4,639 research outputs found
Thermodynamic and dynamic anomalies for a three dimensional isotropic core-softened potential
Using molecular dynamics simulations and integral equations (Rogers-Young,
Percus-Yevick and hypernetted chain closures) we investigate the thermodynamic
of particles interacting with continuous core-softened intermolecular
potential. Dynamic properties are also analyzed by the simulations. We show
that, for a chosen shape of the potential, the density, at constant pressure,
has a maximum for a certain temperature. The line of temperatures of maximum
density (TMD) was determined in the pressure-temperature phase diagram.
Similarly the diffusion constant at a constant temperature, , has a maximum
at a density and a minimum at a density .
In the pressure-temperature phase-diagram the line of extrema in diffusivity is
outside of TMD line. Although in this interparticle potential lacks
directionality, this is the same behavior observed in SPC/E water.Comment: 16 page
Identification of multiple genomic DNA sequences which form i-motif structures at neutral pH
i-Motifs are alternative DNA secondary structures formed in cytosine-rich sequences. Particular examples of these structures, traditionally assumed to be stable only at acidic pH, have been found to form under near-physiological conditions. To determine the potential impact of these structures on physiological processes, investigation of sequences with the capacity to fold under physiological conditions is required. Here we describe a systematic study of cytosine-rich DNA sequences, with varying numbers of consecutive cytosines, to gain insights into i-motif DNA sequence and structure stability. i-Motif formation was assessed using ultraviolet spectroscopy, circular dichroism and native gel electrophoresis. We found that increasing cytosine tract lengths resulted in increased thermal stability; sequences with at least five cytosines per tract folded into i-motif at room temperature and neutral pH. Using these results, we postulated a folding rule for i-motif formation, analogous to (but different from) that for G-quadruplexes. This indicated that thousands of cytosine-rich sequences in the human genome may fold into i-motif structures under physiological conditions. Many of these were found in locations where structure formation is likely to influence gene expression. Characterization of a selection of these identified i-motif forming sequences uncovered 17 genomic i-motif forming sequence examples which were stable at neutral pH
Identification of multiple genomic DNA sequences which form i-motif structures at neutral pH
i-Motifs are alternative DNA secondary structures formed in cytosine-rich sequences. Particular examples of these structures, traditionally assumed to be stable only at acidic pH, have been found to form under near-physiological conditions. To determine the potential impact of these structures on physiological processes, investigation of sequences with the capacity to fold under physiological conditions is required. Here we describe a systematic study of cytosine-rich DNA sequences, with varying numbers of consecutive cytosines, to gain insights into i-motif DNA sequence and structure stability. i-Motif formation was assessed using ultraviolet spectroscopy, circular dichroism and native gel electrophoresis. We found that increasing cytosine tract lengths resulted in increased thermal stability; sequences with at least five cytosines per tract folded into i-motif at room temperature and neutral pH. Using these results, we postulated a folding rule for i-motif formation, analogous to (but different from) that for G-quadruplexes. This indicated that thousands of cytosine-rich sequences in the human genome may fold into i-motif structures under physiological conditions. Many of these were found in locations where structure formation is likely to influence gene expression. Characterization of a selection of these identified i-motif forming sequences uncovered 17 genomic i-motif forming sequence examples which were stable at neutral pH
An Economic Examination of Potential Ethanol Production in Texas
Agribusiness, Agricultural and Food Policy, Resource /Energy Economics and Policy,
EquiFACS: the Equine Facial Action Coding System
Although previous studies of horses have investigated their facial expressions in specific contexts, e.g. pain, until now there has been no methodology available that documents all the possible facial movements of the horse and provides a way to record all potential facial configurations. This is essential for an objective description of horse facial expressions across a range of contexts that reflect different emotional states. Facial Action Coding Systems (FACS) provide a systematic methodology of identifying and coding facial expressions on the basis of underlying facial musculature and muscle movement. FACS are anatomically based and document all possible facial movements rather than a configuration of movements associated with a particular situation. Consequently, FACS can be applied as a tool for a wide range of research questions. We developed FACS for the domestic horse (Equus caballus) through anatomical investigation of the underlying musculature and subsequent analysis of naturally occurring behaviour captured on high quality video. Discrete facial movements were identified and described in terms of the underlying muscle contractions, in correspondence with previous FACS systems. The reliability of others to be able to learn this system (EquiFACS) and consistently code behavioural sequences was highâand this included people with no previous experience of horses. A wide range of facial movements were identified, including many that are also seen in primates and other domestic animals (dogs and cats). EquiFACS provides a method that can now be used to document the facial movements associated with different social contexts and thus to address questions relevant to understanding social cognition and comparative psychology, as well as informing current veterinary and animal welfare practices
Gravitational lensing: a unique probe of dark matter and dark energy
I review the development of gravitational lensing as a powerful tool of the observational cosmologist. After the historic eclipse expedition organized by Arthur Eddington and Frank Dyson, the subject lay observationally dormant for 60 years. However, subsequent progress has been astonishingly rapid, especially in the past decade, so that gravitational lensing now holds the key to unravelling the two most profound mysteries of our Universeâthe nature and distribution of dark matter, and the origin of the puzzling cosmic acceleration first identified in the late 1990s. In this non-specialist review, I focus on the unusual history and achievements of gravitational lensing and its future observational prospects
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Diagnosing observation error correlations for Doppler radar radial winds in the Met Office UKV model using observation-minus-background and observation-minus-analysis statistics
With the development of convection-permitting numerical weather prediction the efficient use of high-resolution observations in data assimilation is becoming increasingly important. The operational assimilation of these observations, such as Doppler radar radial winds (DRWs), is now common, though to avoid violating the assumption of uncorrelated observation errors the observation density is severely reduced. To improve the quantity of observations used and the impact that they have on the forecast requires the introduction of the full, potentially correlated, error statistics. In this work, observation error statistics are calculated for the DRWs that are assimilated into the Met Office high-resolution UK model using a diagnostic that makes use of statistical averages of observation-minus-background and observation-minus-analysis residuals. This is the first in-depth study using the diagnostic to estimate both horizontal and along-beam observation error statistics. The new results obtained show that the DRW error standard deviations are similar to those used operationally and increase as the observation height increases. Surprisingly the estimated observation error correlation length-scales are longer than the operational thinning distance. They are dependent both on the height of the observation and on the distance of the observation away from the radar. Further tests show that the long correlations cannot be attributed to the background error covariance matrix used in the assimilation, although they are, in part, a result of using superobservations and a simplified observation operator. The inclusion of correlated error statistics in the assimilation allows less thinning of the data and hence better use of the high-resolution observations
New way to achieve chaotic synchronization in spatially extended systems
We study the spatio-temporal behavior of simple coupled map lattices with
periodic boundary conditions. The local dynamics is governed by two maps,
namely, the sine circle map and the logistic map respectively. It is found that
even though the spatial behavior is irregular for the regularly coupled
(nearest neighbor coupling) system, the spatially synchronized (chaotic
synchronization) as well as periodic solution may be obtained by the
introduction of three long range couplings at the cost of three nearest
neighbor couplings.Comment: 5 pages (revtex), 7 figures (eps, included
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