MM4Drone: A Multi-spectral Image and mmWave Radar Approach for Identifying Mosquito Breeding Grounds via Aerial Drones

Mosquitoes spread diseases such as Dengue and Zika that affect a significant portion of the world population. One approach to hamper the spread of the diseases is to identify the mosquitoes' breeding places. Recent studies use drones to detect breeding sites, due to their low cost and flexibility. In this paper, we investigate the applicability of drone-based multi-spectral imagery and mmWave radios to discover breeding habitats. Our approach is based on the detection of water bodies. We introduce our Faster R-CNN-MSWD, an extended version of the Faster R-CNN object detection network, which can be used to identify water retention areas in both urban and rural settings using multi-spectral images. We also show promising results for estimating extreme shallow water depth using drone-based multi-spectral images. Further, we present an approach to detect water with mmWave radios from drones. Finally, we emphasize the importance of fusing the data of the two sensors and outline future research directions

Legionella pneumonia as a cause of atypical pneumonia in a tertiary care hospital in Sri Lanka

Atypical pneumonia which contributes to an important proportion of community acquired pneumonia and Legionella pneumophila is a noteworthy pathogen worldwide. Legionnaires’ disease, the severe form of pneumonia is predominantly caused by Legionella pneumophila serogroup 1. This study was conducted to determine the presence of Legionella pneumophila as a pathogen and the associated risk factors among the patients admitted with atypical pneumonia to a tertiary care hospital in Sri Lanka. Seventy-five adult patients diagnosed with atypical pneumonia attending professorial medical unit of Colombo South Teaching Hospital, Sri Lanka were enrolled. Risk factors related to the disease was assessed by an interviewer administered questionnaire. Expectorated sputum was processed on supplemented buffered charcoal yeast extract medium and urine specimens were tested for Legionella pneumophila serogroup 1 antigen. Fifty-six percent of the patients were males and 91% were residing in urban areas. Smoking was admitted by 32% and that of alcohol consumption was in 25%. Composting and potting, distant travelling and frequent use of air conditioning was reported in 28%, 37% and 4% respectively. Majority of participants were not exposed to cooling towers, humidifiers or plumbing and not visited high risk areas. Among the study group, 21% had diabetes, 24% had ischaemic heart disease and 36% had chronic lung diseases. None of the sputum samples grew Legionella pneumophila, and all urine samples were negative for the antigen of Legionella pneumophila serogroup 1. It is concluded that, in this population of community acquired atypical pneumonia, Legionella pneumophila was not identified as a causative agent. KEYWORDS: Atypical pneumonia, community acquired pneumonia, Legionella pneumophil

Reduction of seafood processing wastewater using technologies enhanced by swim–bed technology

The increasing growth of the seafood processing industries considerably requires more industrial process activities and water consumption. It is estimated that approximately 10–40 m3 of wastewater is generated from those industries for processing one-tonne of raw materials. Due to limitations and regulations in natural resources utilization, a suitable and systematic wastewater treatment plant is very important to meet rigorous discharge standards. As a result of food waste biodegradability, the biological treatment and some extent of swim-bed technology, including a novel acryl-fibre (biofilm) material might be used effectively to meet the effluent discharge criteria. This chapter aims to develop understanding on current problems and production of the seafood wastewater regarding treatment efficiency and methods of treatment

Human stomach microbiota: Effects on health and disease

The gut microbiota is a complex ecological community, consisting of trillions of microbes which include bacteria, viruses, fungi and protozoa. The stomach was previously considered as a sterile site uninhabited by microbes due to its hostile environmental conditions. Breaking this concept, Helicobacter pylori was the first pathogen reported to inhabit the stomach. Recent studies have suggested that the stomach harbours transient as well as certain commensal bacterial and fungal species. The five major microbial phyla in the stomach have been identified as Firmicutes, Bacteroidetes, Actinobacteria, Fusobacteria and Proteobacteria. The composition of gastric microbiota is dynamic and is affected by several factors.  These include age group, dietary habits, medication use, inflammation of gastric mucosa and H. pylori colonization.  Further, the role of host genetics has recently been studied in maintaining the stomach microbiota. Mutations in host genes may affect the host’s immune response towards commensal bacteria and reduce their number and diversity. The essential multiple roles of gut microorganisms include maintaining homeostasis in the gut, contributing to immune function and extraction of nutrients and energy from our diets.  Loss of the normal balance between the gut microbiota and host has been associated with several abnormal conditions and disorders such as obesity, malnutrition, inflammatory bowel diseases (IBD), neurological disorders, and cancer. In the stomach, the interaction between H. pylori and the gastric microbiota can also influence gastric dis­ease progression. Further studies should focus on addressing the role of gastric dysbiosis in health and disease. Identifying gastric microbiota is essential to understand how the gut microbiota and H. pylori affect health and disease.</p

What do stroke survivors' value about participating in research and what are the most important research problems related to stroke or transient ischemic attack (TIA)? A survey

Background: Recruitment to stroke clinical trials is challenging, but consumer registers can facilitate participation. Researchers need to understand the key factors that facilitate trial involvement and improve consumer partnerships to identify what research topics important to stroke and transient ischemic attack (TIA) survivors and their carers. We aimed to examine i) the experience of being involved in a stroke research register, and ii) the priorities for stroke research from the perspective of stroke survivors. Methods: Online and paper-based surveys were sent directly to members of a stroke register and disseminated online. Multiple choice questions were reported as counts and percentages and open-ended questions were thematically analysed using Braun and Clarke’s 6-stage process. Results: Of 445 survey respondents, 154 (38%) were a member of the Stroke Research Register. The most frequently reported reason for research participation was to help others in the future. Respondents reported they were less likely to take part in research if the research question was not relevant to them, if transport was an issue, or because they lacked time. The most important research problems reported were targeting specific impairments including recovery of movement, fatigue, and aphasia, improvement of mental health services, and increased support for carers. Conclusions: Recruitment to trials may be improved by research registers if an inclusive research culture is fostered, in which consumers feel valued as members of a community, have direct and timely access to research findings and the opportunity to be meaningfully involved in research around the problems that consumers find most important.Ishanka Weerasekara, Jasmine Baye, Meredith Burke, Gary Crowfoot, Gillian Mason, Rachael Peak, Dawn Simpson, Frederick Rohan Walker, Michael Nilsson, Michael Pollack, and Coralie Englis

Structure-Based Exploration and Exploitation of the S4 Subsite of Norovirus 3CL Protease in the Design of Potent and Permeable Inhibitors

Human noroviruses are the primary cause of epidemic and sporadic acute gastroenteritis. The worldwide high morbidity and mortality associated with norovirus infections, particularly among the elderly, immunocompromised patients and children, constitute a serious public health concern. There are currently no approved human vaccines or norovirus-specific small-molecule therapeutics or prophylactics. Norovirus 3CL protease has recently emerged as a potential therapeutic target for the development of anti-norovirus agents. We hypothesized that the S4 subsite of the enzyme may provide an effective means of designing potent and cell permeable inhibitors of the enzyme. We report herein the structure-guided exploration and exploitation of the S4 subsite of norovirus 3CL protease in the design and synthesis of effective inhibitors of the protease

Wage Differential Compensation Can Women Be Economically Empowered? Empirical Evidence From South Asia

Purpose- This study investigates the responsiveness of South Asian women to wage increment at the macro level and examines the South Asian women's sensitivity on compensating wage differentials in terms of economic empowerment of women in the South Asian region at the micro-level. Design/methodology/approach – In the macro level analysis, the model used annual time series data from four South Asian countries; Sri Lanka, India, Pakistan and Bangladesh over the period of 2000 to 2017. Micro-level analysis of the study was done with the use of primary data gained through a questionnaire survey from the same sample countries and it covers the economic advancement and power and agency dimensions of women's economic empowerment. The women's wage compensation sensitivity index (WWCSI) constructed based on the survey results was used to build up the relationship between wage differential compensation and women's economic empowerment. Findings – According to the results of macro level analysis of this study, wage is a key determinant of female labor force participation. Findings of micro level analysis suggest that compensating wage differentials is a strong tool that can economically empower South Asian women. It further shows that estate females are less sensitive to wage differential compensation than rural and urban females. And educated females show greater sensitivity for wage differential compensation than non-educated females. This research also identified relatively low wage differential compensation sensitivity in terms of power and agency compared to the economic advancement dimension in women's economic empowerment. Originality/value – These findings support the view that wage differential compensation is “gendered”, and therefore, requires a special program to economically empower females