Złośliwy nerwiak osłonkowy szyi imitujący guz tarczycy — opis przypadku i przegląd piśmiennictwa. Praca z ośrodka referencyjnego w chirurgii endokrynologicznej

Malignant peripheral sheath tumors (MPNST) are rare soft tissue sarcomas originating from peripheral sheath cells. The main risk factor is neurofibromatosis type 1 (NF-1). The localization in the head and neck region is uncommon (up to 15% of all cases of MPNST) making the diagnosis difficult due to anatomical and clinical reasons. We present a case of 45-years-old female with the NF-1- linked MPNST localized in the thyroid region with clinical manifestation as a left thyroid tumour. The patient underwent surgery and adjuvant radiation therapy, remaining disease-free for 14 months after the treatment.Złośliwe nerwiaki osłonkowe (MPNST) należą do rzadko spotykanych mięsaków tkanek miękkich, wywodzących się z komórek osłonek nerwów obwodowych. Najważniejszym czynnikiem ryzyka ich rozwoju jest nerwiakowłókniakowatość typu 1 — choroba Recklinghausena. Umiejscowienie tych nowotworów w regionie głowy i szyi zdarza się rzadko, a postawienie prawidłowego rozpoznania jest trudne z przyczyn anatomicznych i skrytego przebiegu klinicznego omawianych guzów. W pracy prezentujemy przypadek 45-letniej kobiety z nerwiakowłókniakowatością typu 1 i złośliwym nerwiakiem osłonkowym umiejscowionym w rzucie lewego płata tarczycy. Chora przebyła zabieg wycięcia guza z następczą radioterapią. W trakcie 14-miesięcznej obserwacji po leczeniu nie stwierdzono nawrotu choroby

OCENA SYSTEMU ELEKTRYCZNEJ TOMOGRAFII POJEMNOŚCIOWEJ DO POMIARÓW Z WYKORZYSTANIEM SONDY 3D

Further tests of EVT4 data acquisition system for electrical capacitance tomography are presented. The modular system, which can have up to 32 channels with an individual analogue to digital converter, was designed to ensure small uncertainty of capacitance measurement at high speed of imaging. The system’s performance in the context of 3D imaging was experimentally verified. In particular, we show that the measurement of changes in capacitance due to a small change of an electric permittivity distribution for the most distant electrodes in a suitably designed 3D sensor is possible using our system. Cross-plane measurements together with the measurements for the pairs of most distant electrodes are essential for accurate reconstruction of 3D distributions. Due to sensitivity of capacitance measurements obtained in the hardware, the measurements for all electrode pairs can be used in the inverse problem – the system of equations can be extended. Although the numerical condition number of a matrix of such a system is high, image reconstruction is possible from the data obtained in our system. The results of 3D image reconstruction for simple test objects are shown.Przedstawiono dalsze testy systemu akwizycji danych EVT4 do elektrycznej tomografii pojemnościowej. Modułowy system, który może mieć do 32 kanałów z indywidualnym przetwornikiem analogowo-cyfrowym, został zaprojektowany w celu zapewnienia małej niepewności pomiaru pojemności przy dużej prędkości obrazowania. Wydajność systemu w kontekście obrazowania 3D została zweryfikowana eksperymentalnie. W szczególności pokazujemy, że możliwy jest pomiar zmian pojemności wywoływanych niewielką zmianą rozkładu przenikalności elektrycznej dla najbardziej odległych elektrod odpowiednio zaprojektowanego czujnika 3D przy pomocy naszego systemu. Pomiary międzypłaszczyznowe wraz z pomiarami par elektrod najbardziej odległych są niezbędne do dokładnej rekonstrukcji rozkładów 3D. Ze względu na wrażliwość pomiarów pojemności uzyskanych w opracowanym urządzeniu, pomiary dla wszystkich par elektrod mogą być wykorzystane w problemie odwrotnym – układ równań może zostać rozszerzony. Chociaż współczynnik uwarunkowania numerycznego macierzy takiego układu jest wysoki, możliwa jest rekonstrukcja obrazu z wykorzystaniem danych uzyskiwanych w naszym systemie. Pokazane są wyniki rekonstrukcji obrazu 3D dla prostych obiektów testowych

Mutations in the Lipopolysaccharide Biosynthesis Pathway Interfere with Crescentin-Mediated Cell Curvature in Caulobacter crescentus

Bacterial cell morphogenesis requires coordination among multiple cellular systems, including the bacterial cytoskeleton and the cell wall. In the vibrioid bacterium Caulobacter crescentus, the intermediate filament-like protein crescentin forms a cell envelope-associated cytoskeletal structure that controls cell wall growth to generate cell curvature. We undertook a genetic screen to find other cellular components important for cell curvature. Here we report that deletion of a gene (wbqL) involved in the lipopolysaccharide (LPS) biosynthesis pathway abolishes cell curvature. Loss of WbqL function leads to the accumulation of an aberrant Opolysaccharide species and to the release of the S layer in the culture medium. Epistasis and microscopy experiments show that neither S-layer nor O-polysaccharide production is required for curved cell morphology per se but that production of the altered O-polysaccharide species abolishes cell curvature by apparently interfering with the ability of the crescentin structure to associate with the cell envelope. Our data suggest that perturbations in a cellular pathway that is itself fully dispensable for cell curvature can cause a disruption of cell morphogenesis, highlighting the delicate harmony among unrelated cellular systems. Using the wbqL mutant, we also show that the normal assembly and growth properties of the crescentin structure are independent of its association with the cell envelope. However, this envelope association is important for facilitating the local disruption of the stable crescentin structure at the division site during cytokinesis

Comparison of openEHR and HL7 FHIR standards

Health informatics is characterized by the need tosecurely store, process and transmit large amounts of sensitivemedical data while ensuring interoperability with other systems.Among many standards used in such systems there are two whichhave gained interest in recent years and cover most of thoseneeds: openEHR and HL7 FHIR. In this paper, both standardsare discussed and compared with each other. The architecture ofboth systems, the similarities and differences, methods of datamodeling and ensuring interoperability were presented

Software Layer For FPGA-based Tesla Cavity Control System (part I)

The paper describes design and practical realization of software for laboratory purposes to control FPGA-based photonic and electronic equipment. There is presented a universal solution for all relevant devices with FPGA chips and gigabit optical links. The paper describes architecture of the software layers and program solutions of hardware communication based on Internal Interface (II) technology. Such a solution was used for superconducting Cavity Controller and Simulator (SIMCON) for the TESLA experiment in DESY (Hamburg). A number of practical examples of the software solutions for the SIMCON system were given in this paper

Early psychosocial intervention in Alzheimer’s disease:Cost utility evaluation alongside the Danish Alzheimer’s Intervention Study (DAISY)

OBJECTIVE: To assess the cost utility of early psychosocial intervention for patients with Alzheimer's disease and their primary caregivers. DESIGN: Cost utility evaluation alongside a multicentre, randomised controlled trial with 3 years of follow-up. SETTING: Primary care and memory clinics in five Danish districts. PARTICIPANTS: 330 community-dwelling patients and their primary caregivers. INTERVENTION: Psychosocial counselling and support lasting 8–12 months after diagnosis and follow-up at 3, 6, 12 and 36 months in the intervention group or follow-up only in the control group. MAIN OUTCOME MEASURES: The primary outcome measure was the cost of additional quality-adjusted life years (QALYs). Costs were measured from a societal perspective, including the costs of healthcare, social care, informal care and production loss. QALYs were estimated separately for the patient and the caregiver before aggregation for the main analysis. RESULTS: None of the observed cost and QALY measures were significantly different between the intervention and control groups, although a tendency was noted for psychosocial care leading to cost increases with informal care that was not outweighed by the tendency for cost savings with formal care. The probability of psychosocial intervention being cost-effective did not exceed 36% for any threshold value. The alternative scenario analysis showed that the probability of cost-effectiveness increased over the range of threshold values used if the cost perspective was restricted to formal healthcare. CONCLUSIONS: A multifaceted, psychosocial intervention programme was found unlikely to be cost-effective from a societal perspective. The recommendation for practice in settings that are similar to the Danish setting is to provide follow-up with referral to available local support programmes when needed, and to restrict large multifaceted intervention programmes to patients and caregivers with special needs until further evidence for cost-effectiveness emerges. TRIAL REGISTRATION: The study was registered in the Clinical Trial Database as ISRCTN74848736

Boundary Terms, Spinors and Kerr/CFT

Similarly as in AdS/CFT, the requirement that the action for spinors be stationary for solutions to the Dirac equation with fixed boundary conditions determines the form of the boundary term that needs to be added to the standard Dirac action in Kerr/CFT. We determine this boundary term and make use of it to calculate the two-point function for spinor fields in Kerr/CFT. This two-point function agrees with the correlator of a two dimensional relativistic conformal field theory.Comment: 15 page