Study of atmospheric and AAP objectives of cross beam experiments Final report, 23 Jan. 1967 - 9 Jan. 1968

Light beam triangulation technique for atmospheric measurement

A hybrid computer study of a dynamic ship positioning system

Hybrid computer program for dynamic ship positioning syste

The psychology of senescence: An introductory study

The following biographical studies have been made with the purpose of showing through concrete cases some aspects of mental decline in senescence. To the objection that each of these cases follows a course in a degree divergent from that of normal mental decline, the reply is that a study of these striking instanced, we believe, afford a more ready insight into the underlying phenomena than would a similar one which deals with average or typical cases. The significance of exceptional cases should not be underestimated. Certain peculiar conditions have been present which have modified the typical phenomena, but after due allowance has been made for these conditions and their effects, the underlying essential causes stand out more clearly

Recent CR1 non-LTR retrotransposon activity in coscoroba reveals an insertion site preference

<p>Abstract</p> <p>Background</p> <p>Chicken repeat 1 (CR1) is a taxonomically widespread non-LTR retrotransposon. Insertion site bias, or lack thereof, has not been demonstrated for CR1. Recent CR1 retrotranspositions were used to examine flanking regions for GC content and nucleotide bias at the insertion site.</p> <p>Results</p> <p>Elucidation of the exact octomer repeat sequence (TTCTGTGA) allowed for the identification of younger insertion events. The number of octomer repeats associated with a CR1 element increases after insertion with CR1s having one octomer being youngest. These young CR1s are flanked by regions of low GC content (38%). Furthermore, a bias for specific bases within the first four positions at the site of insertion was revealed.</p> <p>Conclusion</p> <p>This study focused on those loci where the insertion event has been most recent, as this would tend to minimize noise introduced by post-integration mutational events. Our data suggest that CR1 is not inserting into regions of higher GC content within the coscoroba genome; but rather, preferentially inserting into regions of lower GC content. Furthermore, there appears to be a base preference (TTCT) for the insertion site. The results of this study increase the current level of understanding regarding the elusive CR1 non-LTR retrotransposon.</p

Arctic Security Considerations and the U.S. Navy’s Roadmap for the Arctic

The scope and magnitude of changes to the Arctic region as a result of a changing climate are great—shifts in species populations and distribution, more navigable transportation passages, increased shipping activity and resource extraction, and modified global circulation patterns. The Navy’s Task Force Climate Change is addressing these considerations, which will shape safety and security in the Arctic

Accuracy and bias of visual estimates of numbers, size structure and biomass of a coral reef fish

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Insight into the Carboxyl Transferase Domain Mechanism of Pyruvate Carboxylase from \u3cem\u3eRhizobium etli\u3c/em\u3e

The effects of mutations in the active site of the carboxyl transferase domain of Rhizobium etli pyruvate carboxylase have been determined for the forward reaction to form oxaloacetate, the reverse reaction to form MgATP, the oxamate-induced decarboxylation of oxaloacetate, the phosphorylation of MgADP by carbamoyl phosphate, and the bicarbonate-dependent ATPase reaction. Additional studies with these mutants examined the effect of pyruvate and oxamate on the reactions of the biotin carboxylase domain. From these mutagenic studies, putative roles for catalytically relevant active site residues were assigned and a more accurate description of the mechanism of the carboxyl transferase domain is presented. The T882A mutant showed no catalytic activity for reactions involving the carboxyl transferase domain but surprisingly showed 7- and 3.5-fold increases in activity, as compared to that of the wild-type enzyme, for the ADP phosphorylation and bicarbonate-dependent ATPase reactions, respectively. Furthermore, the partial inhibition of the T882A-catalyzed BC domain reactions by oxamate and pyruvate further supports the critical role of Thr882 in the proton transfer between biotin and pyruvate in the carboxyl transferase domain. The catalytic mechanism appears to involve the decarboxylation of carboxybiotin and removal of a proton from Thr882 by the resulting biotin enolate with either a concerted or subsequent transfer of a proton from pyruvate to Thr882. The resulting enolpyruvate then reacts with CO2 to form oxaloacetate and complete the reaction

Flight Test Results of an Axisymmetric Channeled Center Body Supersonic Inlet at Off-Design Conditions

Flight-testing of a channeled center-body axisymmetric supersonic inlet design concept was conducted at the National Aeronautics and Space Administration (NASA) Dryden Flight Research Center in collaboration with the NASA Glenn Research Center (Cleveland, Ohio) and TechLand Research, Inc. (North Olmsted, Ohio). This testing utilized the Propulsion Flight Test Fixture, flown on the NASA F-15B research test bed airplane (NASA tail number 836) at local experiment Mach numbers up to 1.50. The translating channeled center-body inlet was designed by TechLand Research, Inc. (U.S. Patent No. 6,276,632 B1) to allow for a novel method of off-design flow matching, with original test planning conducted under a NASA Small Business Innovative Research study. Data were collected in flight at various off-design Mach numbers for fixed-geometry representations of both the channeled center-body design and an equivalent area smooth center-body design for direct comparison of total pressure recovery and limited distortion measurements