantation between April 1989 and August 2001 at Papworth Hospital were included (n = 571). Domino donor hearts were used in 81 (14%) of these cases. The pre-operative transpulmonary gradient was not significantly different between the two groups (p = 0.7). There was no significant difference in 30-day mortality (4.9% for domino vs 8.6% for BSD, p = 0.38) or in actuarial survival (p = 0.72). Ischemic time was significantly longer in the BSD group (p < 0.001). Acute rejection and infection episodes were not significantly different (p = 0.24 vs: 0.08). Relative to the BSD group, the risk (95% confidence interval) of acute rejection in the domino group was 0.89 (0.73 to 1.08). Similarly, the relative risk of infection was 0.78 (0.59 to 1.03). The 5-year actuarial survival rates (95% confidence interval) were 78% (69% to 87%) and 69% (65% to 73%) in the domino and BSD groups respectively. Angiography data at 2 years were available in 50 (62%) and 254 (52%) patients in the domino and BSD groups, respectively. The rates for 2-year freedom from cardiac allograft vasculopathy (CAV) were 96% (91% to 100%) and 93% (90% to 96%), respectively. CONCLUSION: Despite the lack of endothelial cell activation after brainstem death and a shorter ischemic time, the performance of domino donor hearts was similar to that of BSD donor hearts. This may indicate a similar pathology (i.e., endothelial cell activation) in the domino donors

The blink reflex magnitude is continuously adjusted according to both current and predicted stimulus position with respect to the face

Published online 22 April 2016The magnitude of the hand-blink reflex (HBR), a subcortical defensive reflex elicited by the electrical stimulation of the median nerve, is increased when the stimulated hand is close to the face ('far-near effect'). This enhancement occurs through a cortico-bulbar facilitation of the polysynaptic medullary pathways subserving the reflex. Here, in two experiments, we investigated the temporal characteristics of this facilitation, and its adjustment during voluntary movement of the stimulated hand. Given that individuals navigate in a fast changing environment, one would expect the cortico-bulbar modulation of this response to adjust rapidly, and as a function of the predicted spatial position of external threats. We observed two main results. First, the HBR modulation occurs without a temporal delay between when the hand has reached the stimulation position and when the stimulus happens (Experiments 1 and 2). Second, the voluntary movement of the hand interacts with the 'far-near effect': stimuli delivered when the hand is far from the face elicit an enhanced HBR if the hand is being moved towards the face, whereas stimuli delivered when the hand is near the face elicit an enhanced HBR regardless of the direction of the hand movement (Experiment 2). These results indicate that the top-down modulation of this subcortical defensive reflex occurs continuously, and takes into account both the current and the predicted position of potential threats with respect to the body. The continuous control of the excitability of subcortical reflex circuits ensures appropriate adjustment of defensive responses in a rapidly-changing sensory environment.Sarah B. Wallwork, Kerwin Talbot, Danny Camfferman, G.L. Moseley and G.D. Iannett

Litter Traits of Native and Non-Native Tropical Trees Influence Soil Carbon Dynamics in Timber Plantations in Panama

Tropical reforestation initiatives are widely recognized as a key strategy for mitigating rising atmospheric CO2 concentrations. Although rapid tree growth in young secondary forests and plantations sequesters large amounts of carbon (C) in biomass, the choice of tree species for reforestation projects is crucial, as species identity and diversity affect microbial activity and soil C cycling via plant litter inputs. The decay rate of litter is largely determined by its chemical and physical properties, and trait complementarity of diverse litter mixtures can produce non-additive effects, which facilitate or delay decomposition. Furthermore, microbial communities may preferentially decompose litter from native tree species (homefield advantage). Hence, information on how different tree species influence soil carbon dynamics could inform reforestation efforts to maximize soil C storage. We established a decomposition experiment in Panama, Central America, using mesocosms and litterbags in monoculture plantations of native species (Dalbergia retusa Hemsl. and Terminalia amazonia J.F.Gmel., Exell) or teak (Tectona grandis L.f.) to assess the influence of different litter types and litter mixtures on soil C dynamics. We used reciprocal litter transplant experiments to assess the homefield advantage and litter mixtures to determine facilitative or antagonistic effects on decomposition rates and soil respiration in all plantation types. Although litter properties explained some of the variation in decomposition, the microclimate and soil properties in the plantations also played an important role. Microbial biomass C and litter decomposition were lower in Tectona than in the native plantations. We observed non-additive effects of mixtures with Tectona and Dalbergia litter on both decomposition and soil respiration, but the effect depended on plantation type. Further, there was a homefield disadvantage for soil respiration in Tectona and Terminalia plantations. Our results suggest that tree species diversity plays an important role in the resilience of tropical soils and that plantations with native tree species could help maintain key processes involved in soil carbon sequestration

Review of Suspended Sediment Transport Mathematical Modelling Studies

YesThis paper reviews existing studies relating to the assessment of sediment concentration profiles within various flow conditions due to their importance in representing pollutant propagation. The effects of sediment particle size, flow depth, and velocity were considered, as well as the eddy viscosity and Rouse number influence on the drag of the particle. It is also widely considered that there is a minimum threshold velocity required to increase sediment concentration within a flow above the washload. The bursting effect has also been investigated within this review, in which it presents the mechanism for sediment to be entrained within the flow at low average velocities. A review of the existing state-of-the-art literature has shown there are many variables to consider, i.e., particle density, flow velocity, and turbulence, when assessing the suspended sediment characteristics within flow; this outcome further evidences the complexity of suspended sediment transport modelling

Identification of multiple root disease resistant wheat germplasm against cereal nematodes and dryland root rot and their validation in regions of economic importance

História da literatura portuguesa coordenada por Giulia Lanciani - primeiras páginas de um total pp. 7-108)História literária do século XVIII portuguêsGoverno de Portuga

Acute leukaemoid reaction following cardiac surgery

Chronic myelomonocytic leukaemia is an atypical myeloproliferative disorder with a natural history of progression to acute myeloid leukaemia, a complex and poorly understood response by the bone marrow to stress. Cardiac surgery activates many inflammatory cascades and may precipitate a systemic inflammatory response syndrome. We present a case of undiagnosed chronic myelomonocytic leukaemia who developed rapidly fatal multi-organ dysfunction following cardiac surgery due to an acute leukaemoid reaction