Simulations of a double-diffusive interface in the diffusive convection regime

Three-dimensional direct numerical simulations are performed that give us an in-depth account of the evolution and structure of the double-diffusive interface. We examine the diffusive convection regime, which, in the oceanographically relevant case, consists of relatively cold fresh water above warm salty water. A ‘double-boundary-layer' structure is found in all of the simulations, in which the temperature ( $T$ ) interface has a greater thickness than the salinity ( $S$ ) interface. Therefore, thin gravitationally unstable boundary layers are maintained at the edges of the diffusive interface. The $TS$ -interface thickness ratio is found to scale with the diffusivity ratio in a consistent manner once the shear across the boundary layers is accounted for. The turbulence present in the mixed layers is not able to penetrate the stable stratification of the interface core, and the $TS$ -fluxes through the core are given by their molecular diffusion values. Interface growth in time is found to be determined by molecular diffusion of the $S$ -interface, in agreement with a previous theory. The stability of the boundary layers is also considered, where we find boundary layer Rayleigh numbers that are an order of magnitude lower than previously assume

Simulations of a double-diffusive interface in the diffusive convection regime

Three-dimensional direct numerical simulations are performed that give us an in-depth account of the evolution and structure of the double-diffusive interface. We examine the diffusive convection regime, which, in the oceanographically relevant case, consists of relatively cold fresh water above warm salty water. A 'double-boundary-layer' structure is found in all of the simulations, in which the temperature (T) interface has a greater thickness than the salinity (S) interface. Therefore, thin gravitationally unstable boundary layers are maintained at the edges of the diffusive interface. The TS-interface thickness ratio is found to scale with the diffusivity ratio in a consistent manner once the shear across the boundary layers is accounted for. The turbulence present in the mixed layers is not able to penetrate the stable stratification of the interface core, and the TS-fluxes through the core are given by their molecular diffusion values. Interface growth in time is found to be determined by molecular diffusion of the S-interface, in agreement with a previous theory. The stability of the boundary layers is also considered, where we find boundary layer Rayleigh numbers that are an order of magnitude lower than previously assumed

Drought-induced building damages from simulations at regional scale

We present a model computing damage costs from drought-induced soil subsidence related to shrinking and swelling soils. The model uses an indicator applicable across different climate regimes. The influence of geology and land use on regional damage levels is taken into account. Simulation results are evaluated at departmental scale, showing a good representation of the regions affected by drought-induced soil subsidence. Substantial differences between simulated and observed damages are however found in some departments

Heavy Metal and Rock in Space: Cluster RAPID Observations of Fe and Si

Metallic and silicate ions carry essential information about the evolution of the Earth and near-Earth small bodies. Despite this, there has so far been very little focus on ions with atomic masses higher than oxygen in the terrestrial magnetosphere. In this paper, we report on abundances and properties of energetic ions with masses corresponding to that of silicon (Si) and iron (Fe) in Earth's geospace. The results are based on a newly derived data product from the Research with Adaptive Particle Imaging Detectors on Cluster. We find traces of both Si and Fe in all of the regions covered by the spacecraft, with the highest occurrence rates and highest intensities in the inner magnetosphere. We also find that the Fe and Si abundances are modulated by solar activity. During solar maximum, the probability of observing Fe and Si in geospace increases significantly. On the other hand, we find little or no direct correlation between geomagnetic activity and Si and Fe abundance in the magnetosphere. Both Si and Fe in the Earth's magnetosphere are inferred to be primarily of solar wind origin.publishedVersio

Physical and chemical impacts of a major storm on a temperate lake: a taste of things to come?

Extreme weather can have a substantial influence on lakes and is expected to become more frequent with climate change. We explored the influence of one particular extreme event, Storm Ophelia, on the physical and chemical environment of England's largest lake, Windermere. We found that the substantial influence of Ophelia on meteorological conditions at Windermere, in particular wind speed, resulted in a 25-fold increase (relative to the study-period average) in the wind energy flux at the lake-air interface. Following Ophelia, there was a short-lived mixing event in which the Schmidt stability decreased by over 100 Jm-2 and the thermocline deepened by over 10 m during a 12-hour period. As a result of changes to the strength of stratification, Ophelia also changed the internal seiche regime of Windermere with the dominant seiche period increasing from ~17 h pre-storm to ~21 h post-storm. Following Ophelia, there was an upwelling of cold and low-oxygenated waters at the southern-end of the lake. This had a substantial influence on the main outflow of Windermere, the River Leven, where dissolved oxygen concentrations decreased by ~48 %, from 9.3 mg L-1 to 4.8 mg L-1, while at the mid-lake monitoring station in Windermere, it decreased by only ~3%. This study illustrates that the response of a lake to extreme weather can cause important effects downstream, the influence of which may not be evident at the lake surface. To understand the impact of future extreme events fully, the whole lake and downstream-river system need to be studied together

Superior antitumoral activity of dimerized targeted single-chain TRAIL fusion proteins under retention of tumor selectivity

Although targeting of the death receptors (DRs) DR4 and DR5 still appears a suitable antitumoral strategy, the limited clinical responses to recombinant soluble TNF-related apoptosis inducing ligand (TRAIL) necessitate novel reagents with improved apoptotic activity/tumor selectivity. Apoptosis induction by a single-chain TRAIL (scTRAIL) molecule could be enhanced >10-fold by generation of epidermal growth factor receptor (EGFR)-specific scFv-scTRAIL fusion proteins. By forcing dimerization of scFv-scTRAIL based on scFv linker modification, we obtained a targeted scTRAIL composed predominantly of dimers (Db-scTRAIL), exceeding the activity of nontargeted scTRAIL ∼100-fold on Huh-7 hepatocellular and Colo205 colon carcinoma cells. Increased activity of Db-scTRAIL was also demonstrated on target-negative cells, suggesting that, in addition to targeting, oligomerization equivalent to an at least dimeric assembly of standard TRAIL per se enhances apoptosis signaling. In the presence of apoptosis sensitizers, such as the proteasomal inhibitor bortezomib, Db-scTRAIL was effective at picomolar concentrations in vitro (EC50 ∼2 × 10−12 M). Importantly, in vivo, Db-scTRAIL was well tolerated and displayed superior antitumoral activity in mouse xenograft (Colo205) tumor models. Our results show that both targeting and controlled dimerization of scTRAIL fusion proteins provides a strategy to enforce apoptosis induction, together with retained tumor selectivity and good in vivo tolerance