EXERCÍCIO FÍSICO E Diabetes mellitus TIPO 2

Um estilo de vida sedentrio deve ser considerado um importante fator de risco capaz de ser modificado para indivduos com diabetes mellitus (DM) tipo 2, j que atividade fsica regular oferece mltiplos benefcios que incluem melhora da sensibilidade insulina e do controle glicmico, aumento do condicionamento cardiorespiratrio e reduo do risco de mortalidade cardiovascular. Entretanto, o estabelecimento de programas de treinamentos e de guias prticos para o manejo adequado na diabetes tipo 2 no tm sido sugeridos num consenso nico. Dessa forma, o presente estudo selecionou publicaes realizadas a partir de dados Pubmed, objetivando discutir informaes que esto sendo descritas na literatura de forma a reforar bases que representem uma resposta adaptativa s demandas do treinamento, apoiando uma positiva funo da atividade fsica no cuidado da diabetes tipo 2

Antidiabetic effects of the medicinal plants

Diabetes mellitus (DM) is a chronic metabolic disease characterized by hyperglycemy that has a significant impact for their patients. Its incidence is raising leading to an increase in the cost of the cares of the disease and of its complications. The treatment involves, besides dietary control and physical activity, the use of drugs that cause side effects to reach wanted pharmacological actions. However, products of plants are, frequently, considered less poisonous and with fewer side effects than synthetic drugs and widely used by the population. In this paper, several species of plants, used experimentally or in the popular medicine, acting by different ways to control glycemia and/or to inhibit symptoms and characteristic complications of the diabetes, they will be reviewed for evaluation of their supposed therapeutic effects

Efeitos antidiabéticos de plantas medicinais

Diabetes mellitus (DM) é uma doença metabólica crônica caracterizada por hipeglicemia que tem impacto significante em seus pacientes. Sua incidência está crescendo rapidamente conduzindo para aumento no custo dos cuidados da doença e de suas complicações. O tratamento envolve, além de controle dietético e atividade física, o uso de fármacos que ocasionam efeitos colaterais para atingir ações farmacológicas desejadas. Entretanto, produtos de plantas são, freqüentemente, considerados menos tóxicos e com menos efeitos colaterais que drogas sintéticas e amplamente utilizadas pela população. Nesse trabalho várias espécies de plantas utilizadas experimentalmente ou na medicina popular, agindo de diferentes formas de modo a controlar glicemia e/ou inibir sintomas e complicações características da diabetes serão revisadas para avaliação de seus supostos efeitos terapêuticos.Diabetes mellitus (DM) is a chronic metabolic disease characterized by hyperglycemy that has a significant impact for their patients. Its incidence is raising leading to an increase in the cost of the cares of the disease and of its complications. The treatment involves, besides dietary control and physical activity, the use of drugs that cause side effects to reach wanted pharmacological actions. However, products of plants are, frequently, considered less poisonous and with fewer side effects than synthetic drugs and widely used by the population. In this paper, several species of plants, used experimentally or in the popular medicine, acting by different ways to control glycemia and/or to inhibit symptoms and characteristic complications of the diabetes, they will be reviewed for evaluation of their supposed therapeutic effects

Oxidative stress causes hypertension and activation of nuclear factor-κB after high-fructose and salt treatments

International audienceThere is evidence that diets rich in salt or simple sugars as fructose are associated with abnormalities in blood pressure regulation. However, the mechanisms underlying pathogenesis of salt- and fructose-induced kidney damage and/or consequent hypertension yet remain largely unexplored. Here, we tested the role of oxidative state as an essential factor along with high salt and fructose treatment in causing hypertension. Fischer male rats were supplemented with a high-fructose diet (20% in water) for 20 weeks and maintained on high-salt diet (8%) associate in the last 10 weeks. Fructose-fed rats exhibited a salt-dependent hypertension accompanied by decrease in renal superoxide dismutase activity, which is the first footprint of antioxidant inactivation by reactive oxygen species (ROS). Metabolic changes and the hypertensive effect of the combined fructose-salt diet (20 weeks) were markedly reversed by a superoxide scavenger, Tempol (10 mg/kg, gavage); moreover, Tempol (50 mM) potentially reduced ROS production and abolished nuclear factor-kappa B (NF-κB) activation in human embryonic kidney HEK293 cells incubated with L-fructose (30 mM) and NaCl (500 mosmol/kg added). Taken together, our data suggested a possible role of oxygen radicals and ROS-induced activation of NF-κB in the fructose- and salt-induced hypertension associated with the progression of the renal disease