Performance analysis of real-time PSO tuned PI controller for regulating voltage and frequency in an AC microgrid

In this study, a control strategy based on the self-tuning method and synchronous reference frame (SRF) with PI regulator is proposed to achieve optimum quality of power in an autonomous micro grid (MG). The MGS is based on multiple distributed generation (DG) connected with 120 kV power grid. The proposed system is first simulated with fixed gain values for PI controller which are not optimal for sudden changes in the system i.e. transition of MG to islanding mode, load variations. So, the particle swarm optimization (PSO) has been utilized for tuning of PI controller parameters which ensure flexible performance and superior quality of power. The principal parameters considered in this study are, regulation of voltage and frequency, steady-state and dynamic response and harmonic distortion, mainly when microgrid is islanded. The performance of PI and PI-PSO is compared in this study by simulating AC microgrid in the MATLAB/Simulink environment. Summarized results of the system are provided to authenticate viability of proposed arrangement. The proposed controller performs intelligently while regulating voltage and frequency of the MGS and utility system.

Chopper Is Prodeath Regardless of the Effect of p75ICD on Sensitivity to Oxidative Stress

Background. The intracellular domain (ICD) of the neurotrophin receptor, p75NTR, exhibits variably pro- and antiapoptotic activity and has been implicated in neurodegenerative and neurodestructive disease. The molecular determinants of these cellular effects are not completely understood. The “Chopper” domain of p75ICD has been shown to be proapoptotic in in vitro systems in which p75ICD is proapoptotic. The effects of Chopper in systems in which p75ICD is antiapoptotic and, therefore, whether or not Chopper accounts for the variability of the cellular effects of p75ICD are not known. We therefore examined the effects of deletion of Chopper on the effects of p75ICD on in vitro cell culture systems in which p75ICD is pro- or antiapoptotic, respectively. Results. In HN33.11 murine neuroblastoma-hippocampal neuron hybrid cells, p75ICD is antiapoptotic. In NIH 3T3 cells, p75ICD is proapoptotic. In both cell lines deletion of the Chopper domain from p75ICD decreases the incidence of apoptosis resulting from oxidative stress. Thus, irrespective of the nature of the effects of p75ICD on the cell, its Chopper domain is proapoptotic. Conclusions. Expression of p75ICD can enhance or attenuate oxidative induction of apoptosis. Variability of the effects of p75ICD is not related to variability of the effects of its Chopper domain

Caregivers knowledge, practices about childhood diarrhea and pneumonia and their perceptions of lady health worker program; findings from NIGRAAN implementation research project

Background: Despite 60% coverage by Lady Health Worker (LHW) Program, 30% of child deaths in Pakistan are still due to diarrhea and pneumonia. Caregivers are an important stakeholder yet there is little information on their case management practices and utilization of LHW Program. This study explored caregivers’ knowledge and practices about childhood diarrhea and pneumonia and utility of LHW services before and after a supportive supervision intervention.Methods: Cross sectional surveys were conducted with caregivers’ (mothers) pre and post intervention in project NIGRAAN. The intervention aimed to improve LHSs clinical and supervisory skills of lady health supervisors in order to improve LHW performance and ultimately impact caregiver practices. 4250 households were surveyed. Questionnaire was adapted from PDHS 2012-13. Differences between intervention and control groups were assessed using chi square test. P-value of Results: Comparing baseline to end line, there were significant overall improvements in caregivers’knowledge of loose motion (62 to 84%) and dehydration (12 to 18%) as signs and symptoms of childhood diarrhea. There was also a significant overall increase in caregivers’ knowledge of presenting features of pneumonia- i.e. fever (58 to 86%), cough (51 to 61%) and breathing problems (25 to 57%). The proportion of caregivers seeking advice for diarrhea from public sector significantly improved in intervention arm from 20% to 29%. Private sector however remained overall preferred choice for care seeking. There was significant overall improvement in awareness about LHWs functioning (93 to 99%) and household visits (91 to 98%). Actual care seeking from LHWs however stayed low (≤ 0.3%) Conclusion: In order to improve utility and expand coverage of LHW Program interventions aimed at providing supportive supervision have the potential to improve caregiver practices and utilization of available services and decrease childhood deaths due to preventable illnesses

Mobility management across converged IP-based heterogeneous access networks

In order to satisfy customer demand for a high performance “global” mobility service, network operators (ISPs, carriers, mobile operators, etc.) are facing the need to evolve to a converged “all-IP” centric heterogeneous access infrastructure. However, the integration of such heterogeneous access networks (e.g. 802.11, 802.16e, UMTS etc) brings major mobility issues. This thesis tackles issues plaguing existing mobility management solutions in converged IP-based heterogeneous networks. In order to do so, the thesis firstly proposes a cross-layer mechanism using the upcoming IEEE802.21 MIH services to make intelligent and optimized handovers. In this respect, FMIPv6 is integrated with the IEEE802.21 mechanism to provide seamless mobility during the overall handover process. The proposed solution is then applied in a simulated vehicular environment to optimize the NEMO handover process. It is shown through analysis and simulations of the signalling process that the overall expected handover (both L2 and L3) latency in FMIPv6 can be reduced by the proposed mechanism by 69%. Secondly, it is expected that the operator of a Next Generation Network will provide mobility as a service that will generate significant revenues. As a result, dynamic service bootstrapping and authorization mechanisms must be in place to efficiently deploy a mobility service (without static provisioning), which will allow only legitimate users to access the service. A GNU Linux based test-bed has been implemented to demonstrate this. The experiments presented show the handover performance of the secured FMIPv6 over the implemented test-bed compared to plain FMIPv6 and MIPv6 by providing quantitative measurements and results on the quality of experience perceived by the users of IPv6 multimedia applications. The results show the inclusion of the additional signalling of the proposed architecture for the purpose of authorization and bootstrapping (i.e. key distribution using HOKEY) has no adverse effect on the overall handover process. Also, using a formal security analysis tool, it is shown that the proposed mechanism is safe/secure from the induced security threats. Lastly, a novel IEEE802.21 assisted EAP based re-authentication scheme over a service authorization and bootstrapping framework is presented. AAA based authentication mechanisms like EAP incur signalling overheads due to large RTTs. As a result, overall handover latency also increases. Therefore, a fast re-authentication scheme is presented which utilizes IEEE802.21 MIH services to minimize the EAP authentication process delays and as a result reduce the overall handover latency. Analysis of the signalling process based on analytical results shows that the overall handover latency for mobility protocols will be approximately reduced by 70% by the proposed scheme.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Mobility management across converged IP-based heterogeneous access networks

In order to satisfy customer demand for a high performance “global” mobility service, network operators (ISPs, carriers, mobile operators, etc.) are facing the need to evolve to a converged “all-IP” centric heterogeneous access infrastructure. However, the integration of such heterogeneous access networks (e.g. 802.11, 802.16e, UMTS etc) brings major mobility issues. This thesis tackles issues plaguing existing mobility management solutions in converged IP-based heterogeneous networks. In order to do so, the thesis firstly proposes a cross-layer mechanism using the upcoming IEEE802.21 MIH services to make intelligent and optimized handovers. In this respect, FMIPv6 is integrated with the IEEE802.21 mechanism to provide seamless mobility during the overall handover process. The proposed solution is then applied in a simulated vehicular environment to optimize the NEMO handover process. It is shown through analysis and simulations of the signalling process that the overall expected handover (both L2 and L3) latency in FMIPv6 can be reduced by the proposed mechanism by 69%. Secondly, it is expected that the operator of a Next Generation Network will provide mobility as a service that will generate significant revenues. As a result, dynamic service bootstrapping and authorization mechanisms must be in place to efficiently deploy a mobility service (without static provisioning), which will allow only legitimate users to access the service. A GNU Linux based test-bed has been implemented to demonstrate this. The experiments presented show the handover performance of the secured FMIPv6 over the implemented test-bed compared to plain FMIPv6 and MIPv6 by providing quantitative measurements and results on the quality of experience perceived by the users of IPv6 multimedia applications. The results show the inclusion of the additional signalling of the proposed architecture for the purpose of authorization and bootstrapping (i.e. key distribution using HOKEY) has no adverse effect on the overall handover process. Also, using a formal security analysis tool, it is shown that the proposed mechanism is safe/secure from the induced security threats. Lastly, a novel IEEE802.21 assisted EAP based re-authentication scheme over a service authorization and bootstrapping framework is presented. AAA based authentication mechanisms like EAP incur signalling overheads due to large RTTs. As a result, overall handover latency also increases. Therefore, a fast re-authentication scheme is presented which utilizes IEEE802.21 MIH services to minimize the EAP authentication process delays and as a result reduce the overall handover latency. Analysis of the signalling process based on analytical results shows that the overall handover latency for mobility protocols will be approximately reduced by 70% by the proposed scheme.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Mortality variability after endovascular versus open abdominal aortic aneurysm repair in a large tertiary vascular center using a Medicare-derived risk prediction model

ObjectivePrevious reports have documented better outcomes after open abdominal aortic aneurysm (AAA) repair in tertiary centers compared with lower-volume hospitals, but outcome variability for endovascular AAA repair (EVAR) vs open AAA repairs in a large tertiary center using a Medicare-derived mortality risk prediction model has not been previously reported. In the current study, we compared the observed vs predicted mortality after EVAR and open AAA repair in a single large tertiary vascular center.MethodsWe retrospectively analyzed all patients who underwent repair of a nonruptured infrarenal AAA in our center from 2003 to 2012. Univariable and multivariable logistic regression were used to evaluate 30-day mortality. Patients were stratified into low-risk, medium-risk, and high-risk groups, and mortality was predicted for each patient based on demographics and comorbidities according to the Medicare risk prediction model.ResultsWe analyzed 297 patients (EVAR, 72%; open AAA repair, 28%; symptomatic, 25%). Most of our patients were of high and moderate risk (48% and 28%, respectively). The observed 30-day mortality was 1.9% after EVAR vs 2.4% after open repair (odds ratio [OR], 0.77; 95% confidence interval [CI], 0.14-4.29; P = .67). There was no difference in mortality with EVAR vs open repair after adjusting for predefined patient characteristics (OR, 0.92; 95% CI, 0.16-7.43; P = .93); only preoperative renal disease was predictive of 30-day mortality after AAA repair in our cohort (OR, 8.39; 95% CI, 1.41-67.0). The observed mortality within our study was significantly lower than the Medicare-derived expected mortality for each treatment group within patients stratified as high risk or medium risk (P ≤ .0002 for all).ConclusionsDespite treating patients with high preoperative risk status, we report a 10-fold decrease in operative mortality for EVAR and open AAA repair in a tertiary vascular center compared with national Medicare-derived predictions. High-risk patients should be considered for aneurysm management in dedicated aortic centers, regardless of approach

Variation in clinical presentation of childhood group A streptococcal pharyngitis in four countries

Funding Information: This study was supported by USAID. The Croatian and Latvian site was funded by the Department of Child and Adolescent Health and Development, World Health Organization, Geneva.We conducted a cross-sectional study from September 2001 to August 2003 during which children between 2 and 12 years of age presenting with complaint of sore throat were recruited from urban pediatric clinics in Brazil, Croatia, Egypt and Latvia. The objective of the study was to compare clinical signs and symptoms of children presenting to urban pediatric clinics with sore throat in and between countries and to identify common clinical criteria predicting group A beta hemolytic streptococcal (GAS) pharyngitis. Using a single standard protocol in all four sites, clinical data were recorded and throat swabs obtained for standard GAS culture in 2040 children. Signs and symptoms were tested for statistical association with GAS positive/negative pharyngitis, and were compared using X2 tests, ANOVA and Odds Ratios. Clinical signs of GAS pharyngitis in children presenting to clinics varied significantly between countries, and there were few signs or symptom that could statistically be associated with GAS pharyngitis in all four countries, though several were useful in two or three countries. Our results indicate that the clinical manifestations of pharyngitis in clinics may vary by region. It is therefore critical that clinical decision rules for management of pharyngitis should have local validation.publishersversionPeer reviewe

The utility of rapid antigen detection testing for the diagnosis of streptococcal pharyngitis in low-resource settings

Funding Information: This study was supported by USAID. The Croatian and Latvian sites were funded by the Department of Child and Adolescent Health and Development, World Health Organization, Geneva. The authors alone are responsible for the views expressed in this publication and they do not necessarily represent the decisions or the stated policy of the World Health Organization. Thermo Biostar donated the STREP A OIA MAX rapid test kits for use in this study free of charge.Objectives: To evaluate the utility of rapid antigen detection testing (RADT) for the diagnosis of group A streptococcal (GAS) pharyngitis in pediatric outpatient clinics in four countries with varied socio-economic and geographic profiles. Methods: We prospectively evaluated the utility of a commercial RADT in children aged 2-12 years presenting with symptoms of pharyngitis to urban outpatient clinics in Brazil, Croatia, Egypt, and Latvia between August 2001 and December 2005. We compared the performance of the RADT to culture using diagnostic and agreement statistics, including sensitivity, specificity, and positive and negative predictive values. The Centor scores for GAS diagnosis were used to assess the potential effect of spectrum bias on RADT results. Results: Two thousand four hundred and seventy-two children were enrolled at four sites. The prevalence of GAS by throat culture varied by country (range 24.5-39.4%) and by RADT (range 23.9-41.8%). Compared to culture, RADT sensitivity ranged from 72.4% to 91.8% and specificity ranged from 85.7% to 96.4%. The positive predictive value ranged from 67.9% to 88.6% and negative predictive value ranged from 88.1% to 95.7%. Conclusions: In limited-resource regions where microbiological diagnosis is not feasible or practical, RADTs should be considered an option that can be performed in a clinic and provide timely results.publishersversionPeer reviewe