Post-depositional subsidence of the Avellino tephra marker bed in the Pontine plain (Lazio, Italy):Implications for Early Bronze Age palaeogeographical, water level and relative sea level reconstruction

Land subsidence has played and is still playing a significant role in coastal wetlands worldwide and in palaeogeographical reconstructions of such wetlands. The varying thickness of compaction-prone sediments over a stable subsurface is a key factor in determining its magnitude and in locating the most affected areas. In the coastal low-lying Agro Pontino (Lazio, Italy), subsidence of the past 90 years has been mapped using historical elevation data. Due to the fortunate preservation of distal Avellino tephra (AV-tephra, ca. 1900 cal. BCE) within its marshy strata, discovered a decade ago, detailed palaeogeographical reconstruction of the landscape in preparation for an assessment of its land use suitability in the Early Bronze Age (EBA) was possible. Current altitude variations of water-lain tephra in lake areas assumed to be connected necessitated a closer look at its original deposition altitude and the role of post-depositional subsidence. Recent subsidence patterns proved very useful for distinguishing stable from subsidence-prone areas. Two different EBA palaeo lake environments are distinguished: an inland and a near-coastal lake. The AV-tephra altitude variation within these lakes partly marks differential post-depositional subsidence within these lakes. Calculation of initial ripening of tephra-bearing lake deposits on top of shallowly buried Pleistocene ridges allowed for an estimation of original tephra deposition altitudes and associated lake levels. For the inland lake, a wide lake edge zone between 0.5 and 2 m above current sea level (m asl) was reconstructed, where EBA habitation or land use was possible. At the near-coastal lake, a water level of −1.5 to −1.3 m asl at the time of AV-tephra deposition was constrained. Because tephra deposition occurred here just after marine influence ceased, this altitude range is proposed to be a Relative Sea Level (RSL) index point at the time of AV-tephra deposition. The altitude range is in agreement with RSL models for tectonically stable areas in this region. The importance of subsidence in palaeogeographical, water level and RSL reconstructions in the region is stressed

From basalts to badlands : modelling long-term landscape response to lava damming of an upland catchment in western Turkey

Combining field reconstruction and landscape evolution modelling can be useful to investigate the relative role of different drivers (tectonics, climate, local base level) on long term catchment evolution. In this thesis, field reconstruction and landscape evolution modelling are combined to unravel the long-term (300 ka) response to lava damming events of evolution of the Geren Catchment, a tributary of the upper Gediz river near Kula, Western Turkey. This catchment was considered suitable for such a study because its high preservationof remnant landscape surfaces and fluvial terraces which could be dated, while its base level evolution could be reconstructed by identifying and dating lava flows. In Chapter 2, landscape evolution modelling of an idealized catchment revealed long-term (15 ka) catchment response to natural damming. Evolution of a high erodible and low erodible landscape was simulated using landscape evolution model (LEM) LAPSUS (LandscApe procesS modelling at mUlti dimensions and Scales). The natural dam was given four different erodibilities, to mimic both the potentially more erodible landslide dams and resistant lava dams. In a low erodible landscape damming led to persistent preservation of the sediment wedge formed behind the dam, while in a high erodible landscape, damming additionally led to knickpoint persistence, hampered incision of the main river and stream rerouting. The highest erodible dam was almost removed after 15 ka, while its sediment wedge was still partly present. Comparison of results with natural dam events from literature showed that modelled response characteristics are observed in actual situations and that simulations on Quaternary timescales are useful. In Chapter 3, field reconstruction resulted in a young lava flow being age constrained to the late Holocene (3.0 – 2.6 ka), by luminescence dating of fluvial sands below and on top of the flow. This lava flow dammed the Gediz river at two locations. the upstream lake was silted, while the downstream lake was not. Dams were breached catastrophically and possibly in a cascading event. The Gediz created an epigenetic gorge and its current river bed is still not at its pre-lava flow level. Results are summarized in a conceptual diagram. Furthermore, field reconstruction and 40Ar/39Ar dating revealed multiple lava dam events which have infrequently raised and lowered the base level of the Geren Catchment in the middle to late Pleistocene (311 – 175 ka). Sediment-capped palaeosurfaces in the Geren suggest change from an active fluvial system to a more lacustrine environment in the middle Pleistocene, followed by fluvial reactivation and stepped incision in the late Pleistocene. A second landscape evolution modelling study was conducted in Chapter 4, on a 300 ka timescale, with a larger catchment. Four scenarios have been applied on a reconstructed paleodem of the Geren Catchment. In the first scenario, the palaeodem was given constant rainfall for 300 ka. In the second scenario, three short (1 ka) damming events were added at its catchment outlet. In the third scenario, the palaeodem endured gradual base level lowering at its outlet, based on the known incision rate of its base level, the Gediz river. In the fourth scenario, base level lowering and damming events were combined. Results were interpreted by evaluating 1 ka-averaged net erosion, catchment sediment storage, longitudinal profile development and spatial differences in net erosion and sediment storage. Results showed that the net erosion signal of the catchment is complex in all cases. However, average net erosion and its variability increased due to constant base level lowering. Additionally, alternating phases of high and low variability occurred in net erosion, where high variability coincided with a strong decrease in total catchment sediment storage. Adding damming events to the gradual base level lowering scenario generated similar average net erosion as the base level lowering scenario, however its temporal pattern showed significantly different alternation of high and low variability periods. Furthermore, dampened upstream erosion was observed. Over time, this dampening migrates upstream indicating a long-term legacy of short term dam events. Field reconstruction and landscape evolution modelling were combined in Chapter 5, to be able to reconstruct and understand actual Geren catchment response to identified base level evolution over a 300 ka period. In all simulations, rainfall and vegetation are varied over time based on arboral pollen. Because exact significance and duration of dam events were not known, three scenarios of landscape evolution in the Geren Catchment were investigated: i) uplift driven gradual base level lowering, ii) gradual base level lowering and short damming events and iii) gradual base level lowering and long damming events. Output was evaluated for erosion-aggradation evolution in trunk gullies at two different distances from the catchment outlet. Climate influences erosion – aggradation activity in the upstream reach, although internal feedbacks influence timing and magnitude. Scenario i shows the most correlation with the climate signal, although its correlation is weak. Lava damming events leave an aggradation signal in the downstream reach, while complex and lagged response to these dams obscure correlations with climate and leave a legacy of the past in current landscape evolution. Catchment response of the long dam scenario correspond best with field reconstruction and dating. The combination of climate and base level explains a significant part of the landscape evolution history of the Geren Catchment. In Chapter 6, a reflection and synthesis of Chapters 2-5 is presented. Indications for response to tectonics, climate and damming events are discussed separately for both field and modelling results. It is concluded that (lava) damming events of Pleistocene age can hamper, but also enhance incision on a 300 ka timescale. Furthermore, they can still have effect on current and future catchment evolution. However, catchment response to this evolution is complex and catchment specific and model results do not exactly reproduce its catchment history. An aggregated landscape evolution model output such as stream bed elevation change can be useful for comparison with fluvial terrace sequences. Combining field reconstruction and modelling suggests that the 300 ka incision history of the Geren is best explained if the catchment endured prolonged dam events. The combination of field reconstruction, dating and landscape evolution modelling therefore can enhance our understanding of long-term evolution of a specific landscape and increases knowledge on long term impact of past events on current catchment complexities and it is suggested to embed this research approach more structurally in long-term landscape reconstructions.</p

Towards a high-precision measurement of the antiproton magnetic moment

The recent observation of single spins flips with a single proton in a Penning trap opens the way to measure the proton magnetic moment with high precision. Based on this success, which has been achieved with our apparatus at the University of Mainz, we demonstrated recently the first application of the so called double Penning-trap method with a single proton. This is a major step towards a measurement of the proton magnetic moment with ppb precision. To apply this method to a single trapped antiproton our collaboration is currently setting up a companion experiment at the antiproton decelerator of CERN. This effort is recognized as the Baryon Antibaryon Symmetry Experiment (BASE). A comparison of both magnetic moment values will provide a stringent test of CPT invariance with baryons.Comment: Submitted to LEAP 2013 conference proceeding

Markers of inflammation and coagulation indicate a prothrombotic state in HIV-infected patients with long-term use of antiretroviral therapy with or without abacavir

Background: Abacavir (ABC) treatment has been associated with an increased incidence of myocardial infarction. The pathophysiological mechanism is unknown. In this study markers of inflammation and coagulation in HIV-infected patients using antiretroviral therapy with or without ABC were examined to pinpoint a pathogenic mechanism. Given the important role of high sensitivity C-reactive protein (hsCRP) levels in predicting cardiovascular risk, patient groups were also analyzed according to hsCRP levels.Method

Promoting occupational health through gamification and e-coaching: A 5-month user engagement study

Social gamification systems have shown potential for promoting healthy lifestyles, but applying them to occupational settings faces unique design challenges. While occupational settings offer natural communities for social interaction, fairness issues due to heterogeneous personal goals and privacy concerns increase the difficulty of designing engaging games. We explored a two-level game-design, where the first level related to achieving personal goals and the second level was a privacy-protected social competition to maximize goal compliance among colleagues. The solution was strengthened by employing occupational physicians who personalized users’ goals and coached them remotely. The design was evaluated in a 5-month study with 53 employees from a Dutch university. Results suggested that the application helped half of the participants to improve their lifestyles, and most appreciated the role of the physician in goal-setting. However, long-term user engagement was undermined by the scalability-motivated design choice of one-way communication between employees and their physician. Implications for social gamification design in occupational health are discussed

Non-Q wave myocardial infarction: Identification of high and low risk subsets by clinical variables

[This corrects the article DOI: 10.1371/journal.pone.0160243.]

Challenges in managing real-time data in health information system (HIS)

© Springer International Publishing Switzerland 2016. In this paper, we have discussed the challenges in handling real-time medical big data collection and storage in health information system (HIS). Based on challenges, we have proposed a model for realtime analysis of medical big data. We exemplify the approach through Spark Streaming and Apache Kafka using the processing of health big data Stream. Apache Kafka works very well in transporting data among different systems such as relational databases, Apache Hadoop and nonrelational databases. However, Apache Kafka lacks analyzing the stream, Spark Streaming framework has the capability to perform some operations on the stream. We have identified the challenges in current realtime systems and proposed our solution to cope with the medical big data streams