Clinical value of neutrophil to lymphocyte ratio in the region of lower extremity deep venous thrombosis

Objectives. Many studies have demonstrated a significant association between cardiovascular disease andneutrophil to lymphocyte ratio (NLR). To our knowledge, no study has been reported in patients with deepvenous thrombosis (DVT) which affecting proximal or distal leg. In this study we analyzed proximal and distalDVT according to the NLR. Methods. This retrospective study was obtained from patients’ records of a tertiaryuniversity hospital between May 2011 to January 2014. A total of 57 patients with the diagnosis of acute primaryDVT and 30 patients as control group included in the study. All of them were confirmed with lower extremityvenous duplex examinations. Of these, 37 examinations with the diagnosis of proximal DVT were comparedto 20 examinations with distal DVT. The groups compared regarding to complete blood counter values. Results.Mean eosinophil level was higher in the distal DVT group (0.28±0.24 vs. 0.12±0.01, p=0.001), whereas medianNLR were higher in the proximal DVT group than the distal DVT group (3.5 [0.5-4.3] vs. 2.3 [1.2-9.7],respectively; p=0.002). In addition, median NLR, leukocyte and neutrophil counts were statistically lower inthe control group than the others (p=0.014, p=0.027 and p=0.004, respectively). Conclusion. NLR, aninexpensive and easily measurable laboratory variable, was independently and significantly associated withthe presence and severity of DVT, especially acute proximal DV

Giant size abdominal aortic aneurysm repair using open proximal anastomosis under hypothermic circulatory arrest: A report of two cases

Hypothermic total circulatory arrest and open proximal anastomosis techniques are not commonly used in abdominal or juxtarenal abdominal aortic aneurysm repair. Proximal aortic clamping is usually adequate for surgical repair of abdominal aortic pathologies. We present two cases of giant-sized abdominal aortic aneurysms, one was juxtarenal and one was a Crawford type IV thoracoabdominal aneurysm, that were repaired by using open proximal anastomosis under hypothermic total circulatory arrest and a transabdominal approach. This technique may be useful for both thoracoabdominal and large abdominal aortic aneurysms because it offers the opportunity to not clamp the aorta and operate in bloodless surgical field

8th Decades Presentation of Subaortic Fibrous Membrane with Left Ventricular Outfow Tract Obstruction

Subaortic membrane is the reason of the left ventricul outflow tract obstruction in the adults and it may causes severe clinical outcomes. A 70-year-old old female patient presented with syncop, tachycardia, anginal pain. Subaortic fibromembraneus ridge shown by echocardiography. She treated with surgical resection of fibrous membrane with no any complication. She discharged from hospital on the 10th postoperative day. At six-month postoperative follow-up there weren't any recurrence on echocardiogram. Recurrence is possible and close follow-up is mandatory

Effects of hyperbaric oxygen therapy combined with platelet-rich plasma on diabetic wounds: an experimental rat model

Introduction: Hyperbaric oxygen and platelet-rich plasma are used in the treatment of diabetic wounds. The aim of this study is to evaluate the effects of hyperbaric oxygen therapy and autologous platelet concentrates in healing diabetic wounds. Material and methods: Thirty-six female Wistar albino rats were used in this study. Diabetes mellitus was induced chemically with an intraperitoneal injection of streptozotocin. The rats were divided into a control group, a hyperbaric oxygen group, a platelet-rich plasma group, and a combined therapy group. Platelet-rich plasma was applied just after the creation of the wound; hyperbaric oxygen treatment was carried out daily over 7 days. Wound healing was evaluated according to four parameters: ulcerations, epidermal thickness, density of dermal collagen fibers, and proliferation of dermal blood vessels. Results: The number of active ulcers in the combined therapy group was fewer than in the control group (p = 0.039), and the wound area was greatest in controls (p < 0.001). The epidermal thickness in platelet-rich plasma and combined therapy groups was non-significantly greater than in the control group (p = 0.097 and p = 0.074, respectively). The amount of fibrous collagen in these two groups was greater than in the control group (p = 0.002). Conclusions: Combined hyperbaric oxygen and platelet-rich plasma therapy was found to be successful in diabetic wound healing. The combination therapy had no additive effect in terms of angiogenesis and the development of new collagen fibers

Snapshot evaluation of acute and chronic heart failure in real-life in Turkey: a follow-up data for mortality

Objective: Heart failure (HF) is a progressive clinical syndrome. SELFIE-TR is a registry illustrating the overall HF patient profile of Turkey. Herein, all-cause mortality (ACM) data during follow-up were provided. Methods: This is a prospective outcome analysis of SELFIE-TR. Patients were classified as acute HF (AHF) versus chronic HF (CHF) and HF with reduced ejection fraction (HFrEF), HF with mid-range ejection fraction, and HF with preserved ejection fraction and were followed up for ACM. Results: There were 1054 patients with a mean age of 63.3±13.3 years and with a median follow-up period of 16 (7–17) months. Survival data within 1 year were available in 1022 patients. Crude ACM was 19.9% for 1 year in the whole group. ACM within 1 year was 13.7% versus 32.6% in patients with CHF and AHF, respectively (p<0.001). Angiotensin-converting enzyme inhibitor/angiotensin receptor blocker, beta blocker, and mineralocorticoid receptor antagonist were present in 70.6%, 88.2%, and 50.7%, respectively. In the whole cohort, survival curves were graded according to guideline-directed medical therapy (GDMT) scores ?1 versus 2 versus 3 as 28% versus 20.2% versus 12.2%, respectively (p<0.001). Multivariate analysis of the whole cohort yielded age (p=0.009) and AHF (p=0.028) as independent predictors of mortality in 1 year. Conclusion: One-year mortality is high in Turkish patients with HF compared with contemporary cohorts with AHF and CHF. Of note, GDMT score is influential on 1-year mortality being the most striking one on chronic HFrEF. On the other hand, in the whole cohort, age and AHF were the only independent predictors of death in 1 yea