The s-process nucleosynthesis : Impact of the uncertainties in the nuclear physics determined by monte carlo variations

We investigated the impact of uncertainties in neutron-capture and weak reactions (on heavy elements) on the s-process nucleosynthesis in low-mass stars and massive stars using a Monte-Carlo based approach. We performed extensive nuclear reaction network calculations that include newly evaluated temperature-dependent upper and lower limits for the individual reaction rates. We found β-decay rate uncertainties affect only a few nuclei near s-process branchings, whereas most of the uncertainty in the final abundances is caused by uncertainties in the neutron capture rates. We suggest a list of uncertain rates as candidates for improved measurement by future experiments.Peer reviewe

Behavioral Modeling of an Off-the-Shelf Damped Sinusoidal Transient Generator

In this letter, experimental characterization and behavioral modeling of an off-the-shelf damped sinusoidal wave generator operating at different frequencies are addressed. Two modeling strategies are developed which lead to an active and a passive circuit representation of the generator, whose involved parameters are optimized by making use of time-domain measurement results obtained with the generator connected to different load impedances. It is shown that either the active or the passive model can assure accurate prediction of the generated waveforms, depending on the specific frequency. The proposed models can be effortlessly implemented in common circuit simulators, and used for systematic design of injection devices for transient conducted susceptibility testing as well as for simulation of the corresponding test setups. As an illustrative example, the proposed models are exploited to predict the actual waveform induced at the input pins of the device under test in a simplified pulse current injection test setup

A prototype system for observing the Atlantic Meridional Overturning Circulation - scientific basis, measurement and risk mitigation strategies, and first results

The Atlantic Meridional Overturning Circulation (MOC) carries up to one quarter of the global northward heat transport in the Subtropical North Atlantic. A system monitoring the strength of the MOC volume transport has been operating since April 2004. The core of this system is an array of moored sensors measuring density, bottom pressure and ocean currents. A strategy to mitigate risks of possible partial failures of the array is presented, relying on backup and complementary measurements. The MOC is decomposed into five components, making use of the continuous moored observations, and of cable measurements across the Straits of Florida, and wind stress data. The components compensate for each other, indicating that the system is working reliably. The year-long average strength of the MOC is 18.7±5.6 Sv, with wind-driven and density-inferred transports contributing equally to the variability. Numerical simulations suggest that the surprisingly fast density changes at the western boundary are partially linked to westward propagating planetary wave

Numerical evaluation of one-loop QCD amplitudes

We present the publicly available program NGluon allowing the numerical evaluation of primitive amplitudes at one-loop order in massless QCD. The program allows the computation of one-loop amplitudes for an arbitrary number of gluons. The focus of the present article is the extension to one-loop amplitudes including an arbitrary number of massless quark pairs. We discuss in detail the algorithmic differences to the pure gluonic case and present cross checks to validate our implementation. The numerical accuracy is investigated in detail.Comment: Talk given at ACAT 2011 conference in London, 5-9 Septembe

Determining North Atlantic meridional transport variability from pressure on the western boundary: a model investigation.

In this paper we investigate the possibility of determining North Atlantic meridional transport variability using pressure on the western boundary, focusing on the 42degN latitude of the Halifax WAVE array. We start by reviewing the theoretical foundations of this approach. Next we present results from a model analysis, both statistical and dynamic, that demonstrate the feasibility of the approach. We consider how well we can quantify the meridional transport variability at 42degN given complete knowledge of bottom pressure across the basin, and to what degree this quantification is degraded by first ignoring the effect of intervening topography, and then by using only bottom pressure on the western boundary. We find that for periods of greater than one year we can recover more than 90% of the variability of the main overturning cell at 42degN using only the western boundary pressure, provided we remove the depth-average boundary pressure signal. This signal arises from a basin mode of bottom pressure variability, which has power at all timescales, but that does not in truth have a meridional transport signal associated with it, and from the geostrophic depth-independent compensation of the Ekman transport. An additional benefit of the removal of the depth-average pressure is that this high-frequency Ekman signal, which is essentially noise as far as monitoring the MOC for climatically important changes is concerned, is clearly separated from other modes

Obesity accelerates endothelial-to-mesenchymal transition in adipose tissues of mice and humans

IntroductionVascular dysfunction and chronic inflammation are characteristics of obesity-induced adipose tissue dysfunction. Proinflammatory cytokines can drive an endothelial-to-mesenchymal transition (EndoMT), where endothelial cells undergo a phenotypic switch to mesenchymal-like cells that are pro-inflammatory and pro-fibrotic. In this study, we sought to determine whether obesity can promote EndoMT in adipose tissue.MethodsMice in which endothelial cells are lineage-traced with eYFP were fed a high-fat/high-sucrose (HF/HS) or Control diet for 13, 26, and 52 weeks, and EndoMT was assessed in adipose tissue depots as percentage of CD45−CD31−Acta2+ mesenchymal-like cells that were eYFP +. EndoMT was also assessed in human adipose endothelial cells through cell culture assays and by the analysis of single cell RNA sequencing datasets obtained from the visceral adipose tissues of obese individuals.ResultsQuantification by flow cytometry showed that mice fed a HF/HS diet display a time-dependent increase in EndoMT over Control diet in subcutaneous adipose tissue (+3.0%, +2.6-fold at 13 weeks; +10.6%, +3.2-fold at 26 weeks; +11.8%, +2.9-fold at 52 weeks) and visceral adipose tissue (+5.5%, +2.3-fold at 13 weeks; +20.7%, +4.3-fold at 26 weeks; +25.7%, +4.8-fold at 52 weeks). Transcriptomic analysis revealed that EndoMT cells in visceral adipose tissue have enriched expression of genes associated with inflammatory and TGFβ signaling pathways. Human adipose-derived microvascular endothelial cells cultured with TGF-β1, IFN-γ, and TNF-α exhibited a similar upregulation of EndoMT markers and induction of inflammatory response pathways. Analysis of single cell RNA sequencing datasets from visceral adipose tissue of obese patients revealed a nascent EndoMT sub-cluster of endothelial cells with reduced PECAM1 and increased ACTA2 expression, which was also enriched for inflammatory signaling genes and other genes associated with EndoMT.DiscussionThese experimental and clinical findings show that chronic obesity can accelerate EndoMT in adipose tissue. We speculate that EndoMT is a feature of adipose tissue dysfunction that contributes to local inflammation and the systemic metabolic effects of obesity.