Nonantagonistic interactions between the sexes revealed by the ecological consequences of reproductive traits

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/73504/1/j.1420-9101.2004.00779.x.pd

The Current State of Women Print Journalists: An Analysis of the Status and Careers of Females in Newspapers Sports Departments

The purpose of this study was to provide an analysis of the current state of women journalists within the sports departments at newspapers across the United States. This investigation involved a determination of their demographic make-up, job status within the sports department, rationale for entering the field, and advice for younger women preparing to follow in their footsteps. The findings suggest that although the large majority of women have faced discrimination in the sport media, they believe improvements have been made towards equity. The majority of respondents noted that they were happy with the assignments they had been given. Subjects did, however, feel that they were assigned to cover females more than their male counterparts, and some responses regarding dissatisfaction with their positions was also noted. Copyright Springer Science + Business Media, Inc. 2005media, sport, female, journalist, reporters,

The translation factor eIF5A and human cancer

The eukaryotic initiation factor eIF5A is a translation factor that, unusually, has been assigned functions in both initiation and elongation. Additionally, it is implicated in transcription, mRNA turnover and nucleocytoplasmic transport. Two eIF5A isoforms are generated from distinct but related genes. The major isoform, eIF5A1, is considered constitutive, is abundantly expressed in most cells, and is essential for cell proliferation. The second isoform, eIF5A2, is expressed in few normal tissues but is highly expressed in many cancers and has been designated a candidate oncogene. Elevated expression of either isoform carries unfavorable prognostic implications for several cancers, and both have been advanced as cancer biomarkers. The amino acid hypusine, a presumptively unique eIF5A post-translational modification, is required for most known eIF5A functions and it renders eIF5A susceptible to inhibitors of the modification pathway as therapeutic targets. eIF5A has been shown to regulate a number of gene products specifically, termed the eIF5A regulon, and its role in translating proline-rich sequences has recently been identified. A model is advanced that accommodates eIF5A in both the initiation and elongation phases of translation. We review here the biochemical functions of eIF5A, the relationship of its isoforms with human cancer, and evolving clinical applications