Role-taking in free improvisation and collaborative composition

Role-taking, the adoption of solo, accompanying or punctuating roles by a given part or parts may exist in any form of music. In Part 1, I have argued that the structure of free improvised pieces can be articulated in terms of player-functional or material-generative roles taken by ensemble members, and that these roles may, in turn, reflect the interpersonal dynamics of the group. The first four chapters uncover possible roles, and propose a methodology for mapping the structure of improvised pieces. Part 2 is a portfolio of backbone compositions - compositions written for one or two instruments with the intention of adding further parts in collaboration with other musicians. The compositions, including the process of their realisation, make use of the roles uncovered in Part 1, leading to musical structures suggestive of long-term or large-scale human interaction. The technique is expanded to encompass interaction with another art form - film. The final piece in the portfolio demonstrates how the two media interrelate by means of an awareness of role-taking within and between them

Identification of novel Cyclooxygenase-2-dependent genes in Helicobacter pylori infection in vivo

<p>Abstract</p> <p>Background</p> <p><it>Helicobacter pylori </it>is a crucial determining factor in the pathogenesis of benign and neoplastic gastric diseases. Cyclooxygenase-2 (Cox-2) is the inducible key enzyme of arachidonic acid metabolism and is a central mediator in inflammation and cancer. Expression of the <it>Cox-2 </it>gene is up-regulated in the gastric mucosa during <it>H. pylori </it>infection but the pathobiological consequences of this enhanced Cox-2 expression are not yet characterized. The aim of this study was to identify novel genes down-stream of Cox-2 in an <it>in vivo </it>model, thereby identifying potential targets for the study of the role of Cox- 2 in <it>H. pylori </it>pathogenesis and the initiation of pre- cancerous changes.</p> <p>Results</p> <p>Gene expression profiles in the gastric mucosa of mice treated with a specific Cox-2 inhibitor (NS398) or vehicle were analysed at different time points (6, 13 and 19 wk) after <it>H. pylori </it>infection. <it>H. pylori </it>infection affected the expression of 385 genes over the experimental period, including regulators of gastric physiology, proliferation, apoptosis and mucosal defence. Under conditions of Cox-2 inhibition, 160 target genes were regulated as a result of <it>H. pylori </it>infection. The Cox-2 dependent subset included those influencing gastric physiology (<it>Gastrin, Galr1</it>), epithelial barrier function (<it>Tjp1, connexin45, Aqp5</it>), inflammation (<it>Icam1</it>), apoptosis (<it>Clu</it>) and proliferation (<it>Gdf3, Igf2</it>). Treatment with NS398 alone caused differential expression of 140 genes, 97 of which were unique, indicating that these genes are regulated under conditions of basal Cox-2 expression.</p> <p>Conclusion</p> <p>This study has identified a panel of novel Cox-2 dependent genes influenced under both normal and the inflammatory conditions induced by <it>H. pylori </it>infection. These data provide important new links between Cox-2 and inflammatory processes, epithelial repair and integrity.</p

Third City 2017: Improvisational Roles in Performances Using Live Sampling

The 2017 set by the electroacoustic duo Third City comprised five pieces, each defined by an audio path linking different acoustic musical instruments to digital musical instruments to enable live sampling. Performances were then improvised within structures developed in rehearsal. The authors here ask how the different instruments and audio paths influenced the improvisational roles taken by the performers. Previously established differences between acoustic musical instruments and digital musical instruments are highlighted, and questions regarding their use within improvisation are articulated. A taxonomy of improvisational roles is then selected and applied to the pieces. In identifying correlations between the instruments and audio paths of the five pieces and the improvisational roles used by the performers, conclusions are reached to serve as guidance in the setting up of audio paths for other electroacoustic improvisation pieces using live sampling. This article is the result of research into practice, an asynchronous post hoc consideration (Onsman and Burke 210) of the 2017 Third City set carried out by the duo having repositioned themselves relative to their music-making selves as researchers referring to both the experience of performers and the projected experience of the audience as inferred from archive footage

Neurodiverse Worlds: Articulating the Subjective Experience of Autistic Girls Through Music and Sound

Background: Autistic Spectrum Conditions (ASC) in women and girls are frequently under-recognised or misdiagnosed, as diagnostic criteria derive from observations of core behaviours of autistic males (Carpenter et al., 2019). An accumulating body of research supports a “female” autistic phenotype, where distinctive neurodivergent characteristics are masked by intentional imitation of neurotypical behaviours (‘camouflaging’) (Bargiela et al., 2016). Although a number of projects within autism research centre on benefits of participatory arts with relation to diagnostic criteria (deficits), far fewer profile/support qualities of autistic subjectivity per se (including lived experiences of autistic females), reflecting a medical rather than social model of disability. Aims: The study reported (a pilot project exploring the use of music, sound and movement as creative tools for probing the lived experience of autistic girls, together with their perceived value in negotiating everyday life) is part of a larger AHRC-funded mixed-methods interdisciplinary project, informed by an ecological approach, exploring the identities and experience of autistic girls through participatory arts (drama and media arts). The project’s overarching aims are to explore: 1) what participatory arts can contribute to understanding/ documenting the subjective experiences of autistic girls; 2) the role participatory arts practices play in enhancing psychological well-being; 3) how autistic experience can gain visibility through arts and media practices. Method: 6 girls with an ASC diagnosis (aged 11-16), from a specialist school (UK) for autistic girls participated in an 8-week workshop series (including ensemble music-making, foley and sound design, sound walks, multisensory den-making) led by two experienced arts practitioners (a music specialist and a physical theatre/movement specialist). Semi-structured interviews were conducted at start/end points of the project (analysed via inductive thematic analysis). Standardized baseline measures were collected at start/end points. (Social Self-Efficacy Scale (SSES); Creative Self-Efficacy (CSE); Warwick-Edinburgh Mental Wellbeing Scale (WEMWBS); Healthy and Unhealthy Music Scale (HUMS))

Helicobacter pylori Infection Promotes Methylation and Silencing of Trefoil Factor 2, Leading to Gastric Tumor Development in Mice and Humans

Background & Aims Trefoil factors (TFFs) regulate mucosal repair and suppress tumor formation in the stomach. Tff1 deficiency results in gastric cancer, whereas Tff2 deficiency increases gastric inflammation. TFF2 expression is frequently lost in gastric neoplasms, but the nature of the silencing mechanism and associated impact on tumorigenesis have not been determined. Methods We investigated the epigenetic silencing of TFF2 in gastric biopsy specimens from individuals with Helicobacter pylori-positive gastritis, intestinal metaplasia, gastric cancer, and disease-free controls. TFF2 function and methylation were manipulated in gastric cancer cell lines. The effects of Tff2 deficiency on tumor growth were investigated in the gp130[superscript F/F] mouse model of gastric cancer. Results In human tissue samples, DNA methylation at the TFF2 promoter began at the time of H pylori infection and increased throughout gastric tumor progression. TFF2 methylation levels were inversely correlated with TFF2 messenger RNA levels and could be used to discriminate between disease-free controls, H pylori-infected, and tumor tissues. Genome demethylation restored TFF2 expression in gastric cancer cell lines, so TFF2 silencing requires methylation. In Tff2-deficient gp130[superscript F/F]/Tff2[superscript −/−] mice, proliferation of mucosal cells and release of T helper cell type-1 (Th-1) 1 cytokines increased, whereas expression of gastric tumor suppressor genes and Th-2 cytokines were reduced, compared with gp130[superscript F/F]controls. The fundus of gp130[superscript F/F]/Tff2[superscript −/−] mice displayed glandular atrophy and metaplasia, indicating accelerated preneoplasia. Experimental H pylori infection in wild-type mice reduced antral expression of Tff2 by increased promoter methylation. Conclusions TFF2 negatively regulates preneoplastic progression and subsequent tumor development in the stomach, a role that is subverted by promoter methylation during H pylori infection.National Health and Medical Research Council (Australia

Practitioner Review: effectiveness and mechanisms of change in participatory arts-based programmes for promoting youth mental health and well-being – a systematic review

Background: Participatory arts-based (PAB) programmes refer to a diverse range of community programmes involving active engagement in the creation process that appear helpful to several aspects of children's and young people's (CYP) mental health and well-being. This mixed-methods systematic review synthesises evidence relating to the effectiveness and mechanisms of change in PAB programmes for youth. Method: Studies were identified following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses approach. Eleven electronic databases were searched for studies of PAB programmes conducted with CYP (aged 4–25 years), which reported mental health and well-being effectiveness outcomes and/or mechanisms of change. A mixed-methods appraisal tool assessed study quality. A narrative synthesis was conducted of effectiveness and challenges in capturing this. Findings relating to reported mechanisms of change were integrated via a metasummary. Results: Twenty-two studies were included. Evidence of effectiveness from quantitative studies was limited by methodological issues. The metasummary identified mechanisms of change resonant with those proposed in talking therapies. Additionally, PAB programmes appear beneficial to CYP by fostering a therapeutic space characterised by subverting restrictive social rules, communitas that is not perceived as coercive, and inviting play and embodied understanding. Conclusions: There is good evidence that there are therapeutic processes in PAB programmes. There is a need for more transdisciplinary work to increase understanding of context–mechanism–outcome pathways, including the role played by different art stimuli and practices. Going forward, transdisciplinary teams are needed to quantify short- and long-term mental health and well-being outcomes and to investigate optimal programme durations in relation to population and need. Such teams would also be best placed to work on resolving inter-disciplinary methodological tensions

Correlation of T cell response and bacterial clearance in human volunteers challenged with Helicobacter pylori revealed by randomised controlled vaccination with Ty21a-based Salmonella vaccines

Background: Helicobacter pylori remains a global health hazard, and vaccination would be ideal for its control. Natural infection appears not to induce protective immunity. Thus, the feasibility of a vaccine for humans is doubtful. Methods: In two prospective, randomised, double-blind, controlled studies (Paul Ehrlich Institute application nos 0802/02 and 1097/01), live vaccines against H pylori were tested in human volunteers seronegative for, and without evidence of, active H pylori infection. Volunteers (n = 58) were immunised orally with Salmonella enterica serovar Typhi Ty21a expressing H pylori urease or HP0231, or solely with Ty21a, and then challenged with 2×105 cagPAI- H pylori. Adverse events, infection, humoral, cellular and mucosal immune response were monitored. Gastric biopsies were taken before and after vaccination, and postchallenge. Infection was terminated with antibiotics. Results: Vaccines were well tolerated. Challenge infection induced transient, mild to moderate dyspeptic symptoms, and histological and transcriptional changes in the mucosa known from chronic infection. Vaccines did not show satisfactory protection. However, 13 of 58 volunteers, 8 vaccinees and 5 controls, became breath test negative and either cleared Hpylori (5/13) completely or reduced the H pylori burden (8/13). H pylori-specific T helper cells were detected in 9 of these 13 (69%), but only in 6 of 45 (13%) breath test-positive volunteers (p = 0.0002; Fisher exact test). T cells were either vaccine induced or pre-existing, depending on the volunteer. Conclusion: Challenge infection offers a controlled model for vaccine testing. Importantly, it revealed evidence for T cell-mediated immunity against H pylori infection in humans

Training Music Leaders in a Time of Covid

Report from symposium hosted by Sound Connections exploring how to train music leaders to work in online contexts. The report captures examples of emergent community music practices during the initial months of lockdown in 2020