366 research outputs found
Apparent finite-size effects in the dynamics of supercooled liquids
Molecular dynamics simulations are performed for a supercooled simple liquid
with changing the system size from N=108 to to examine possible
finite-size effects. Although almost no systematic deviation is detected in the
static pair correlation functions, it is demonstrated that the structural
relaxation in a small system becomes considerably slower than that in
larger systems for temperatures below at which the size of the
cooperative particle motions becomes comparable to the unit cell length of the
small system. The discrepancy increases with decreasing temperature.Comment: 4 pages 5 figure
Single Spin Measurement using Single Electron Transistors to Probe Two Electron Systems
We present a method for measuring single spins embedded in a solid by probing
two electron systems with a single electron transistor (SET). Restrictions
imposed by the Pauli Principle on allowed two electron states mean that the
spin state of such systems has a profound impact on the orbital states
(positions) of the electrons, a parameter which SET's are extremely well suited
to measure. We focus on a particular system capable of being fabricated with
current technology: a Te double donor in Si adjacent to a Si/SiO2 interface and
lying directly beneath the SET island electrode, and we outline a measurement
strategy capable of resolving single electron and nuclear spins in this system.
We discuss the limitations of the measurement imposed by spin scattering
arising from fluctuations emanating from the SET and from lattice phonons. We
conclude that measurement of single spins, a necessary requirement for several
proposed quantum computer architectures, is feasible in Si using this strategy.Comment: 22 Pages, 8 Figures; revised version contains updated references and
small textual changes. Submitted to Phys. Rev.
Meditation-induced bliss viewed as release from conditioned neural (thought) patterns that block reward signals in the brain pleasure center
The nucleus accumbens orchestrates processes related to reward and pleasure,
including the addictive consequences of repeated reward (e.g., drug addiction and
compulsive gambling) and the accompanying feelings of craving and anhedonia.
The neurotransmitters dopamine and endogenous opiates play interactive roles in
these processes. They are released by natural rewards (i.e., food, water, sex, money,
play, etc.) and are released or mimicked by drugs of abuse. Repeated drug use
induces conditioned down-regulation of these neurotransmitters, thus causing
painful suppression of everyday pleasure. As with many spiritual traditions,
Buddhism provides strong advice against the pursuit of worldly pleasures to
attain the ‘‘good life.’’ In contrast, many forms of meditation give rise to an
immense and abiding joy. Most of these practices involve ‘‘stilling the mind,’’
whereby all content-laden thought (e.g., fantasies, daydreams, plans) ceases, and
the mind enters a state of openness, formlessness, clarity, and bliss. This can be
explained by the Buddhist suggestion that almost all of our everyday thoughts are
a form of addiction. It follows that if we turn off this internal ‘‘gossip of ego,’’ we
will find relief from the biochemical dopamine/opiate down-regulation, which is,
perhaps, the perpetual concomitant of our daily rumination
Nacubactam enhances meropenem activity against carbapenem-resistant klebsiella pneumoniae producing KPC
Carbapenem-resistant Enterobacteriaceae (CRE) are resistant to most antibiotics, making CRE infections extremely difficult to treat with available agents. Klebsiella pneumoniae carbapenemases (KPC-2 and KPC-3) are predominant carbapenemases in CRE in the United States. Nacubactam is a bridged diazabicyclooctane (DBO) -lactamase inhibitor that inactivates class A and C -lactamases and exhibits intrinsic antibiotic and -lactam “enhancer” activity against Enterobacteriaceae. In this study, we examined a collection of meropenem-resistant K. pneumoniae isolates carrying blaKPC-2 or blaKPC-3; meropenem-nacubactam restored susceptibility. Upon testing isogenic Escherichia coli strains producing KPC-2 variants with single-residue substitutions at important Ambler class A positions (K73, S130, R164, E166, N170, D179, K234, E276, etc.), the K234R variant increased the meropenem-nacubactam MIC compared to that for the strain producing KPC-2, without increasing the meropenem MIC. Correspondingly, nacubactam inhibited KPC-2 (apparent Ki [Kiapp] 31 3 M) more efficiently than the K234R variant (Kiapp 270 27 M) and displayed a faster acylation rate (k2/K), which was 5,815 582 M1 s1 for KPC-2 versus 247 25 M1 s1 for the K234R variant. Unlike avibactam, timed mass spectrometry revealed an intact sulfate on nacubactam and a novel peak (337 Da) with the K234R variant. Molecular modeling of the K234R variant showed significant catalytic residue (i.e., S70, K73, and S130) rearrangements that likely interfere with nacubactam binding and acylation. Nacubactam’s aminoethoxy tail formed unproductive interactions with the K234R variant’s active site. Molecular modeling and docking observations were consistent with the results of biochemical analyses. Overall, the meropenem-nacubactam combination is effective against carbapenem-resistant K. pneumoniae. Moreover, our data suggest that -lactamase inhibition by nacubactam proceeds through an alternative mechanism compared to that for avibactam
Nontuberculous mycobacteria: I: Multicenter prevalence study in cystic fibrosis
Nontuberculous mycobacteria (NTM) are potential respiratory pathogens in cystic fibrosis (CF). To assess the species-specific prevalence and risk factors for acquisition, we conducted a prospective, cross-sectional study of the prevalence of NTM and clinical features of patients at 21 U.S. centers. Almost 10% of patients with CF who were 10 years or older were included (n = 986). The overall prevalence of NTM in sputum was 13.0% (range by center, 7-24%). Mycobacterium avium complex (72%) and Mycobacterium abscessus (16%) were the most common species. When compared with patients with CF without NTM, culture-positive subjects were older (26 vs. 22 years, p < 0.001), had a higher FEV1 (60 vs. 54%, p 0.01), higher frequency of Staphylococcus aureus (43 vs. 31%, p 0.01), and lower frequency of Pseudomonas aeruginosa (71 vs. 82%, p < 0.01). Molecular typing revealed that almost all patients within each center had unique NTM strains. In summary, NTM are common in patients with CF, but neither person-to-person nor nosocomial acquisition explained the high prevalence. Older age was the most significant predictor for isolation of NTM. The clinical significance of NTM in CF is incompletely defined, but patients with these organisms should be monitored with repeat cultures
Localization of thyrotropin-releasing hormone receptor and thyrotroph embryonic factor on mouse Chromosome 15
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/46999/1/335_2004_Article_BF00361398.pd
Study of the production of and hadrons in collisions and first measurement of the branching fraction
The product of the () differential production
cross-section and the branching fraction of the decay () is
measured as a function of the beauty hadron transverse momentum, ,
and rapidity, . The kinematic region of the measurements is and . The measurements use a data sample
corresponding to an integrated luminosity of collected by the
LHCb detector in collisions at centre-of-mass energies in 2011 and in 2012. Based on previous LHCb
results of the fragmentation fraction ratio, , the
branching fraction of the decay is
measured to be \begin{equation*} \mathcal{B}(\Lambda_b^0\rightarrow J/\psi
pK^-)= (3.17\pm0.04\pm0.07\pm0.34^{+0.45}_{-0.28})\times10^{-4},
\end{equation*} where the first uncertainty is statistical, the second is
systematic, the third is due to the uncertainty on the branching fraction of
the decay , and the
fourth is due to the knowledge of . The sum of the
asymmetries in the production and decay between and
is also measured as a function of and .
The previously published branching fraction of , relative to that of , is updated.
The branching fractions of are determined.Comment: 29 pages, 19figures. All figures and tables, along with any
supplementary material and additional information, are available at
https://lhcbproject.web.cern.ch/lhcbproject/Publications/LHCbProjectPublic/LHCb-PAPER-2015-032.htm
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