Evaluation of selected chemical processes for production of low-cost silicon phase 2. silicon material task, low-cost silicon solar array project

Progress from October 1, 1977, through December 31, 1977, is reported in the design of the 50 MT/year experimental facility for the preparation of high purity silicon by the zinc vapor reduction of silicon tetrachloride in a fluidized bed of seed particles to form a free flowing granular product

Outcome from Spontaneous CP Violation for B Decays

In the aspon model solution of the strong $CP$ problem, there is a gauged $U(1)$ symmetry, spontaneously broken by the same vacuum expectation value which breaks $CP$, whose massive gauge boson provides an additional mechanism of weak $CP$ violation. We calculate the $CP$ asymmetries in $B$ decays for the aspon model and show that they are typically smaller than those predicted from the standard model. A linear relation between the $CP$ asymmetries of different decay processes is obtained.Comment: REVTEX, 9 pages, IFP-486-UNC, NSF-PT-94-1, and UDHEP-01-9

Sufficiently Small θˉ\bar{\theta} in SU(3)3×S3SU(3)^3 \times S_3 Unification Model

Since CP violation in weak decays is successfully described by the KM mechanism, the strong CP problem cannot easily be accommodated. This leads us to reconsider the issue. If the axion and massless up quark are abandoned, we must extend the standard model. Extension to $SU(3)^3 \times S_3$ unification leads to the following situation: {\it if} CP is a high-energy symmetry and the appropriate symmetry-breaking hierarchy of scales is in place, then the $\bar{\theta}$ parameter of the QCD sub-theory is guaranteed to be sufficiently small. We find $\bar{\theta} < 10^{-11}$ while the empirical limit from the neutron electric dipole moment requires only that $\bar{\theta} < 1.3 \times 10^{-10}$.Comment: 14 pages LaTeX including 10 figures. Typo correcte

Brain tumour diagnostics using a DNA methylation-based classifier as a diagnostic support tool

Aims: Methylation profiling (MP) is increasingly incorporated in the diagnostic process of central nervous system (CNS) tumours at our centres in The Netherlands and Scandinavia. We aimed to identify the benefits and challenges of MP as a support tool for CNS tumour diagnostics. Methods: About 502 CNS tumour samples were analysed using (850 k) MP. Profiles were matched with the DKFZ/Heidelberg CNS Tumour Classifier. For each case, the final pathological diagnosis was compared to the diagnosis before MP. Results: In 54.4% (273/502) of all analysed cases, the suggested methylation class (calibrated score ≥0.9) corresponded with the initial pathological diagnosis. The diagnosis of 24.5% of these cases (67/273) was more refined after incorporation of the MP result. In 9.8% of cases (49/502), the MP result led to a new diagnosis, resulting in an altered WHO grade in 71.4% of these cases (35/49). In 1% of cases (5/502), the suggested class based on MP was initially disregarded/interpreted as misleading, but in retrospect, the MP result predicted the right diagnosis for three of these cases. In six cases, the suggested class was interpreted as ‘discrepant but noncontributory’. The remaining 33.7% of cases (169/502) had a calibrated score <0.9, including 7.8% (39/502) for which no class indication was given at all (calibrated score <0.3). Conclusions: MP is a powerful tool to confirm and fine-tune the pathological diagnosis of CNS tumours, and to avoid misdiagnoses. However, it is crucial to interpret the results in the context of clinical, radiological, histopathological and other molecular information

The role of the chemokine receptor CXCR4 in infection with feline immunodeficiency virus

Infection with feline immunodeficiency virus (FIV) leads to the development of a disease state similar to AIDS in man. Recent studies have identified the chemokine receptor CXCR4 as the major receptor for cell culture-adapted strains of FIV, suggesting that FIV and human immunodeficiency virus (HIV) share a common mechanism of infection involving an interaction between the virus and a member of the seven transmembrane domain superfamily of molecules. This article reviews the evidence for the involvement of chemokine receptors in FIV infection and contrasts these findings with similar studies on the primate lentiviruses HIV and SIV (simian immunodeficiency virus)

Exploring the sensitivity of next generation gravitational wave detectors

The second-generation of gravitational-wave detectors are just starting operation, and have already yielding their first detections. Research is now concentrated on how to maximize the scientific potential of gravitational-wave astronomy. To support this effort, we present here design targets for a new generation of detectors, which will be capable of observing compact binary sources with high signal-to-noise ratio throughout the Universe

GW170817: Implications for the Stochastic Gravitational-Wave Background from Compact Binary Coalescences

The LIGO Scientific and Virgo Collaborations have announced the event GW170817, the first detection of gravitational waves from the coalescence of two neutron stars. The merger rate of binary neutron stars estimated from this event suggests that distant, unresolvable binary neutron stars create a significant astrophysical stochastic gravitational-wave background. The binary neutron star component will add to the contribution from binary black holes, increasing the amplitude of the total astrophysical background relative to previous expectations. In the Advanced LIGO-Virgo frequency band most sensitive to stochastic backgrounds (near 25 Hz), we predict a total astrophysical background with amplitude ΩGW(f=25 Hz)=1.8-1.3+2.7×10-9 with 90% confidence, compared with ΩGW(f=25 Hz)=1.1-0.7+1.2×10-9 from binary black holes alone. Assuming the most probable rate for compact binary mergers, we find that the total background may be detectable with a signal-to-noise-ratio of 3 after 40 months of total observation time, based on the expected timeline for Advanced LIGO and Virgo to reach their design sensitivity

GW170608: Observation of a 19 Solar-mass Binary Black Hole Coalescence

On 2017 June 8 at 02:01:16.49 UTC, a gravitational-wave (GW) signal from the merger of two stellar-mass blackholes was observed by the two Advanced Laser Interferometer Gravitational-Wave Observatory detectors with anetwork signal-to-noise ratio of 13. This system is the lightest black hole binary so far observed, with componentmasses of 12+7-2M⊙7+2-2 (90% credible intervals). These lie in the range of measured black hole masses inlow-mass X-ray binaries, thus allowing us to compare black holes detected through GWs with electromagneticobservations. The source\u27s luminosity distance is 340+140-140corresponding to redshift -0.07+0.03003. We verify thatthe signal waveform is consistent with the predictions of general relativity

First narrow-band search for continuous gravitational waves from known pulsars in advanced detector data

Spinning neutron stars asymmetric with respect to their rotation axis are potential sources of continuous gravitational waves for ground-based interferometric detectors. In the case of known pulsars a fully coherent search, based on matched filtering, which uses the position and rotational parameters obtained from electromagnetic observations, can be carried out. Matched filtering maximizes the signal-to-noise (SNR) ratio, but a large sensitivity loss is expected in case of even a very small mismatch between the assumed and the true signal parameters. For this reason, narrow-band analysis methods have been developed, allowing a fully coherent search for gravitational waves from known pulsars over a fraction of a hertz and several spin-down values. In this paper we describe a narrow-band search of 11 pulsars using data from Advanced LIGO\u27s first observing run. Although we have found several initial outliers, further studies show no significant evidence for the presence of a gravitational wave signal. Finally, we have placed upper limits on the signal strain amplitude lower than the spin-down limit for 5 of the 11 targets over the bands searched; in the case of J1813-1749 the spin-down limit has been beaten for the first time. For an additional 3 targets, the median upper limit across the search bands is below the spin-down limit. This is the most sensitive narrow-band search for continuous gravitational waves carried out so far