Intranasal insulin to improve developmental delay in children with 22q13 deletion syndrome: an exploratory clinical trial

Background: The 22q13 deletion syndrome (Phelan– McDermid syndrome) is characterised by a global developmental delay, absent or delayed speech, generalised hypotonia, autistic behaviour and characteristic phenotypic features. Intranasal insulin has been shown to improve declarative memory in healthy adult subjects and in patients with Alzheimer disease. Aims: To assess if intranasal insulin is also able to improve the developmental delay in children with 22q13 deletion syndrome. Methods: We performed exploratory clinical trials in six children with 22q13 deletion syndrome who received intranasal insulin over a period of 1 year. Short-term (during the first 6 weeks) and long-term effects (after 12 months of treatment) on motor skills, cognitive functions, or autonomous functions, speech and communication, emotional state, social behaviour, behavioural disorders, independence in daily living and education were assessed. Results: The children showed marked short-term improvements in gross and fine motor activities, cognitive functions and educational level. Positive long-term effects were found for fine and gross motor activities, nonverbal communication, cognitive functions and autonomy. Possible side effects were found in one patient who displayed changes in balance, extreme sensitivity to touch and general loss of interest. One patient complained of intermittent nose bleeding. Conclusions: We conclude that long-term administration of intranasal insulin may benefit motor development, cognitive functions and spontaneous activity in children with 22q13 deletion syndrome

Reciprocally-rotating Velocity Obstacles

Modern multi-agent systems frequently use high-level planners to extract basic paths for agents, and then rely on local collision avoidance to ensure that the agents reach their destinations without colliding with one another or dynamic obstacles. One state-of-the-art local collision avoidance technique is Optimal Reciprocal Colli- sion Avoidance (ORCA). Despite being fast and efficient for circular-shaped agents, ORCA may deadlock when polygonal shapes are used. To address this shortcom- ing, we introduce Reciprocally-Rotating Velocity Obstacles (RRVO). RRVO extends ORCA by introducing a notion of rotation. This extension permits more realistic motion than ORCA for polygonally-shaped agents and does not suffer from as much deadlock. In this thesis, we present the theory of RRVO and show empirically that it does not suffer from the deadlock issue ORCA has, that it permits agents to reach goals faster, and that it has a comparable collision rate at the cost of some performance overhead

Controlling induced coherence for quantum imaging

Induced coherence in parametric down-conversion between two coherently pumped nonlinear crystals that share a common idler mode can be used as an imaging technique. Based on the interference between the two signal modes of the crystals, an image can be reconstructed. By obtaining an expression for the interference pattern that is valid in both the low- and the high-gain regimes of parametric down-conversion, we show how the coherence of the light emitted by the two crystals can be controlled. With our comprehensive analysis we provide deeper insight into recent discussions about the application of induced coherence to imaging in different regimes. Moreover, we propose a scheme for optimizing the visibility of the interference pattern so that it directly corresponds to the degree of coherence of the light generated in the two crystals. We find that this scheme leads in the high-gain regime to a visibility arbitrarily close to unity.Comment: 9 pages, 4 figure

Double Bragg diffraction: A tool for atom optics

The use of retro-reflection in light-pulse atom interferometry under microgravity conditions naturally leads to a double-diffraction scheme. The two pairs of counterpropagating beams induce simultaneously transitions with opposite momentum transfer that, when acting on atoms initially at rest, give rise to symmetric interferometer configurations where the total momentum transfer is automatically doubled and where a number of noise sources and systematic effects cancel out. Here we extend earlier implementations for Raman transitions to the case of Bragg diffraction. In contrast with the single-diffraction case, the existence of additional off-resonant transitions between resonantly connected states precludes the use of the adiabatic elimination technique. Nevertheless, we have been able to obtain analytic results even beyond the deep Bragg regime by employing the so-called "method of averaging," which can be applied to more general situations of this kind. Our results have been validated by comparison to numerical solutions of the basic equations describing the double-diffraction process.Comment: 26 pages, 20 figures; minor changes to match the published versio

The phase sensitivity of a fully quantum three-mode nonlinear interferometer

We study a nonlinear interferometer consisting of two consecutive parametric amplifiers, where all three optical fields (pump, signal and idler) are treated quantum mechanically, allowing for pump depletion and other quantum phenomena. The interaction of all three fields in the final amplifier leads to an interference pattern from which we extract the phase uncertainty. We find that the phase uncertainty oscillates around a saturation level that decreases as the mean number $N$ of input pump photons increases. For optimal interaction strengths, we also find a phase uncertainty below the shot-noise level and obtain a Heisenberg scaling $1/N$. This is in contrast to the conventional treatment within the parametric approximation, where the Heisenberg scaling is observed as a function of the number of down-converted photons inside the interferometer.Comment: 8 pages, 7 figure

Measurement of the Photon-Plasmon Coupling Phase

Scattering processes have played a crucial role in the development of quantum theory. In the field of optics, scattering phase shifts have been utilized to unveil interesting forms of light-matter interactions. Here, we investigate the mode-coupling phase of single photons to surface plasmon polaritons in a quantum plasmonic tritter. We observe that the coupling process induces a phase jump that occurs when photons scatter into surface plasmons and vice versa. This interesting coupling phase dynamics is of particular relevance for quantum plasmonic experiments. Furthermore, it is demonstrated that this photon-plasmon interaction can be modeled through a quantum-mechanical tritter. We show that the visibility of a double-slit and a triple-slit interference patterns are convenient observables to characterize the interaction at a slit and determine the coupling phase. Our accurate and simple model of the interaction, validated by simulations and experiments, has important implications not only for quantum plasmonic interference effects, but is also advantageous to classical applications

Hierarchical Spatio-Temporal Morphable Models for Representation of complex movements for Imitation Learning

Imitation learning is a promising technique for teaching robots complex movement sequences. One key problem in this area is the transfer of perceived movement characteristics from perception to action. For the solution of this problem, representations are required that are suitable for the analysis and the synthesis of complex action sequences. We describe the method of Hierarchical Spatio-Temporal Morphable Models that allows an automatic segmentation of movements sequences into movement primitives, and a modeling of these primitives by morphing between a set of prototypical trajectories. We use HSTMMs in an imitation learning task for human writing movements. The models are learned from recorded trajectories and transferred to a human-like robot arm. Due to the generalization proper- ties of our movement representation, the arm is capable of synthesizing new writing movements with only a few learning examples