51 research outputs found
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Stratification effects in the turbulent boundary layer beneath a melting ice shelf: Insights from resolved large-eddy simulations
AbstractOcean turbulence contributes to the basal melting and dissolution of ice shelves by transporting heat and salt toward the ice. The meltwater causes a stable salinity stratification to form beneath the ice that suppresses turbulence. Here we use large-eddy simulations motivated by the ice shelf–ocean boundary layer (ISOBL) to examine the inherently linked processes of turbulence and stratification, and their influence on the melt rate. Our rectangular domain is bounded from above by the ice base where a dynamic melt condition is imposed. By varying the speed of the flow and the ambient temperature, we identify a fully turbulent, well-mixed regime and an intermittently turbulent, strongly stratified regime. The transition between regimes can be characterized by comparing the Obukhov length, which provides a measure of the distance away from the ice base where stratification begins to dominate the flow, to the viscous length scale of the interfacial sublayer. Upper limits on simulated turbulent transfer coefficients are used to predict the transition from fully to intermittently turbulent flow. The predicted melt rate is sensitive to the choice of the heat and salt transfer coefficients and the drag coefficient. For example, when coefficients characteristic of fully developed turbulence are applied to intermittent flow, the parameterized three-equation model overestimates the basal melt rate by almost a factor of 10. These insights may help to guide when existing parameterizations of ice melt are appropriate for use in regional or large-scale ocean models, and may also have implications for other ice–ocean interactions such as fast ice or drifting ice.Catherin
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Geostrophic and chimney regimes in rotating horizontal convection with imposed heat flux
Convection in a rotating rectangular basin with differential thermal forcing at one horizontal boundary is examined using laboratory experiments. The experiments have an imposed heat flux boundary condition, are at large values of the flux Rayleigh number ( based on the box length ), use water with Prandtl number and have a small depth to length aspect ratio. The results show the conditions for transition from non-rotating horizontal convection governed by an inertial–buoyancy balance in the thermal boundary layer, to circulation governed by geostrophic flow in the boundary layer. The geostrophic balance constrains mean flow and reduces the heat transport as Nusselt number , where is the convective Rossby number, is the imposed buoyancy flux and is the Coriolis parameter. Thus flow in the geostrophic boundary layer regime is governed by the relative roles of horizontal convective accelerations and Coriolis accelerations, or buoyancy and rotation, in the boundary layer. Experimental evidence suggests that for more rapid rotation there is another transition to a regime in which the momentum budget is dominated by fluctuating vertical accelerations in a region of vortical plumes, which we refer to as a ‘chimney’ following related discussion of regions of deep convection in the ocean. Coupling of the chimney convection in the region of destabilising boundary flux to the diffusive boundary layer of horizontal convection in the region of stabilising boundary flux gives heat transport independent of rotation in this ‘inertial chimney’ regime, and the new scaling . Scaling analysis predicts the transition conditions observed in the experiments, as well as a further ‘geostrophic chimney’ regime in which the vertical plumes are controlled by local geostrophy. When Ro<10^{-1}, the convection is also observed to produce a set of large basin-scale gyres at all depths in the time-averaged flow.</jats:p
Transport by deep convection in basin-scale geostrophic circulation: Turbulence-resolving simulations
Direct numerical simulations are used to investigate the nature of fully resolved small-scale convection and its role in large-scale circulation in a rotating -plane rectangular basin with imposed surface temperature difference. The large-scale circulation has a horizontal geostrophic component and a deep vertical overturning. This paper focuses on convective circulation with no wind stress, and buoyancy forcing sufficiently strong to ensure turbulent convection within the thermal boundary layer (horizontal Rayleigh numbers ). The dynamics are found to depend on the value of a convective Rossby number, Ro_{\unicode[STIX]{x0394}T}, which represents the strength of buoyancy forcing relative to Coriolis forces. Vertical convection shifts from a mean endwall plume under weak rotation (Ro_{\unicode[STIX]{x0394}T}>10^{-1}) to ‘open ocean’ chimney convection plus mean vertical plumes at the side boundaries under strong rotation (Ro_{\unicode[STIX]{x0394}T}<10^{-1}). The overall heat throughput, horizontal gyre transport and zonally integrated overturning transport are then consistent with scaling predictions for flow constrained by thermal wind balance in the thermal boundary layer coupled to vertical advection–diffusion balance in the boundary layer. For small Rossby numbers relevant to circulation in an ocean basin, vertical heat transport from the surface layer into the deep interior occurs mostly in ‘open ocean’ chimney convection while most vertical mass transport is against the side boundaries. Both heat throughput and the mean circulation (in geostrophic gyres, boundary currents and overturning) are reduced by geostrophic constraints.</jats:p
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The influence of submesoscales and vertical mixing on the export of sinking tracers in large-eddy simulations
AbstractWe use idealized large-eddy simulations (LES) and a simple analytical theory to study the influence of submesoscales on the concentration and export of sinking particles from the mixed layer. We find that restratification of the mixed layer following the development of submesoscales reduces the rate of vertical mixing which, in turn, enhances the export rate associated with gravitational settling. For a neutral tracer initially confined to the mixed layer, subinertial (submesoscale) motions enhance the downward tracer flux, consistent with previous studies. However, the sign of the advective flux associated with the concentration of sinking particles reverses, indicating reentrainment into the mixed layer. A new theory is developed to model the gravitational settling flux when the particle concentration is nonuniform. The theory broadly agrees with the LES results and allows us to extend the analysis to a wider range of parameters.</jats:p
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Numerical Simulations of Melt-Driven Double-Diffusive Fluxes in a Turbulent Boundary Layer beneath an Ice Shelf
AbstractThe transport of heat and salt through turbulent ice shelf–ocean boundary layers is a large source of uncertainty within ocean models of ice shelf cavities. This study uses small-scale, high-resolution, 3D numerical simulations to model an idealized boundary layer beneath a melting ice shelf to investigate the influence of ambient turbulence on double-diffusive convection (i.e., convection driven by the difference in diffusivities between salinity and temperature). Isotropic turbulence is forced throughout the simulations and the temperature and salinity are initialized with homogeneous values similar to observations. The initial temperature and the strength of forced turbulence are varied as controlling parameters within an oceanographically relevant parameter space. Two contrasting regimes are identified. In one regime double-diffusive convection dominates, and in the other convection is inhibited by the forced turbulence. The convective regime occurs for high temperatures and low turbulence levels, where it is long lived and affects the flow, melt rate, and melt pattern. A criterion for identifying convection in terms of the temperature and salinity profiles, and the turbulent dissipation rate, is proposed. This criterion may be applied to observations and theoretical models to quantify the effect of double-diffusive convection on ice shelf melt rates.</jats:p
Preconception Brief: Occupational/Environmental Exposures
In the last decade, more than half of U.S. children were born to working mothers and 65% of working men and women were of reproductive age. In 2004 more than 28 million women age 18–44 were employed full time. This implies the need for clinicians to possess an awareness about the impact of work on the health of their patients and their future offspring. Most chemicals in the workplace have not been evaluated for reproductive toxicity, and where exposure limits do exist, they were generally not designed to mitigate reproductive risk. Therefore, many toxicants with unambiguous reproductive and developmental effects are still in regular commercial or therapeutic use and thus present exposure potential to workers. Examples of these include heavy metals, (lead, cadmium), organic solvents (glycol ethers, percholoroethylene), pesticides and herbicides (ethylene dibromide) and sterilants, anesthetic gases and anti-cancer drugs used in healthcare. Surprisingly, many of these reproductive toxicants are well represented in traditional employment sectors of women, such as healthcare and cosmetology. Environmental exposures also figure prominently in evaluating a woman’s health risk and that to a pregnancy. Food and water quality and pesticide and solvent usage are increasingly topics raised by women and men contemplating pregnancy. The microenvironment of a woman, such as her choices of hobbies and leisure time activities also come into play. Caregivers must be aware of their patients’ potential environmental and workplace exposures and weigh any risk of exposure in the context of the time-dependent window of reproductive susceptibility. This will allow informed decision-making about the need for changes in behavior, diet, hobbies or the need for added protections on the job or alternative duty assignment. Examples of such environmental and occupational history elements will be presented together with counseling strategies for the clinician
Excitotoxic cell death induces delayed proliferation of endogenous neuroprogenitor cells in organotypic slice cultures of the rat spinal cord
The aim of the present report was to investigate whether, in the mammalian spinal cord, cell death induced by transient excitotoxic stress could trigger activation and proliferation of endogenous neuroprogenitor cells as a potential source of a lesion repair process and the underlying time course. Because it is difficult to address these issues in vivo, we used a validated model of spinal injury based on rat organotypic slice cultures that retain the fundamental tissue cytoarchitecture and replicate the main characteristics of experimental damage to the whole spinal cord. Excitotoxicity evoked by 1 h kainate application produced delayed neuronal death (40%) peaking after 1 day without further losses or destruction of white matter cells for up to 2 weeks. After 10 days, cultures released a significantly larger concentration of endogenous glutamate, suggesting functional network plasticity. Indeed, after 1 week the total number of cells had returned to untreated control level, indicating substantial cell proliferation. Activation of progenitor cells started early as they spread outside the central area, and persisted for 2 weeks. Although expression of the neuronal progenitor phenotype was observed at day 3, peaked at 1 week and tapered off at 2 weeks, very few cells matured to neurons. Astroglia precursors started proliferating later and matured at 2 weeks. These data show insult-related proliferation of endogenous spinal neuroprogenitors over a relatively brief time course, and delineate a narrow temporal window for future experimental attempts to drive neuronal maturation and for identifying the factors regulating this process. \ua9 2013 Macmillan Publishers Limited. All rights reserved
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
Feasibility of a combined aerobic and strength training program and its effects on cognitive and physical function in institutionalized dementia patients. A pilot study
OBJECTIVES: We examined the feasibility of a combined aerobic and strength training program in institutionalized dementia patients and studied the effects on cognitive and physical function. METHODS: Thirty-three patients with dementia, recruited from one nursing home, participated in this non-randomized pilot study (25 women; age = 85.2±4.9 years; Mini Mental State Examination = 16.8±4.0). In phase 1 of the study, seventeen patients in the Exercise group (EG) received a combined aerobic and strength training program for six weeks, five times per week, 30 minutes per session, in an individually supervised format and successfully concluded the pre and posttests. In phase 2 of the study, sixteen patients in the Social group (SG) received social visits at the same frequency, duration, and format and successfully concluded the pre and posttests. RESULTS: Indices of feasibility showed that the recruitment and adherence rate, respectively were 46.2% and 86.3%. All EG patients completed the exercise program according to protocol without adverse events. After the six-week program, no significant differences on cognitive function tests were found between the EG and SG. There was a moderate effect size in favor for the EG for the Visual Memory Span Forward; a visual attention test. There were significant differences between groups in favor for the EG with moderate to large effects for the physical tests Walking Speed (p = .003), Six-Minute Walk Test (p = .031), and isometric quadriceps strength (p = .012). CONCLUSIONS: The present pilot study showed that it is feasible to conduct a combined aerobic and strength training program in institutionalized patients with dementia. The selective cognitive visual attention improvements and more robust changes in motor function in favor of EG vs. SG could serve as a basis for large randomized clinical trials. TRIAL REGISTRATION: trialregister.nl 1230
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