The role of nuclear receptors in the differentiation of oligodendrocyteprecursor cells derived from fetal and adult neural stem cells.

Oligodendrocyte precursor cells (OPCs) differentiation from multipotent neural stem cells (NSCs) into mature oligodendrocytes is driven by thyroid hormone and mediated by thyroid hormone receptors (TRs). We show that several nuclear receptors display strong changes in expression levels between fetal and adult NSCs, with an overexpression of TR\u3b2 and a lower expression of RXR\u3b3 in adult. Such changes may determine the reduced capacity of adult OPCs to differentiate as supported by reduced yield of maturation and compromised mRNA expression of key genes. RXR\u3b3 may be the determinant of these differences, on the evidence of reduced number of mature oligodendrocytes and increased number of proliferating OPCs in RXR\u3b3-/- cultures. Such data also points to RXR\u3b3 as an important regulator of the cell cycle exit, as proved by the dysregulation of T3-induced cell cycle exit-related genes. Our data highlight the biological differences between fetal and adult OPCs and demonstrate the essential role of RXR\u3b3 in the T3-mediated OPCs maturation process

Higher Loop Spin Field Correlators in D=4 Superstring Theory

We develop calculational tools to determine higher loop superstring correlators involving massless fermionic and spin fields in four space time dimensions. These correlation functions are basic ingredients for the calculation of loop amplitudes involving both bosons and fermions in D=4 heterotic and superstring theories. To obtain the full amplitudes in Lorentz covariant form the loop correlators of fermionic and spin fields have to be expressed in terms of SO(1,3) tensors. This is one of the main achievements in this work.Comment: 59 pages, 1 figure; v2: final version published in JHE

Boundary Conditions for Singular Perturbations of Self-Adjoint Operators

Let A:D(A)\subseteq\H\to\H be an injective self-adjoint operator and let \tau:D(A)\to\X, X a Banach space, be a surjective linear map such that \|\tau\phi\|_\X\le c \|A\phi\|_\H. Supposing that \text{\rm Range} (\tau')\cap\H' =\{0\}, we define a family $A^\tau_\Theta$ of self-adjoint operators which are extensions of the symmetric operator $A_{|\{\tau=0\}.}$. Any $\phi$ in the operator domain $D(A^\tau_\Theta)$ is characterized by a sort of boundary conditions on its univocally defined regular component \phireg, which belongs to the completion of D(A) w.r.t. the norm \|A\phi\|_\H. These boundary conditions are written in terms of the map $\tau$, playing the role of a trace (restriction) operator, as \tau\phireg=\Theta Q_\phi, the extension parameter $\Theta$ being a self-adjoint operator from X' to X. The self-adjoint extension is then simply defined by A^\tau_\Theta\phi:=A \phireg. The case in which $A\phi=T*\phi$ is a convolution operator on LD, T a distribution with compact support, is studied in detail.Comment: Revised version. To appear in Operator Theory: Advances and Applications, vol. 13

A Search for leptophilic Z_(l) boson at future linear colliders

We study the possible dynamics associated with leptonic charge in future linear colliders. Leptophilic massive vector boson, Z_(l), have been investigated through the process e^(+)e^(-) -> mu^(+)mu^(-). We have shown that ILC and CLIC will give opportunity to observe Z_(l) with masses up to the center of mass energy if the corresponding coupling constant g_(l) exceeds 10^(-3).Comment: 12 pages, 10 figure

The influence of the atmospheric boundary layer on nocturnal layers of noctuids and other moths migrating over southern Britain

Insects migrating at high altitude over southern Britain have been continuously monitored by automatically-operating, vertical-looking radars over a period of several years. During some occasions in the summer months, the migrants were observed to form well-defined layer concentrations, typically at heights of 200-400 m, in the stable night-time atmosphere. Under these conditions, insects are likely to have control over their vertical movements and are selecting flight heights which are favourable for long-range migration. We therefore investigated the factors influencing the formation of these insect layers by comparing radar measurements of the vertical distribution of insect density with meteorological profiles generated by the UK Met. Office’s Unified Model (UM). Radar-derived measurements of mass and displacement speed, along with data from Rothamsted Insect Survey light traps provided information on the identity of the migrants. We present here three case studies where noctuid and pyralid moths contributed substantially to the observed layers. The major meteorological factors influencing the layer concentrations appeared to be: (a) the altitude of the warmest air, (b) heights corresponding to temperature preferences or thresholds for sustained migration and (c), on nights when air temperatures are relatively high, wind-speed maxima associated with the nocturnal jet. Back-trajectories indicated that layer duration may have been determined by the distance to the coast. Overall, the unique combination of meteorological data from the UM and insect data from entomological radar described here show considerable promise for systematic studies of high-altitude insect layering

Conservation laws and tachyon potentials in the sliver frame

Conservation laws have provided an elegant and efficient tool to evaluate the open string field theory interaction vertex, they have been originally implemented in the case where the string field is expanded in the Virasoro basis. In this work we derive conservation laws in the case where the string field is expanded in the so-called sliver $\mathcal{L}_0$-basis. As an application of these conservation laws derived in the sliver frame, we compute the open string field action relevant to the tachyon condensation and in order to present not only an illustration but also an additional information, we evaluate the action without imposing a gauge choice.Comment: 26 pages, some typos fixed, comments added, references adde

The influence of D-branes' backreaction upon gravitational interactions between open strings

We argue that gravitational interactions between open strings ending on D3-branes are largely shaped by the D3-branes' backreaction. To this end we consider classical open strings coupled to general relativity in Poincare AdS5 backgrounds. We compute the linear gravitational backreaction of a static string extending up to the Poincare horizon, and deduce the potential energy between two such strings. If spacetime is non-compact, we find that the gravitational potential energy between parallel open strings is independent of the strings' inertial masses and goes like 1/r at large distance r. If the space transverse to the D3-branes is suitably compactified, a collective mode of the graviton propagates usual four-dimensional gravity. In that case the backreaction of the D3-branes induces a correction to the Newtonian potential energy that violates the equivalence principle. The observed enhancement of the gravitational attraction is specific to string theory; there is no similar effect for point-particles.Comment: 28 pages, 7 figures. Typos corrected, minor addition

Supergravity Black Holes and Billiards and Liouville integrable structure of dual Borel algebras

In this paper we show that the supergravity equations describing both cosmic billiards and a large class of black-holes are, generically, both Liouville integrable as a consequence of the same universal mechanism. This latter is provided by the Liouville integrable Poissonian structure existing on the dual Borel algebra B_N of the simple Lie algebra A_{N-1}. As a by product we derive the explicit integration algorithm associated with all symmetric spaces U/H^{*} relevant to the description of time-like and space-like p-branes. The most important consequence of our approach is the explicit construction of a complete set of conserved involutive hamiltonians h_{\alpha} that are responsible for integrability and provide a new tool to classify flows and orbits. We believe that these will prove a very important new tool in the analysis of supergravity black holes and billiards.Comment: 48 pages, 7 figures, LaTex; V1: misprints corrected, two references adde

Gravitational Energy Loss and Binary Pulsars in the Scalar Ether-Theory of Gravitation

Motivation is given for trying a theory of gravity with a preferred reference frame (``ether'' for short). One such theory is summarized, that is a scalar bimetric theory. Dynamics is governed by an extension of Newton's second law. In the static case, geodesic motion is recovered together with Newton's attraction field. In the static spherical case, Schwarzschild's metric is got. An asymptotic scheme of post-Minkowskian (PM) approximation is built by associating a conceptual family of systems with the given weakly-gravitating system. It is more general than the post-Newtonian scheme in that the velocity may be comparable with $c$. This allows to justify why the 0PM approximation of the energy rate may be equated to the rate of the Newtonian energy, as is usually done. At the 0PM approximation of this theory, an isolated system loses energy by quadrupole radiation, without any monopole or dipole term. It seems plausible that the observations on binary pulsars (the pulse data) could be nicely fitted with a timing model based on this theory.Comment: Text of a talk given at the 4th Conf. on Physics Beyond the Standard Model, Tegernsee, June 2003, submitted to the Proceedings (H. V. Klapdor-Kleingrothaus, ed.

Large Representation Recurrences in Large N Random Unitary Matrix Models

In a random unitary matrix model at large N, we study the properties of the expectation value of the character of the unitary matrix in the rank k symmetric tensor representation. We address the problem of whether the standard semiclassical technique for solving the model in the large N limit can be applied when the representation is very large, with k of order N. We find that the eigenvalues do indeed localize on an extremum of the effective potential; however, for finite but sufficiently large k/N, it is not possible to replace the discrete eigenvalue density with a continuous one. Nonetheless, the expectation value of the character has a well-defined large N limit, and when the discreteness of the eigenvalues is properly accounted for, it shows an intriguing approximate periodicity as a function of k/N.Comment: 24 pages, 11 figure