Modeling and prediction of surgical procedure times

Accurate prediction of medical operation times is of crucial importance for cost efficient operation room planning in hospitals. This paper investigates the possible dependence of procedure times on surgeon factors like age, experience, gender, and team composition. The effect of these factors is estimated for over 30 different types of medical operations in two hospitals, by means of ANOVA models for logarithmic case durations. The estimation data set contains about 30,000 observations from 2005 till 2008. The relevance of surgeon factors depends on the type of operation. The factors found most often to be significant are team composition, experience, and daytime. Contrary to widespread opinions among surgeons, gender has nearly never a significant effect. By incorporating surgeon factors, the accuracy of out-of-sample prediction of case durations of about 1,250 surgical operations in 2009 is improved by up to more than 15 percent as compared to current planning procedures.planning;ANOVA model;European hospital;current procedure terminology (CPT);health care management;lognormal distribution;operation room;surgeon factors

Tortuous ways to the extraction of neutron observables from inclusive lepton scattering

We analyze new JLAB data for inclusive electron scattering on various targets. Computed and measured total inclusive cross sections in the range $0.3\lesssim x\lesssim 0.95$ show on a logarithmic scale reasonable agreement for all targets. However, closer inspection of the Quasi-Elastic components bares serious discrepancies. EMC ratios which may contain less systematic errors fare the same. The above observations for the new data do not enable the extraction of the magnetic form factor (FF) $G_M^n$ and the Structure Function (SFs) $F_2^n$ of the neutron, although the application of exactly the same analysis to older data had been successful. We add to the above analysis older CLAS collaboration on $F_2^D$. Removing some scattered points, it appears possible to obtain the above mentioned neutron information. We compare our results with others from alternative sources. Particular attention is paid to the A=3 iso-doublet. Present data exist only for $^3$He, but the available input and charge symmetry also enable computations for $^3$H. Their average is the computed iso-scalar part and is compared with the empirical modification of $^3$He towards a fictitious A=3 iso-singlet.Comment: 27 pages, 30 figure

A study of the parity-odd nucleon-nucleon potential

We investigate the parity-violating nucleon-nucleon potential as obtained in chiral effective field theory. By using resonance saturation we compare the chiral potential to the more traditional one-meson exchange potential. In particular, we show how parameters appearing in the different approaches can be compared with each other and demonstrate that analyses of parity violation in proton-proton scattering within the different approaches are in good agreement. In the second part of this work, we extend the parity-violating potential to next-to-next-to-leading order. We show that generally it includes both one-pion- and two-pion-exchange corrections, but the former play no significant role. The two-pion-exchange corrections depend on five new low-energy constants which only become important if the leading-order weak pion-nucleon constant $h_\pi$ turns out to be very small.Comment: Published versio

Disordering to Order: de Vries behavior from a Landau theory for smectics

We show that Landau theory for the isotropic, nematic, smectic A, and smectic C phases generically, but not ubiquitously, implies de Vries behavior. I.e., a continuous AC transition can occur with little layer contraction; the birefringence decreases as temperature T is lowered above this transition, and increases again below the transition. This de Vries behavior occurs in models with unusually small orientational order, and is preceded by a first order I − A transition. A first order AC transition with elements of de Vries behavior can also occur. These results correspond well with experimental work to date.Comment: 4 pages, 2 page appendi

Dust absorption and scattering in the silicon K-edge

The composition and properties of interstellar silicate dust are not well understood. In X-rays, interstellar dust can be studied in detail by making use of the fine structure features in the Si K-edge. The features in the Si K-edge offer a range of possibilities to study silicon-bearing dust, such as investigating the crystallinity, abundance, and the chemical composition along a given line of sight. We present newly acquired laboratory measurements of the silicon K-edge of several silicate-compounds that complement our measurements from our earlier pilot study. The resulting dust extinction profiles serve as templates for the interstellar extinction that we observe. The extinction profiles were used to model the interstellar dust in the dense environments of the Galaxy. The laboratory measurements, taken at the Soleil synchrotron facility in Paris, were adapted for astrophysical data analysis and implemented in the SPEX spectral fitting program. The models were used to fit the spectra of nine low-mass X-ray binaries located in the Galactic center neighborhood in order to determine the dust properties along those lines of sight. Most lines of sight can be fit well by amorphous olivine. We also established upper limits on the amount of crystalline material that the modeling allows. We obtained values of the total silicon abundance, silicon dust abundance, and depletion along each of the sightlines. We find a possible gradient of $0.06\pm0.02$ dex/kpc for the total silicon abundance versus the Galactocentric distance. We do not find a relation between the depletion and the extinction along the line of sight.Comment: 18 pages, 16 figures. Accepted for publication in Astronomy and Astrophysic

Fat tail distributions and local thin tail alternatives

The behaviour of the Hill estimator for the tail index of fat tailed distributions in the presence of local alternatives which have a thin tail is investigated. The converse problem is also briefly addressed. A local thin tail alternative can severely bias the Hill statistic. The relevance of this issue for the class of stable distributions is discussed. We conduct a small simulation study to support the analysis. In the conclusion it is argued that for moderate out of sample quantile analysis the problem of local alternatives may be less pressing

Trehalose is required for the acquisition of tolerance to a variety of stresses in the filamentous fungus Aspergillus nidulans

Trehalose is a non-reducing disaccharide found at high concentrations in Aspergillus nidulans conidia and rapidly degraded upon induction of conidial germination. Furthermore, trehalose is accumulated in response to a heat shock or to an oxidative shock. The authors have characterized the A. nidulans tpsA gene encoding trehalose-6-phosphate synthase, which catalyses the first step in trehalose biosynthesis. Expression of tpsA in a Saccharomyces cerevisiae tps1 mutant revealed that the tpsA gene product is a functional equivalent of the yeast Tps1 trehalose-6-phosphate synthase. The A. nidulans tpsA-null mutant does not produce trehalose during conidiation or in response to various stress conditions. While germlings of the tpsA mutant show an increased sensitivity to moderate stress conditions (growth at 45 °C or in the presence of 2 mM H2O2), they display a response to severe stress (60 min at 50 °C or in the presence of 100 mM H2O2) similar to that of wild-type germlings. Furthermore, conidia of the tpsA mutant show a rapid loss of viability upon storage. These results are consistent with a role of trehalose in the acquisition of stress tolerance. Inactivation of the tpsA gene also results in increased steady-state levels of sugar phosphates but does not prevent growth on rapidly metabolizable carbon sources (glucose, fructose) as seen in Saccharomyces cerevisiae. This suggests that trehalose 6-phosphate is a physiological inhibitor of hexokinase but that this control is not essential for proper glycolytic flux in A. nidulans. Interestingly, tpsA transcription is not induced in response to heat shock or during conidiation, indicating that trehalose accumulation is probably due to a post-translational activation process of the trehalose 6-phosphate synthase