Synthesis of 2-azidoethyl α-d-mannopyranoside orthogonally protected and selective deprotections

4 páginas, 1 figura, 2 esquemas.We present the synthesis of a fully orthogonally protected mannosyl glycoside 1 and the corresponding methods for selective deprotections. Mannosyl glycoside 1 contains a functionalized linker at the anomeric position to allow for the attachment of carbohydrate units to scaffolds in order to prepare carbohydrate multivalent systems.We would like to thank FIS (PI030093), for financial supportPeer reviewe

Dobutamine stress echocardiography in healthy adult male rats

<p>Abstract</p> <p>Background</p> <p>Dobutamine stress echocardiography is used to investigate a wide variety of heart diseases in humans. Dobutamine stress echocardiography has also been used in animal models of heart disease despite the facts that the normal response of healthy rat hearts to this type of pharmacological stress testing is unknown. This study was performed to assess this normal response.</p> <p>Methods</p> <p>15 normal adult male Wistar rats were evaluated. Increasing doses of dobutamine were infused intravenously under continuous imaging of the heart by a 12 MHz ultrasound probe.</p> <p>Results</p> <p>Dobutamine stress echocardiography reduced gradually LV diastolic and systolic dimensions. Ejection fraction increased by a mean of +24% vs. baseline. Heart rate increased progressively without reaching a plateau. Changes in LV dimensions and ejection fraction reached a plateau after a mean of 4 minutes at a constant infusion rate.</p> <p>Conclusion</p> <p>DSE can be easily performed in rats. The normal response is an increase in heart rate and ejection fraction and a decrease in LV dimensions. A plateau in echocardiographic measurements is obtained after 4 minutes of a constant infusion rate in most animals.</p

Measurement of hadron and lepton-pair production at 161 GeV<root s<172 GeV at LEP

Contains fulltext : 26256.pdf (publisher's version ) (Open Access

Searches for scalar top and scalar bottom quarks in e(+)e(-) interactions at 161GeV &lt;=root s &lt;= 183GeV

Searches for scalar top and scalar bottom quarks have been performed at center-of-mass energies between 161 GeV and 183 GeV using the L3 detector at LEP. No signal is observed. Model-independent limits on production cross sections are determined for the two decay channels t̃1 → cχ̃0 1 and b̃1 → b χ̃0 1. Within the framework of the Minimal Supersymmetric extension of the Standard Model mass limits are derived. For mass differences between t̃1 and χ̃0 1 greater than 10 GeV a 95% C.L. limit of 81.5 GeV is set on the mass of the Supersymmetric partner of the left-handed top. A supersymmetric partner of the left-handed bottom with a mass below 80 GeV is excluded at 95% C.L. if the mass difference between b̃1 and χ̃1 is greater than 20 GeV. © 1999 Published by Elsevier Science B.V. All rights reserved