Sex differences in anatomical parameters of acetabulum among asymptomatic Serbian population

Background/Aim. Anatomical parameters of the bony components of the hip joint are essential for better under- standing of etiopathogenesis of diseases like primary osteo- arthrosis of the hip joint. The aim of this reserch was to ex- amine the normal acetabular morphometry in Serbian popu- lation and to determine whether there are sex differences in anatomical parameters of the acetabulum among asympto- matic subjects. Methods. Pelvic radiographics of 320 adult asymptomatic patients (640 hips) were analyzed in 170 men and 150 women to determine the morphology of the ace- tabulum in Serbian population. For each hip the center edge angle of Wiberg (CEA), the acetabular angle of Sharp (AA), acetabular depth (AD), acetabular roof obliquity (ARO) and roof angle (RA) were measured. Results. The following aver- age measurements for acetabulum geometry were obtained (x ± SD): CEA - 33.5 ± 6.5° (33.6 ± 5.8° in male, 33.3 ± 6.9° in female), AA - 38.0 ± 3.8° (37.5 ± 3.6° in male, 38.5 ± 3.9° in female), AD - 11.9 ± 2.8 mm (12.5 ± 2.7 mm in male, 11.2 ± 2.7 mm in female), ARO - 7.6 ± 5.7° (6.2 ± 4.9° in male, 9.0 ± 6.0° in female) and RA - 18.4 ± 10.0° (19.6 ± 8.5° in male, 17.1 ± 9.5° in female). There were significant differences in the CEA, AA, AD, ARO and RA related to gender (p < 0.01, t-test). Conclu- sion. There are significant gender differences in Serbian population for all the examined anatomical parameters of acetabulum. We found sex-related differences in acetabular morphology, female acetabulum being marginally more dys- plastic than male acetabulum. There is also a clear tendency of female hips to be more dysplastic than male ones

Supplementary data for the article: Vulovic, B.; Kolarski, D.; Bihelovic, F.; Matovic, R.; Gruden, M.; Saicic, R. N. Gold(I)-Catalyzed Domino Cyclizations of Diynes for the Synthesis of Functionalized Cyclohexenone Derivatives. Total Synthesis of (-)-Gabosine H and (-)-6-Epi-Gabosine H. Organic Letters 2016, 18 (15), 3886–3889. https://doi.org/10.1021/acs.orglett.6b01898

Supplementary material for: [https://doi.org/10.1021/acs.orglett.6b01898]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/2290

Gold(I)-Catalyzed Domino Cyclizations of Diynes for the Synthesis of Functionalized Cyclohexenone Derivatives. Total Synthesis of (-)-Gabosine H and (-)-6-epi-Gabosine H

1,6-Diynes with a t-butylcarbonate group in the propargylic position undergo gold(I)-catalyzed dominocyclization which affords alpha-hydroxycyclohexenones. The described sequence can be applied on functionalized, highly oxygenated substrates, as examplified in the synthesis of (-)-gabosine H and its epimer.Supplementary material: [http://cherry.chem.bg.ac.rs/handle/123456789/3520

Simultaneous Bilateral Joint Arthroplasties in Treatment of Osteoarthritis

Osteoarthrosis is the most common chronic joint condition, the aetiology of which is still not completely clear. Initial phases of disease are treated conservatively applying physical rehabilitation procedures and medications. Advanced stages need surgical treatment with numerous procedures, depending on the joint affected. Joint arthroplasties are procedure of choice, especially for big joints of the extremities. As osteoarthrosis occurs bilaterally very frequently, there are a growing number of patients in need for operation of both joints. Those procedures can be performed under single anaesthesia or staged procedure, with delay between two surgeries. There are many advantages and disadvantages of both approaches cited by different authors. There is consensus of authors in available articles regarding benefits of single-stage procedure: lower cost, shorter hospital stay, single rehabilitation period and better functional results. Authors disagree about safety of a single-stage bilateral procedure as well as incidence of complications and criteria for selection of patients for safe performing of simultaneous procedure

Supplementary data for the article: Vulovic, B.; Kolarski, D.; Bihelovic, F.; Matovic, R.; Gruden, M.; Saicic, R. N. Gold(I)-Catalyzed Domino Cyclizations of Diynes for the Synthesis of Functionalized Cyclohexenone Derivatives. Total Synthesis of (-)-Gabosine H and (-)-6-Epi-Gabosine H. Organic Letters 2016, 18 (15), 3886–3889. https://doi.org/10.1021/acs.orglett.6b01898

Supplementary material for: [https://doi.org/10.1021/acs.orglett.6b01898]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/2290

Stable population structure in Europe since the Iron Age, despite high mobility

Ancient DNA research in the past decade has revealed that European population structure changed dramatically in the prehistoric period (14,000–3000 years before present, YBP), reflecting the widespread introduction of Neolithic farmer and Bronze Age Steppe ancestries. However, little is known about how population structure changed from the historical period onward (3000 YBP - present). To address this, we collected whole genomes from 204 individuals from Europe and the Mediterranean, many of which are the first historical period genomes from their region (e.g. Armenia and France). We found that most regions show remarkable inter-individual heterogeneity. At least 7% of historical individuals carry ancestry uncommon in the region where they were sampled, some indicating cross-Mediterranean contacts. Despite this high level of mobility, overall population structure across western Eurasia is relatively stable through the historical period up to the present, mirroring geography. We show that, under standard population genetics models with local panmixia, the observed level of dispersal would lead to a collapse of population structure. Persistent population structure thus suggests a lower effective migration rate than indicated by the observed dispersal. We hypothesize that this phenomenon can be explained by extensive transient dispersal arising from drastically improved transportation networks and the Roman Empire’s mobilization of people for trade, labor, and military. This work highlights the utility of ancient DNA in elucidating finer scale human population dynamics in recent history

Sex differences in anatomical parameters of acetabulum among asymptomatic Serbian population

Background/Aim. Anatomical parameters of the bony components of the hip joint are essential for better understanding of etiopathogenesis of diseases like primary osteoarthrosis of the hip joint. The aim of this reserch was to examine the normal acetabular morphometry in Serbian population and to determine whether there are sex differences in anatomical parameters of the acetabulum among asymptomatic subjects. Methods. Pelvic radiographics of 320 adult asymptomatic patients (640 hips) were analyzed in 170 men and 150 women to determine the morphology of the acetabulum in Serbian population. For each hip the center edge angle of Wiberg (CEA), the acetabular angle of Sharp (AA), acetabular depth (AD), acetabular roof obliquity (ARO) and roof angle (RA) were measured. Results. The following average measurements for acetabulum geometry were obtained (X ± SD): CEA - 33.5 ± 6.5° (33.6 ± 5.8° in male, 33.3 ± 6.9° in female), AA - 38.0 ± 3.8° (37.5 ± 3.6° in male, 38.5 ± 3.9° in female), AD - 11.9 ± 2.8 mm (12.5 ± 2.7 mm in male, 11.2 ± 2.7 mm in female), ARO - 7.6 ± 5.7° (6.2 ± 4.9° in male, 9.0 ± 6.0° in female) and RA - 18.4 ± 10.0° (19.6 ± 8.5° in male, 17.1 ± 9.5° in female). There were significant differences in the CEA, AA, AD, ARO and RA related to gender (p &lt; 0.01, t-test). Conclusion. There are significant gender differences in Serbian population for all the examined anatomical parameters of acetabulum. We found sex-related differences in acetabular morphology, female acetabulum being marginally more dysplastic than male acetabulum. There is also a clear tendency of female hips to be more dysplastic than male ones

Substrate Stereocontrol in the Intramolecular Organocatalyzed Tsuji-Trost Reaction: Enantioselective Synthesis of Allokainates

Organocatalyzed Tsuji-Trost cyclization of 3b proceeds with asymmetric induction and allows for stereoselective synthesis of (+)-allokainic acid. The stereochemical outcome of the cyclization was predicted by calculations

Ilizarov method as limb salvage in treatment of massive femoral defect after unsuccessful tumor arthroplasty

Introduction. Surgical management of massive bone defects is very challenging in terms of estimating possibilities of saving the extremity and adequate method that can make it possible. Selection of methods is additionally limited in the presence of infection at site of defect. Case report. The female patient, diagnosed with Ewing sarcoma was treated by segmental bone resection and implantation of Kotz modular tumor endoprosthesis. After 5 years the signs of infection occured and persisted with low grade intensity. After falling, 12 years following implantation, the patient acquired periprosthetic fracture. Then endoprosthesis was removed, all along with surgical debridement of wound and application of the Ilizarov apparatus. The apparatus was applied, osteotomy of callus and the tibia performed with transport of bone segments, untill reconstruction of defect and arthrodesis of the knee was achieved. Conclusion. The Ilizarov apparatus offered us huge possibilities for management of massive bone defects with natural bone which has superior biomechanical characteristics comparing to the implant. The most frequent complication of this method is a prolonged treatment period that demands good patient selection and preparation and wide surgical experience