Shape Invariance in the Calogero and Calogero-Sutherland Models

We show that the Calogero and Calogero-Sutherland models possess an N-body generalization of shape invariance. We obtain the operator representation that gives rise to this result, and discuss the implications of this result, including the possibility of solving these models using algebraic methods based on this shape invariance. Our representation gives us a natural way to construct supersymmetric generalizations of these models, which are interesting both in their own right and for the insights they offer in connection with the exact solubility of these models.Comment: Latex file, 23 pages, no picture

Investigating the timecourse of accessing conversational implicatures during incremental sentence interpretation

Many contextual inferences in utterance interpretation are explained as following from the nature of conversation and the assumption that participants are rational. Recent psycholinguistic research has focussed on certain of these ‘Gricean’ inferences and have revealed that comprehenders can access them in online interpretation. However there have been mixed results as to the time-course of access. Some results show that Gricean inferences can be accessed very rapidly, as rapidly as any other contextually specified information (Sedivy, 2003; Grodner, Klein, Carbery, & Tanenhaus, 2010); while other studies looking at the same kind of inference suggest that access to Gricean inferences are delayed relative to other aspects of semantic interpretation (Huang & Snedeker, 2009; in press). While previous timecourse research has focussed on Gricean inferences that support the online assignment of reference to definite expressions, the study reported here examines the timecourse of access to scalar implicatures, which enrich the meaning of an utterance beyond the semantic interpretation. Even if access to Gricean inference in support of reference assignment may be rapid, it is still unknown whether genuinely enriching scalar implicatures are delayed. Our results indicate that scalar implicatures are accessed as rapidly as other contextual inferences. The implications of our results are discussed in reference to the architecture of language comprehension

Cosmogenic-nuclide data from Antarctic nunataks can constrain past ice sheet instabilities

We apply geologic evidence from ice-free areas in Antarctica to evaluate model simulations of ice sheet response to warm climates. This is important because such simulations are used to predict ice sheet behaviour in future warm climates, but geologic evidence of smaller-than-present past ice sheets is buried under the present ice sheet and therefore generally unavailable for model benchmarking. We leverage an alternative accessible geologic dataset for this purpose: cosmogenic-nuclide concentrations in bedrock surfaces of interior nunataks. These data produce a frequency distribution of ice thickness over multimillion-year periods, which is also simulated by ice sheet modelling. End-member transient models, parameterized with strong and weak marine ice sheet instability processes and ocean temperature forcings, simulate large and small sea-level impacts during warm periods and also predict contrasting and distinct frequency distributions of ice thickness. We identify regions of Antarctica where predicted frequency distributions reveal differences in end-member ice sheet behaviour. We then demonstrate that a single comprehensive dataset from one bedrock site in West Antarctica is sufficiently detailed to show that the data are consistent only with a weak marine ice sheet instability end-member, but other less extensive datasets are insufficient and/or ambiguous. Finally, we highlight locations where collecting additional data could constrain the amplitude of past and therefore future response to warm climates.</p

Cosmogenic-nuclide data from Antarctic nunataks can constrain past ice sheet instabilities

We apply geologic evidence from ice-free areas in Antarctica to evaluate model simulations of ice sheet response to warm climates. This is important because such simulations are used to predict ice sheet behaviour in future warm climates, but geologic evidence of smaller-than-present past ice sheets is buried under the present ice sheet and therefore generally unavailable for model benchmarking. We leverage an alternative accessible geologic dataset for this purpose: cosmogenic-nuclide concentrations in bedrock surfaces of interior nunataks. These data produce a frequency distribution of ice thickness over multimillion-year periods, which is also simulated by ice sheet modelling. End-member transient models, parameterized with strong and weak marine ice sheet instability processes and ocean temperature forcings, simulate large and small sea-level impacts during warm periods and also predict contrasting and distinct frequency distributions of ice thickness. We identify regions of Antarctica where predicted frequency distributions reveal differences in end-member ice sheet behaviour. We then demonstrate that a single comprehensive dataset from one bedrock site in West Antarctica is sufficiently detailed to show that the data are consistent only with a weak marine ice sheet instability end-member, but other less extensive datasets are insufficient and/or ambiguous. Finally, we highlight locations where collecting additional data could constrain the amplitude of past and therefore future response to warm climates.</p

Individualized outcome prognostication for patients with laryngeal cancer

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/142424/1/cncr31087.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/142424/2/cncr31087_am.pd

Goos-H\"{a}nchen-like shifts for Dirac fermions in monolayer graphene barrier

We investigate the Goos-H\"{a}nchen-like shifts for Dirac fermions in transmission through a monolayer graphene barrier. The lateral shifts, as the functions of the barrier's width and the incidence angle, can be negative and positive in Klein tunneling and classical motion, respectively. Due to their relations to the transmission gap, the lateral shifts can be enhanced by the transmission resonances when the incidence angle is less than the critical angle for total reflection, while their magnitudes become only the order of Fermi wavelength when the incidence angle is larger than the critical angle. These tunable beam shifts can also be modulated by the height of potential barrier and the induced gap, which gives rise to the applications in graphene-based devices.Comment: 5 pages, 5 figure

Receptor-mediated delivery of engineered nucleases for genome modification

Engineered nucleases, which incise the genome at predetermined sites, have a number of laboratory and clinical applications. There is, however, a need for better methods for controlled intracellular delivery of nucleases. Here, we demonstrate a method for ligand-mediated delivery of zinc finger nucleases (ZFN) proteins using transferrin receptor-mediated endocytosis. Uptake is rapid and efficient in established mammalian cell lines and in primary cells, including mouse and human hematopoietic stem-progenitor cell populations. In contrast to cDNA expression, ZFN protein levels decline rapidly following internalization, affording better temporal control of nuclease activity. We show that transferrin-mediated ZFN uptake leads to site-specific in situ cleavage of the target locus. Additionally, despite the much shorter duration of ZFN activity, the efficiency of gene correction approaches that seen with cDNA-mediated expression. The approach is flexible and general, with the potential for extension to other targeting ligands and nuclease architectures

A Comparison of Total Food Intake at a Personalised Buffet in People with Obesity, before and 24 Months after Roux-en-Y-Gastric Bypass Surgery

Long-term reductions in the quantity of food consumed, and a shift in intake away from energy dense foods have both been implicated in the potent bariatric effects of Roux-en-Y gastric bypass (RYGB) surgery. We hypothesised that relative to pre-operative assessment, a stereotypical shift to lower intake would be observed at a personalised ad libitum buffet meal 24 months after RYGB, driven in part by decreased selection of high energy density items. At pre-operative baseline, participants (n = 14) rated their preference for 72 individual food items, each of these mapping to one of six categories encompassing high and low-fat choices in combination with sugar, complex carbohydrate or and protein. An 18-item buffet meal was created for each participant based on expressed preferences. Overall energy intake was reduced on average by 60% at the 24-month buffet meal. Reductions in intake were seen across all six food categories. Decreases in the overall intake of all individual macronutrient groups were marked and were generally proportional to reductions in total caloric intake. Patterns of preference and intake, both at baseline and at follow-up appear more idiosyncratic than has been previously suggested by verbal reporting. The data emphasise the consistency with which reductions in ad libitum food intake occur as a sequel of RYGB, this being maintained in the setting of a self-selected ad libitum buffet meal. Exploratory analysis of the data also supports prior reports of a possible relative increase in the proportional intake of protein after RYGB

On the computational content of Zorn's lemma

We give a computational interpretation to an abstract instance of Zorn's lemma formulated as a wellfoundedness principle in the language of arithmetic in all finite types. This is achieved through G\"odel's functional interpretation, and requires the introduction of a novel form of recursion over non-wellfounded partial orders whose existence in the model of total continuous functionals is proven using domain theoretic techniques. We show that a realizer for the functional interpretation of open induction over the lexicographic ordering on sequences follows as a simple application of our main results