41 research outputs found
“The Indian Who Bombed Berlin”: German Encounters in Ralph Salisbury’s Work – Modulating Modern Precariousness
Ralph Salisbury's canon is laced with encounters with Germans and Germany, serving to lend his stories and autobiography, So Far, So Good (2013), a transnational edginess in connection with his self-identification as Native American. At times the Germans are presented as the dangerously inimical Other, although the jeopardy and alienation are generally undercut by Salisbury's or his narrators' realizations of inclusive human kinship. Salisbury spent extended time in Germany in many capacities, including Fulbright Fellow (1983, 2004, 2005) and networking sojourner, and writes of his experiences there, ranging from dealing with a formidable East German guard at Checkpont Charlie to joy in teaching enthusiastic students Native American literature. In the autobiography Salisbury refers to the many German American neighbors and the Wessels family of his mother's first husband - themselves dealing with issues of otherness in patriotic America - in (in)direct confrontation with his alcohol-troubled and frequently violent "English-Cherokee-Shawnee father (So Far, So Good 5). In the semi-autobiographical tall tale "The Chicken Affliction and a Man of God," Salisbury changes his Irish American mother's heritage to German American descent for the boy-focalizer's mother, re-dressing - in Faulkneresque Southern modernist manner - his underlying boyhood trauma with humorous-grotesque exaggerations when the young narrator's staunch mother futilely attempts to protect the boy from his abusive father. Salisbury shows literary kinship with other modernist writers in the short story "Silver Mercedes and Big Blue Buick: An Indian War"; a Babbitt-like shoe-store owner, who could possibly have felt at home in Sinclair Lewis' Main Street, conducts a Hemingway-flavored gender battle with his Sioux German-descended wife, as well as a perilous driving contest with a skilled Mercedes driver on narrow Bavarian roads. In the short story titled "The Indian Who Bombed Berlin," a Native American exchange professor in an ancient German city recalls his callous wartime destruction of enemy "cathedrals and homes" (202) in Germany, but finds himself costantly, transculturally, and ironically readjusting his lines of affiliation during a riotous demonstration by students of color. Modulating modernism to produce a "Cherokee modern" approach, Salisbury's complex instrumentalization of Native American and German stereotypes and the accompanying issues of precariousness, alterity, agency, and reinforcement of Indigenous presence can be compared to and contrasted with strategies employed by two Anishinaabe authors in different genres and literary modes: Gerald Vizenor's in Blue Ravens: Historical Novel (2014) and Drew Hayden Taylor's in The Berlin Blues, a 2007 play
Consuming, Incarcerating, and “Transmoting” Misery: Border Practice in Vizenor’s Bearheart and Jones’s The Fast Red Road
Drawing on Gerald Vizenor's complex notion of "transmotion" and concepts from carceral theory, an intertextual reading of two rich, initial novels by first and second-generation postmodern Native writers, namely Gerald Vizenor's seminal Bearheart: The Heirship Chronicles (1990; first published in 1978 as Darkness in Saint Louis Bearheart) and Stehen Graham Jones's The Fast Red Road: A Plainsong (2000), reveals both systemic miseries and strategies for combatting them. In the two novels, brutal imagery and experience of cannibalization, enclosure, and displacement menace the Native protagonists, but, paradoxically, these strong images also offer modes of resourceful and imaginative action - for my purposes here particularly at territorial borders - which enable totemic laughter and viable Native "survivance," to use Vizenor's own much-quoted term.Recent carceral theory tells us that the mapping of imprisonment must include a differentiated study of "practice" as well as of enclosed space and enforced borders (cf. Dominique Moran, 2015). Indeed, the border crossing in the two books at hand encodes centuries of discriminatory practice based on dangerously fixed stereotypes, demarcation of ethnic boundaries, and binary "terminal creeds" that Gerald Vizenor has always critiqued in his oeuvre. The miserable but epiphanic realization by Pidgin, one of Jones's protagonists, in yet another 'win-or-lose' trap that he "was consumed" (153) echoes on many levels in a synergetic analysis of the two experimental and engagé novels, which nonetheless demonstrate the creativity, transformation, convention defiance, the wisely grotesque clowning and trickery, the imagination involved in crafting and enabling Native transmotion.
Ueber Lücken und Risse in dem elastischen Gewebe der Aortenwand : Inaugural-Dissertation zur Erlangung des Grades eines Doctors der Medicin
http://tartu.ester.ee/record=b1967650~S1*es
Dissertatio medico-inauguralis de exitu morborum
http://tartu.ester.ee/record=b1973240~S1*es
Usability - Bericht: Beitrag zur Usability Evaluation Challenge 2010 der Gesellschaft für Informatik
Der vorliegende Usability-Bericht entstand im Rahmen eines Multimedia-Tutoriums, das dazu vorgesehen ist, praktisch umzusetzen, was in anderen Seminaren über Multimediapsychologie, Diagnostik der Mensch-Maschine-Interaktion, Softwaregestaltung und –evaluation sowie Screendesign theoretisch vermittelt wurde. Der Wettbewerb zur Evaluation der Webseite des Fachbereichs Mensch-Computer-Interaktion (FB MCI) der Gesellschaft für Informatik e.V. (GI) bot uns durch die Aufgabenstellung eine geeignete Möglichkeit, übergreifendes theoretisches und psychologisch fundiertes Wissen an einem realen Beispiel anzuwenden und somit in die Praxis umzusetzen.
Unser Team, bestehend aus sieben angehenden Usability-Experten, hat die Webseite des MCI ausführlich inspiziert und mit ausgewählten Methoden systematisch evaluiert. Dazu wurden in einem Auswahlprozess zwei geeignete Methoden gewählt. Unser Vorgehen ist in einem Projektplan festgehalten. Die Ergebnisse der Evaluation, deren Erhebung und die verwendeten Methoden sind in diesem Bericht ausführlich protokolliert.:1. Einleitung
2. Erläuterung angewendeter Methoden
2.1. Heuristische Evaluation
2.2. Card Sorting
3. Projektplan
4. Wichtigste Erkenntnisse und Empfehlungen – Zusammenfassung
5. Heuristische Evaluation
5.1. Auswahl und Spezifikation der Heuristiken
5.2. Darstellung des Vorgehens
5.3. Erläuterung zu den Tabellen
5.4. Erläuterung zu Schweregrad und Behebbarkeit
5.5. Ergebnisse heuristische Betrachtung: Übersicht
5.5.1. Heuristische Betrachtung: Gesamte Homepage
5.5.2. Heuristische Betrachtung: Startseite
5.5.3. Heuristische Betrachtung: Hauptnavigation
5.5.4. Heuristische Betrachtung: Fachgruppen
5.5.5. Heuristische Betrachtung: Arbeitskreise
5.6. Visualisierung ausgewählter Verbesserungsvorschläge
6. Card Sorting
6.1. Psychologische Fundierung
6.2. Darstellung des Vorgehens
6.3. Auswertung
6.3.1. Ergebnisse Hauptmenü (Gruppe A)
6.3.2. Ergebnisse Fachgruppen und Arbeitskreise (Gruppe B)
7. Design-Vorschläge
8. Evaluation der Barrierefreiheit nach BITV
9. Schlusswort
10. Literaturverzeichnis
Anhang
A) Heuristiken
B) Auswertung Card Sorting Gruppe A
C) Auswertung Card Sorting Aufgabe A
D) Auswertung Fachgruppen und Arbeitskreise (Gruppe B
Narrative Delikatessen : kulturelle Dimensionen von Ernährung
Die im ersten Band der neuen "Schriftenreihe für Kulturökologie und Literaturdidaktik" versammelten "Narrativen Delikatessen" eröffnen ein breites Spektrum kultureller Dimensionen von Ernährung und stecken damit ein neues Forschungsgebiet ab, das im Zuge globaler Ernährungskrisen von immer größerer Relevanz ist.
Die Beiträge untersuchen literarische, mediale und künstlerische Darstellungen von Ernährung in diachroner und synchroner Perspektive und legen komplexe Wechselwirkungen zwischen gesellschaftlichen und ästhetisch transformierten Diskursen offen. Dezidierte Mikroanalysen einzelner Texte stehen dabei neben überblicksartigen Untersuchungen zu spezifischen Motiven oder kulturellen Konstanten in der Inszenierung von Essen. Durch interdisziplinäre Verschränkungen gehen die Betrachtungen über den literaturwissenschaftlichen Tellerrand hinaus und erweitern die Forschungsperspektiven zum Themenkomplex Ernährung auf vielfältige Weise
Differential expression of Lp-PLA2 in obesity and type 2 diabetes and the influence of lipids
Aims/hypothesis
Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a circulatory macrophage-derived factor that increases with obesity and leads to a higher risk of cardiovascular disease (CVD). Despite this, its role in adipose tissue and the adipocyte is unknown. Therefore, the aims of this study were to clarify the expression of Lp-PLA2 in relation to different adipose tissue depots and type 2 diabetes, and ascertain whether markers of obesity and type 2 diabetes correlate with circulating Lp-PLA2. A final aim was to evaluate the effect of cholesterol on cellular Lp-PLA2 in an in vitro adipocyte model.
Methods
Analysis of anthropometric and biochemical variables from a cohort of lean (age 44.4 ± 6.2 years; BMI 22.15 ± 1.8 kg/m2, n = 23), overweight (age 45.4 ± 12.3 years; BMI 26.99 ± 1.5 kg/m2, n = 24), obese (age 49.0 ± 9.1 years; BMI 33.74 ± 3.3 kg/m2, n = 32) and type 2 diabetic women (age 53.0 ± 6.13 years; BMI 35.08 ± 8.6 kg/m2, n = 35), as part of an ethically approved study. Gene and protein expression of PLA2 and its isoforms were assessed in adipose tissue samples, with serum analysis undertaken to assess circulating Lp-PLA2 and its association with cardiometabolic risk markers. A human adipocyte cell model, Chub-S7, was used to address the intracellular change in Lp-PLA2 in adipocytes.
Results
Lp-PLA2 and calcium-independent PLA2 (iPLA2) isoforms were altered by adiposity, as shown by microarray analysis (p < 0.05). Type 2 diabetes status was also observed to significantly alter gene and protein levels of Lp-PLA2 in abdominal subcutaneous (AbdSc) (p < 0.01), but not omental, adipose tissue. Furthermore, multivariate stepwise regression analysis of circulating Lp-PLA2 and metabolic markers revealed that the greatest predictor of Lp-PLA2 in non-diabetic individuals was LDL-cholesterol (p = 0.004). Additionally, in people with type 2 diabetes, oxidised LDL (oxLDL), triacylglycerols and HDL-cholesterol appeared important predictors, accounting for 59.7% of the variance (p < 0.001). Subsequent in vitro studies determined human adipocytes to be a source of Lp-PLA2, as confirmed by mRNA expression, protein levels and immunochemistry. Further in vitro experiments revealed that treatment with LDL-cholesterol or oxLDL resulted in significant upregulation of Lp-PLA2, while inhibition of Lp-PLA2 reduced oxLDL production by 19.8% (p < 0.05).
Conclusions/interpretation
Our study suggests adipose tissue and adipocytes are active sources of Lp-PLA2, with differential regulation by fat depot and metabolic state. Moreover, levels of circulating Lp-PLA2 appear to be influenced by unfavourable lipid profiles in type 2 diabetes, which may occur in part through regulation of LDL-cholesterol and oxLDL metabolism in adipocytes