Daily Mutual Fund Flows and Redemption Policies

We examine how redemption policies affect daily fund flows in open-end mutual funds. Since short-term trading of fund shares, as manifested in daily fund flows, can have an adverse impact on returns to the fund’s shareholders, mutual funds might find it desirable to discourage short-term trading through the use of redemption fees. However, if daily fund flows are due to fund shareholders’ legitimate liquidity demands, the redemption fee would have little effect on daily fund flows and possibly adversely affect fund shareholders by imposing a liquidity cost on them. We find that the likelihood of a fund charging a redemption fee is largely a function of its overall fee structure. We also use a sample of funds that imposed redemption fees to examine whether the distribution of daily fund flows changes after the initiation of the redemption fee. We find that the redemption fee is an effective tool in controlling the volatility of fund flows

Topological Modes in Dual Lattice Models

Lattice gauge theory with gauge group $Z_{P}$ is reconsidered in four dimensions on a simplicial complex $K$. One finds that the dual theory, formulated on the dual block complex $\hat{K}$, contains topological modes which are in correspondence with the cohomology group $H^{2}(\hat{K},Z_{P})$, in addition to the usual dynamical link variables. This is a general phenomenon in all models with single plaquette based actions; the action of the dual theory becomes twisted with a field representing the above cohomology class. A similar observation is made about the dual version of the three dimensional Ising model. The importance of distinct topological sectors is confirmed numerically in the two dimensional Ising model where they are parameterized by $H^{1}(\hat{K},Z_{2})$.Comment: 10 pages, DIAS 94-3

Mechanical and Tribological Properties of Carbon-Based Graded Coatings

The paper presents research on coatings with advanced architecture, composed of a Cr/Cr2N ceramic/metal multilayer and graded carbon layers with varying properties from Cr/a-C:H to a-C:N. The microstructure of the coatings was analysed using transmission electron microscopy and Energy Dispersive Spectroscopy, the mechanical properties were tested by nanoindentation, spherical indentation, and scratch testing, and tribological tests were also conducted. The proper selection of subsequent layers in graded coatings allowed high hardness and fracture resistance to be obtained as well as good adhesion to multilayers. Moreover, these coatings have higher wear resistance than single coatings and a friction coefficient equal to 0.25

On Dijkgraaf-Witten Type Invariants

We explicitly construct a series of lattice models based upon the gauge group $Z_{p}$ which have the property of subdivision invariance, when the coupling parameter is quantized and the field configurations are restricted to satisfy a type of mod-$p$ flatness condition. The simplest model of this type yields the Dijkgraaf-Witten invariant of a $3$-manifold and is based upon a single link, or $1$-simplex, field. Depending upon the manifold's dimension, other models may have more than one species of field variable, and these may be based on higher dimensional simplices.Comment: 18 page

River Data Package for Hanford Assessments

This data package documents the technical basis for selecting physical and hydraulic parameters and input values that will be used in river modeling for Hanford assessments. This work was originally conducted as part of the Characterization of Systems Task of the Groundwater Remediation Project managed by Fluor Hanford, Inc. and revised as part of the Characterization of Systems Project managed by PNNL for DOE. The river data package provides calculations of flow and transport in the Columbia River system. The module is based on the legacy code for the Modular Aquatic Simulation System II (MASS2), which is a two-dimensional, depth-averaged model that provides the capability to simulate the lateral (bank-to-bank) variation of flow and contaminants. It simulates river hydrodynamics (water velocities and surface elevations), sediment transport, contaminant transport, biotic transport, and sediment-contaminant interaction, including both suspended sediments and bed sediments. This document presents the data assembled to run the river module components for the section of the Columbia River from Vernita Bridge to the confluence with the Yakima River. MASS2 requires data on the river flow rate, downstream water surface elevation, groundwater influx and contaminants flux, background concentrations of contaminants, channel bathymetry, and the bed and suspended sediment properties. Stochastic variability for some input parameters such as partition coefficient (kd) values and background radionuclide concentrations is generated by the Environmental Stochastic Preprocessor. River flow is randomized on a yearly basis. At this time, the conceptual model does not incorporate extreme flooding (for example, 50 to 100 years) or dam removal scenarios

The dynamic relationships between the three events that release individual Na+ ions from the Na+/K+-ATPase

© Macmillan Publishers Limited, 2012. This article is distributed under the terms of the Creative Commons Attribution License. The definitive version was published in Nature Communications 3 (2012): 669, doi:10.1038/ncomms1673.Na+/K+ pumps move net charge through the cell membrane by mediating unequal exchange of intracellular Na+ and extracellular K+. Most charge moves during transitions that release Na+ to the cell exterior. When pumps are constrained to bind and release only Na+, a membrane voltage-step redistributes pumps among conformations with zero, one, two or three bound Na+, thereby transiently generating current. By applying rapid voltage steps to squid giant axons, we previously identified three components in such transient currents, with distinct relaxation speeds: fast (which nearly parallels the voltage-jump time course), medium speed (τm=0.2–0.5 ms) and slow (τs=1–10 ms). Here we show that these three components are tightly correlated, both in their magnitudes and in the time courses of their changes. The correlations reveal the dynamics of the conformational rearrangements that release three Na+ to the exterior (or sequester them into their binding sites) one at a time, in an obligatorily sequential manner.This research was directly supported by the Intramural Research Program of the National Institutes of Health (NIH), NINDS, grants NIH HL36783 to D.C.G., and NIH U54GM087519 and R01GM030376 to F.B

Synchronization modulation increases transepithelial potentials in MDCK monolayers through Na/K pumps

Peer reviewedPublisher PD

Mammography stages of change in middle-aged women with schizophrenia: An exploratory analysis

BACKGROUND: Health care providers and educators who seek to create health promotion programs and individualized comprehensive care plans for women with schizophrenia are hindered by the lack of data to guide their efforts. PURPOSE: This study tested the hypothesis that women with schizophrenia adhere to mammography screening guidelines at the same rate as other same-age women. The study also investigated the validity of the Health Belief (HB) and Stages of Change (SOC) models for breast cancer screening among women with schizophrenia. METHODS: Socio-demographic and clinical variables, as well as knowledge, attitudes, and barriers were assessed as a function of stage of change related to breast cancer screening in 46 women with schizophrenia. RESULTS: Women with schizophrenia were statistically less likely to be adherent to the screening recommendations than those without schizophrenia. Some support was found for the validity of the HB and SOC models for breast cancer screening in women with schizophrenia. Women in the Precontemplation stage had significantly higher negative attitude scores compared to Contemplation and Action/Maintenance stages (59.7, 45.7, and 43.2, respectively), and there was a trend for more barriers in the Precontemplation group (4.6, 2.6, 2.7 respectively). CONCLUSION: Given the small sample size, further research on the rates of breast cancer screening in women with schizophrenia is warranted. Nonetheless, these data suggest that providers who care for women with schizophrenia may need to make take additional measures to ensure that this population receives appropriate screening so as to not put them at greater risk for a late-stage diagnosis of breast cancer. Furthermore, these pilot data suggest that HB and SOC theory-based interventions may be valid for increasing mammography rates in women with schizophrenia

Cancer screening in a middle-aged general population: factors associated with practices and attitudes

<p>Abstract</p> <p>Background</p> <p>The aim of this study was to identify factors associated with cancer screening practices and with general attitudes toward cancer screening in a general population.</p> <p>Methods</p> <p>Mailed survey of 30–60 year old residents of Geneva, Switzerland, that included questions about screening for five cancers (breast, cervix uteri, prostate, colon, skin) in the past 3 years, attitudes toward screening, health care use, preventive behaviours and socio-demographic characteristics. Cancer screening practice was dichotomised as having done at least one screening test in the past 3 years versus none.</p> <p>Results</p> <p>The survey response rate was 49.3% (2301/4670). More women than men had had at least one cancer screening test in the past 3 years (83.2% vs 34.5%, p < 0.001). A majority of women had had a cervical smear (76.6%) and a mammography (age 30–49: 35.0%; age 50 and older: 90.3%); and 55.1% of men 50–60 years old had been screened for prostate cancer. Other factors associated with screening included older age, higher income, a doctor visit in the past 6 months, reporting a greater number of preventive behaviours and a positive attitude toward screening. Factors linked with positive attitudes included female gender, higher level of education, gainful employment, higher income, a doctor visit in the past 6 months and a personal history of cancer.</p> <p>Conclusion</p> <p>Attitudes play an important role in cancer screening practices among middle-aged adults in the general population, independent of demographic variables (age and sex) that determine in part screening recommendations. Negative attitudes were the most frequent among men and the most socio-economically disadvantaged. The moderate participation rate raises the possibility of selection bias.</p