Homocysteine and nitric oxide in patients undergoing diagnostic coronary angiography.

We evaluated the plasma homocysteine (tHcy) and nitric oxide metabolites (nitrite plus nitrate; NOx) data of consecutive patients undergoing diagnostic coronary angiography (n=79) with respect to the presence and severity of coronary artery disease (CAD), the presence of acute coronary syndromes (ACS), and the risk status of patients. Hyperhomocysteinemia (&#62;15 micromol/L) was detected in 11% of the controls (n=19) and 37% of CAD patients (n=60) (p=0.03). Plasma tHcy in CAD patients was not significantly different from controls, but those with 3-vessel disease had a significantly higher tHcy concentrations than did controls (p=0.049). The patients with 3-vessel disease and ACS had the highest concentrations of tHcy (16.9 +- 4.4 micromol/L), and the difference from the ACS patients with 1- and 2-vessel involvement was significant (p=0.03). In patients with 1-vessel involvement, tHcy was correlated with NOx (r=0.62, p=0.005); in patients with 2- and 3-vessel disease this correlation could not be observed. The high-risk patients (n=51) had a higher mean number of vessel involvement and tHcy (p&#60;0.001, p&#60;0.05, respectively) but lower NOx (p&#60;0.05) when compared to the low-risk patients (n=28). It appears that in the early stages of atherosclerosis hyperhomocysteinemia causes an increase in NOx production, but with progression of the disease this compensatory increase disappears.</p

Design, Analysis and Performance Evaluation of Electrical Power Subsystem based on Triple-Junctions Solar PV Cells and SEPIC for a Conceptual 1u Cubesat Mission

This study aims to popularize low voltage power supply design especially for space satellite Cubesat mission and other portable consumer electronic devices. In this context, a preliminary design of an electrical power subsystem (EPS) is carried out for a conceptual 1u Cubesat mission in this paper. Mathematical modeling of the basic elements of the EPS is presented. Photovoltaic (PV) power generation system that is selected is made up of triple-junction solar cells, and the battery charging system based on lithium technology as well as the power conditioning converters are selected based on single ended primary inductance converter topology popularly abbreviated as SEPIC. Triple-junction solar PV cell results are verified by comparing with the datasheet values. A maximum power point tracking algorithm which is known as perturb and observe is implemented and proportional-integral controller is used for the SEPIC. All of these are well analyzed, mathematically modeled and simulated. Feasibility of the designed EPS is verified by comparing with similar devices from different manufacturers

THE EFFECT OF INSPIRATORY MUSCLE WARM-UP PROTOCOL ON ACCELERATION AND MAXIMAL SPEED IN 12-14 YEARS OLD CHILDREN

The aim of this study is to investigate the effect of the inspiratory muscle warm-up protocol on acceleration and maximal speed in children aged 12-14. Thirty sedentary boys (age: 12.63 ± 0.89 years) participated in the study. Participants were randomly included in 4 different trials (T1, T2, T3, T4). Acceleration (10m, 20m) and maximal speed tests (30m, 50m) were randomly tested at 10 minutes intervals in each trial. Acceleration and speed tests were performed without any warm-up in T1 trial, with general warm-up in T2 trial, placebo inspiratory muscle warm-up in T3 trial, and inspiratory muscle warm-up in T4 trial. As a result of the statistical analysis, it was seen that general warm-up (T2) and inspiratory muscle warm-up (T4) increased performance significantly compared to control (T1) and placebo (T3) trials in all acceleration and speed tests (

The mediating role of meaninglessness in the relationship between religiosity and depression

The research focuses on the relationship and interaction between religiosity, depression, and the sense of meaninglessness. Accordingly, the study aims to determine whether meaninglessness has a mediating role in the effect of religiosity on depression. The research sample consists of 1007 people whose ages range from 18 to 78 (SD=11.33) and who reside in different provinces of Turkey. In order to test the hypotheses developed before the research, a questionnaire form consisting of personal information form, religiosity scale, depression scale, and meaninglessness scale was applied to the participants. The findings of the study revealed that there is a negative relationship among religiosity, depression, and meaninglessness. On the other hand, in the study, positive significant relationships and interactions were found between depression and meaninglessness. Furthermore, mediation analysis showed that meaninglessness is ascertained as a full mediator in the effect of religiosity on depression. The findings obtained as a result of the research were discussed in the light of the literature and some suggestions were made

Effect of royal jelly supplementation on aerobic power output and anaerobic power output

This study with a placebo-controlled experimental design intends to investigate the effect of Royal Jelly (RJ) on the aerobic and anaerobic power output of sedentary men at a dose of 1000 mg/day. For this purpose, a total of 20 adult sedentary men aged 21 to 23 years were included in this study. The subjects visited the laboratory every day for 15 days between 08:00 and 10:00 to get their portion of royal jelly. The subjects were randomly divided into two groups, namely the experimental group (n = 10 individuals, 1000 mg/day Royal Jelly) and the placebo (n = 10 individuals, corn starch mixed with 1000 mg/day water) group and they took royal jelly in glass bottles at the same hour during these visits. In both groups, aerobic and anaerobic power measurements were performed in the laboratory one day before and after the 15-day period. 2×2 mixed factor ANOVA and LSD tests were used to analyze data obtained from the experimental and the placebo group. No significant difference was found in the analysis performed between the pre- and post tests for anaerobic power outputs of the placebo group (p > 0.05). Concerning the anaerobic power output of the experimental group, there was a significant difference in the fatigue index value in favor of the post-test (p 0.05). A significant difference was found in the pre- and post-test analysis of the experimental group in favor of the post-test in terms of aerobic power output (p < 0.05). The intergroup analysis of the difference between pre- and post-test showed a significant difference in favor of the experimental group in terms of aerobic power outputs (p< 0.05). Consequently, it can be argued that royal jelly supplementation taken daily for 15 days at 1000 mg has a positive effect on the aerobic capacity of sedentary men. © Mattioli 1885

A novel approach for sustainable supply Chain management with analyzing the effective governance under fuzzy uncertainty

Nowadays, knowledge has become one of the most important tools of power, distributing public services that accept the audience as citizens and not consumers and provide the principle of services without financial worries. Moreover, the urban products have a specific production and distribution channel that should be assessed. In this research, a mathematical framework is proposed for designing the supply chain network of urban products. The main contribution of this research is to incorporate the effect of public service into urban products' supply chain planning. In this regard, a mixed-integer mathematical model is proposed. In this mathematical model, an attempt is made to minimize the costs of the product distribution system by considering the effects of production, maintenance, and distribution. Moreover, fuzzy uncertainty has been applied to adapt the mathematical model to real conditions. The numerical results show that if manufacturers and distributors want to strengthen their institutions and maintain their leadership roles as in the past, they can optimize their distribution network structure to achieve the best possible performance. Moreover, technological advances and innovations in production and distribution systems can create a huge leap in profitability

INFLUENCE OF AEROBIC AND ANAEROBIC EXERCISE ON OXYGEN SATURATION

The aim of this study was to examine to acute effects of aerobic and anaerobic exercises on oxygen saturation. Twenty three sedentary male subjects were voluntarily participated in the study. Oxygen saturation was measured with four different trials such as before warming up, after warming up, after anaerobic exercise, and after aerobic exercise, acutely. Repeated measures one way ANOVA and LSD correction tests were used for statistical analysis. According to obtained data, oxygen saturation parameter showed statistically changes between trials (p&lt;0.05). Especially, after anaerobic trial, oxygen saturation showed significant changes. In conclusion, it could be considered that warm-up, and aerobic exercise does not affect oxygen saturation, however anaerobic exercise has significant effect on it.  Article visualizations

Prediction of Low Factor V Levels in Patients with Herbal Medicine Related Acute Liver Injury

&nbsp; Background: Prior epidemiologic studies predicted a rapid rise in herbal medicine-related acute liver injury (HILI) and liver transplantation (LT) as trading of traditional herbal medicine drugs is expanded. HILI is the leading cause of liver transplantation in the world. The indication for LT was defined as acute liver failure (ALF) with the factor V (FV) level below 35%. Objective: To explore the possible impact of herbal medicine-related to the liver failure on the laboratory parameters and to determine if simple laboratory values play a role in determining lower FV levels. Materials and methods: Totally, 38 HILI cases who were admitted to a tertiary care hospital between May 2016 and May 2018 were scanned, retrospectively. Need for LT was assessed by the determination of FV levels. Results: The mean age of participants was 37±13 years where 27 (71%) were female while the rest were male and 81% of the total population were farmers. Total 78% patients were reportedly consuming herbal medicine pills, and 22% reported consuming traditional Turkish herbs. Among 38 cases with HILI in critical care, 2 (5.2%) have died, 3 (7.8%) underwent LT and 33 (87%) were recovered and discharged. Results of 38 patients with available data also showed that factor V levels were positively correlated with the hemoglobin and platelet levels (p&lt;0.05) and negatively correlated with prothrombin time (p&lt;0.05). Conclusion: These findings suggest that detecting anemia and thrombocytopenia could be an important, economically feasible strategy for improving outcomes in HILI