Local Maximum Entropy Shape Functions Based FE-EFGM Coupling

In this paper, a new method for coupling the finite element method (FEM)and the element-free Galerkin method (EFGM) is proposed for linear elastic and geometrically nonlinear problems using local maximum entropy shape functions in theEFG zone of the problem domain. These shape functions possess a weak Kroneckerdelta property at the boundaries which provides a natural way to couple the EFGand the FE regions as compared to the use of moving least square basis functions.In this new approach, there is no need for interface/transition elements between theEFG and the FE regions or any other special treatment for shape function continuity across the FE-EFG interface. One- and two-dimensional linear elastic and two-dimensional geometrically nonlinear benchmark numerical examples are solved by the new approach to demonstrate the implementation and performance of the current approach

Boundary conditions and Berry phase in magnetic nanostructures

The effect of micromagnetic boundary conditions on the Berry curvature and topological Hall effect in granular nanostructures is investi- gated by model calculations. Both free surfaces and grain boundaries between interacting particles or grains affect the spin structure. The Dzyaloshinskii-Moriya interactions yield corrections to the Erdmann-Weierstrass boundary conditions, but the Berry curvature remains an exclusive functional of the local spin structure, which greatly simplifies the treatment of nanostructures. An explicit example is a model nanostructure with cylindrical symmetry whose spin structure is described by Bessel function and which yields a mean-field-type Hall-effect contribution that can be related to magnetic-force-microscopy images

Contact force and atrial fibrillation ablation.

Catheters able to measure the force and vector of contact between the catheter tip and myocardium are now available. Pre-clinical work has established that the degree of contact between the radiofrequency ablation catheter and myocardium correlates with the size of the delivered lesion. Excess contact is associated with steam pops and perforation. Catheter contact varies within the left atrium secondary to factors including respiration, location, atrial rhythm and the trans-septal catheter delivery technology used. Compared with procedures performed without contact force (CF)-sensing, the use of this technology has, in some studies, been found to improve complication rates, procedure and fluoroscopy times, and success rates. However, for each of these parameters there are also studies suggesting a lack of difference from the availability of CF data. Nevertheless, CF-sensing technology has been adopted as a standard of care in many institutions. It is likely that use of CF-sensing technology will allow for the optimization of each individual radiofrequency application to maximize efficacy and procedural safety. Recent work has attempted to define what these optimal targets should be, and approaches to do this include assessing for sites of pulmonary vein reconnection after ablation, or comparing the impedance response to ablation. Based on such work, it is apparent that factors including mean CF, force time integral (the area under the force-time curve) and contact stability are important determinants of ablation efficacy. Multicenter prospective randomized data are lacking in this field and required to define the CF parameters required to produce optimal ablation

The endophytic fungus Piriformospora indica protects wheat from Fusarium crown rot disease in simulated UK autumn conditions

The root endophytic fungus Piriformospora indica (Sebacinacea) forms mutualistic symbioses with a broad range of host plants, increasing their biomass production and resistance to fungal pathogens. We evaluated the effect of P. indica on Fusarium crown rot disease of wheat, under in vitro and glasshouse conditions. Interaction of P. indica and Fusarium isolates under axenic culture conditions indicated no direct antagonistic activity of P. indica against Fusarium isolates. Seedlings of wheat were inoculated with P. indica and pathogenic Fusarium culmorum or F. graminearum and grown in sterilised soil-free medium or in a non-sterilised mix of soil and sand. Fusarium alone reduced emergence and led to visible browning and reduced root growth. Roots of seedlings in pots inoculated with both Fusarium isolates and P. indica were free of visible symptoms; seed emergence and root biomass were equivalent to the uninoculated. DNA was quantified by real-time polymerase chain reaction (qPCR). The ratio of Fusarium DNA to wheat DNA rose rapidly in the plants inoculated with Fusarium alone; isolates and species were not significantly different. P. indica inoculation reduced the ratio of Fusarium to host DNA in the root systems. The reduction increased with time. The ratio of P. indica to wheat DNA initially rose but then declined in root systems without Fusarium. With Fusarium, the ratio rose throughout the experiment. The absolute amount of Fusarium DNA in root systems increased in the absence of P. indica but was static in plants co-inoculated with P. indica

Bubble-based EMMS mixture model applied to turbulent fluidization Powder Technology

Turbulent fluidization is now widely recognized as a distinct flow regime and is commonly utilized in industrial fluidized-bed reactors. However, relatively fewer attempts have been made to rigorously model these systems in comparison to bubbling and circulating fluidized beds. In this work, we have rewritten the original bubble based EMMS model in form of a mixture to apply it to turbulent fluidization. At microscale this mixture is composed of gas and particles whereas voids and gas-particle suspension make up this mixture at mesoscale level. Subsequently, all the system properties are then calculated in terms of mixture rather than individual phases. With the minimization of the objective function for the bubbling mixture, the set of equations is then solved numerically. The objective function, used to close the system of equations, is composed of the energy consumption rates required to suspend gas-particle suspension and the energy consumed due to interaction between suspension and voids. The model is then applied to simulate gas-solid turbulent fluidized beds. Simulation results are encouraging as the model is able to predict the dense bottom and dilute top zones along the height of the bed. Comparison of results with experimental data and homogeneous drag model has been made for validation purposes

Percutaneous Intervention or Bypass Graft for Left Main Coronary Artery Disease? A Systematic Review and Meta-Analysis

Background. The safety and efficacy of percutaneous coronary intervention (PCI) versus coronary artery bypass grafting (CABG) for stable left main coronary artery disease (LMCAD) remains controversial.Methods. Digital databases were searched to compare the major adverse cardiovascular and cerebrovascular events (MACCE) and its components. A random effect model was used to compute an unadjusted odds ratio (OR).Results. A total of 43 studies (37 observational and 6 RCTs) consisting of 29,187 patients (PCI 13,709 and CABG 15,478) were identified. The 30-day rate of MACCE (OR, 0.56; 95% CI, 0.42-0.76;p = 0.0002) and all-cause mortality (OR, 0.52; 95% CI, 0.30-0.91;p = 0.02) was significantly lower in the PCI group. There was no significant difference in the rate of myocardial infarction (MI) (p = 0.17) and revascularization (p = 0.12). At 5 years, CABG was favored due to a significantly lower rate of MACCE (OR, 1.67; 95% CI, 1.18-2.36;p = <0.04), MI (OR, 1.67; 95% CI, 1.35-2.06;p = <0.00001), and revascularization (OR, 2.80; 95% CI, 2.18-3.60;p = <0.00001), respectively. PCI was associated with a lower overall rate of a stroke, while the risk of all-cause mortality was not significantly different between the two groups at 1- (p = 0.75), 5- (p = 0.72), and 10-years (p = 0.20). The Kaplan-Meier curve reconstruction revealed substantial variations over time; the 5-year incidence of MACCE was 38% with CABG, significantly lower than 45% with PCI (p = <0.00001).Conclusion. PCI might offer early safety advantages, while CABG provides greater durability in terms of lower long-term risk of ischemic events. There appears to be an equivalent risk for all-cause mortality

Three-dimensional FE-EFGM adaptive coupling with application to nonlinear adaptive analysis

Three-dimensional problems with both material and geometrical nonlinearities are of practical importance in many engineering applications, e.g. geomechanics, metal forming and biomechanics. Traditionally, these problems are simulated using an adaptive finite element method (FEM). However, the FEM faces many challenges in modeling these problems, such as mesh distortion and selection of a robust refinement algorithm. Adaptive meshless methods are a more recent technique for modeling these problems and can overcome the inherent mesh based drawbacks of the FEM but are computationally expensive. To take advantage of the good features of both methods, in the method proposed in this paper, initially the whole of the problem domain is modeled using the FEM. During an analysis those elements which violate a predefined error measure are automatically converted to a meshless zone. This zone can be further refined by adding nodes, overcoming computationally expensive FE remeshing. Therefore an appropriate coupling between the FE and the meshless zone is vital for the proposed formulation. One of the most widely used meshless methods, the element-free Galerkin method (EFGM), is used in this research. Maximum entropy shape functions are used instead of the conventional moving least squares based formulations'. These shape functions posses a weak Kronecker delta property at the boundaries of the problem domain, which allows the essential boundary conditions to be imposed directly and also helps to avoid the use of a transition region in the coupling between the FE and the EFG regions. Total Lagrangian formulation is preferred over the updated Lagrangian formulation for modeling finite deformation due to its computational efficiency. The well-established error estimation procedure of Zienkiewicz-Zhu is used in the FE region to determine the elements requiring conversion to the EFGM. The Chung and Belytschko error estimator is used in the EFG region for further adaptive refinement. Numerical examples are presented to demonstrate the performance of the current approach in thre

Potential ecological effects of Piriformospora indica, a possible biocontrol agent, in UK agricultural systems

Piriformospora indica (Sebacinaceae), a root endophytic fungus, was originally isolated from an arid sub-tropical soil. P. indica forms mutualistic symbioses with a broad range of host plants, increases biomass production, resistance and tolerance to fungal pathogens and abiotic stresses. These characteristics make it a very attractive component of more sustainable agriculture. So, it is desirable to understand its wider ecosystem effects. We determined how long P. indica could survive in the soil and how it interacts with other soil microorganisms and some important arable weeds. Survival of P. indica in the soil, under winter and summer conditions in the UK was tested by isolating DNA and RNA of P. indica from pots of soil which had been left open to winter-summer weather conditions without host plants, followed by PCR and reverse transcription-PCR (RT-PCR) with P. indica-specific primers. P. indica effects on other soil and root microorganisms were tested by PCR-denaturing gradient gel electrophoresis analysis of DNA extracted from soil and roots from pots in which P. indica-infected wheat had been grown. The effect of P. indica on growth of black-grass (Alopecuris myosuroides), wild-oat (Avena fatua) and cleavers (Galium aparine) was tested alone and in competition with wheat. In soil P. indica-mRNA and DNA could still be detected after eight months, but not after 15 months. Soils from P. indica-inoculated pots had distinct fungal and bacterial species communities which were more diverse than non-inoculated controls. P. indica infected A. myosuroides and A. fatua but was not detected in G. aparine. The average above-ground competitiveness of the weeds with wheat was decreased. If applied to field crops in the UK, P. indica would be persistent for up to 15 months and likely to alter competitive relations within vegetation. Increased soil microbial diversity during the first eight weeks after inoculation, although usually desirable, could alter soil composition or functioning