Combined intraarterial/intravenous thrombolysis for acute ischemic stroke

BACKGROUND AND PURPOSE: The intravenous use of recombinant tissue-type plasminogen activator (rTPA) in acute ischemic stroke has been investigated in three large trials. Limited series have reflected outcome after local intraarterial thrombolysis (LIT) in the cerebral territory. The purpose of this study was to evaluate the safety and efficacy of combined intraarterial/intravenous thrombolysis using rTPA (actilyse) for acute ischemic stroke. METHODS: Forty-five patients with acute onset of severe hemispheric stroke and without signs of major cerebral infarction on early CT scans were randomized by order of admission. Twelve patients were treated with 50 mg actilyse (maximal dose, 0.7 mg/kg); three had occlusion of the internal carotid artery and nine had occlusion of the middle cerebral artery. Thrombolysis was started by LIT and continued intravenously within 6 hours of stroke onset. Outcome, assessed after 1 and 12 months according to the modified Rankin scale (MRS), was considered good (MRS score, 0-3) for patients who were functionally independent and poor (MRS score, 4-5) for those who were dependent or had died. RESULTS: In the thrombolysis group, outcome was good in eight patients at 1 month and in 10 patients at 12 months; in the control group, outcome was good in seven (21%) and 11 (33%) patients, respectively. Of the eight patients with a good outcome after thrombolysis, four had complete and one had partial recanalization. In the control group, the rate of intracerebral hemorrhage was 6%. Mortality at 1 month in the thrombolysis and control groups was 17% and 48%, respectively. CONCLUSIONS: Combined intraarterial/intravenous thrombolysis with low-dose rTPA may be a safe and effective treatment for acute ischemic stroke within 6 hours in carefully selected patients.Peer reviewe

Metabolic syndrome: review

The psychosomatic component of the metabolic syndrome, historical aspect of the problem under study, physiological and biochemical mechanisms of pathogenesis are considered in the article. The symptomatic components of the metabolic syndrome and their interrelation are outlined, the ways of diagnosis and therapy and  directions of modern research in this field are outlined

Формування психологічного механізму регуляції поведінки неповнолітніх

Ворона, С. В. Формування психологічного механізму регуляції поведінки неповнолітніх / Софія Володимирівна Ворона // Особистість, суспільство, закон : тези доп. учасників міжнар. наук.-практ. конф., присвяч. пам’яті проф. С. П. Бочарової (м. Харків, 25 квіт. 2019 р.) / МВС України, Харк. нац. ун-т внутр. справ. – Харків, 2019. – С. 30-34.Розглянуто морально-правове формування особистості неповнолітніх в процесі їх соціалізації. Проаналізовано психологічний механізм регуляції поведінки підлітків.The moral and legal formation of the personality of minors in the process of their socialization is considered. The psychological mechanism of adolescent behavior regulation is analyzed.Рассмотрено морально-правовое формирование личности несовершеннолетних в процессе их социализации. Проанализирован психологический механизм регуляции поведения подростков

Феномен агресивної поведінки в підлітковому віці

Ворона С. В. Феномен агресивної поведінки в підлітковому віці / С. В. Ворона // Психологічні та педагогічні проблеми професійної освіти та патріотичного виховання персоналу системи МВС України : тези доп. Всеукр. наук.-практ. конф. (м. Харків, 5 квіт. 2019 р.) / МВС України, Харків. нац. ун-т внутр. справ. — Харків, 2019. — С. 294 — 296.Визначено поняття, психологічні та соціальні чинники агресивної поведінки. Збільшення інтенсивності проявів агресії спостерігається у підлітковому віці. Агресивна поведінка у більшості випадків характеризується деструктивними наслідками як для самого підлітка, так і для його оточення.Concepts, psychological and social factors of aggressive behavior are defined. An increase in the intensity of manifestations of aggression is observed in adolescence. Aggressive behavior in most cases is characterized by destructive consequences for both the teenager himself and his environment.Определено понятие, психологические и социальные факторы агрессивного поведения. Увеличение интенсивности проявлений агрессии наблюдается в подростковом возрасте. Агрессивное поведение в большинстве случаев характеризуется деструктивными последствиями как для самого подростка, так и его окружения

THE METHOD FOR DETERMINING THE ABSOLUTE CONFIGURATION USING NSUBSTITUTED CYCLIC AMINO ACIDS

Determining the absolute configuration of biologically active chiral substances is a current issue in drug development since biological properties of enantiomers may greatly vary. The absolute configuration of enantiomers can be determined using crystallography, circular dichroism, or by the method that involves chiral derivatizing agents and analysis of NMR spectra.This work was supported by the Russian Science Foundation, project no. 16-13-10358

Improving the Sphere of Customs Administration in Russia Based on the Chinese Experience

The widespread use of new technologies based on digitalization has recently intensified, due to the processes associated with changes in business organization. Serious attention is paid to this direction of development by business representatives engaged in economic activities in international trade and governments of the leading economies of the world, including China and Russia. The introduction of digitalization processes in various sectors of the economy has become a conscious necessity. In order to theoretically substantiate and subsequently achieve the necessary level of development of information technologies and communications, analytical studies and testing of changes in this area are being conducted in many countries. The economy based on the introduction of digital technologies determines the vector of development of the economies of countries for the long term.Aim. Analyze the digital transformation of the Chinese economy, identify positive experience in the application of digital solutions and their impact on the simplification of customs procedures and correlate the results with Russia.Tasks. Consider technological trends in digital transformation; to study the results of the policy in carrying out the digitalization of the economy of China and Russia; to consider possible promising areas for the development of cooperation between China and Russia in the field of digital.Methods. Statistical analysis of data and synthesis of the results obtained for comparison purposes.Results. As a result of the study, the following results were obtained: a) a comparative analysis of the changes in the values of indicators on the Global Connectivity Index (GCI) of China and Russia in 2020 compared to 2015 was carried out, the reasons for the changes that occurred were substantiated; b) the dynamics of exports and imports of China, as well as data on trade turnover between China and Russia for the period from 1991 to October 2021; c) the experience of customs administration in China is considered and possible directions of its application in Russia are determined.Conclusion. The positive experience of China’s customs administration in the light of the digitalization of economic processes can be used in Russia, which can certainly improve the current situation in the field of customs administration in our country

Оценка противоречивости логической структуры учебного плана

Purpose of the study. The main purpose of creating a curriculum is to regulate academic disciplines in accordance with the logic of the learning process, defined by the relationship between the basic concepts of the disciplines. Violation of this logic becomes apparent only directly during the training sessions.A large variety of quantitative methods uses indicators that do not reveal structural deficiencies in the curriculum. This makes it difficult to improve the curriculum.The purpose of this work is to demonstrate the application of a general approach to the assessment of the structural inconsistency of systems in relation to the evaluation of the logical structure of the curriculum.Materials and methods. The paper applies a general approach to the assessment of structural integrity, developed on the basis of the provisions of the general theory of systems and graph theory. The approach involves the construction of three interrelated structural models of the system and using them to determine the initial data for calculating the index of inconsistency of the system structure.Results. The overall approach to the assessment of structural integrity is adapted to assess the logical structure of the curriculum. Three models of curriculum structure are developed:Elementary model of interdisciplinary communication;Curriculum network model;Hierarchical curriculum model.Based on the parameters of the hierarchical curriculum model, using three adapted algorithms, the value of the inconsistency index of the curriculum structure in the direction of preparation “Applied Informatics” is calculated. Recommendations on changing the structure of the studied curriculum to reduce the degree of its structural inconsistency are proposed. Conclusion. As a result of the research, the methods were proposed that allow identifying possible contradictions in the structure of the curriculum and evaluating its inconsistency. As the experiments have shown, it is extremely difficult to study the curricula in a manual manner, the number of disciplines in which exceeds 50. In this regard, the development of a complex of computer programs that will automate the assessment of the inconsistency of large curricula is being completed.Цель исследования. Основной целью создания учебного плана является упорядочение учебных дисциплин в соответствии с логикой процесса обучения, определенной взаимосвязями между основными понятиями дисциплин. Нарушение данной логики становится очевидным только непосредственно в ходе проведения учебных занятий.Большое разнообразие количественных методов используют показатели, которые не позволяют выявить структурные недоработки учебного плана. Это затрудняет процесс улучшения учебного плана.Целью данной работы является продемонстрировать применение общего подхода к оценке структурной противоречивости систем применительно к оценке логической структуры учебного плана.Материалы и методы. В работе применен общий подход к оценке структурной целостности, разработанный на основе положений общей теории систем и теория графов. Подход предусматривает построение трех взаимосвязанных структурных моделей системы и определения с их помощью исходных данных для расчета показателя противоречивости структуры системы.Результаты. Общий подход к оценке структурной целостности адаптирован для оценки логической структуры учебного плана. Разработаны три модели структуры учебного плана:– элементарная модель междисциплинарных связей;– сетевая модель учебного плана;– иерархическая модель учебного плана.На основе параметров иерархической модели учебного плана с использованием трех адаптированных алгоритмов рассчитано значение показателя противоречивости структуры учебного плана по направлению подготовки Прикладная информатика. Предложены рекомендации по изменению структуры исследуемого учебного плана для понижения степени его структурной противоречивости.Заключение. В результате проведенных исследований предложена методика, которая позволяет выявить возможные противоречия в структуре учебного плана и дать оценку его противоречивости.Как показали проведенные эксперименты, исследовать ручным способом учебные планы, количество дисциплин в которых превышает 50, крайне сложно. В связи с этим завершается разработка комплекса компьютерных программ, которые позволят автоматизировать оценку противоречивости больших учебных планов

Body weight, metabolism and clock genes

Biological rhythms are present in the lives of almost all organisms ranging from plants to more evolved creatures. These oscillations allow the anticipation of many physiological and behavioral mechanisms thus enabling coordination of rhythms in a timely manner, adaption to environmental changes and more efficient organization of the cellular processes responsible for survival of both the individual and the species. Many components of energy homeostasis exhibit circadian rhythms, which are regulated by central (suprachiasmatic nucleus) and peripheral (located in other tissues) circadian clocks. Adipocyte plays an important role in the regulation of energy homeostasis, the signaling of satiety and cellular differentiation and proliferation. Also, the adipocyte circadian clock is probably involved in the control of many of these functions. Thus, circadian clocks are implicated in the control of energy balance, feeding behavior and consequently in the regulation of body weight. In this regard, alterations in clock genes and rhythms can interfere with the complex mechanism of metabolic and hormonal anticipation, contributing to multifactorial diseases such as obesity and diabetes. The aim of this review was to define circadian clocks by describing their functioning and role in the whole body and in adipocyte metabolism, as well as their influence on body weight control and the development of obesity

Національна доповідь про стан і перспективи розвитку освіти в Україні: монографія (До 30-річчя незалежності України)

The publication provides a comprehensive analysis of the state and development of national education over the 30 years of Ukraine’s independence, identifies current problems in education, ascertains the causes of their emergence, offers scientifically reasoned ways to modernise domestic education in the context of globalisation, European integration, innovative development, and national self-identification. Designed for legislators, state officials, education institutions leaders, teaching and academic staff, the general public, all those who seek to increase the competitiveness of Ukrainian education in the context of civilisation changes.У виданні здійснено всебічний аналіз стану і розвитку національної освіти за 30-річний період незалежності України, визначено актуальні проблеми освітньої сфери, виявлено причини їх виникнення, запропоновано науково обґрунтовані шляхи модернізації вітчизняної освіти в умовах глобалізації, європейської інтеграції, інноваційного розвитку та національної самоідентифікації. Розраховано на законодавців, державних управлінців, керівників закладів освіти, педагогічних і науково-педагогічних працівників, широку громадськість, усіх, хто прагне підвищення конкурентоспроможності української освіти в контексті цивілізаційних змін

WAYS TO IMPROVE POSTOPERATIVE WOUND HEALING IN THE SURGICAL TREATMENT OF LOCALLY ADVANCED TUMORS OF THE HEAD AND NECK

The paper deals with the prevention of suture failure after surgery for locally advanced malignancies of the head and neck. According to the data of different authors, postoperative festering wounds may be noted in 40–60 % of patients and persistent pharyngeal defects are seen in 10–35 % of cases. The efficacy of applying rich-enriched autoplasma membranes to the suture area is clinically evaluated. Platelets are known to be the most convenient and inexpensive source of proteins, the growth factors involved in the regeneration of affected tissues. The experience in their use in dentistry, cardiovascular surgery, and traumatology is richest. The above properties of platelets are a theoretical premise for their employment when forming a pharyngeal suture to enhance its stability