Timescale of Emplacement and Rheomorphism of the Green Tuff Ignimbrite (Pantelleria, Italy)

We present a multidisciplinary study based on Differential Scanning Calorimetry (DSC), paleomagnetic analysis, and numerical modeling to gain information on the timescales of syn- and post-depositional ductile deformation of the strongly welded and rheomorphic Green Tuff ignimbrite (GT; Pantelleria, Italy). DSC measurements allow the determination of glass fictive temperatures (Tf; i.e., the parameter accounting for the cooling dependence of glass structure and properties). Using a Tf-based geospeedometry procedure, we infer the cooling rate (qc) experienced by the glassy phases in different lithofacies within the GT formation. Glass shards from the basal pumice fall deposit record a fast qc of ∼10°C/s. In contrast, the ignimbrite body returns slow qc values depending on the stratigraphic position and lithofacies (basal/upper vitrophyres, fiamme-rich and rheomorphic layers), ranging from ∼10−2 to ∼10−6 °C/s. Moreover, paleomagnetic analyses of the natural remanent magnetization of ignimbrite matrix and embedded lithic clasts indicate an emplacement temperature higher than 550–600°C. By integrating calorimetric and paleomagnetic datasets, we constrain a conductive cooling model, describing the ignimbrite's temperature-time-viscosity (T–t–η) evolution from the eruptive temperature to below Tf. Outcomes suggest that the upper and basal vitrophyres deformed and quenched over hours, indicating that the entire GT underwent intense syn-depositional ductile deformation. Furthermore, the central body remained above Tf for a much longer timespan (>1 month), enabling post-emplacement rheomorphic flow. Lastly, we discuss the critical role of mechanisms such as shear heating and retrograde solubility of volatiles, in locally controlling the rheological behavior of the GT

A case of acute promyelocytic leukemia variant with derivative chromosome 3 der(3)t(3;8) associated with 8q partial gain

Background: Acute promyelocytic leukemia (APL) is characterized by fusion of PML/RARα genes as a result of t(15; 17)(q24;q21). APL is now one of the curable hematological malignancies thanks to molecularly targeted therapies based on all-trans retinoic acid (ATRA) and arsenic trioxide (ATX). Extramedullary (EM) relapse is a rare event in APL, ear involvement being even more infrequent, with only six cases so far described. About 30–35% of patients with newly diagnosed APL have additional cytogenetics abnormalities, whose prognostic significance is still controversial. The most common additional aberration is trisomy 8 or partial gain 8q. Case presentation: We describe here a novel unbalanced translocation der(3)t(3;8)(q29;q23.3-q24.3) associated with 8q partial gain in a 41 year-old man affected by APL in molecular remission after first line treatment, who had a responsive EM relapse in the auditory canal. Conclusions: EM relapse is a rare event in APL and ear involvement is even more infrequent. To our knowledge, this is the first reported case of APL with a new der(3)t(3;8)(q29;q23.3-q24.3) and 8q partial gain associated with t(15;17)(q24; q21). Despite the recurrence of the disease at EM level, the clinical outcome of this patients was favorable

Using HoloLens Mixed Reality to research correlations between language and movement: a case study

Communication can be defined as the understanding and exchanging of meaningful messages. The role of communication is central to the lives of human beings as, everyday, we use language to interact with the world around us. Linguistic skills play a fundamental role in this scenario and Language Disorders (LD) are impairments that limit the processing of linguistic information. Early and accurate identification of LD is thus essential to promote lifelong learning and well-being. From an evolutionary perspective, some human language constructs evolved from an ancestral motor system and share the same neural pathways in the Broca’s area of the brain. This suggests a correlation between action and language. If such a relationship is well established and reliable, it would be possible to use the former as a marker of the latter. The hypothesis of our work, in a nutshell, is that movement can be a predictor of language. To study this correlation, we developed C(H)o(L)ordination, a Mixed Reality (MR) application for HoloLens 2. The application offers several activities based on visual stimuli involving motor movements, which tap on the same skills needed to perform some language tasks. We performed an exploratory study with N=22 users to test the application usability and user experience. The results suggest that C(H)o(L)ordination is a usable and powerful tool to gather insights on the ongoing debate about language evolution and language disorders

Building damage scenarios based on exploitation of Housner intensity derived from finite faults ground motion simulations

In this paper earthquake damage scenarios for residential buildings (about 4200 units) in Potenza (Southern Italy) have been estimated adopting a novel probabilistic approach that involves complex source models, site effects, building vulnerability assessment and damage estimation through Damage Probability Matrices. Several causative faults of single seismic events, with magnitude up to 7, are known to be close to the town. A seismic hazard approach based on finite faults ground motion simulation techniques has been used to identify the sources producing the maximum expected ground motion at Potenza and to generate a set of ground motion time histories to be adopted for building damage scenarios. Additionally, site effects, evaluated in a previouswork through amplification factors of Housner intensity, have been combined with the bedrock values provided by hazard assessment. Furthermore, a new relationship between Housner and EMS-98 macroseismic intensity has been developed. This relationship has been used to convert the probability mass functions of Housner intensity obtained from synthetic seismograms amplified by the site effects coefficients into probability mass function of EMS-98 intensity. Finally, the Damage Probability Matrices have been applied to estimate the damage levels of the residential buildings located in the urban area of Potenza. The proposed methodology returns the full probabilistic distribution of expected damage, thus avoiding average damage index or uncertainties expressed in term of dispersion indexes

Building damage scenarios based on exploitation of Housner Intensity derived from finite faults ground motion simulations

In this paper earthquake damage scenarios for residential buildings (about 4200 units) in Potenza (Southern Italy) have been estimate adopting a probabilistic approach that involves complex source models, site effects, building vulnerability assessment and damage estimation through Damage Probability Matrices (DPMs). The studied area experienced several destructive earthquakes in historical and recent times. Several causative faults of single seismic events, with magnitude up to 7, are known to be close to the town. A seismic hazard approach based on finite faults ground motion simulation techniques has been used to identify the sources producing the maximum expected ground motion at Potenza and to generate a set of ground motion time histories to be used for building damage scenarios. Additionally, site effects, evaluated in the framework of the DPC-INGV S3 project through amplification factors of Housner intensity (IH), have been combined with the bedrock values provided by hazard assessment. Furthermore, a new relationship between IH and macroseismic intensity in terms of EMS98 has been developed. This relationship has been used to convert the Probability Density Functions (PDFs) for IH obtained from synthetic seismograms and convolved by the site effects coefficients into PDFs for EMS98 intensity. Finally, the DPMs approach has been applied to estimate the damage levels of the residential buildings in the urban area of Potenza

Endovascular Management of Juxtarenal and Pararenal Abdominal Aortic Aneurysms: Role of Chimney Technique

The use of chimney technique in endovascular repair of abdominal aortic aneurysms (ChEVAR) has had a secondary role. Although it was first developed in an emergent/urgent setting, the publication of various important studies has helped overcome scepticism towards this technique in elective procedures. This paper reviews current evidence about ChEVAR, focusing on clinical results, technical notes and comparisons with other techniques. The new ChEVAR findings show favourable mid- and long-term clinical outcomes, even in elective patients. These results, comparable to those related to fenestrated endografts, have been achieved through standardisation in planning and materials. An adequate endograft oversizing associated to the right aortic neck length is fundamental to avoid ChEVAR-related complications, such as type 1a endoleaks. These data indicate that ChEVAR, compared to other complex endovascular treatments, has comparable outcomes along with features that could make it an essential option in every clinical settin

Unbalanced segregation of a paternal t(9;11)(p24.3;p15.4) translocation causing familial Beckwith-Wiedemann syndrome: a case report.

BACKGROUND: The vast majority of cases with Beckwith-Wiedemann syndrome (BWS) are caused by a molecular defect in the imprinted chromosome region 11p15.5. The underlying mechanisms include epimutations, uniparental disomy, copy number variations, and structural rearrangements. In addition, maternal loss-of-function mutations in CDKN1C are found. Despite growing knowledge on BWS pathogenesis, up to 20% of patients with BWS phenotype remain without molecular diagnosis. CASE PRESENTATION: Herein, we report an Iranian family with two females affected with BWS in different generations. Bisulfite pyrosequencing revealed hypermethylation of the H19/IGF2: intergenic differentially methylated region (IG DMR), also known as imprinting center 1 (IC1) and hypomethylation of the KCNQ1OT1: transcriptional start site (TSS) DMR (IC2). Array CGH demonstrated an 8 Mb duplication on chromosome 11p15.5p15.4 (205,827-8,150,933) and a 1 Mb deletion on chromosome 9p24.3 (209,020-1,288,114). Chromosome painting revealed that this duplication-deficiency in both patients is due to unbalanced segregation of a paternal reciprocal t(9;11)(p24.3;p15.4) translocation. CONCLUSIONS: This is the first report of a paternally inherited unbalanced translocation between the chromosome 9 and 11 short arms underlying familial BWS. Copy number variations involving the 11p15.5 region are detected by the consensus diagnostic algorithm. However, in complex cases which do not only affect the BWS region itself, characterization of submicroscopic chromosome rearrangements can assist to estimate the recurrence risk and possible phenotypic outcomes

The restoration of the Colosso di Barletta: EDXRF analysis

The Colosso di Barletta is an imposing outdoor bronze statue, dating back the V century, located near the Basilica of “Santo Sepolcro” in Barletta (Apulia, Southern Italy). The monument underwent a structural restoration in 1981, during which the Central Institute of Restoration in Rome performed cleaning treatments and consolidation of the patinas. Currently, the Laboratory of Archaeometry of the University of Salento is carrying on a campaign of non-destructive and in situ measurements by using energy dispersion X-ray fluorescence (EDXRF) in order to assess the chemical composition of the alloy and to study its patinas