Logic-controlled solid state switchgear for 270 volts dc

A feasibility study to design and demonstrate solid state switchgear in the form of circuit breakers and a power transfer switch is described. The switchgear operates on a nominal 270 V dc circuit and controls power to a load of up to 15 amperes. One circuit breaker may be interconnected to a second breaker to form a power transfer switch. On-off and transfer functions of the breakers or the transfer switch are remotely controlled. A number of reclosures with variable time delay between tripout and reclosure are programmed and controlled by integrated analog and COSMOS logic circuits. A unique commutation circuit, that generates only minimal transient disturbance to either source or load, was developed to interrupt current flow through the main SCR switching element. Laboratory tests demonstrated performance of the solid state circuit breakers over specified voltage and temperature ranges

Weathering the storm: developments in the acoustic sensing of wind and rain

An Acoustic Rain Gauge (ARG) analyses the underwater sound levels across a wide frequency range, classifies the observed spectrum according to likely source and then determines the local wind speed or rain rate as appropriate. Thispaper covers a trial on the Scotian Shelf off Canada, comparing the geophysical information derived from the acoustic signals with those obtained from other sources

Archaeology and Environment in Northumberland

Eventful, influential and absorbing, the early history of Northumberland is a fascinating story that has rarely been brought together under one cover. In this authoritative historical account, the authors bring to bear a huge quantity of old and new data and craft it into an in-depth synthesis. The authors deliver this history in chronological order from a perspective that places human activity and environment at its core. The narrative extends from the Palaeolithic through to, and including, the Anglo-Saxon period. This enormous sweep of history is supported by a robust radiocarbon chronology, with all available dates for the region brought together and calibrated against the most recent calibration curves for the first time. The geographic focus of the volume is North Northumberland but the narrative frequently extends to cover the whole county and occasionally further afield into neighbouring areas so as to deal with key topics at an appropriate geographic scale and to take account of important information from nearby areas. This second volume in the Till-Tweed monograph series follows on from the first volume, Managing Archaeological Landscapes in Northumberland , which provided a considerable quantity of new field data, in addition to presenting a landscape management methodology based around the "landform element" approach

Differentiation of human fetal mesenchymal stem cells into cells with an oligodendrocyte phenotype

This article is available open access through the publisher’s website at the link below. Copyright @ 2009 Landes Bioscience.The potential of mesenchymal stem cells (MSC) to differentiate into neural lineages has raised the possibility of autologous cell transplantation as a therapy for neurodegenerative diseases. We have identified a population of circulating human fetal mesenchymal stem cells (hfMSC) that are highly proliferative and can readily differentiate into mesodermal lineages such as bone, cartilage, fat and muscle. Here, we demonstrate for the first time that primary hfMSC can differentiate into cells with an oligodendrocyte phenotype both in vitro and in vivo. By exposing hfMSC to neuronal conditioned medium or by introducing the pro-oligodendrocyte gene, Olig-2, hfMSC adopted an oligodendrocyte-like morphology, expressed oligodendrocyte markers and appeared to mature appropriately in culture. Importantly we also demonstrate the differentiation of a clonal population of hfMSC into both mesodermal (bone) and ectodermal (oligodendrocyte) lineages. In the developing murine brain transplanted hfMSC integrated into the parenchyma but oligodendrocyte differentiation of these naïve hfMSC was very low. However, the proportion of cells expressing oligodendrocyte markers increased significantly (from 0.2% to 4%) by pre-exposing the cells to differentiation medium in vitro prior to transplantation. Importantly, the process of in vivo differentiation occurred without cell fusion. These findings suggest that hfMSC may provide a potential source of oligodendrocytes for study and potential therapy

Replica symmetry breaking in an adiabatic spin-glass model of adaptive evolution

We study evolutionary canalization using a spin-glass model with replica theory, where spins and their interactions are dynamic variables whose configurations correspond to phenotypes and genotypes, respectively. The spins are updated under temperature T_S, and the genotypes evolve under temperature T_J, according to the evolutionary fitness. It is found that adaptation occurs at T_S < T_S^{RS}, and a replica symmetric phase emerges at T_S^{RSB} < T_S < T_S^{RS}. The replica symmetric phase implies canalization, and replica symmetry breaking at lower temperatures indicates loss of robustness.Comment: 5pages, 2 figure

Impaired cellular bioenergetics caused by GBA1 depletion sensitizes neurons to calcium overload

Heterozygous mutations of the lysosomal enzyme glucocerebrosidase (GBA1) represent the major genetic risk for Parkinson’s disease (PD), while homozygous GBA1 mutations cause Gaucher disease, a lysosomal storage disorder, which may involve severe neurodegeneration. We have previously demonstrated impaired autophagy and proteasomal degradation pathways and mitochondrial dysfunction in neurons from GBA1 knockout (gba1^{-/-}) mice. We now show that stimulation with physiological glutamate concentrations causes pathological [Ca^{2+}]_{c} esponses and delayed calcium deregulation, collapse of mitochondrial membrane potential and an irreversible fall in the ATP/ADP ratio. Mitochondrial Ca^{2+} uptake was reduced in gba1^{−/−} cells as was expression of the mitochondrial calcium uniporter. The rate of free radical generation was increased in gba1^{−/−} neurons. Behavior of gba1^{+/−} neurons was similar to gba1^{−/−} in terms of all variables, consistent with a contribution of these mechanisms to the pathogenesis of PD. These data signpost reduced bioenergetic capacity and [Ca^{2+}]_{c} dysregulation as mechanisms driving neurodegeneration

Clustering of galaxies at 3.6 microns in the Spitzer Wide-area Infrared Extragalactic legacy survey

We investigate the clustering of galaxies selected in the 3.6 micron band of the Spitzer Wide-area Infrared Extragalactic (SWIRE) legacy survey. The angular two-point correlation function is calculated for eleven samples with flux limits of S_3.6 > 4-400 mujy, over an 8 square degree field. The angular clustering strength is measured at >5-sigma significance at all flux limits, with amplitudes of A=(0.49-29)\times10^{-3} at one degree, for a power-law model, A\theta^{-0.8}. We estimate the redshift distributions of the samples using phenomological models, simulations and photometric redshifts, and so derive the spatial correlation lengths. We compare our results with the GalICS (Galaxies In Cosmological Simulations) models of galaxy evolution and with parameterized models of clustering evolution. The GalICS simulations are consistent with our angular correlation functions, but fail to match the spatial clustering inferred from the phenomological models or the photometric redshifts. We find that the uncertainties in the redshift distributions of our samples dominate the statistical errors in our estimates of the spatial clustering. At low redshifts (median z<0.5) the comoving correlation length is approximately constant, r_0=6.1\pm0.5h^{-1} Mpc, and then decreases with increasing redshift to a value of 2.9\pm0.3h^{-1} Mpc for the faintest sample, for which the median redshift is z=1. We suggest that this trend can be attributed to a decrease in the average galaxy and halo mass in the fainter flux-limited samples, corresponding to changes in the relative numbers of early- and late-type galaxies. However, we cannot rule out strong evolution of the correlation length over 0.5<z<1.Comment: 14 pages, 9 (colour) figures. Published in MNRA

Shaping Robust System through Evolution

Biological functions are generated as a result of developmental dynamics that form phenotypes governed by genotypes. The dynamical system for development is shaped through genetic evolution following natural selection based on the fitness of the phenotype. Here we study how this dynamical system is robust to noise during development and to genetic change by mutation. We adopt a simplified transcription regulation network model to govern gene expression, which gives a fitness function. Through simulations of the network that undergoes mutation and selection, we show that a certain level of noise in gene expression is required for the network to acquire both types of robustness. The results reveal how the noise that cells encounter during development shapes any network's robustness, not only to noise but also to mutations. We also establish a relationship between developmental and mutational robustness through phenotypic variances caused by genetic variation and epigenetic noise. A universal relationship between the two variances is derived, akin to the fluctuation-dissipation relationship known in physics

Using ‘sport in the community schemes’ to tackle crime and drug use among young people: Some policy issues and problems

This is a PDF version of an article published in European physical education review © Sage, 2004. The definitive version is available at www.sagepub.com.This article discusses the effectiveness of sport in the community schemes such as the Positive Futures initative and Summer Splsh/Splash Extra in reducing crime and drug use amongst young people

Mapping between dissipative and Hamiltonian systems

Theoretical studies of nonequilibrium systems are complicated by the lack of a general framework. In this work we first show that a transformation introduced by Ao recently (J. Phys. A {\bf 37}, L25 (2004)) is related to previous works of Graham (Z. Physik B {\bf 26}, 397 (1977)) and Eyink {\it et al.} (J. Stat. Phys. {\bf 83}, 385 (1996)), which can also be viewed as the generalized application of the Helmholtz theorem in vector calculus. We then show that systems described by ordinary stochastic differential equations with white noise can be mapped to thermostated Hamiltonian systems. A steady-state of a dissipative system corresponds to the equilibrium state of the corresponding Hamiltonian system. These results provides a solid theoretical ground for corresponding studies on nonequilibrium dynamics, especially on nonequilibrium steady state. The mapping permits the application of established techniques and results for Hamiltonian systems to dissipative non-Hamiltonian systems, those for thermodynamic equilibrium states to nonequilibrium steady states. We discuss several implications of the present work.Comment: 18 pages, no figure. final version for publication on J. Phys. A: Math & Theo