Integración LDAP con el Servicio PAPI

Sección: SolucionesEl servicio PAPI es el protocolo de autenticación que emplea la Red de Bibliotecas del CSIC para que cualquier usuario de la institución pueda acceder a los recursos electrónicos desde cualquier lugar y a cualquier hora bajo reconocimiento de usuario y contraseña. El objetivo es hacer coincidir las credenciales de acceso al Servicio PAPI con los datos que maneja el Directorio de datos de la Institución y por otro lado integrar casi de forma automática al Servicio PAPI a todas las personas que se integren en la plantilla del CSIC.N

Numerical Simulation of Fish Passage Over a Weir

Downstream migration over weir structures has been a mostly neglected element of ecological continuity in the last decades. The guidelines currently applied in Germany to prevent damage to fish do not sufficiently consider the conditions present at weirs. To improve knowledge of the risks of fish passage over a weir due to physical strike, pressure changes and shear stress, a numerical method using the three-dimensional computational fluid dynamics package OpenFOAM® was developed to simulate fish passage over a weir by tracking passively transported particles. In this study, the method is tested on an overshot and an undershot weir and the results are compared to known critical parameters to assess the hazard potential of these weirs. As expected, pressure changes are much more relevant in the undershot scenario, physical strike and shear stress are dominant in the overshot scenario. Altogether both situations result in only collisions with low impact velocities and relatively low shear stress and pressure changes, assuming little threat to fish due to the relatively low drop height and absence of baffle blocks or an end sill. To improve the methods reliability, additional enhancements are necessary

Damage analysis and fracture toughness evaluation in a thin woven composite laminate under static tension using infrared thermography

This work deals with the issue of damage growth in thin woven composite laminates subjected to tensile loading. The conducted tensile tests were monitored on-line with an infrared camera, and tested specimens were analysed using Scanning Electron Microscopy (SEM). Combined with SEM micrographs, observation of heat source fields enabled us to assess the damage sequence. Transverse weft cracking was confirmed to be the main damage mode and fiber breakage was the final damage leading to failure. For cracks which induce little variation of specimen stiffness, the classic “Compliance method” could not be used to compute energy release rate. Hence, we present here a new procedure based on the estimation of heat source fields to calculate the energy release rate associated with transverse weft cracking. The results are then compared to those computed with a simple 3D inverse model of the heat diffusion problem and those presented in the literature

Preliminary measurements of lumbar spine kinematics and stiffness

The purpose of the presented study was the experimental measurement of lumbar spine stiffness and its range of motion. The dependence of torsion moment of lumbar spine segment on deflection of flexion, extension and torsion was observed during experiments. Stiffness of spine segment was determined from measured data. Human lumbar spine was used for verification of the experimental technique. The sample consisted of one lumbar vertebrae composed by five vertebral bodies and four intervertebral discs. All muscles were removed, however all ligaments were preserved. Experiments were ca rried out on the test system MTS 858.2 MiniBionix, where loading by axial force and torsion moment is possible at the same time. Special Modular Bionix Spine Test Fixator, attached to the test system was used for the measurements. Loading was controlled kinematically (gradual turning) by keeping the axial force equal zero. Measurement was timedependent. The results of these experiments are going to be used as input data for creating a model of artificial lumbar spine and new type of artificial disc replacement

Class I histone deacetylases 1, 2 and 3 are highly expressed in renal cell cancer

Background Enhanced activity of histone deacetylases (HDAC) is associated with more aggressive tumour behaviour and tumour progression in various solid tumours. The over-expression of these proteins and their known functions in malignant neoplasms has led to the development of HDAC inhibitors (HDI) as new anti-neoplastic drugs. However, little is known about HDAC expression in renal cell cancer. Methods We investigated the expression of HDAC 1, 2 and 3 in 106 renal cell carcinomas and corresponding normal renal tissue by immunohistochemistry on tissue micro arrays and correlated expression data with clinico-pathological parameters including patient survival. Results Almost 60% of renal cell carcinomas expressed the HDAC isoforms 1 and 2. In contrast, HDAC 3 was only detected in 13% of all renal tumours, with particular low expression rates in the clear cell subtype. HDAC 3 was significantly higher expressed in pT1/2 tumours in comparison to pT3/4 tumours. Expression of class I HDAC isoforms correlated with each other and with the proliferative activity of the tumours. We found no prognostic value of the expression of any of the HDAC isoforms in this tumour entity. Conclusion Class I HDAC isoforms 1 and 2 are highly expressed in renal cell cancer, while HDAC 3 shows low, histology dependent expression rates. These unexpected differences in the expression patterns suggests alternative regulatory mechanisms of class I HDACs in renal cell cancer and should be taken into account when trials with isoform selective HDI are being planned. Whether HDAC expression in renal cancers is predictive of responsiveness for HDI will have to be tested in further studies

The Impact of Harvesting and Site Preparation on Stormflow and Water Quality in East Texas

In 1979, nine small forested watersheds were instrumented in East Texas to determine the effect of intensive forest management practices on water quantity and quality. Three replications of three treatments were used: 1) clearcutting - followed by shearing ant windrowing, 2) clearcutting - followed by roller chopping and 3) undisturbed control. Following treatment, the sheared and windrowed sites exposed 57% of the surface soil compared to 16% for the chopped watersheds. During 1981, the first year after treatment, stormflow volumes increased with the intensity of the site disturbance. Sites sheared produced the greatest amount of stormflow (5.76 inches), followed by chopped (3.26 inches) and the undisturbed watersheds (1.03 inches). Stormflow volumes decreased 66% and 57% on the sheared and chopped watersheds the second year following treatment. Stormflow volumes in 1983 were 2.46, 1.75 and 0.84 inches for the sheared, chopped and control watersheds, respectively. Sediment losses were significantly higher on the sheared watersheds (2,620 lb/acre) than the chopped (22 lb/acre), during 1981. By the fall of 1982, the exposure of mineral soil on the sheared sites decreased to 20% and to 4% on the chopped sites. For this reason and the lower volume of runoff, sediment loss for 1982 dropped to 71.3, 4.9 and 4.5 lb/acre for the sheared, chopped and undisturbed watersheds, respectively. Sediment losses in the third year following treatment continued decreasing on the sheared sites (30.9) and remained approximately the same on the chopped and control sites. Nitrate concentrations were significantly different between treatments during 1981: Sheared - 205 ppb, chopped - 96 ppb and control ~ 10 ppb. During 1982, although nitrate concentrations were lower, the sheared watersheds still had a significantly higher concentration. Nitrate concentrations in 1983 remained low at 54, 20 and 10 ppb for the sheared, chopped and control watersheds, respectively. Total nitrogen concentration on the sheared sites was 2,155 ppb, which was significantly higher than the chopped (999 ppb) or the control sites (996 ppb) for 1981. The first year total nitrogen export from the sheared sites (2.79 lb/acre) was 3.5 times greater than the chopped loss (0.76 lb/acre) and 12 times greater than the loss on the control sites (0.24 lb/acre). The second year following treatment, total nitrogen concentrations were not significantly different and total nitrogen loss on the sheared areas was less than half of the loss recorded from the control sites during 1981. Total nitrogen loss in the third year after treatment was reduced to 0.37, 0.20 and 0.08 lb/ acre for the sheared, chopped and control treatments, respectively. Total phosphorus concentrations for 1981 were 221, 85 and 54 ppb for the sheared, chopped and control watersheds, respectively. Total phosphorus loss for this period was only 0.297 lb/acre from the sheared treatments, but was significantly higher than the chopped or undisturbed treatments. A drop in sediment concentrations and runoff in 1982 reduced phosphorus losses on the sheared watersheds by over 90%. Total phosphorus export in 1983 decreased on sheared sites (0.019 lb/acre), but increased slightly on chopped (0.011 lb/acre) and control sites (0.006 lb/acre). Calcium, potassium and sodium concentrations during 1981, were highest for the chopped treatments, while magnesium concentrations were highest on the sheared treatments. Export of these elements was greatest from the sheared sites, except for calcium, which was lost in greater quantities on the chopped sites. During 1982 there was no significant difference between treatments for Ca, Mg, K and Na concentrations. Cation concentrations and losses on the treated watersheds continued declining in the third year following treatment. Increases in stormflow and sediment and nutrient losses appear to be temporary on sheared and chopped treatments. Rapid revegetation established surface cover and reduced mineral soil exposure. As the stabilization of sites continues, treatment differences should diminish. Limiting shearing and windrowing activities to the more gentle slopes will reduce first year erosion and prevent increases in sediment and nutrient losses. Roller chopping on the other hand, appears to cause only minor changes to water yield and quality on slopes of up to 25%

Anticholinergic medications in patients admitted with cognitive impairment or falls (AMiCI). The impact of hospital admission on anticholinergic cognitive medication burden. Results of a multicentre observational study

What is known and objectiveDrugs with anticholinergic properties increase the risk of falls, delirium, chronic cognitive impairment, and mortality and counteract procholinergic medications used in the treatment of dementia. Medication review and optimisation to reduce anticholinergic burden in patients at risk is recommended by specialist bodies. Little is known how effective this review is in patients who present acutely and how often drugs with anticholinergic properties are used temporarily during an admission. The aim of the study was to describe the changes in the anticholinergic cognitive burden (ACB) in patients admitted to hospital with a diagnosis of delirium, chronic cognitive impairment or falls and to look at the temporary use of anticholinergic medications during hospital stay. MethodsThis is a multi-centre observational study that was conducted in seven different hospitals in the UK, Finland, The Netherlands and Italy. Results and discussion21.1% of patients had their ACB score reduced by a mean of 1.7%, 19.7% had their ACB increased by a mean of 1.6%, 22.8% of DAP naive patients were discharged on anticholinergic medications. There was no change in the ACB scores in 59.2% of patients. 54.1% of patients on procholinergics were taking anticholinergics. Out of the 98 medications on the ACB scale, only 56 were seen. Medications with a low individual burden were accounting for 64.9% of the total burden. Anticholinergic drugs were used temporarily during the admission in 21.9% of all patients. A higher number of DAPs used temporarily during admission was associated with a higher risk of ACB score increase on discharge (OR=1.82, 95% CI for OR: 1.36-2.45, P What is new and conclusionThere was no reduction in anticholinergic cognitive burden during the acute admissions. This was the same for all diagnostic subgroups. The anticholinergic load was predominantly caused by medications with a low individual burden. More than 1 in 5 patients not taking anticholinergics on admission were discharged on them and similar numbers saw temporary use of these medications during their admission. More than half of patients on cholinesterase-inhibitors were taking anticholinergics at the same time on admission, potentially directly counteracting their effects.Peer reviewe