Unit bar architecture in a highly‐variable fluvial discharge regime: Examples from the Burdekin River, Australia

Unit bars are relatively large bedforms that develop in rivers over a wide range of climatic regimes. Unit bars formed within the highly-variable discharge Burdekin River in Queensland, Australia, were examined over three field campaigns between 2015 and 2017. These bars had complex internal structures, dominated by co-sets of cross-stratified and planar-stratified sets. The cross-stratified sets tended to down-climb. The development of complex internal structures was primarily a result of three processes: (i) superimposed bedforms reworking the unit bar avalanche face; (ii) variable discharge triggering reactivation surfaces; and (iii) changes in bar growth direction induced by stage change. Internal structures varied along the length and across the width of unit bars. For the former, down-climbing cross-stratified sets tended to pass into single planar cross-stratified deposits at the downstream end of emergent bars; such variation related to changes in fluvial conditions whilst bars were active. A hierarchy of six categories of fluvial unsteadiness is proposed, with these discussed in relation to their effects on unit bar (and dune) internal structure. Across-deposit variation was caused by changes in superimposed bedform and bar character along bar crests; such changes related to the three-dimensionality of the channel and bar geometry when bars were active. Variation in internal structure is likely to be more pronounced in unit bar deposits than in smaller bedform (for example, dune) deposits formed in the same river. This is because smaller bedforms are more easily washed out or modified by changing discharge conditions and their smaller dimensions restrict the variation in flow conditions that occur over their width. In regimes where unit bar deposits are well-preserved, their architectural variability is a potential aid to their identification. This complex architecture also allows greater resolution in interpreting the conditions before and during bar initiation and development

Lives versus Livelihoods? Perceived economic risk has a stronger association with support for COVID-19 preventive measures than perceived health risk

This paper examines whether compliance with COVID-19 mitigation measures is motivated by wanting to save lives or save the economy (or both), and which implications this carries to fight the pandemic. National representative samples were collected from 24 countries (N = 25,435). The main predictors were (1) perceived risk to contract coronavirus, (2) perceived risk to suffer economic losses due to coronavirus, and (3) their interaction effect. Individual and country-level variables were added as covariates in multilevel regression models. We examined compliance with various preventive health behaviors and support for strict containment policies. Results show that perceived economic risk consistently predicted mitigation behavior and policy support—and its effects were positive. Perceived health risk had mixed effects. Only two significant interactions between health and economic risk were identified—both positive

Identifying important individual‐ and country‐level predictors of conspiracy theorizing: a machine learning analysis

Psychological research on the predictors of conspiracy theorizing—explaining important social and political events or circumstances as secret plots by malevolent groups—has flourished in recent years. However, research has typically examined only a small number of predictors in one, or a small number of, national contexts. Such approaches make it difficult to examine the relative importance of predictors, and risk overlooking some potentially relevant variables altogether. To overcome this limitation, the present study used machine learning to rank-order the importance of 115 individual- and country-level variables in predicting conspiracy theorizing. Data were collected from 56,072 respondents across 28 countries during the early weeks of the COVID-19 pandemic. Echoing previous findings, important predictors at the individual level included societal discontent, paranoia, and personal struggle. Contrary to prior research, important country-level predictors included indicators of political stability and effective government COVID response, which suggests that conspiracy theorizing may thrive in relatively well-functioning democracies

Tumor-Associated Macrophages Promote Invasion while Retaining Fc-Dependent Anti-Tumor Function

Abstract Tumor-associated macrophages (TAMs) have been shown to promote tumor progression, and increased TAM infiltration often correlates with poor prognosis. However, questions remain regarding the phenotype of macrophages within the tumor and their role in mAb-dependent cytotoxicity. This study demonstrates that whereas TAMs have protumor properties, they maintain Fc-dependent anti-tumor function. CD11b+CD14+ TAMs isolated from primary human breast tumors expressed activating FcγRs. To model breast cancer TAMs in vitro, conditioned medium from breast cancer cells was used to drive human peripheral monocyte differentiation into macrophages. Tumor-conditioned macrophages were compared with in vitro derived M1 and M2a macrophages and were found to promote tumor cell invasion and express M2a markers, confirming their protumor potential. However, unlike M2a macrophages, tumor-conditioned macrophages expressed FcγRs and phagocytosed tumor cells in the presence of a tumor Ag-targeting mAb, unmasking an underappreciated tumoricidal capacity of TAMs. In vivo macrophage depletion reduced the efficacy of anti-CD142 against MDA-MB-231 xenograft growth and metastasis in SCID/beige mice, implicating a critical role for macrophages in Fc-dependent cell killing. M-CSF was identified in tumor-conditioned media and shown to be capable of differentiating macrophages with both pro- and anti-tumor properties. These results highlight the plasticity of TAMs, which are capable of promoting tumor progression and invasion while still retaining tumoricidal function in the presence of tumor-targeting mAbs.</jats:p