Augmented input: The effect of visuographic supports on the auditory comprehension of people with chronic aphasia

Background: Augmented input (AI), or the use of visuographic images and linguistic supports, is a strategy for facilitating the auditory comprehension of people with chronic aphasia. To date, researchers have not systematically evaluated the effects of various types of AI strategies on auditory comprehension. Aims: The purpose of the study was to perform an initial evaluation of the changes in auditory comprehension accuracy experienced by people with aphasia when they received one type of AI. Specifically, the authors examined the effect four types of non-personalized visuographic image conditions on the comprehension of people with aphasia when listening to narratives. Methods & Procedures: A total of 21 people with chronic aphasia listened to four stories, one in each of four conditions (i.e., no-context photographs, low-context drawings with embedded no-context photographs, high-context photographs, and no visuographic support). Auditory comprehension was measured by assessing participants’ accuracy in responding to 15 multiple- choice sentence completion statements related to each story. Outcomes & Results: Results showed no significant differences in response accuracy across the four visuographic conditions. Conclusions: The type of visuographic image provided as AI in this study did not influence participants’ response accuracy for sentence completion comprehension tasks. However, the authors only examined non-personalized visuographic images as a type of AI support. Future researchers should systematically examine the benefits provided to people with aphasia by other types of visuographic and linguistic AI supports

Augmented input: The effect of visuographic supports on the auditory comprehension of people with chronic aphasia

Background: Augmented input (AI), or the use of visuographic images and linguistic supports, is a strategy for facilitating the auditory comprehension of people with chronic aphasia. To date, researchers have not systematically evaluated the effects of various types of AI strategies on auditory comprehension. Aims: The purpose of the study was to perform an initial evaluation of the changes in auditory comprehension accuracy experienced by people with aphasia when they received one type of AI. Specifically, the authors examined the effect four types of non-personalized visuographic image conditions on the comprehension of people with aphasia when listening to narratives. Methods & Procedures: A total of 21 people with chronic aphasia listened to four stories, one in each of four conditions (i.e., no-context photographs, low-context drawings with embedded no-context photographs, high-context photographs, and no visuographic support). Auditory comprehension was measured by assessing participants’ accuracy in responding to 15 multiple- choice sentence completion statements related to each story. Outcomes & Results: Results showed no significant differences in response accuracy across the four visuographic conditions. Conclusions: The type of visuographic image provided as AI in this study did not influence participants’ response accuracy for sentence completion comprehension tasks. However, the authors only examined non-personalized visuographic images as a type of AI support. Future researchers should systematically examine the benefits provided to people with aphasia by other types of visuographic and linguistic AI supports

Augmented input: The effect of visuographic supports on the auditory comprehension of people with chronic aphasia

Background: Augmented input (AI), or the use of visuographic images and linguistic supports, is a strategy for facilitating the auditory comprehension of people with chronic aphasia. To date, researchers have not systematically evaluated the effects of various types of AI strategies on auditory comprehension. Aims: The purpose of the study was to perform an initial evaluation of the changes in auditory comprehension accuracy experienced by people with aphasia when they received one type of AI. Specifically, the authors examined the effect four types of non-personalized visuographic image conditions on the comprehension of people with aphasia when listening to narratives. Methods & Procedures: A total of 21 people with chronic aphasia listened to four stories, one in each of four conditions (i.e., no-context photographs, low-context drawings with embedded no-context photographs, high-context photographs, and no visuographic support). Auditory comprehension was measured by assessing participants’ accuracy in responding to 15 multiple- choice sentence completion statements related to each story. Outcomes & Results: Results showed no significant differences in response accuracy across the four visuographic conditions. Conclusions: The type of visuographic image provided as AI in this study did not influence participants’ response accuracy for sentence completion comprehension tasks. However, the authors only examined non-personalized visuographic images as a type of AI support. Future researchers should systematically examine the benefits provided to people with aphasia by other types of visuographic and linguistic AI supports

Photovoice and Youth on Violence and Related Topics: A Systematic Review

Background and Purpose: Photovoice is a qualitative method that empowers youth to identify community issues and assets through photo-taking and photo discussions. The purpose of this systematic review was to explore the characteristics of studies using photovoice in violence and related topics among youth, and the rationale, strengths and limitations of the photovoice methodology when applied to youth. Methods: Inclusion criteria, search strategy, and data extraction and analysis plan were specified in advance and documented in a protocol (Registration: PROSPERO-CRD42018087290). The search strategy included three search concepts: photovoice, youth, and violence-related topics. Two rounds of formal searches were executed across the following electronic databases: PubMed, CINAHL, PsycINFO, Embase, and Web of Science, using the predefined search terms and strings in the registered protocol. Searching records were screened and selected based on inclusion criteria. Included studies were extracted to a predefined spreadsheet and synthesized narratively. Results: A total of 23 studies were included in this systematic review, of which, 17 studies described the cameras used for photo taking, 15 studies used the SHOWeD framework for photo discussions, 12 studies provided an in-depth description of the thematic analysis process, and 11 studies addressed dissemination activities and social actions. Most studies mentioned the rationale of using photovoice, stating that it empowered youth to express their concerns on community issues while inspiring their critical thinking for social action in youth participatory action research (YPAR) and community-based participatory research (CBPR). The strengths and limitations of the photovoice methodology were also discussed from the perspective of youth participants, researchers, and communities. Discussion: To the best of our knowledge, this is the first systematic review that provides thorough summaries on the characteristics of photovoice studies on violence and related topics among youth, as well as the strengths and limitations of using the photovoice methodology in these studies

Levetiracetam-loaded biodegradable polymer implants in the tetanus toxin model of temporal lobe epilepsy in rats

Approximately one-third of people with epilepsy receive insufficient benefit from currently available anticonvulsant medication, and some evidence suggests that this may be due to a lack of effective penetration into brain parenchyma. The current study investigated the ability of biodegradable polymer implants loaded with levetiracetam to ameliorate seizures following implantation above the motor cortex in the tetanus toxin model of temporal lobe epilepsy in rats. The implants led to significantly shorter seizures and a trend towards fewer seizures for up to 1 week. The results of this study indicate that drug-eluting polymer implants represent a promising evolving treatment option for intractable epilepsy. Future research is warranted to investigate issues of device longevity and implantation site

Opportunities for Competency Support of Virginia Cooperative Extension Professionals at the Colleague Stage

This study focused on the professional development needs of Cooperative Extension agents and specialists with between four and seven years of experience, placing them roughly within the colleague career stage. Data were collected through focus groups and validated through member checking and the use of a modified World Café approach. A research team collaborated, increasing the reliability of the findings through intentional reflection in the development of the findings. Areas of competency strength and weakness vary for agents and specialists, and specific topic areas within competencies vary. While many of the emergent competencies identified in this study fit within the competency framework of Harder et al. (2011) and previous competency studies, more specific topic areas were identified. However, the top priorities identified for professional development focus included communication, educational design, leadership, and budget and fiscal management. Attention to these areas can increase the ability of these professionals to work more effectively and productively. Providing professional development in areas of need for both agents and specialists can support the development of collegiality within the Extension organization. Supporting professionals in this stage of their career growth will position them well for advancing to additional career stages within Cooperative Extension

Genetic influence on scar height and pliability after burn injury in individuals of European ancestry: A prospective cohort study

After similar extent of injury there is considerable variability in scarring between individuals, in part due to genetic factors. This study aimed to identify genetic variants associated with scar height and pliability after burn injury. An exome-wide array association study and gene pathway analysis were performed on a prospective cohort of 665 patients treated for burn injury. Outcomes were scar height (SH) and scar pliability (SP) sub-scores of the modified Vancouver Scar Scale (mVSS). DNA was genotyped using the Infinium® HumanCoreExome-24 BeadChip. Associations between genetic variants (single nucleotide polymorphisms) and SH and SP were estimated using an additive genetic model adjusting for age, sex, number of surgical procedures and % total body surface area of burn in subjects of European ancestry. No individual genetic variants achieved the cut-off threshold of significance. Gene regions were analysed for spatially correlated single nucleotide polymorphisms and significant regions identified using comb-p software. This gene list was subject to gene pathway analysis to find which biological process terms were over-represented. Using this approach biological processes related to the nervous system and cell adhesion were the predominant gene pathways associated with both SH and SP. This study suggests genes associated with innervation may be important in scar fibrosis. Further studies using similar and larger datasets will be essential to validate these findings

Antiepileptic effects of lacosamide loaded polymers implanted subdurally in GAERS

The current experiment investigated the ability of coaxial electrospun poly(D,L-lactide-co-glycolide) (PLGA) biodegradable polymer implants loaded with the antiepileptic drugs (AED) lacosamide to reduce seizures following implantation above the motor cortex in the Genetic Absence Epilepsy Rat from Strasbourg (GAERS). In this prospective, randomized, masked experiments, GAERS underwent surgery for implantation of skull electrodes (n = 6), skull electrodes and blank polymers (n = 6), or skull electrodes and lacosamide loaded polymers (n = 6). Thirty-minute electroencephalogram (EEG) recordings were started at day 7 after surgery and continued for eight weeks. The number of SWDs and mean duration of one SWD were compared week-by-week between the three groups. There was no difference in the number of SWDs between any of the groups. However, the mean duration of one SWD was significantly lower in the lacosamide polymer group for up to 7 weeks when compared to the control group (0.004 \u3c p \u3c 0.038). The mean duration of one seizure was also lower at weeks 3, 5, 6, and 7 when compared to the blank polymer group (p = 0.016, 0.037, 0.025, and 0.025, resp.). We have demonstrated that AED loaded PLGA polymer sheets implanted on the surface of the cortex could affect seizure activity in GAERS for a sustained period

Enhanced surveillance of COVID-19 in Scotland: population-based seroprevalence surveillance for SARS-CoV-2 during the first wave of the epidemic

This work was funded by the Scottish Government.Objectives: The impact of the COVID-19 pandemic in Scotland has been amongst the most severe in Europe. Serological surveillance is critical to determine the overall extent of infection across populations and to inform the public health response. This study aimed to estimate the proportion of people who have antibodies to SARS-CoV-2 ('seroprevalence') in the general population of Scotland and to see if this changes over time. Study Design/Methods: Between International Organization for Standardization (ISO) week 17 (i.e. week commencing 20th April) and ISO week 25 (week commencing 15 June), 4751 residual blood samples were obtained from regional biochemistry laboratories in six participating regional health authority areas covering approximately 75% of the Scottish population. Samples were tested for the presence of anti-SARS-CoV-2 IgG antibodies using the LIAISON®SARS-CoV-2 S1/S2 IgG assay (DiaSorin, Italy). Seroprevalence rates were adjusted for the sensitivity and specificity of the assay using Bayesian methods. Results: The combined adjusted seroprevalence across the study period was 4.3% (95% confidence interval: 4.2%-4.5%). The proportion varied each week between 1.9% and 6.8% with no difference in antibody positivity by age, sex or geographical area. Conclusions: At the end of the first wave of the COVID-19 pandemic, only a small fraction of the Scottish population had antibodies to SARS-CoV-2. Control of COVID-19 requires the ability to detect asymptomatic and mild infections that would otherwise remain undetected through existing surveillance systems. This is important to determine the true number of infections within the general population which, in turn, can help to understand transmission, inform control measures and provide a denominator for the estimation of severity measures such as the proportion of infected people who have been hospitalised and/or have died.PostprintPeer reviewe