Gorenstein Projective Modules Over Triangular Matrix Rings

We study totally acyclic complexes of projective modules over triangular matrix rings and then use it to classify Gorenstein projective modules over such rings. We also use this classification to obtain some information concerning Cohen-Macaulay finite and virtually Gorenstein triangular matrix artin algebras.Comment: This paper is now accepted for publication in the Algebra Colloquiu

Results of the Mariner 6 and 7 Mars occultation experiments

Final profiles of temperature, pressure, and electron density on Mars were obtained for the Mariner 6 and 7 entry and exit cases, and results are presented for both the lower atmosphere and ionosphere. The results of an analysis of the systematic and formal errors introduced at each stage of the data-reduction process are also included. At all four occulation points, the lapse rate of temperature was subdadiabatic up to altitudes in excess of 20 km. A pronounced temperature inversion was present above the surface at the Mariner 6 exit point. All four profiles exhibit a sharp, superadiabatic drop in temperature at high altitudes, with temperatures falling below the frost point of CO2. These results give a strong indication of frozen CO2 in the middle atmosphere of Mars

Synthesis, spectral characterization and bioactivity evaluation of sulfonamide derivatives of p-nitrobenzene sulfonylchloride

1375-1383A simple and convenient method for the synthesis of biologically active sulfonamide derivatives of p-nitrobenzene sulfonylchloride has been achieved. All the title compounds have been characterized by spectral and elemental analysis. They have been further screened in vitro for their antibacterial and antifungal activities. All the compounds show good to moderate activity against both bacteria and fungi when compared with standard bactericide, Streptomycin and fungicide, Nystatin

Fibril specific, conformation dependent antibodies recognize a generic epitope common to amyloid fibrils and fibrillar oligomers that is absent in prefibrillar oligomers

<p>Abstract</p> <p>Background</p> <p>Amyloid-related degenerative diseases are associated with the accumulation of misfolded proteins as amyloid fibrils in tissue. In Alzheimer disease (AD), amyloid accumulates in several distinct types of insoluble plaque deposits, intracellular Aβ and as soluble oligomers and the relationships between these deposits and their pathological significance remains unclear. Conformation dependent antibodies have been reported that specifically recognize distinct assembly states of amyloids, including prefibrillar oligomers and fibrils.</p> <p>Results</p> <p>We immunized rabbits with a morphologically homogeneous population of Aβ42 fibrils. The resulting immune serum (OC) specifically recognizes fibrils, but not random coil monomer or prefibrillar oligomers, indicating fibrils display a distinct conformation dependent epitope that is absent in prefibrillar oligomers. The fibril epitope is also displayed by fibrils of other types of amyloids, indicating that the epitope is a generic feature of the polypeptide backbone. The fibril specific antibody also recognizes 100,000 × G soluble fibrillar oligomers ranging in size from dimer to greater than 250 kDa on western blots. The fibrillar oligomers recognized by OC are immunologically distinct from prefibrillar oligomers recognized by A11, even though their sizes overlap broadly, indicating that size is not a reliable indicator of oligomer conformation. The immune response to prefibrillar oligomers and fibrils is not sequence specific and antisera of the same specificity are produced in response to immunization with islet amyloid polypeptide prefibrillar oligomer mimics and fibrils. The fibril specific antibodies stain all types of amyloid deposits in human AD brain. Diffuse amyloid deposits stain intensely with anti-fibril antibody although they are thioflavin S negative, suggesting that they are indeed fibrillar in conformation. OC also stains islet amyloid deposits in transgenic mouse models of type II diabetes, demonstrating its generic specificity for amyloid fibrils.</p> <p>Conclusion</p> <p>Since the fibril specific antibodies are conformation dependent, sequence-independent, and recognize epitopes that are distinct from those present in prefibrillar oligomers, they may have broad utility for detecting and characterizing the accumulation of amyloid fibrils and fibrillar type oligomers in degenerative diseases.</p

Ambient measurements of monoterpenes near Cannabis cultivation facilities in Denver, Colorado

Colorado was one of the first US states to legalize the industrial-scale cultivation of Cannabis spp. for recreational purposes. In March 2018, there were 609 indoor Cannabis cultivation facilities (CCFs) in operation in Denver County with a recorded 550,000 mature plants (higher than 8 inches) under cultivation at any given time. It is known that cultivation of Cannabis spp. produces emissions of a group of highly reactive hydrocarbons, monoterpenes. There have been limited studies that have quantified mixing ratios of emitted monoterpenes in air outside CCFs. A field campaign was conducted in August 2016 in Denver County focused on six different CCF clusters near the intersection of interstate highways I-25 and I-70 during which a total of 150 ambient air samples were collected. Monoterpene mixing ratios near CCFs were ~408 ± 203 pptv; 4–8 times higher than samples collected from a “background” site located at the Denver City Park (75 ± 25 pptv). The composition of samples taken near CCFs were dominated by d-limonene (30%), β-myrcene (20%), and α-pinene (15%), which is similar to previously reported emission factors for Cannabis spp. Since β-myrcene was only detected in leaf enclosure studies, indoor CCF observations and ambient samples near CCFs and not detected at a background site, this particular compound could be used as a tracer for the Denver Cannabis production industry. The monoterpene speciation in ambient measurements varied across Denver suggesting differences in emissions between different Cannabis spp., or different growth stages. Given the observed variabilities in both composition and emission rates, it is critical for the accuracy of emissions inventories to develop strain-specific emission factors. This information, coupled with detailed information on each CCF, would greatly reduce the uncertainties currently present in monoterpene emission estimates for the Cannabis industry and their potential impact on air quality. © 2020 Elsevier Lt

Chronic opioid use following surgery for head and neck cancer patients undergoing free flap reconstruction

Abstract Background Physician opioid-prescribing patterns have significant impacts on the current opioid crisis. Patients who use opioids in the postoperative period are at risk of developing chronic postoperative opioid use. This study determined the rate of chronic postoperative opioid use among head and neck cancer patients undergoing primary surgery with free-flap reconstruction. Additionally, this study identified major risk factors associated with the development of chronic postoperative opioid use. Methods A retrospective chart review was performed for all adults (age ≥ 18 years) undergoing primary head and neck surgical resection with free-flap reconstruction between January 2008 and December 2015. Patients were identified from a prospectively collected database, Otobase™. Data from the provincial drug insurance program were used to capture drug dispensing information to determine chronic opioid use at 3- and 12-months postoperatively. Data extracted from Otobase™ included patient demographics, social habits, clinical stage, pathological stage, type of surgery, and adjuvant treatment. Results The total cohort was comprised of 212 patients. Chronic opioid use at 3- and 12- months postoperatively was observed in 136 (64%) and 116 (55%) patients, respectively. Of the 212 patients, 85 patients (40%) were identified as preoperative opioid users and 127 were opioid naïve (60%). Of the 85 patients who were preoperative opioid users, 70 (82%) and 63 (77%) patients continued to use opioids 3- and 12-months postoperatively, respectively. The proportion of opioid-naïve patients who were using opioids at 3- and 12-months postoperatively was 52% (66 patients) and 42% (53 patients), respectively. Identified risk factors included preoperative opioid use, prior tobacco use, advanced pathologic T-stage, and adjuvant treatment. Conclusions Among head and neck cancer patients that have undergone major resection with free-flap reconstruction, the prevalence of chronic postoperative opioid users was considerable. Identified risk factors included preoperative opioid use, prior tobacco use, tumor stage, and adjuvant treatment. Graphical abstrac

Challenges and Considerations in Assessing GERD: A Critical Review of a Study in Southern Punjab, Pakistan [Response to Letter]

Muhammad Fawad Rasool,1 Rimsha Sarwar,1 Muhammad Subhan Arshad,1,2 Imran Imran,3 Hamid Saeed,4 Abdul Majeed,1 Muqarrab Akbar,5 Muhammad Omer Chaudhry,6 Anees Ur Rehman,1 Waseem Ashraf,3 Tanveer Ahmad,7 Waleed Badoghaish,8 Faleh Alqahtani9 1Department of Pharmacy Practice, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, 60800, Pakistan; 2Department of Pharmacy, Southern Punjab Institute of Health Sciences, Multan, 60000, Pakistan; 3Department of Pharmacology, Faculty of Pharmacy, Bahauddin Zakariya University, Multan, 60800, Pakistan; 4University College of Pharmacy, Allama Iqbal Campus, University of the Punjab, Lahore, 54000, Pakistan; 5Department of Political Science, Bahauddin Zakariya University, Multan, 60800, Pakistan; 6School of Economics, Bahauddin Zakariya University, Multan, 60800, Pakistan; 7Institute for Advanced Biosciences (Iab), CNRS UMR5309, INSERM U1209, Grenoble Alpes University, La Tronche, 38700, France; 8Department of Internal Medicine, College of Medicine, University of Tabuk, Tabuk, 71411, Saudi Arabia; 9Department of Pharmacology and Toxicology, College of Pharmacy, King Saud University, Riyadh, 11451, Saudi ArabiaCorrespondence: Muhammad Fawad Rasool; Faleh Alqahtani, Email [email protected]; [email protected]

Investigation of enhanced double weight code in point to point access networks

© 2020 Published under licence by IOP Publishing Ltd. In this paper, an investigation and evaluation to enhanced double weight (EDW) code is performed, a new technique for code structuring and building using modified arithmetical model has been given for the code in place of employing previous technique based on Trial Inspections. Innovative design has been employed for the code into P2P networks using diverse weighted EDW code to be fitting into optical CDMA relevance applications. A new developed relation for EDW code is presented, the relation is based on studying and experimenting the effect of input transmission power with code weight, and the relation developed using numerical analysis method. This relation makes the estimation for the system input power needed more efficient. The results of the code has been explained by eye diagram and parametric illustrations from the simulated results. The result shows a magnificent performance of the code during high number of users and weight. On the other hand, the relation developed for power measurement helps to prevent power loss and consumption