Nanoscale roughness and morphology affect the IsoElectric Point of titania surfaces

We report on the systematic investigation of the role of surface nanoscale roughness and morphology on the charging behaviour of nanostructured titania (TiO2) surfaces in aqueous solutions. IsoElectric Points (IEPs) of surfaces have been characterized by direct measurement of the electrostatic double layer interactions between titania surfaces and the micrometer-sized spherical silica probe of an atomic force microscope in NaCl aqueous electrolyte. The use of a colloidal probe provides well-defined interaction geometry and allows effectively probing the overall effect of nanoscale morphology. By using supersonic cluster beam deposition to fabricate nanostructured titania films, we achieved a quantitative control over the surface morphological parameters. We performed a systematical exploration of the electrical double layer properties in different interaction regimes characterized by different ratios of characteristic nanometric lengths of the system: the surface rms roughness Rq, the correlation length {\xi} and the Debye length {\lambda}D. We observed a remarkable reduction by several pH units of IEP on rough nanostructured surfaces, with respect to flat crystalline rutile TiO2. In order to explain the observed behavior of IEP, we consider the roughness-induced self-overlap of the electrical double layers as a potential source of deviation from the trend expected for flat surfaces.Comment: 63 pages, including 7 figures and Supporting Informatio

Review on etiopathogenesis and role of lifestyle modification in the management of Khalitya (hairfall)

Now a days, the world is full of glamour and glory. The concept of beauty is gaining more and more attention globally, which is defined on some factors, amongst them hair is an important one. Hair is a mirror of healthy or unhealthy state of the body. Ayurvedic approach, falling of hair is coined as Khalitya. In Ayurvedic texts management of Khalitya has been described in the form of Nasya, Shiroabhyanga, Shirolepa and Rasayana therapy. The main aim of this paper is to explain the Nidana of Khalitya in present era and treat the disease too

DEVELOPMENT, CHARACTERIZATION AND IN VITRO RELEASE KINETIC STUDIES OF IBANDRONATE LOADED CHITOSAN NANOPARTICLES FOR EFFECTIVE MANAGEMENT OF OSTEOPOROSIS

Objective: The objective of the present study was to develop, optimize, and evaluate Ibandronate-sodium loaded chitosan nanoparticles (Ib-CS NPs) to treat osteoporosis. Methods: NPs were prepared by the Ionic gelation method and optimized for various parameters such as the effect of concentration of chitosan, sodium tripolyphosphate (TPP), and pH effect on particle size polydispersity index (PDI), zeta potential, and entrapment efficiency. The prepared nanoparticles were characterized using particle size analyzer (DLS), transmission electron microscopy (TEM), scanning electron microscopy (SEM), and Fourier-Transform Infrared spectroscopy (FTIR).  Results: Formulated NPs were obtained in the average nano size in the range below 200 nm in TEM, SEM, and DLS studies. The particle size and encapsulation efficiency of the optimized formulation were 176.1 nm and 63.28%, respectively. The release profile of NPs was depended on the dissolution medium and followed the First-order release kinetics. Conclusion: Bisphosphonates are the most commonly prescribed drugs for treating osteoporosis in the US and many other countries, including India. Ibandronate is a widely used anti-osteoporosis drug, exhibits a strong inhibitory effect on bone resorption performed by osteoclast cells. Our results indicated that Ibandronate sodium-loaded chitosan nanoparticles provide an effective medication for the treatment of osteoporosis

Central nervous system tumors: a histopathological study

Background: Brain tumors can originate in almost any type of tissue, cell or mixture of cell types in the brain or spinal cord. Tumors in different areas of the central nervous system may be treated differently and have a different prognosis.Methods: In the period between 2011-2015, we studied on 59 patients diagnosed with CNS tumors according to the World Health Organization’s diagnostic criteria. Patient data were retrieved from the archives of the department of Pathology, Sardar Patel Medical College, Bikaner. The diagnosis in all the cases were made on hematoxylin & eosin stained slides of processed tissue.Results: Patients ages ranged from 3.5-65 years with a mean age of 41.2 years and a male to female ratio of 1.8:1. Majority of tumors had intracranial location (55 cases, 93.23%). 91.5% tumors were solid in consistency. Frontal lobe (37.3%) was the predominant affected region. Most tumors were originated from neuroepithelium (67.8%) followed by meninges (22.03%). When examining the data pertaining to specific types of tumors, most frequent type of CNS tumors was astrocytoma (31 cases, 52.5%), followed by meningioma (13 cases, 22%).Conclusion: The most frequent type of CNS tumours in this study was astrocytoma, followed by meningioma. Males are at much higher risk of developing CNS tumour in comparison to females (1.8:1). WHO Grade IV lesions were more common in our institutional set up. The exact histological diagnosis of CNS tumors is essential to predict the prognostic factors.

Performance Analysis of Multiple Access Techniques for LTE system under Symbol Error Rate (SER) Calculation

In the recent years, so many technologies in multiple access trends have influenced the field of Wireless Sensor Networks in significant ways. Various trends are readily available technology of ubiquitous wireless sensor networks as well as wireless communication networks and progress in the development of two multiple access techniques are compared in this scenario: the OFDMA and SC-FDMA. The OFDMA and SC-FDMA transceivers are modeled and simulated considering both the interleaved and localized subcarriers mapping schemes. WSNs have the potentiality to connect the physical world with the virtual world by forming a network of sensor nodes. To prolong the networklsquo;s hop in terms of single and two hop using both techniques should be used in the sensor nodes. The minimization of computing and storage platforms as well as the development of novel micro sensors and sensor materials with high reliability force encourages technology in research on WSN. In this paper, we will proposed the field of multipath routing in wireless sensor networks, and mainly focus on the technology of SER of WSNs

Literature Survey of Security Enhancement in MANET Routing Protocols of WLANs

A Mobile Ad-hoc Network (MANET) is an autonomous collection of mobile users that communicate over relatively bandwidth constrained wireless links. One of the main issues in such networks is performance- in a dynamically changing topology; the nodes are expected to be power-aware due to the bandwidth constrained network. Another issue in such networks is security - since every node participates in the operation of the network equally, Malicious nodes are difficult to detect. There are several applications of mobile ad hoc networks such as disaster recovery operations, battle field communications, etc. The most active research area under MANET routing protocol is security. MANETs have certain unique characteristics that make them vulnerable to several types of attacks. Since they are deployed an open environment where all nodes co-operate in forwarding the packets in the network, Malicious nodes are difficult to detect

Review on special emphasis of bortezomib on relapsed/refractory myeloma

Refractory or relapsed Multiple Myeloma (MM) is a plasma cell neoplasia characterized by paraproteins in the urine or serum and a bone marrow plasmacytosis of over 10%. Multiple/refractory myeloma is a neoplasm of plasma cells and exact cause of multiple myeloma is remain unidentified, it is characterized by accumulation of malignant plasma cells in the bone marrow, leading to bone marrow failure, anemia, skeletal destruction, renal failure, increased susceptibility to infection and hypercalcemia. The survival time for the patients with refractory or multiple myeloma can be prolonged with treatment of newer and more target specific approach. The proteasome inhibitors are an important class of anti-myeloma drugs that have efficacy to disrupt the proteolytic structure of tumor cells and enhancing their susceptibility to apoptosis. Bortezomib has a significant clinical efficacy against refractory multiple myeloma. Bortezomib is the most commonly used and clinically tested proteasome inhibitor and which is effective in prolonging the overall survival in several trials. Bortezomib combinations with other drugs such as dexamethasone and cyclophosphamide are the choice of treatment for standard risk patients following the mSMART guidelines. The success with lower dosage of bortezomib in elderly patient’s proven efficacious subcutaneous usage and its useful proteasome inhibitor to enhance patient’s compliance and reduces toxicity and costs of therapy. This review discusses on special emphasis of bortezomib on relapsed/refractory multiple myeloma as front-line treatment.