Search for Solar Axions Produced in the p+d→3He+Ap + d \rightarrow\rm{^3He}+ A Reaction

A search for the axioelectric absorption of 5.5-MeV solar axions produced in the $p+d\rightarrow \rm{^3He}+\gamma(5.5 \rm{MeV})$ reaction was performed with two BGO detectors placed inside a low-background setup. A model independent limit on axion-photon and axion-nucleon couplings was obtained: $|g_{Ae}\times g_{AN}| \leq 3.2\times 10^{-9} (m_A=0)$. Constraints on the axion-electron coupling constant were obtained for axions with masses in the $(0.1-1.0)$ MeV range: $g_{Ae}\leq (1.8-9.0)\times 10^{-7}$. The solar positron flux from $A\rightarrow e^-+e^+$ decay was determined for axions with masses $m_A > 2m_e$. Using the existing experimental data on the interplanetary positron flux, a new constraint on the axion-electron coupling constant for axions with masses in the $(1.2-5.4)$ MeV range was obtained: $g_{Ae} \leq (1-5)\times 10^{-17}$.Comment: 6 pages, 5 figure

Virologic suppression and CD4 + cell count recovery after initiation of raltegravir or efavirenz-containing HIV treatment regimens

Objective: To explore the effectiveness of raltegravir-based antiretroviral therapy (ART) on treatment response among ART-naive patients seeking routine clinical care. Design: Cohort study of adults enrolled in HIV care in the United States. Methods: We compared virologic suppression and CD4 + cell count recovery over a 2.5 year period after initiation of an ART regimen containing raltegravir or efavirenz using observational data from a US clinical cohort, generalized to the US population of people with diagnosed HIV. We accounted for nonrandom treatment assignment, informative censoring, and nonrandom selection from the US target population using inverse probability weights. Results: Of the 2843 patients included in the study, 2476 initiated the efavirenz-containing regimen and 367 initiated the raltegravir-containing regimen. In the weighted intent-To-Treat analysis, patients spent an average of 74 (95% confidence interval: 41, 106) additional days alive with a suppressed viral load on the raltegravir regimen than on the efavirenz regimen over the 2.5-year study period. CD4 + cell count recovery was also superior under the raltegravir regimen. Conclusion: Patients receiving raltegravir spent more time alive and suppressed than patients receiving efavirenz, but the probability of viral suppression by 2.5 years after treatment was similar between groups. Optimizing the amount of time spent in a state of viral suppression is important to improve survival among people living with HIV and to reduce onward transmission

What can we learn from neutrinoless double beta decay experiments?

We assess how well next generation neutrinoless double beta decay and normal neutrino beta decay experiments can answer four fundamental questions. 1) If neutrinoless double beta decay searches do not detect a signal, and if the spectrum is known to be inverted hierarchy, can we conclude that neutrinos are Dirac particles? 2) If neutrinoless double beta decay searches are negative and a next generation ordinary beta decay experiment detects the neutrino mass scale, can we conclude that neutrinos are Dirac particles? 3) If neutrinoless double beta decay is observed with a large neutrino mass element, what is the total mass in neutrinos? 4) If neutrinoless double beta decay is observed but next generation beta decay searches for a neutrino mass only set a mass upper limit, can we establish whether the mass hierarchy is normal or inverted? We base our answers on the expected performance of next generation neutrinoless double beta decay experiments and on simulations of the accuracy of calculations of nuclear matrix elements.Comment: Added reference

Steiner t-designs for large t

One of the most central and long-standing open questions in combinatorial design theory concerns the existence of Steiner t-designs for large values of t. Although in his classical 1987 paper, L. Teirlinck has shown that non-trivial t-designs exist for all values of t, no non-trivial Steiner t-design with t > 5 has been constructed until now. Understandingly, the case t = 6 has received considerable attention. There has been recent progress concerning the existence of highly symmetric Steiner 6-designs: It is shown in [M. Huber, J. Algebr. Comb. 26 (2007), pp. 453-476] that no non-trivial flag-transitive Steiner 6-design can exist. In this paper, we announce that essentially also no block-transitive Steiner 6-design can exist.Comment: 9 pages; to appear in: Mathematical Methods in Computer Science 2008, ed. by J.Calmet, W.Geiselmann, J.Mueller-Quade, Springer Lecture Notes in Computer Scienc

Neutrino Masses and Lepton Flavour Violation in Thick Brane Scenarios

We address the issue of lepton flavour violation and neutrino masses in the ``fat-brane'' paradigm, where flavour changing processes are suppressed by localising different fermion field wave-functions at different positions (in the extra dimensions) in a thick brane. We study the consequences of suppressing lepton number violating charged lepton decays within this scenario for lepton masses and mixing angles. In particular, we find that charged lepton mass matrices are constrained to be quasi-diagonal. We further consider whether the same paradigm can be used to naturally explain small Dirac neutrino masses by considering the existence of three right-handed neutrinos in the brane, and discuss the requirements to obtain phenomenologically viable neutrino masses and mixing angles. Finally, we examine models where neutrinos obtain a small Majorana mass by breaking lepton number in a far away brane and show that, if the fat-brane paradigm is the solution to the absence of lepton number violating charged lepton decays, such models predict, in the absence of flavour symmetries, that charged lepton flavour violation will be observed in the next round of rare muon/tau decay experiments.Comment: 33 pages, 9 eps figure

Hadron yields and spectra in Au+Au collisions at the AGS

Inclusive double differential multiplicities and rapidity density distributions of hadrons are presented for 10.8 A GeV/c Au+Au collisions as measured at the AGS by the E877 collaboration. The results indicate that large amounts of stopping and collective transverse flow effects are present. The data are also compared to the results from the lighter Si+Al system.Comment: 12 pages, latex, 10 figures, submitted to Nuclear Physics A (Quark Matter 1996 Proceedings

Supernova Bounds on Majoron-emitting decays of light neutrinos

Neutrino masses arising from the spontaneous violation of ungauged lepton-number are accompanied by a physical Goldstone boson, generically called Majoron. In the high-density supernova medium the effects of Majoron-emitting neutrino decays are important even if they are suppressed in vacuo by small neutrino masses and/or small off-diagonal couplings. We reconsider the influence of these decays on the neutrino signal of supernovae in the light of recent Super-Kamiokande data on solar and atmospheric neutrinos. We find that majoron-neutrino coupling constants in the range 3\times 10^{-7}\lsim g\lsim 2\times 10^{-5} or g \gsim 3 \times 10^{-4} are excluded by the observation of SN1987A. Then we discuss the potential of Superkamiokande and the Sudbury Neutrino Observatory to detect majoron neutrino interactions in the case of a future galactic supernova. We find that these experiments could probe majoron neutrino interactions with improved sensitivity.Comment: 28 pages, 5 figure

Geniculo-Cortical Projection Diversity Revealed within the Mouse Visual Thalamus

This is the final version of the article. It was first available from PLOS via http://dx.doi.org/10.1371/journal.pone.0144846All dLGN cell co-ordinates, V1 injection sites, dLGN boundary coordinates, experimental protocols and analysis scripts are available for download from figshare at https://figshare.com/s/36c6d937b1844eec80a1.The mouse dorsal lateral geniculate nucleus (dLGN) is an intermediary between retina and primary visual cortex (V1). Recent investigations are beginning to reveal regional complexity in mouse dLGN. Using local injections of retrograde tracers into V1 of adult and neonatal mice, we examined the developing organisation of geniculate projection columns: the population of dLGN-V1 projection neurons that converge in cortex. Serial sectioning of the dLGN enabled the distribution of labelled projection neurons to be reconstructed and collated within a common standardised space. This enabled us to determine: the organisation of cells within the dLGN-V1 projection columns; their internal organisation (topology); and their order relative to V1 (topography). Here, we report parameters of projection columns that are highly variable in young animals and refined in the adult, exhibiting profiles consistent with shell and core zones of the dLGN. Additionally, such profiles are disrupted in adult animals with reduced correlated spontaneous activity during development. Assessing the variability between groups with partial least squares regression suggests that 4?6 cryptic lamina may exist along the length of the projection column. Our findings further spotlight the diversity of the mouse dLGN?an increasingly important model system for understanding the pre-cortical organisation and processing of visual information. Furthermore, our approach of using standardised spaces and pooling information across many animals will enhance future functional studies of the dLGN.Funding was provided by a Wellcome Trust grant jointly awarded to IDT and SJE (083205, www.wellcome.ac.uk), and by MRC PhD Studentships awarded to MNL and ACH (http://www.mrc.ac.uk/)