Neutrino degeneracy and cosmological nucleosynthesis, revisited

A reexamination of the effects of non-zero degeneracies on Big Bang Nucleosynthesis is made. As previously noted, non-trivial alterations of the standard model conclusions can be induced only if excess lepton numbers L sub i, comparable to photon number densities eta sub tau, are assumed (where eta sub tau is approx. 3 times 10(exp 9) eta sub b). Furthermore, the required lepton number densities (L sub i eta sub tau) must be different for upsilon sub e than for upsilon sub mu and epsilon sub tau. It is shown that this loophole in the standard model of nucleosynthesis is robust and will not vanish as abundance and reaction rate determinations improve. However, it is also argued that theoretically (L sub e) approx. (L sub mu) approx. (L sub tau) approx. eta sub b is much less than eta sub tau which would preclude this loophole in standard unified models

Experimentally Observed Features of the Turbulent Near-Wake of a Model Ship

http://deepblue.lib.umich.edu/bitstream/2027.42/116057/1/39015075172091.pd

On the Disinfectant Properties of Hypochlorites of Sodium and Magnesium as Produced by Electrolysis.

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Experimentally Observed Features of the Turbulent Near-Wake of a Model Ship

https://deepblue.lib.umich.edu/bitstream/2027.42/154136/1/39015075172091.pd

Candidates for asteroid dust trails

The contribution of different sources to the circumsolar dust cloud (known as the zodiacal cloud) can be deduced from diagnostic observations. We used the Spitzer Space Telescope to observe the diffuse thermal emission of the zodiacal cloud near the ecliptic. Several structures were identified in these observations, including previously known asteroid dust bands, which are thought to have been produced by recent asteroid collisions, and cometary trails. Interestingly, two of the detected dust trails, denoted t1 and t2 here, cannot be linked to any known comet. Trails t1 and t2 represent a much larger integrated brightness than all known cometary trails combined and may therefore be major contributors to the circumsolar dust cloud. We used our Spitzer observations to determine the orbits of these trails and were able to link them to two ("orphan" or type II) trails that were discovered by the Infrared Astronomical Satellite (IRAS) in 1983. The orbits of trails t1 and t2 that we determined by combining the Spitzer and IRAS data have semimajor axes, eccentricities, and inclinations like those of the main-belt asteroids. We therefore propose that trails t1 and t2 were produced by very recent (<~100 kyr old) collisional breakups of small, <~10 km diameter main-belt asteroids

Docking protein domains in contact space

BACKGROUND: Many biological processes involve the physical interaction between protein domains. Understanding these functional associations requires knowledge of the molecular structure. Experimental investigations though present considerable difficulties and there is therefore a need for accurate and reliable computational methods. In this paper we present a novel method that seeks to dock protein domains using a contact map representation. Rather than providing a full three dimensional model of the complex, the method predicts contacting residues across the interface. We use a scoring function that combines structural, physicochemical and evolutionary information, where each potential residue contact is assigned a value according to the scoring function and the hypothesis is that the real configuration of contacts is the one that maximizes the score. The search is performed with a simulated annealing algorithm directly in contact space. RESULTS: We have tested the method on interacting domain pairs that are part of the same protein (intra-molecular domains). We show that it correctly predicts some contacts and that predicted residues tend to be significantly closer to each other than other pairs of residues in the same domains. Moreover we find that predicted contacts can often discriminate the best model (or the native structure, if present) among a set of optimal solutions generated by a standard docking procedure. CONCLUSION: Contact docking appears feasible and able to complement other computational methods for the prediction of protein-protein interactions. With respect to more standard docking algorithms it might be more suitable to handle protein conformational changes and to predict complexes starting from protein models

RdgB2 is required for dim-light input into intrinsically photosensitive retinal ganglion cells.

A subset of retinal ganglion cells is intrinsically photosensitive (ipRGCs) and contributes directly to the pupillary light reflex and circadian photoentrainment under bright-light conditions. ipRGCs are also indirectly activated by light through cellular circuits initiated in rods and cones. A mammalian homologue (RdgB2) of a phosphoinositide transfer/exchange protein that functions in Drosophila phototransduction is expressed in the retinal ganglion cell layer. This raised the possibility that RdgB2 might function in the intrinsic light response in ipRGCs, which depends on a cascade reminiscent of Drosophila phototransduction. Here we found that under high light intensities, RdgB2(-/-) mutant mice showed normal pupillary light responses and circadian photoentrainment. Consistent with this behavioral phenotype, the intrinsic light responses of ipRGCs in RdgB2(-/-) were indistinguishable from wild-type. In contrast, under low-light conditions, RdgB2(-/-) mutants displayed defects in both circadian photoentrainment and the pupillary light response. The RdgB2 protein was not expressed in ipRGCs but was in GABAergic amacrine cells, which provided inhibitory feedback onto bipolar cells. We propose that RdgB2 is required in a cellular circuit that transduces light input from rods to bipolar cells that are coupled to GABAergic amacrine cells and ultimately to ipRGCs, thereby enabling ipRGCs to respond to dim light

Defamation Law and Free Speech: Reynolds v. Times Newspapers and the English Media

The common law of defamation cut the balance between speech and reputation decisively in favor of reputation and allowed for the imposition of significant damages against media outlets that defamed. For the last four decades, U.S. media outlets have been insulated against the common law rules by the United States Supreme Court\u27s landmark decision in New York Times Co. v. Sullivan. Following Sullivan, Commonwealth countries clung steadfastly to common law rules and are only now beginning to modify the common law rules to provide speech and media protections. Rather than following Sullivan by adopting constitutional protections, however, Commonwealth courts have opted to provide that protection by expanding common-law qualified privilege protections. The Authors examine the Reynolds\u27 standard with particular emphasis on how that decision has affected media practices and reporting. They do so through empirical evidence rather than doctrinal analysis. The Authors engaged in extensive interviews with the British media during 2003 and 2004, four to five years after Reynolds was decided. Since some of the authors also conducted extensive interviews with the British media in the early 1990s, years before Reynolds was decided, the authors were able to compare and contrast their pre-Reynolds interviews with their post-Reynolds interviews, and thereby gain a better understanding of Reynolds\u27 impact. The Authors conclude that, although Reynolds has had some impact on British defamation law as well as on the practices of the British media, the impact has not been as dramatic as the Sullivan decision\u27s impact on U.S. press and media practices

Numerical Modeling of Ablation Heat Transfer

A unique numerical method has been developed for solving one-dimensional ablation heat transfer problems. This paper provides a comprehensive description of the method, along with detailed derivations of the governing equations. This methodology supports solutions for traditional ablation modeling including such effects as heat transfer, material decomposition, pyrolysis gas permeation and heat exchange, and thermochemical surface erosion. The numerical scheme utilizes a control-volume approach with a variable grid to account for surface movement. This method directly supports implementation of nontraditional models such as material swelling and mechanical erosion, extending capabilities for modeling complex ablation phenomena. Verifications of the numerical implementation are provided using analytical solutions, code comparisons, and the method of manufactured solutions. These verifications are used to demonstrate solution accuracy and proper error convergence rates. A simple demonstration of a mechanical erosion (spallation) model is also provided to illustrate the unique capabilities of the method