Cosmic Calibration: Constraints from the Matter Power Spectrum and the Cosmic Microwave Background

Several cosmological measurements have attained significant levels of maturity and accuracy over the last decade. Continuing this trend, future observations promise measurements of the statistics of the cosmic mass distribution at an accuracy level of one percent out to spatial scales with k~10 h/Mpc and even smaller, entering highly nonlinear regimes of gravitational instability. In order to interpret these observations and extract useful cosmological information from them, such as the equation of state of dark energy, very costly high precision, multi-physics simulations must be performed. We have recently implemented a new statistical framework with the aim of obtaining accurate parameter constraints from combining observations with a limited number of simulations. The key idea is the replacement of the full simulator by a fast emulator with controlled error bounds. In this paper, we provide a detailed description of the methodology and extend the framework to include joint analysis of cosmic microwave background and large scale structure measurements. Our framework is especially well-suited for upcoming large scale structure probes of dark energy such as baryon acoustic oscillations and, especially, weak lensing, where percent level accuracy on nonlinear scales is needed.Comment: 15 pages, 14 figure

An Optimal Linear Time Algorithm for Quasi-Monotonic Segmentation

Monotonicity is a simple yet significant qualitative characteristic. We consider the problem of segmenting a sequence in up to K segments. We want segments to be as monotonic as possible and to alternate signs. We propose a quality metric for this problem using the l_inf norm, and we present an optimal linear time algorithm based on novel formalism. Moreover, given a precomputation in time O(n log n) consisting of a labeling of all extrema, we compute any optimal segmentation in constant time. We compare experimentally its performance to two piecewise linear segmentation heuristics (top-down and bottom-up). We show that our algorithm is faster and more accurate. Applications include pattern recognition and qualitative modeling.Comment: This is the extended version of our ICDM'05 paper (arXiv:cs/0702142

Organisational participation and women - an attitude problem?

Employee participation is a dynamic and contested area of organisational behaviour, attracting continuing academic, practitioner and policy interest and debate. This chapter focuses on organisational participation and women

Adaptive estimation in circular functional linear models

We consider the problem of estimating the slope parameter in circular functional linear regression, where scalar responses Y1,...,Yn are modeled in dependence of 1-periodic, second order stationary random functions X1,...,Xn. We consider an orthogonal series estimator of the slope function, by replacing the first m theoretical coefficients of its development in the trigonometric basis by adequate estimators. Wepropose a model selection procedure for m in a set of admissible values, by defining a contrast function minimized by our estimator and a theoretical penalty function; this first step assumes the degree of ill posedness to be known. Then we generalize the procedure to a random set of admissible m's and a random penalty function. The resulting estimator is completely data driven and reaches automatically what is known to be the optimal minimax rate of convergence, in term of a general weighted L2-risk. This means that we provide adaptive estimators of both the slope function and its derivatives

A Catalog of Transient X-ray Sources in M31

From October 1999 to August 2002, 45 transient X-ray sources were detected in M31 by Chandra and XMM-Newton. We have performed spectral analysis of all XMM-Newton and Chandra ACIS detections of these sources, as well as flux measurements of Chandra HRC detections. The result is absorption-corrected X-ray lightcurves for these sources covering this 2.8 year period, along with spectral parameters for several epochs of the outbursts of most of the transient sources. We supply a catalog of the locations, outburst dates, peak observed luminosities, decay time estimates, and spectral properties of the transient sources, and we discuss similarities with Galactic X-ray novae. Duty cycle estimates are possible for 8 of the transients and range from 40% to 2%; upper limits to the duty cycles are estimated for an additional 15 transients and cover a similar range. We find 5 transients which have rapid decay times and may be ultra-compact X-ray binaries. Spectra of three of the transients suggest they may be faint Galactic foreground sources. If even one is a foreground source, this suggests a surface density of faint transient X-ray sources of >~1 deg$^{-2}$.Comment: 63 pages, 22 figures, 3 tables, accepted for publication in Ap

Corticosteroids inhibit sphingosine 1-phosphate-induced interleukin-6 secretion from human airway smooth muscle via mitogen-activated protein kinase phosphatase 1-mediated repression of mitogen and stress-activated protein kinase 1

Sphingosine 1-phosphate (S1P) is a bioactive sphingolipid that plays an important proinflammatory role in asthmatic airways. Corticosteroids are first-line antiinflammatories in asthma; however, their repressive effects on S1P-induced cytokine secretion have not been investigated. To address this, our in vitro study reveals the molecular mechanisms by which corticosteroids inhibit S1P-induced IL-6 expression in the pivotal immunomodulatory cell type, airway smooth muscle (ASM). We first uncover the cellular signaling pathways responsible: S1P activates a cyclic adenosine monophosphate/cAMP response-element-binding protein (CREB)/ CRE-dependent pathway to induce IL-6 transcription, concomitant with stimulation of the mitogen-activated protein kinase (MAPK) superfamily and downstream mitogen and stress-activated protein kinase 1 (MSK1) and histone H3 phosphorylation. In this way, S1P stimulates parallel signaling pathways to induce IL-6 secretion via CRE-driven transcription of the IL-6 gene promoter in a relaxed chromatin environment achieved through histone H3 phosphorylation. Second, we investigated how corticosteroids mediate their repressive effects. The corticosteroid dexamethasone inhibits S1P-induced IL-6 protein secretion and mRNA expression, but CREB/CRE transrepression, inhibition of IL-6 mRNA stability, or subcellular relocation of MSK1 were not responsible for the repressive effects of dexamethasone. Rather, we show that dexamethasone rapidly induces up-regulation of the MAPK deactivator MAPK phosphatase 1 (MKP-1) and that MKP-1 blocks the MAPK-driven activation of MSK1 and phosphorylation of histone H3. This was confirmed by treatment with triptolide, an inhibitor of MKP-1 up-regulation, where repressive effects of corticosteroids were reversed. Our study reveals the molecular mechanism underlying the antiinflammatory capacity of corticosteroids to repress proinflammatory functions induced by the potent bioactive sphingolipid S1P in the lung. Copyright © 2014 by the American Thoracic Society

Performance of LED-Based Fluorescence Microscopy to Diagnose Tuberculosis in a Peripheral Health Centre in Nairobi.

Sputum microscopy is the only tuberculosis (TB) diagnostic available at peripheral levels of care in resource limited countries. Its sensitivity is low, particularly in high HIV prevalence settings. Fluorescence microscopy (FM) can improve performance of microscopy and with the new light emitting diode (LED) technologies could be appropriate for peripheral settings. The study aimed to compare the performance of LED-FM versus Ziehl-Neelsen (ZN) microscopy and to assess feasibility of LED-FM at a low level of care in a high HIV prevalence country

An XMM-Newton observation of the nova-like variable UX UMa: spatially and spectrally resolved two-component X-ray emission

In the optical and ultraviolet regions of the electromagnetic spectrum, UX Ursae Majoris is a deeply eclipsing cataclysmic variable. However, no soft X-ray eclipse was detected in ROSAT observations. We have obtained a 38 ksec XMM-Newton observation to further constrain the origin of the X-rays. The combination of spectral and timing information allows us to identify two components in the X-ray emission of the system. The soft component, dominant below photon energies of 2 keV, can be fitted with a multi-temperature plasma model and is uneclipsed. The hard component, dominant above 3 keV, can be fitted with a kT ~ 5 keV plasma model and appears to be deeply eclipsed. We suggest that the most likely source of the hard X-ray emission in UX UMa, and other systems in high mass transfer states, is the boundary layer.Comment: To appear in MNRAS Letter

The Three Dimensional Structure of EUV Accretion Regions in AM Herculis Stars: Modeling of EUV Photometric and Spectroscopic Observations

We have developed a model of the high-energy accretion region for magnetic cataclysmic variables and applied it to {\it Extreme Ultraviolet Explorer} observations of 10 AM Herculis type systems. The major features of the EUV light curves are well described by the model. The light curves exhibit a large variety of features such as eclipses of the accretion region by the secondary star and the accretion stream, and dips caused by material very close to the accretion region. While all the observed features of the light curves are highly dependent on viewing geometry, none of the light curves are consistent with a flat, circular accretion spot whose lightcurve would vary solely from projection effects. The accretion region immediately above the WD surface is a source of EUV radiation caused by either a vertical extent to the accretion spot, or Compton scattering off electrons in the accretion column, or, very likely, both. Our model yields spot sizes averaging 0.06 R$_{WD}$, or $f \sim 1 \times 10^{-3}$ the WD surface area, and average spot heights of 0.023 R$_{WD}$. Spectra extracted during broad dip phases are softer than spectra during the out-of-dip phases. This spectral ratio measurement leads to the conclusion that Compton scattering, some absorption by a warm absorber, geometric effects, an asymmetric temperature structure in the accretion region and an asymmetric density structure of the accretion columnare all important components needed to fully explain the data. Spectra extracted at phases where the accretion spot is hidden behind the limb of the WD, but with the accretion column immediately above the spot still visible, show no evidence of emission features characteristic of a hot plasma.Comment: 30 Pages, 11 Figure

Orogen-parallel deformation of the Himalayan mid-crust: Insights from structural and magnetic fabric analyses of the Greater Himalayan Sequence, Annapurna-Dhaulagiri Himalaya, central Nepal

The metamorphic core of the Himalaya (Greater Himalayan Sequence, GHS), in the Annapurna-Dhaulagiri region, central Nepal, recorded orogen-parallel stretching during midcrustal evolution. Anisotropy of magnetic susceptibility and field-based structural analyses suggest that midcrustal deformation of the amphibolite facies core of the GHS occurred under an oblate/suboblate strain regime with associated formation of low-angle northward dipping foliation. Magnetic and mineral stretching lineations lying within this foliation from the top of the GHS record right-lateral orogen-parallel stretching. We propose that oblate strain within a midcrustal flow accommodated oblique convergence between India and the arcuate orogenic front without the need for strain partitioning in the upper crust. Oblate flattening may have also promoted orogen-parallel melt migration and development of melt-depleted regions between km3 scale leucogranite culminations at ~50–100 km intervals along orogen strike. Following the cessation of flow, continued oblique convergence led to upper crustal strain partitioning between orogen-perpendicular convergence on thrust faults and orogen-parallel extension on normal and strike-slip faults. In the Annapurna-Dhaulagiri Himalaya, orogen-parallel stretching lineations are interpreted as a record of transition from midcrustal orogen-perpendicular extrusion to upper crustal orogen-parallel stretching. Our findings suggest that midcrustal flow and upper crustal extension could not be maintained simultaneously and support other studies from across the Himalaya, which propose an orogen-wide transition from midcrustal orogen-perpendicular extrusion to upper crustal orogen-parallel extension during the mid-Miocene. The 3-D nature of oblate strain and orogen-parallel stretching cannot be replicated by 2-D numerical simulations of the Himalayan orogen