Service quality, experiential value and repurchase intention for medical cosmetology clinic: Moderated effect of generation

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Radiative Corrections to Fixed Target Moller Scattering Including Hard Bremsstrahlung Effects

We present a calculation of the complete $O(\alpha)$ electroweak radiative corrections to the Moller scattering process e^-e^- -> e^-e^-, including hard bremsstrahlung contributions. We study the effects of these corrections on both the total cross section and polarization asymmetry measured in low energy fixed target experiments. Numerical results are presented for the experimental cuts relevant for E-158, a fixed target e^-e^- experiment being performed at SLAC; the effect of hard bremsstrahlung is to shift the measured polarization asymmetry by approximately +4%. We briefly discuss the remaining theoretical uncertainty in the prediction for the low energy Moller scattering polarization asymmetry.Comment: 22 pgs; minor clarifications added and typos fixe

Effect of Phosphorus and Strontium Additions on Formation Temperature and Nucleation Density of Primary Silicon in Al-19 Wt Pct Si Alloy and Their Effect on Eutectic Temperature

The influence of P and Sr additions on the formation temperature and nucleation density of primary silicon in Al-19 wt pct Si alloy has been determined, for small volumes of melt solidified at cooling rates _T of ~0.3 and 1 K/s. The proportion of ingot featuring primary silicon decreased progressively with increased Sr addition, which also markedly reduced the temperature for first formation of primary silicon and the number of primary silicon particles per unit volume �Nv: When combined with previously published results, the effects of amount of P addition and cooling rate on �Nv are in reasonable accord with �Nv� _T ¼ ðp=6fÞ1=2 109 [250 � 215 (wt pct P)0.17]�3, where �Nv is in mm�3, _T is in K/s, and f is volume fraction of primary silicon. Increased P addition reduces the eutectic temperature, while increased Sr appears to generate a minimum in eutectic temperature at about 100 ppmw Sr

The Simplest Little Higgs

We show that the SU(3) little Higgs model has a region of parameter space in which electroweak symmetry breaking is natural and in which corrections to precision electroweak observables are sufficiently small. The model is anomaly free, generates a Higgs mass near 150 GeV, and predicts new gauge bosons and fermions at 1 TeV.Comment: 13 pages + appendix, typos corrected, version to appear in JHE

The NuTeV Anomaly, Neutrino Mixing, and a Heavy Higgs Boson

Recent results from the NuTeV experiment at Fermilab and the deviation of the Z invisible width, measured at LEP/SLC, from its Standard Model (SM) prediction suggest the suppression of neutrino-Z couplings. Such suppressions occur naturally in models which mix the neutrinos with heavy gauge singlet states. We postulate a universal suppression of the Z-nu-nu couplings by a factor of (1-epsilon) and perform a fit to the Z-pole and NuTeV observables with epsilon and the oblique correction parameters S and T. Compared to a fit with S and T only, inclusion of epsilon leads to a dramatic improvement in the quality of the fit. The values of S and T preferred by the fit can be obtained within the SM by a simple increase in the Higgs boson mass. However, if the W mass is also included in the fit, a non-zero U parameter becomes necessary which cannot be supplied within the SM. The preferred value of epsilon suggests that the seesaw mechanism may not be the reason why neutrinos are so light.Comment: 19 pages, REVTeX4, 8 postscript figures. Updated references. Typos correcte

Phenomenological Consequences of Singlet Neutrinos

In this paper, we study the phenomenology of right-handed neutrino isosinglets. We consider the general situation where the neutrino masses are not necessarily given by $m_D^2/M$, where $m_D$ and $M$ are the Dirac and Majorana mass terms respectively. The consequent mixing between the light and heavy neutrinos is then not suppressed, and we treat it as an independent parameter in the analysis. It turns out that $\mu-e$ conversion is an important experiment in placing limits on the heavy mass scale ($M$) and the mixing. Mixings among light neutrinos are constrained by neutrinoless double beta decay, as well as by solar and atmospheric neutrino experiments. Detailed one-loop calculations for lepton number violating vertices are provided.Comment: Revtex file,TRI-PP-94-1,VPI-IHEP-94-1, 23 pages, a compressed for 8 figures is appende

Oscillating magnetoresistance in diluted magnetic semiconductor barrier structures

Ballistic spin polarized transport through diluted magnetic semiconductor (DMS) single and double barrier structures is investigated theoretically using a two-component model. The tunneling magnetoresistance (TMR) of the system exhibits oscillating behavior when the magnetic field are varied. An interesting beat pattern in the TMR and spin polarization is found for different NMS/DMS double barrier structures which arises from an interplay between the spin-up and spin-down electron channels which are splitted by the s-d exchange interaction.Comment: 4 pages, 6 figures, submitted to Phys. Rev.

Biomarker-guided sequential targeted therapies to overcome therapy resistance in rapidly evolving highly aggressive mammary tumors

Combinatorial targeted therapies are more effective in treating cancer by blocking by-pass mechanisms or inducing synthetic lethality. However, their clinical application is hampered by resistance and toxicity. To meet this important challenge, we developed and tested a novel concept of biomarker-guided sequential applications of various targeted therapies using ErbB2-overexpressing/PTEN-low, highly aggressive breast cancer as our model. Strikingly, sustained activation of ErbB2 and downstream pathways drives trastuzumab resistance in both PTEN-low/trastuzumab-resistant breast cancers from patients and mammary tumors with intratumoral heterogeneity from genetically-engineered mice. Although lapatinib initially inhibited trastuzumab-resistant mouse tumors, tumors by-passed the inhibition by activating the PI3K/mTOR signaling network as shown by the quantitative protein arrays. Interestingly, activation of the mTOR pathway was also observed in neoadjuvant lapatinib-treated patients manifesting lapatinib resistance. Trastuzumab + lapatinib resistance was effectively overcome by sequential application of a PI3K/mTOR dual kinase inhibitor (BEZ235) with no significant toxicity. However, our p-RTK array analysis demonstrated that BEZ235 treatment led to increased ErbB2 expression and phosphorylation in genetically-engineered mouse tumors and in 3-D, but not 2-D, culture, leading to BEZ235 resistance. Mechanistically, we identified ErbB2 protein stabilization and activation as a novel mechanism of BEZ235 resistance, which was reversed by subsequent treatment with lapatinib + BEZ235 combination. Remarkably, this sequential application of targeted therapies guided by biomarker changes in the tumors rapidly evolving resistance doubled the life-span of mice bearing exceedingly aggressive tumors. This fundamentally novel approach of using targeted therapies in a sequential order can effectively target and reprogram the signaling networks in cancers evolving resistance during treatment. © 2014 IBCB, SIBS, CAS All rights reserved