4,130 research outputs found
Recommended from our members
14C-Cobalamin Absorption from Endogenously Labeled Chicken Eggs Assessed in Humans Using Accelerator Mass Spectrometry.
Traditionally, the bioavailability of vitamin B-12 (B12) from in vivo labeled foods was determined by labeling the vitamin with radiocobalt (57Co, 58Co or 60Co). This required use of penetrating radioactivity and sometimes used higher doses of B12 than the physiological limit of B12 absorption. The aim of this study was to determine the bioavailability and absorbed B12 from chicken eggs endogenously labeled with 14C-B12 using accelerator mass spectrometry (AMS). 14C-B12 was injected intramuscularly into hens to produce eggs enriched in vivo with the 14C labeled vitamin. The eggs, which provided 1.4 to 2.6 μg of B12 (~1.1 kBq) per serving, were scrambled, cooked and fed to 10 human volunteers. Baseline and post-ingestion blood, urine and stool samples were collected over a one-week period and assessed for 14C-B12 content using AMS. Bioavailability ranged from 13.2 to 57.7% (mean 30.2 ± 16.4%). Difference among subjects was explained by dose of B12, with percent bioavailability from 2.6 μg only half that from 1.4 μg. The total amount of B12 absorbed was limited to 0.5-0.8 μg (mean 0.55 ± 0.19 μg B12) and was relatively unaffected by the amount consumed. The use of 14C-B12 offers the only currently available method for quantifying B12 absorption in humans, including food cobalamin absorption. An egg is confirmed as a good source of B12, supplying approximately 20% of the average adult daily requirement (RDA for adults = 2.4 μg/day)
Mapping the Evolution of Optically-Generated Rotational Wavepackets in a Room Temperature Ensemble of D
A coherent superposition of rotational states in D has been excited by
nonresonant ultrafast (12 femtosecond) intense (2 10
Wcm) 800 nm laser pulses leading to impulsive dynamic alignment.
Field-free evolution of this rotational wavepacket has been mapped to high
temporal resolution by a time-delayed pulse, initiating rapid double
ionization, which is highly sensitive to the angle of orientation of the
molecular axis with respect to the polarization direction, . The
detailed fractional revivals of the neutral D wavepacket as a function of
and evolution time have been observed and modelled theoretically.Comment: 4 pages, 3 figures. Accepted for publication in Phys. Rev. A. Full
reference to follow.
Large Car-following Data Based on Lyft level-5 Open Dataset: Following Autonomous Vehicles vs. Human-driven Vehicles
Car-Following (CF), as a fundamental driving behaviour, has significant
influences on the safety and efficiency of traffic flow. Investigating how
human drivers react differently when following autonomous vs. human-driven
vehicles (HV) is thus critical for mixed traffic flow. Research in this field
can be expedited with trajectory datasets collected by Autonomous Vehicles
(AVs). However, trajectories collected by AVs are noisy and not readily
applicable for studying CF behaviour. This paper extracts and enhances two
categories of CF data, HV-following-AV (H-A) and HV-following-HV (H-H), from
the open Lyft level-5 dataset. First, CF pairs are selected based on specific
rules. Next, the quality of raw data is assessed by anomaly analysis. Then, the
raw CF data is corrected and enhanced via motion planning, Kalman filtering,
and wavelet denoising. As a result, 29k+ H-A and 42k+ H-H car-following
segments are obtained, with a total driving distance of 150k+ km. A diversity
assessment shows that the processed data cover complete CF regimes for
calibrating CF models. This open and ready-to-use dataset provides the
opportunity to investigate the CF behaviours of following AVs vs. HVs from
real-world data. It can further facilitate studies on exploring the impact of
AVs on mixed urban traffic.Comment: 6 pages, 9 figure
Stereolithography for 3D photoelasticity
Recently, the use of photoelasticity has become more widespread due to the development of digital methods of fringe analysis [1] that allow a significant reduction in the time taken to achieve a stress map for any given model, particularly when only fractional fringe orders are displayed. However, in order for the full potential of the photoelastic method to be realised, a technique for rapidly producing complex 3-dimensional photoelastic models must be developed. Stereolithography is one so-called ‘rapid-prototype’ method that works by building a laminar model from a tank of photo-curing resin. A perforated metal plate is submerged in the liquid resin to a depth of typically around 0.1mm. A laser then traces the shape of the first layer of the component onto the plate, curing a thin layer of the resin. The plate is lowered by 0.1mm, and a further layer of resin cured by the laser. By this method, complex structures may be ‘laid-up’ in a matter of hours.
Previous studies concerned with the use of stereolithography for the production of photoelastic models [2] have noted that unacceptable levels of residual birefringence and stress have remained in the photoelastic model even after conventional annealing methods. Thus the use of such methods has been limited. If the stereolithographic method were developed for photoelasticity, one possible area of interest would be the design and analysis of orthopedic implants.
This paper outlines a series of studies looking at the requirements of photoelastic materials for three-dimensional stress analysis
Effectiveness and cost-effectiveness of prognostic markers in prostate cancer
This paper demonstrates how economic modelling can be used to derive estimates of the cost-effectiveness of prognostic markers in the management of clinically localised and moderately graded prostate cancer. The model uses a Markov process and is populated using published evidence and local data. The robustness of the results has been tested using sensitivity analysis. Three treatment policies of 'monitoring' (observation), radical prostatectomy, or a selection-based management policy using DNA-ploidy as an experimental marker, have been evaluated. Modelling indicates that a policy of managing these tumours utilising experimental markers has an estimated cost per quality-adjusted life year (QALY) of pound 12 068. Sensitivity analysis shows the results to be relatively sensitive to quality-of-life variables. If novel and experimental markers can achieve specificity in excess of 80%, then a policy of radical surgery for those identified as being at high risk and conservative treatment for the remainder would be both better for patients and cost-effective. The analysis suggests that a radical prostatectomy treatment policy for the moderately graded tumours (Gleason grades -7) modelled in this paper may be inferior to a conservative approach in the absence of reliable prognostic markers, being both more costly and yielding fewer QALYs
Mechanisms of Manganese-Assisted Nonradiative Recombination in Cd(Mn)Se/Zn(Mn)Se Quantum Dots
Mechanisms of nonradiative recombination of electron-hole complexes in
Cd(Mn)Se/Zn(Mn)Se quantum dots accompanied by interconfigurational excitations
of Mn ions are analyzed within the framework of single electron model of
deep {\it 3d}-levels in semiconductors. In addition to the mechanisms caused by
Coulomb and exchange interactions, which are related because of the Pauli
principle, another mechanism due to {\it sp-d} mixing is considered. It is
shown that the Coulomb mechanism reduces to long-range dipole-dipole energy
transfer from photoexcited quantum dots to Mn ions. The recombination
due to the Coulomb mechanism is allowed for any states of Mn ions and
{\it e-h} complexes. In contrast, short-range exchange and
recombinations are subject to spin selection rules, which are the result of
strong {\it lh-hh} splitting of hole states in quantum dots. Estimates show
that efficiency of the {\it sp-d} mechanism can considerably exceed that of the
Coulomb mechanism. The phonon-assisted recombination and processes involving
upper excited states of Mn ions are studied. The increase in PL
intensity of an ensemble of quantum dots in a magnetic field perpendicular to
the sample growth plane observed earlier is analyzed as a possible
manifestation of the spin-dependent recombination.Comment: 14 pages, 2 figure
- …