Trypanosomes are monophyletic: evidence from genes for glyceraldehyde phosphate dehydrogenase and small subunit ribosomal RNA.

The genomes of Trypanosoma brucei, Trypanosoma cruzi and Leishmania major have been sequenced, but the phylogenetic relationships of these three protozoa remain uncertain. We have constructed trypanosomatid phylogenies based on genes for glycosomal glyceraldehyde phosphate dehydrogenase (gGAPDH) and small subunit ribosomal RNA (SSU rRNA). Trees based on gGAPDH nucleotide and amino acid sequences (51 taxa) robustly support monophyly of genus Trypanosoma, which is revealed to be a relatively late-evolving lineage of the family Trypanosomatidae. Other trypanosomatids, including genus Leishmania, branch paraphyletically at the base of the trypanosome clade. On the other hand, analysis of the SSU rRNA gene data produced equivocal results, as trees either robustly support or reject monophyly depending on the range of taxa included in the alignment. We conclude that the SSU rRNA gene is not a reliable marker for inferring deep level trypanosome phylogeny. The gGAPDH results support the hypothesis that trypanosomes evolved from an ancestral insect parasite, which adapted to a vertebrate/insect transmission cycle. This implies that the switch from terrestrial insect to aquatic leech vectors for fish and some amphibian trypanosomes was secondary. We conclude that the three sequenced pathogens, T. brucei, T. cruzi and L. major, are only distantly related and have distinct evolutionary histories

Algebraic geometric methods for the stabilizability and reliability of multivariable and of multimode systems

The extent to which feedback can alter the dynamic characteristics (e.g., instability, oscillations) of a control system, possibly operating in one or more modes (e.g., failure versus nonfailure of one or more components) is examined

Evolutionary design of a full-envelope full-authority flight control system for an unstable high-performance aircraft

The use of an evolutionary algorithm in the framework of H1 control theory is being considered as a means for synthesizing controller gains that minimize a weighted combination of the infinite norm of the sensitivity function (for disturbance attenuation requirements) and complementary sensitivity function (for robust stability requirements) at the same time. The case study deals with a complete full-authority longitudinal control system for an unstable high-performance jet aircraft featuring (i) a stability and control augmentation system and (ii) autopilot functions (speed and altitude hold). Constraints on closed-loop response are enforced, that representing typical requirements on airplane handling qualities, that makes the control law synthesis process more demanding. Gain scheduling is required, in order to obtain satisfactory performance over the whole flight envelope, so that the synthesis is performed at different reference trim conditions, for several values of the dynamic pressure, used as the scheduling parameter. Nonetheless, the dynamic behaviour of the aircraft may exhibit significant variations when flying at different altitudes, even for the same value of the dynamic pressure, so that a trade-off is required between different feasible controllers synthesized at different altitudes for a given equivalent airspeed. A multiobjective search is thus considered for the determination of the best suited solution to be introduced in the scheduling of the control law. The obtained results are then tested on a longitudinal non-linear model of the aircraft

Synonymy and stratigraphic ranges of Belemnopsis in the Heterian and Ohauan Stages (Callovian-Tithonian), southwest Auckland, New Zealand.

Belemnopsis stevensi, Belemnopsis maccrawi, and Belemnopsis sp. A (Challinor 1979a) are synonymous; B. stevensi has priority. New belemnite material from Kawhia Harbour and Port Waikato, together with graphical study methods, indicates that many small fragmentary specimens associated with B. stevensi in the lower part of its stratigraphic range are probably the same taxon. B. stevensi has been found only in the Middle and Upper Heterian Stage (Lower Kimmeridgian) at Kawhia and only in the Lower Ohauan Stage (Upper Kimmeridgian) at Port Waikato. This apparently disjunct distribution is attributed to poor exposure in the relevant sections. Belemnopsis kiwiensis n.sp., Belemnopsis cf. sp. B, Belemnopsis sp. B, Belemnopsis sp. D, and Belemnopsis spp. are associated with B. stevensi near the lowest known point in its stratigraphic range. The distribution of stratigraphically useful belemnites within the Heterian and Ohauan Stages is: Conodicoelites spp. (Lower Heterian; correlated with Lower Callovian); Belemnopsis annae (Lower and Middle Heterian; Lower Callovian/Lower Kimmeridgian); Belemnopsis stevensi (Middle Heterian/Lower Ohauan; Kimmeridgian); Belemnopsis keari (Upper Heterian; Kimmeridgian); Belemnopsis trechmanni (Upper Ohauan; Upper Kimmeridgian/Middle Tithonian). The apparently extreme range of Belemnopsis annae remains unexplained. Klondyke Sandstone (new) is recognised as the basal member of Moewaka Formation (Port Waikato area)

Charge renormalization and phase separation in colloidal suspensions

We explore the effects of counterion condensation on fluid-fluid phase separation in charged colloidal suspensions. It is found that formation of double layers around the colloidal particles stabilizes suspensions against phase separation. Addition of salt, however, produces an instability which, in principle, can lead to a fluid-fluid separation. The instability, however, is so weak that it should be impossible to observe a fully equilibrated coexistence experimentally.Comment: 7 pages, Europhysics Letters (in press

Effects of Static and Dynamic Hamstring Stretching on Anaerobic Exercise Performance

Please view abstract in the attached PDF file

Worker heterogeneity, new monopsony, and training

A worker's output depends not only on his/her own ability but also on that of colleagues, who can facilitate the performance of tasks that each individual cannot accomplish on his/her own. We show that this common-sense observation generates monopsony power and is sufficient to explain why employers might expend resources on training employees even when the training is of use to other firms. We show that training will take place in better-than-average or ‘good’ firms enjoying greater monopsony power, whereas ‘bad’ firms will have low-ability workers unlikely to receive much training

Crystalline electric field effects in the electrical resistivity of PrOs4_4Sb12_{12}

The temperature $T$ and magnetic field $H$ dependencies of the electrical resistivity $\rho$ of the recently discovered heavy fermion superconductor \PrOsSb{} have features that are associated with the splitting of the Pr$^{3+}$ Hund's rule multiplet by the crystalline electric field (CEF). These features are apparently due to magnetic exchange and aspherical Coulomb scattering from the thermally populated CEF-split Pr$^{3+}$ energy levels. The $\rho(T)$ data in zero magnetic field can be described well by calculations based on CEF theory for various ratios of magnetic exchange and aspherical Coulomb scattering, and yield CEF parameters that are qualitatively consistent with those previously derived from magnetic susceptibility, specific heat, and inelastic neutron scattering measurements. Calculated $\rho(H)$ isotherms for a $\Gamma_{3}$ ground state qualitatively account for the `dome-shaped' feature in the measured $\rho(H)$ isotherms.Comment: 8 pages, 2 figures, submitted to Journal of Physics: Condensed Matte

Non-equilibrium dynamics and floral trait interactions shape extant angiosperm diversity.

Why are some traits and trait combinations exceptionally common across the tree of life, whereas others are vanishingly rare? The distribution of trait diversity across a clade at any time depends on the ancestral state of the clade, the rate at which new phenotypes evolve, the differences in speciation and extinction rates across lineages, and whether an equilibrium has been reached. Here we examine the role of transition rates, differential diversification (speciation minus extinction) and non-equilibrium dynamics on the evolutionary history of angiosperms, a clade well known for the abundance of some trait combinations and the rarity of others. Our analysis reveals that three character states (corolla present, bilateral symmetry, reduced stamen number) act synergistically as a key innovation, doubling diversification rates for lineages in which this combination occurs. However, this combination is currently less common than predicted at equilibrium because the individual characters evolve infrequently. Simulations suggest that angiosperms will remain far from the equilibrium frequencies of character states well into the future. Such non-equilibrium dynamics may be common when major innovations evolve rarely, allowing lineages with ancestral forms to persist, and even outnumber those with diversification-enhancing states, for tens of millions of years