An analysis of long-term relationships among count statistics and metrics of synthetic tropical cyclones downscaled from CMIP5 models

In a changing climate, the impact of tropical cyclones on the United States Atlantic and Gulf Coasts will be affected both by how intense and how frequent these storms become. The observational record of tropical cyclones in the Atlantic Basin is too short (A.D. 1851 to present) to allow for accurate assessment of low-frequency variability in storm activity. In order to overcome the limitations of the short observational record, we downscale four Coupled Model Intercomparison Project Phase 5 models to generate synthetic tropical cyclone data sets for the Atlantic Basin that span the interval of A.D. 850–2005. Using these long-term synthetic tropical cyclone data sets, we investigate the relationship between power dissipation and ocean temperature metrics, as well as the relationship between basin-wide and landfalling tropical cyclone count statistics over the past millennium. Contrary to previous studies, we find only a very weak relationship between power dissipation and main development region sea surface temperature in the Atlantic Basin. Consistent with previous studies, we find that basin-wide and landfalling tropical cyclone counts are significantly correlated with one another, lending further support for the use of paleohurricane landfall records to infer long-term basin-wide tropical cyclone trends.United States. National Oceanic and Atmospheric Administration (grant 424-18 45GZ

Properties of the triplet metastable states of the alkaline-earth-metal atoms

A configuration interaction approach with a semiempirical model potential for the core was used to study the static and dynamic properties of the alkaline-earth-metal atoms. The alkaline-earth-metal atoms properties determined were the scalar and tensor polarizabilities, the quadrupole moment, some of the oscillator strengths and the dispersion coefficents of the van der Waals intearaction. It was observed that the use of a polarization potential to the experimental binding energy consider the influence of relativistic effects upon the core electron distribution. The resulting polarizabilities, and dispersion parameters for homonuclear pairs of atoms were within 0.1% and within 1-2 % for heavier atoms

Profil Lipid sebagai Kontrol Glikemik pada Pasien Diabetes Mellitus Tipe II

Latar Belakang: Jumlah penderita diabetes mellitus (DM) meningkat setiap tahunnya. Kontrol glikemik yang buruk dapat menimbulkan kerusakan jangka panjang pada organ vital seperti ginjal, saraf, mata dan pembuluh darah. Penderita DM memiliki kecenderungan dislipidemia yang merupakan resiko terjadi penyakit kardiovaskuler. HbA1c merupakan kontrol glikemik jangka panjang DM. HbA1c diharapkan mampu berperan sebagai prediktor profil lipid dan kontrol glikemik pada pasien DM.Metode: Penelitian dengan observasi retrospektif bersifat analitik dengan pendekatan corss sectional. Data sekunder menggunakan data rekam medis. Teknik pengambilan sampel dengan purposive sampling. Populasi adalah penderita DM tipe 2.Hasil : Data dari 63 responden penelitian didapatkan karakteristik mayoritas responden adalah perempuan 41 (65.1%). Sebagian besar responden termasuk kategori lansia akhir 19 (30.2%). Uji Chi square didapatkan p<0.1 pada hubungan HbA1c dengan kolesterol total pada usia lansia awal, lansia akhir dan manula baik perempuan dan laki laki. Hubungan HbA1c dengan Trigliserid pada usia lansia awal, lansia akhir dan manula nilai p<0.1. Hubungan kadar HbA1c dengan LDL pada ketegori usia manula dan dewasa berjenis kelamin laki-laki nilai p<0.1. Hubungan kadar HbA1c dengan HDL pada kategori usia manula berjenis kelamin laki laki dan perempuan nilai p<0.1.Simpulan: HbA1c dapat digunakan sebagai biomarker kontrol glikemik jangka panjang dan memprediksi keadaan profil lipid pada penderita DM tipe II. Kata kunci : DM tipe 2,dislipidemia, HbA1c, profil lipid

Toward a Manifold Encoding Neural Responses

Understanding circuit properties from physiological data presents two challenges: (i) recordings do not reveal connectivity, and (ii) stimuli only exercise circuits to a limited extent. We address these challenges for the mouse visual system with a novel neural manifold obtained using unsupervised algorithms. Each point in our manifold is a neuron; nearby neurons respond similarly in time to similar parts of a stimulus ensemble. This ensemble includes drifting gratings and flows, i.e., patterns resembling what a mouse would “see” running through fields. Regarding (i), our manifold differs from the standard practice in computational neuroscience: embedding trials in neural coordinates. Topology matters: we infer that, if the circuit consists of separate components, the manifold is discontinuous (illustrated with retinal data). If there is significant overlap between circuits, the manifold is nearly-continuous (cortical data). Regarding (ii), most of the cortical manifold is not activated with conventional gratings, despite their prominence in laboratory settings. Our manifold suggests organizing cortical circuitry by a few specialized circuits for specific members of the stimulus ensemble, together with circuits involving ‘multi-stimuli’-responding neurons. To approach real circuits, local neighborhoods in the manifold are identified with actual circuit components. For retinal data, we show these components correspond to distinct ganglion cell types by their mosaic-like receptive field organization, while for cortical data, neighborhoods organize neurons by type (excitatory/inhibitory) and anatomical layer. In summary: the topology of neural organization reflects well the underlying anatomy and physiology of the retina and the visual cortex

Use of rapid-deployment extracorporeal membrane oxygenation for the resuscitation of pediatric patients with heart disease after cardiac arrest

AbstractIntroduction: We have recently used extracorporeal membrane oxygenation as a means of rapidly resuscitating pediatric patients with heart disease after cardiopulmonary arrest, in whom conventional resuscitation measures have failed. Methods: We developed a fully portable extracorporeal membrane oxygenation circuit that is maintained vacuum and carbon dioxide–primed at all times. When needed, the circuit is crystalloid-primed and can be ready for use within 15 minutes. Since February 1996, we have used this rapid-deployment circuit to resuscitate 11 pediatric patients in full cardiopulmonary arrest. Results: The median age of the 11 patients was 120 days (2 days to 4.6 years). Nine patients had a cardiac arrest after cardiac surgery. One patient had a cardiac arrest during cardiac catheterization and one patient had a cardiac arrest before cardiac surgery. Median duration of cardiopulmonary resuscitation was 55 minutes (range 20 to 103 minutes), with no difference in the duration of cardiopulmonary resuscitation between survivors and nonsurvivors. Ten of 11 patients (91%) were weaned from extracorporeal membrane oxygenation and seven (64%) survived to hospital discharge. Six patients are long-term survivors, five of whom are in New York Heart Association class I; one survivor is in class II. Seven patients resuscitated with extracorporeal membrane oxygenation before the use of this rapid-deployment circuit had a median duration of cardiopulmonary resuscitation of 90 minutes, with two (28.6%) survivors. Conclusions: The use of rapid-deployment extracorporeal membrane oxygenation results in shorter resuscitation times and improved survival in pediatric patients with heart disease after cardiopulmonary arrest. (J Thorac Cardiovasc Surg 1998;116:305-11

Changing impacts of Alaska-Aleutian subduction zone tsunamis in California under future sea-level rise

The amplification of coastal hazards such as distant-source tsunamis under future relative sea-level rise (RSLR) is poorly constrained. In southern California, the Alaska-Aleutian subduction zone has been identified as an earthquake source region of particular concern for a worst-case scenario distant-source tsunami. Here, we explore how RSLR over the next century will influence future maximum nearshore tsunami heights (MNTH) at the Ports of Los Angeles and Long Beach. Earthquake and tsunami modeling combined with local probabilistic RSLR projections show the increased potential for more frequent, relatively low magnitude earthquakes to produce distant-source tsunamis that exceed historically observed MNTH. By 2100, under RSLR projections for a high-emissions representative concentration pathway (RCP8.5), the earthquake magnitude required to produce \u3e1 m MNTH falls from ~Mw9.1 (required today) to Mw8.0, a magnitude that is ~6.7 times more frequent along the Alaska-Aleutian subduction zone

Recent Eruptions Between 2012 and 2018 Discovered at West Mata Submarine Volcano (NE Lau Basin, SW Pacific) and Characterized by New Ship, AUV, and ROV Data

West Mata is a submarine volcano located in the SW Pacific Ocean between Fiji and Samoa in the NE Lau Basin. West Mata was discovered to be actively erupting at its summit in September 2008 and May 2009. Water-column chemistry and hydrophone data suggest it was probably continuously active until early 2011. Subsequent repeated bathymetric surveys of West Mata have shown that it changed to a style of frequent but intermittent eruptions away from the summit since then. We present new data from ship-based bathymetric surveys, high-resolution bathymetry from an autonomous underwater vehicle, and observations from remotely operated vehicle dives that document four additional eruptions between 2012 and 2018. Three of those eruptions occurred between September 2012 and March 2016; one near the summit on the upper ENE rift, a second on the NE flank away from any rift zone, and a third at the NE base of the volcano. The latter intruded a sill into a basin with thick sediments, uplifted them, and then extruded lava onto the seafloor around them. The most recent of the four eruptions occurred between March 2016 and November 2017 along the middle ENE rift zone and produced pillow lava flows with a shingled morphology and tephra as well as clastic debris that mantled the SE slope. ROV dive observations show that the shallower recent eruptions at West Mata include a substantial pyroclastic component, based on thick (>1 m) tephra deposits near eruptive vents. The deepest eruption sites lack these near-vent tephra deposits, suggesting that pyroclastic activity is minimal below ∼2500 mbsl. The multibeam sonar re-surveys constrain the timing, thickness, area, morphology, and volume of the new eruptions. The cumulative erupted volume since 1996 suggests that eruptions at West Mata are volume-predictable with an average eruption rate of 7.8 × 106 m3/yr. This relatively low magma supply rate and the high frequency of eruptions (every 1–2 years) suggests that the magma reservoir at West Mata is relatively small. With its frequent activity, West Mata continues to be an ideal natural laboratory for the study of submarine volcanic eruptions

Preface

Reproductive tract bleeding in women is a naturally occurring event during menstruation and childbirth. In women with menorrhagia, however, congenital bleeding disorders historically have been underdiagnosed. This consensus is intended to allow physicians to better recognize bleeding disorders as a cause of menorrhagia and consequently offer effective disease-specific therapies. © 2009 Mosby, Inc. All rights reserved

Gastric transit and small intestinal transit time and motility assessed by a magnet tracking system

<p>Abstract</p> <p>Background</p> <p>Tracking an ingested magnet by the Magnet Tracking System MTS-1 (Motilis, Lausanne, Switzerland) is an easy and minimally-invasive method to assess gastrointestinal transit. The aim was to test the validity of MTS-1 for assessment of gastric transit time and small intestinal transit time, and to illustrate transit patterns detected by the system.</p> <p>Methods</p> <p>A small magnet was ingested and tracked by an external matrix of 16 magnetic field sensors (4 × 4) giving a position defined by 5 coordinates (position: <b>x, y, z, and angle: θ, ϕ)</b>. Eight healthy subjects were each investigated three times: (1) with a small magnet mounted on a capsule endoscope (PillCam); (2) with the magnet alone and the small intestine in the fasting state; and (3) with the magnet alone and the small intestine in the postprandial state.</p> <p>Results</p> <p>Experiment (1) showed good agreement and no systematic differences between MTS-1 and capsule endoscopy when assessing gastric transit (median difference 1 min; range: 0-6 min) and small intestinal transit time (median difference 0.5 min; range: 0-52 min). Comparing experiments (1) and (2) there were no systematic differences in gastric transit or small intestinal transit when using the magnet-PillCam unit and the much smaller magnetic pill. In experiments (2) and (3), short bursts of very fast movements lasting less than 5% of the time accounted for more than half the distance covered during the first two hours in the small intestine, irrespective of whether the small intestine was in the fasting or postprandial state. The mean contraction frequency in the small intestine was significantly lower in the fasting state than in the postprandial state (9.90 min^-1vs. 10.53 min^-1) (p = 0.03).</p> <p>Conclusion</p> <p>MTS-1 is reliable for determination of gastric transit and small intestinal transit time. It is possible to distinguish between the mean contraction frequency of small intestine in the fasting state and in the postprandial state.</p