Unsupervised Feature Selection with Adaptive Structure Learning

The problem of feature selection has raised considerable interests in the past decade. Traditional unsupervised methods select the features which can faithfully preserve the intrinsic structures of data, where the intrinsic structures are estimated using all the input features of data. However, the estimated intrinsic structures are unreliable/inaccurate when the redundant and noisy features are not removed. Therefore, we face a dilemma here: one need the true structures of data to identify the informative features, and one need the informative features to accurately estimate the true structures of data. To address this, we propose a unified learning framework which performs structure learning and feature selection simultaneously. The structures are adaptively learned from the results of feature selection, and the informative features are reselected to preserve the refined structures of data. By leveraging the interactions between these two essential tasks, we are able to capture accurate structures and select more informative features. Experimental results on many benchmark data sets demonstrate that the proposed method outperforms many state of the art unsupervised feature selection methods

Expression of polyhedrin-hEGF fusion protein in cultured cells and larvae of Bombyx mori

For mass production of human epidermal growth factor (hEGF), silkworm baculovirus expression vector system (BEVS) was adopted in this study. hEGF gene was in-frame fused with polyhedrin (Ph) gene under the control of Ph promoter and was used to co-transfect BmN cell with the modifiedBombyx mori baculovirus DNA to obtained recombinant virus. The ELISA showed a maximum expression on day 4 in larvae and pupae. Both cellular extracts and haemolymph of silkworm larvae infected with rBacPh-EGF could all support the proliferation of Balb/c 3T3 cell. The correspondingmaterials from BmN cell and silkworm larvae infected with wild virus also indicated a weak effect of upregulation on 3T3 cells proliferation. The animal study showed that both pupae infected with rBacPh-EGF virus and wild virus protected the gastric mucosa against ethanol-induced damage in rats,although the protection from pupae infected with wild virus was slightly weak. The mechanism is under investigatin

Evidence from Ab Initio and Transport Modeling for Diffusion-Driven Zirconium Isotopic Fractionation in Igneous Rocks

We use density functional theory to calculate the equilibrium isotopic fractionation factors of zirconium (Zr) in a variety of minerals including zircon, baddeleyite, Ca-catapleiite, ilmenite, geikielite, magnetite, apatite, K-feldspar, quartz, olivine, clinopyroxene, orthopyroxene, amphibole, and garnet. We also report equilibrium isotopic fractionation factors for Hf in zircons, Ca-catapleiite, and ilmenite. These calculations show that coordination environment is an important control on Zr and Hf isotopic fractionation, with minerals with Zr and Hf in low coordinations predicted to be enriched in the heavy isotopes of Zr and Hf, relative to those with Zr and Hf in high coordinations. At equilibrium, zircon, which hosts Zr and Hf in 8-fold coordination, is predicted to have low 94Zr/90Zr and 179Hf/177Hf ratios compared to silicate melt, which hosts Zr and Hf in 6-fold coordination. However, our modeling results indicate that little equilibrium isotopic fractionation for Zr is expected during magmatic differentiation and zircon crystallization. We show through isotopic transport modeling that the Zr isotopic variations that were documented in igneous rocks are likely due to diffusion-driven kinetic isotopic fractionation. The two settings where this could take place are (i) diffusion-limited crystallization of zircon (DLC model) and (ii) diffusion-triggered crystallization of zircon (DTC model) in the boundary layer created by the growth of Zr-poor minerals. Fractional crystallization of zircons enriched in light Zr isotopes by diffusion can drive residual magmas toward heavy Zr isotopic compositions. Our diffusive transport model gives the framework to interpret Zr isotope data and gain new insights into the cooling history of igneous rocks and the setting of zircon crystallization

The cTnT response to acute exercise at the onset of an endurance training program: evidence of exercise preconditioning?

PURPOSE: Exercise induces a cardioprotective effect referred to as "preconditioning". Whether the preconditioning impacts upon the cardiac troponin T (cTnT) response to subsequent exercise bouts is unclear. This study investigated the effects of an initial exercise bout, a second exercise bout 48 h later, as well as subsequent exercise every 48 h for 4 days or a single identical exercise bout after 8 days of inactivity gap on cTnT response to acute exercise. METHODS: Twenty-eight sedentary overweight young women were randomly assigned to either six bouts of exercise each separated by 48 h or three bouts of exercise with 48 h between the first two bouts and 8 days between the second and third bouts. All exercise bouts were identical (60% [Formula: see text], 200 kJ) and the total testing period (10 days) was the same for both groups. cTnT was assessed before and after the 1st, 2nd, and final exercise bouts. RESULTS: cTnT increased (129%, P  0.05) effect on post-exercise cTnT (< 3.00[< 3.00-21.96]). The final exercise bout resulted in an increase (190%, P < 0.05) in cTnT (4.35[< 3.00-13.05]) in both groups. CONCLUSIONS: A single bout exercise resulted in a temporary blunting of cTnT response to acute exercise 48 h later. The effect of exercise preconditioning was not preserved, regardless of whether followed by repeated exercise every 48 h or a cessation of exercise for 8 days

Evolution of In-Plane Magnetic Anisotropy In Sputtered FeTaN/TaN/FeTaN Sandwich Films

FeTaN/TaN/FeTaN sandwich films, FeTaN/TaN and TaN/FeTaN bilayers were synthesized by using RF magnetron sputtering. The magnetic properties, crystalline structures, microstructures and surface morphologies of the as-deposited samples were characterized using angle-resolved M-H loop tracer, VSM, XRD, TEM, AES and AFM. An evolution of the in-plane anisotropy was observed with the changing thickness of the nonmagnetic TaN interlayer in the FeTaN/TaN/FeTaN sandwiches, such as the easy-hard axis switching and the appearing of biaxial anisotropy. It is ascribed to three possible mechanisms, which are interlayer magnetic coupling, stress, and interface roughness, respectively. Interlayer coupling and stress anisotropies may be the major reasons to cause the easy-hard axis switching in the sandwiches. Whereas, magnetostatic and interface anisotropies may be the major reasons to cause biaxial anisotropy in the sandwiches, in which magnetostatic anisotropy is the dominant one.Comment: 6 pages, 3 figure

Interspecific hybridization between Mauremys reevesii and Mauremys sinensis: Evidence from morphology and DNA sequence data

Turtle hybrids have been found in some taxa, but so far, studies on interspecific hybridization between Mauremy reevesii and Mauremy sinensis have not been reported. Recently, we obtained three specimens (Hy1, Hy2, Hy3）with unusual morphological characteristics from pet trade Market, which are suspected to be hybrids rather than new species, because they were morphologies intermediate between M. reevesii and M. sinensis. In further study, we analyzed two aspects; morphological characteristics and molecular data, separately. The morphological characteristics showed that the pattern of the carapace, the plastron and neck stripes of the three specimens was between that of M. reevesii and M. sinensis (the morphological features of Hy1 and Hy2 have more resemblance with those of M. sinensis, and those of Hy3 have more resemblance with those of M. reevesii). In molecular analyses, two mitochondrial genes (12S, cytb) and two nuclear genes (RAG-1, R35) were respectively cloned from each suspected specimen. One sequence was obtained for each mitochondrial gene, while two different sequences were obtained for each nuclear gene. Phylogenetic analyses revealed that mitochondrial genes sequences from each suspected specimen clustered into the corresponding sequences of their putative female parents, while the two pairs nuclear parental alleles sequences were strongly paraphyletic, for they were included in two different genetic lineages (M. reevesii and M. sinensis). Therefore, we concluded that the three suspected specimens are hybrids (Hy1 and Hy2: M. reevesii♂ × M. sinensis♀; Hy3: M. sinensis♂ × M. reevesii♀). It is the first report that interspecies hybridization of M. reevesii and M. sinensis can cross completely.Key words: Mauremys reevesii, Mauremys sinensis, hybridization, morphology, DNA sequence

Colossal Elastocaloric Effect in Ferroelastic Ni-Mn-Ti Alloys

Energy-efficient and environment-friendly elastocaloric refrigeration, which is a promising replacement of the conventional vapor-compression refrigeration, requires extraordinary elastocaloric properties. Hitherto the largest elastocaloric effect is obtained in small-size films and wires of the prototype NiTi system. Here, we report a colossal elastocaloric effect, well exceeding that of NiTi alloys, in a class of bulk polycrystalline NiMn-based materials designed with the criterion of simultaneously having large volume change across phase transition and good mechanical properties. The reversible adiabatic temperature change reaches a strikingly high value of 31.5 K and the isothermal entropy change is as large as 45  J kg−1 K−1. The achievement of such a colossal elastocaloric effect in bulk polycrystalline materials should push a significant step forward towards large-scale elastocaloric refrigeration applications. Moreover, our design strategy may inspire the discovery of giant caloric effects in a broad range of ferroelastic materials