204 research outputs found

    Study of Photometric Variability of Selected SU UMa Dwarf Novae

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    In this work we present time-resolved photometry of several poorly-studied dwarf novae during recent superoutbursts. Observations were made with a CCD, mounted on 50- and 60-cm telescopes of the Sternberg Astronomical Institute in Crimea in April - May and October 2012 and June - July 2013. Superhumps were detected in light curves of all the dwarf novae. The amplitudes and periods of detected light variations were calculated. Superhumps evolution was also followed up for all systems and classification is improved

    Morphological and Physiological Characteristics of the Representatives of Melilotus Albus and Melilotus Officinalis, Growing on the Territory of Kalmykia

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    A comparative analysis of leaf blades of two kinds of clover (Melilotus albus, Melilotus officinalis) growing on the territory of Kalmykia has been carried out. Identified diagnostic features in the anatomical structure of the leaves of each species. The parameters of leaf tissue are set. The results of the work give an idea of the degree of plasticity of a characteristic of a leaf plate of two types of clover. Demonstrated features of plates of the same species can be equally, as well as specific for this species, and adaptive variability, due to which the plant has adapted to life in arid conditions. The water regime, indicators of transpiration and productivity of the clover were studied. Changes in physiological parameters were determined before the onset of the summer drought and at its height. The established morphological and physiological characteristics of the two species of clover allow them to be defined as plants that are well adapted to growing under the arid conditions of Kalmykia. The combination of the structural features of the clover with its physiological capabilities, valuable feeding properties and a positive effect on the soil, testifies to the effectiveness of the use of clover in the lean, saline areas of the region. The obtained data can be used in further systematic studies of the genus Melilotus, as well as in planning reclamation measures

    Personal autonomy as a factor of professional self-determination students of the pedagogical University

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    The results of the study of the features of professional self-determination of students of a pedagogical university with different levels of autonomy are presentedΠŸΡ€Π΅Π΄ΡΡ‚Π°Π²Π»Π΅Π½Ρ‹ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ исслСдования особСнностСй ΠΏΡ€ΠΎΡ„Π΅ΡΡΠΈΠΎΠ½Π°Π»ΡŒΠ½ΠΎΠ³ΠΎ самоопрСдСлСния студСнтов пСдагогичСского Π²ΡƒΠ·Π° с Ρ€Π°Π·Π½Ρ‹ΠΌ ΡƒΡ€ΠΎΠ²Π½Π΅ΠΌ автономност

    Main directions digitalization in the higher education in the world and Russia (based on the example of physical culture and sports)

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    On the basis of the analysis of scientific research, we have made an attempt to determine the main directions of the development of digitalization in the system of higher education in the field of physical culture and sports in Russia for the next decade. In our opinion, four main areas of use of modern digitalization in physical culture and sports can be distinguished: in the educational process; in the process of sports training; in the process of competition; in health improving physical cultur

    Supply Chain Strategy and Labor Partnership as a National Priority in the Economic Development of Russia

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    Abstractβ€” Global competition has intensified geographic repositioning of supply chain activities with implications for the economic prosperity of specific regions and geographies affected by such shift. The article reflects the results of studies based on an interdisciplinary approach to the economic development by supply chain strategy and labor partnership. The work is aimed at clarifying the concept of supply chain management and labor partnership as an economic category. Therefore, this concept has been studied through the synthesis of jurisprudence, conflict management, sociology and political science, which allows to identify the economic and microeconomic substances of this phenomenon. The former is considered through the labor market trends and conditions, and quantified in derived parameters of supply chain and social-labor relations depending on it. The latter, as a specific type of management, is formed at the intersection of entrepreneurial, systemic management under limited conditions for self-management model implementation, typical for modern transition to the information, digital economy. Thus, a model of supply chain strategy and labor partnership has been developed as a microeconomic category, implying the impact characteristic of such management tools as investments in human capital, development of corporate culture, adequacy of compensation policies and supply chain responsibility tools, on social capital, considered as a synergistic amount of company’s human capital realized to the full. Additionally, a set of indicators developed in the course of research, and their dynamics can be used to monitor general trends in supply chain and labor partnership as an economic category. Our findings allow expanding the field of research and providing a scientific background for practical tools to improve economic relations

    The kabachnik-fields and pudovik reactions on the basis of E,Z-citral and its imines and (R,S)-citronellal

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    The Kabachnik-Fields reaction of E,Z-citral with diethyl phosphite in the presence of isobutylamine has been found to form Ξ±-aminophosphonates. The Pudovik reactions of diethyl phosphite with prenyl imines prepared on the basis of E,Z-citral with isobutylamine also allowed us to obtain the same Ξ±-aminophosphonates. We have managed to synthesize Ξ±- aminophosphonates by the reaction of O,O-dialkyl trimethylsilyl phosphites with prenyl imines in the presence of water or diethylamine. Ξ±- Aminophosphonates were also synthesized by the reaction of diethyl phosphite with (R,S)-citronellal in the presence of alkylamines. Ξ±-Aminophosphonates obtained showed bacteriostatic activity against Staphylococcus aureus and Bacillus cereus. Β© 2012 Wiley Periodicals, Inc

    Π“Ρ–Π°Π»ΡƒΡ€ΠΎΠ½ΠΎΠ²Π° кислота: біосинтСз Ρ‚Π° використання

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    Topicality. Hyaluronic acid with its antimicrobial and antiviral properties has found applications in medicine and cosmetics. Due to the high molecular weight, it prolongs the action of the active pharmaceutical components. The application spectrum of hyaluronic acid and hyaluronic acid-based products is increasing permanently. Therefore, new microbial producers of hyaluronic acid and new technologies for its biosynthesis are intensively developed.Β Aim. To compile integration of the advances in producers selection, and advances in the development of technologies and the hyaluronic acid applications.Results and discussion. The strains from the genera Streptococcus and Pasteurella are the main bacterial producers of hyaluronic acid. However, they are able to synthesize hyaluronic acid in concentrations lower than 7 g/l after 120 hours of cultivation and their use limited by potential pathogenic properties. To improve technological parameters of biosynthesis, new genetically modified strains of Lactococcus lactis, Corynebacterium glutamicum, Escherichia coli, and Pichia pastoris were constructed. The highest yield of hyaluronic acid, 8.3 g/l , is observed during the cultivation of C. glutamicum for 48 hours.Conclusions. Searching and construction of new hyaluronic acid producers andΒ  biotechnological improving when cultivated are the major points in the development of hyaluronic acid production for pharmaceuticals and cosmetic applications.ΠΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½ΠΎΡΡ‚ΡŒ. Гиалуроновая кислота нашла ΡˆΠΈΡ€ΠΎΠΊΠΎΠ΅ ΠΏΡ€ΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ Π² ΠΌΠ΅Π΄ΠΈΡ†ΠΈΠ½Π΅, Ρ…ΠΈΡ€ΡƒΡ€Π³ΠΈΠΈ, Π΄Π΅Ρ€ΠΌΠ°Ρ‚ΠΎΠ»ΠΎΠ³ΠΈΠΈ, Π³ΠΈΠ½Π΅ΠΊΠΎΠ»ΠΎΠ³ΠΈΠΈ, ΠΎΠ±Π»Π°Π΄Π°Π΅Ρ‚ Π°Π½Ρ‚ΠΈΠΌΠΈΠΊΡ€ΠΎΠ±Π½Ρ‹ΠΌΠΈ ΠΈ противовирусными свойствами, Π° Π·Π° счСт высокой молСкулярной массы являСтся ΠΏΡ€ΠΎΠ»ΠΎΠ½Π³Π°Ρ‚ΠΎΡ€ΠΎΠΌ дСйствия Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΠ³ΠΎ фармацСвтичСского ΠΈΠ½Π³Ρ€Π΅Π΄ΠΈΠ΅Π½Ρ‚Π° (АЀИ) Π² составС лСкарствСнных срСдств. Π’Π°ΠΊΠΈΠΌ ΠΎΠ±Ρ€Π°Π·ΠΎΠΌ, спСктр примСнСния Π³ΠΈΠ°Π»ΡƒΡ€ΠΎΠ½ΠΎΠ²ΠΎΠΉ кислоты достаточно ΡˆΠΈΡ€ΠΎΠΊ ΠΈ постоянно пополняСтся, Ρ‡Ρ‚ΠΎ ΠΏΡ€ΠΈΠ²ΠΎΠ΄ΠΈΡ‚ ΠΊ ΠΏΠΎΠ²Ρ‹ΡˆΠ΅Π½ΠΈΡŽ спроса Π½Π° Π΄Π°Π½Π½Ρ‹ΠΉ Π²ΠΈΠ΄ Π±ΠΈΠΎΠΏΠΎΠ»ΠΈΠΌΠ΅Ρ€Π°, Π° ΡΠ»Π΅Π΄ΠΎΠ²Π°Ρ‚Π΅Π»ΡŒΠ½ΠΎ, Π²ΠΎΠ·Ρ€Π°ΡΡ‚Π°Π½ΠΈΡŽ интСрСса ΠΊ Π°Π»ΡŒΡ‚Π΅Ρ€Π½Π°Ρ‚ΠΈΠ²Π½Ρ‹ΠΌ источникам Π΅Γ« получСния. Π‘Ρ‚Π°Ρ‚ΡŒΡ посвящСна Π°ΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½Ρ‹ΠΌ направлСниям ΠΎΠΏΡ‚ΠΈΠΌΠΈΠ·Π°Ρ†ΠΈΠΈ биосинтСза Π³ΠΈΠ°Π»ΡƒΡ€ΠΎΠ½ΠΎΠ²ΠΎΠΉ кислоты ΠΎΠ±Ρ‹Ρ‡Π½Ρ‹ΠΌΠΈ ΠΈ гСнСтичСски ΠΌΠΎΠ΄ΠΈΡ„ΠΈΡ†ΠΈΡ€ΠΎΠ²Π°Π½Π½Ρ‹ΠΌΠΈ ΡˆΡ‚Π°ΠΌΠΌΠ°ΠΌΠΈ Π±Π°ΠΊΡ‚Π΅Ρ€ΠΈΠΉ, Π°Π½Π°Π»ΠΈΠ·Π° Π²Ρ‹Π±ΠΎΡ€Π° ΠΏΠΈΡ‚Π°Ρ‚Π΅Π»ΡŒΠ½Ρ‹Ρ… срСд для ΠΈΡ… ΠΊΡƒΠ»ΡŒΡ‚ΠΈΠ²ΠΈΡ€ΠΎΠ²Π°Π½ΠΈΡ ΠΈ примСнСния Π±ΠΈΠΎΠΏΠΎΠ»ΠΈΠΌΠ΅Ρ€Π°.ЦСль Ρ€Π°Π±ΠΎΡ‚Ρ‹. ЦСлью нашСй Ρ€Π°Π±ΠΎΡ‚Ρ‹ ΠΏΡ€Π΅Π΄ΡΡ‚Π°Π²Π»ΡΠ»ΠΎΡΡŒ ΠΎΠ±ΠΎΠ±Ρ‰Π΅Π½ΠΈΠ΅ ΠΈΠΌΠ΅ΡŽΡ‰ΠΈΡ…ΡΡ Π² Π½Π°ΡƒΡ‡Π½ΠΎΠΉ Π»ΠΈΡ‚Π΅Ρ€Π°Ρ‚ΡƒΡ€Π΅ свСдСний ΠΎΠ± извСстных ΡˆΡ‚Π°ΠΌΠΌΠ°Ρ…-ΠΏΡ€ΠΎΠ΄ΡƒΡ†Π΅Π½Ρ‚Π°Ρ…, ΠΊΠΎΡ‚ΠΎΡ€Ρ‹Π΅ ΠΈΡΠΏΠΎΠ»ΡŒΠ·ΡƒΡŽΡ‚ΡΡ для биосинтСза Π³ΠΈΠ°Π»ΡƒΡ€ΠΎΠ½ΠΎΠ²ΠΎΠΉ кислоты, ΠΈ ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½ΠΈΠ΅ Π°Π½Π°Π»ΠΈΠ·Π° Π²ΠΎΠ·ΠΌΠΎΠΆΠ½Ρ‹Ρ… сфСр примСнСния ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚ΠΎΠ² Π½Π° Π΅Γ« основС.Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚Ρ‹ ΠΈ ΠΈΡ… обсуТдСниС.Β ΠŸΡ€ΠΎΠ°Π½Π°Π»ΠΈΠ·ΠΈΡ€ΠΎΠ²Π°Π² Π»ΠΈΡ‚Π΅Ρ€Π°Ρ‚ΡƒΡ€Ρƒ, ΠΌΠΎΠΆΠ½ΠΎ ΡΠΊΠ°Π·Π°Ρ‚ΡŒ, Ρ‡Ρ‚ΠΎ сущСствуСт ΠΌΠ½ΠΎΠ³ΠΎ Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹Ρ… ΡˆΡ‚Π°ΠΌΠΌΠΎΠ²-ΠΏΡ€ΠΎΠ΄ΡƒΡ†Π΅Π½Ρ‚ΠΎΠ² Π³ΠΈΠ°Π»ΡƒΡ€ΠΎΠ½ΠΎΠ²ΠΎΠΉ кислоты, Π° ΠΈΠΌΠ΅Π½Π½ΠΎ Π±Π°ΠΊΡ‚Π΅Ρ€ΠΈΠΈ Streptococcus ΠΈ Pasteurella. Однако ΠΎΠ½ΠΈ ΠΌΠΎΠ³ΡƒΡ‚ ΠΎΠ±Π»Π°Π΄Π°Ρ‚ΡŒ ΠΏΠ°Ρ‚ΠΎΠ³Π΅Π½Π½Ρ‹ΠΌΠΈ свойствами ΠΈ способны ΡΠΈΠ½Ρ‚Π΅Π·ΠΈΡ€ΠΎΠ²Π°Ρ‚ΡŒ Π³ΠΈΠ°Π»ΡƒΡ€ΠΎΠ½ΠΎΠ²ΡƒΡŽ кислоту Π΄ΠΎ 6-7 Π³/Π» Π² Ρ‚Π΅Ρ‡Π΅Π½ΠΈΠ΅ 120 часов. Π’Π°ΠΊΠΆΠ΅ ΡƒΡ‡Π΅Π½Ρ‹Π΅ ΡΠΎΠ·Π΄Π°ΡŽΡ‚ Π½ΠΎΠ²Ρ‹Π΅ гСнСтичСски ΠΌΠΎΠ΄ΠΈΡ„ΠΈΡ†ΠΈΡ€ΠΎΠ²Π°Π½Π½Ρ‹Π΅ ΡˆΡ‚Π°ΠΌΠΌΡ‹ Lactococcus lactis, Corynebacterium glutamicum, Escherichia coli, Pichia pastoris. Наибольший Π²Ρ‹Ρ…ΠΎΠ΄ Π³ΠΈΠ°Π»ΡƒΡ€ΠΎΠ½ΠΎΠ²ΠΎΠΉ кислоты Π½Π°Π±Π»ΡŽΠ΄Π°Π΅Ρ‚ΡΡ ΠΏΡ€ΠΈ ΠΊΡƒΠ»ΡŒΡ‚ΠΈΠ²ΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠΈ C. glutamicum (8,3 Π³/Π» Π² Ρ‚Π΅Ρ‡Π΅Π½ΠΈΠ΅ 48 часов). Поиск Π½ΠΎΠ²Ρ‹Ρ… ΡˆΡ‚Π°ΠΌΠΌΠΎΠ² Π°ΠΊΡ‚ΡƒΠ°Π»Π΅Π½ Π΅Ρ‰Π΅ ΠΈ ΠΏΠΎΡ‚ΠΎΠΌΡƒ, Ρ‡Ρ‚ΠΎ гиалуроновая кислота благодаря своСй ΡƒΠ½ΠΈΠΊΠ°Π»ΡŒΠ½ΠΎΠΉ биосовмСстимости ΠΈ вязкоупругим свойствам являСтся ΠΎΡ‡Π΅Π½ΡŒ Π²Π°ΠΆΠ½ΠΎΠΉ ΡΠΎΡΡ‚Π°Π²Π»ΡΡŽΡ‰Π΅ΠΉ лСкарствСнных ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚ΠΎΠ², примСняСмых Π² ΠΌΠ΅Π΄ΠΈΡ†ΠΈΠ½Π΅, космСтологии ΠΈ Π²Π΅Ρ‚Π΅Ρ€ΠΈΠ½Π°Ρ€ΠΈΠΈ.Π’Ρ‹Π²ΠΎΠ΄Ρ‹. НСобходимо ΠΏΡ€ΠΎΠ²ΠΎΠ΄ΠΈΡ‚ΡŒ поиск Π½ΠΎΠ²Ρ‹Ρ… ΠΏΡ€ΠΎΠ΄ΡƒΡ†Π΅Π½Ρ‚ΠΎΠ² Π³ΠΈΠ°Π»ΡƒΡ€ΠΎΠ½ΠΎΠ²ΠΎΠΉ кислоты ΠΈ ΠΏΡ€ΠΎΠ΄ΠΎΠ»ΠΆΠ°Ρ‚ΡŒ Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹Π΅ манипуляции с ΡΡƒΡ‰Π΅ΡΡ‚Π²ΡƒΡŽΡ‰ΠΈΠΌΠΈ ΠΈ гСнСтичСски ΠΌΠΎΠ΄ΠΈΡ„ΠΈΡ†ΠΈΡ€ΠΎΠ²Π°Π½Π½Ρ‹ΠΌΠΈ ΡˆΡ‚Π°ΠΌΠΌΠ°ΠΌΠΈ, ΠΏΠΎΡΠΊΠΎΠ»ΡŒΠΊΡƒ ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚Ρ‹ Π½Π° Π΅Π΅ основС Ρ‡Ρ€Π΅Π·Π²Ρ‹Ρ‡Π°ΠΉΠ½ΠΎ вострСбованы Π½Π° Ρ€Ρ‹Π½ΠΊΠ΅ фармацСвтичСских ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚ΠΎΠ² ΠΈ космСтологичСских срСдств.Β ΠΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½Ρ–ΡΡ‚ΡŒ. Π“Ρ–Π°Π»ΡƒΡ€ΠΎΠ½ΠΎΠ²Π° кислота знайшла ΡˆΠΈΡ€ΠΎΠΊΠ΅ застосування Π² ΠΌΠ΅Π΄ΠΈΡ†ΠΈΠ½Ρ–, Ρ…Ρ–Ρ€ΡƒΡ€Π³Ρ–Ρ—, Π΄Π΅Ρ€ΠΌΠ°Ρ‚ΠΎΠ»ΠΎΠ³Ρ–Ρ—, Π³Ρ–Π½Π΅ΠΊΠΎΠ»ΠΎΠ³Ρ–Ρ—, Π²ΠΎΠ»ΠΎΠ΄Ρ–Ρ” Π°Π½Ρ‚ΠΈΠΌΡ–ΠΊΡ€ΠΎΠ±Π½ΠΈΠΌΠΈ Ρ‚Π° противірусними властивостями, Π° Π·Π° Ρ€Π°Ρ…ΡƒΠ½ΠΎΠΊ високої молСкулярної маси Ρ” ΠΏΡ€ΠΎΠ»ΠΎΠ½Π³Π°Ρ‚ΠΎΡ€ΠΎΠΌ Π΄Ρ–Ρ— Π°ΠΊΡ‚ΠΈΠ²Π½ΠΎΠ³ΠΎ Ρ„Π°Ρ€ΠΌΠ°Ρ†Π΅Π²Ρ‚ΠΈΡ‡Π½ΠΎΠ³ΠΎ Ρ–Π½Π³Ρ€Π΅Π΄Ρ–Ρ”Π½Ρ‚Π° (АЀІ) Ρƒ складі Π»Ρ–ΠΊΠ°Ρ€ΡΡŒΠΊΠΈΡ… засобів. Π’Π°ΠΊΠΈΠΌ Ρ‡ΠΈΠ½ΠΎΠΌ, спСктр застосування Π³Ρ–Π°Π»ΡƒΡ€ΠΎΠ½ΠΎΠ²ΠΎΡ— кислоти Π΄ΠΎΡΠΈΡ‚ΡŒ ΡˆΠΈΡ€ΠΎΠΊΠΈΠΉ Ρ– постійно ΠΏΠΎΠΏΠΎΠ²Π½ΡŽΡ”Ρ‚ΡŒΡΡ, Ρ‰ΠΎ ΠΏΡ€ΠΈΠ²ΠΎΠ΄ΠΈΡ‚ΡŒ Π΄ΠΎ підвищСння ΠΏΠΎΠΏΠΈΡ‚Ρƒ Π½Π° Π΄Π°Π½ΠΈΠΉ Π²ΠΈΠ΄ Π±Ρ–ΠΎΠΏΠΎΠ»Ρ–ΠΌΠ΅Ρ€Π°, Π°, ΠΎΡ‚ΠΆΠ΅, ΠΏΡ–Π΄Π²ΠΈΡ‰ΡƒΡ” інтСрСс Π΄ΠΎ Π°Π»ΡŒΡ‚Π΅Ρ€Π½Π°Ρ‚ΠΈΠ²Π½ΠΈΡ… Π΄ΠΆΠ΅Ρ€Π΅Π» ΠΉΠΎΠ³ΠΎ отримання.Бтаття присвячСна Π°ΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½ΠΈΠΌ напрямкам ΠΎΠΏΡ‚ΠΈΠΌΡ–Π·Π°Ρ†Ρ–Ρ— біосинтСзу Π³Ρ–Π°Π»ΡƒΡ€ΠΎΠ½ΠΎΠ²ΠΎΡ— кислоти Π·Π²ΠΈΡ‡Π°ΠΉΠ½ΠΈΠΌΠΈ Ρ– Π³Π΅Π½Π΅Ρ‚ΠΈΡ‡Π½ΠΎ ΠΌΠΎΠ΄ΠΈΡ„Ρ–ΠΊΠΎΠ²Π°Π½ΠΈΠΌΠΈ ΡˆΡ‚Π°ΠΌΠ°ΠΌΠΈ Π±Π°ΠΊΡ‚Π΅Ρ€Ρ–ΠΉ, Π°Π½Π°Π»Ρ–Π·Ρƒ Π²ΠΈΠ±ΠΎΡ€Ρƒ ΠΏΠΎΠΆΠΈΠ²Π½ΠΈΡ… сСрСдовищ для Ρ—Ρ… ΠΊΡƒΠ»ΡŒΡ‚ΠΈΠ²ΡƒΠ²Π°Π½Π½Ρ Ρ‚Π° застосування Π±Ρ–ΠΎΠΏΠΎΠ»Ρ–ΠΌΠ΅Ρ€Ρƒ.ΠœΠ΅Ρ‚Π° Ρ€ΠΎΠ±ΠΎΡ‚ΠΈ. Π£ своїй Ρ€ΠΎΠ±ΠΎΡ‚Ρ– ΠΌΠΈ ΠΌΠ°Π»ΠΈ Π½Π° ΠΌΠ΅Ρ‚Ρ– ΡƒΠ·Π°Π³Π°Π»ΡŒΠ½ΠΈΡ‚ΠΈ наявні Ρƒ Π½Π°ΡƒΠΊΠΎΠ²Ρ–ΠΉ Π»Ρ–Ρ‚Π΅Ρ€Π°Ρ‚ΡƒΡ€Ρ– відомості Ρ‰ΠΎΠ΄ΠΎ Π²Ρ–Π΄ΠΎΠΌΠΈΡ… ΡˆΡ‚Π°ΠΌΡ–Π²-ΠΏΡ€ΠΎΠ΄ΡƒΡ†Π΅Π½Ρ‚Ρ–Π², які Π²ΠΈΠΊΠΎΡ€ΠΈΡΡ‚ΠΎΠ²ΡƒΡŽΡ‚ΡŒΡΡ для біосинтСзу Π³Ρ–Π°Π»ΡƒΡ€ΠΎΠ½ΠΎΠ²ΠΎΡ— кислоти Ρ‚Π° провСсти Π°Π½Π°Π»Ρ–Π· ΠΌΠΎΠΆΠ»ΠΈΠ²ΠΈΡ… сфСр застосування ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚Ρ–Π² Π½Π° Ρ—Ρ— основі.Π Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚ΠΈ Ρ‚Π° Ρ—Ρ… обговорСння. ΠŸΡ€ΠΎΠ°Π½Π°Π»Ρ–Π·ΡƒΠ²Π°Π²ΡˆΠΈ Π»Ρ–Ρ‚Π΅Ρ€Π°Ρ‚ΡƒΡ€Ρƒ, ΠΌΠΎΠΆΠ½Π° сказати, Ρ‰ΠΎ існує Π±Π°Π³Π°Ρ‚ΠΎ Ρ€Ρ–Π·Π½ΠΈΡ… ΡˆΡ‚Π°ΠΌΡ–Π²-ΠΏΡ€ΠΎΠ΄ΡƒΡ†Π΅Π½Ρ‚Ρ–Π² Π³Ρ–Π°Π»ΡƒΡ€ΠΎΠ½ΠΎΠ²ΠΎΡ— кислоти, Π° самС Π±Π°ΠΊΡ‚Π΅Ρ€Ρ–Ρ— Streptococcus Ρ– Pasteurella. Однак Π²ΠΎΠ½ΠΈ ΠΌΠΎΠΆΡƒΡ‚ΡŒ Π²ΠΎΠ»ΠΎΠ΄Ρ–Ρ‚ΠΈ ΠΏΠ°Ρ‚ΠΎΠ³Π΅Π½Π½ΠΈΠΌΠΈ властивостями Ρ– Π·Π΄Π°Ρ‚Π½Ρ– синтСзувати Π³Ρ–Π°Π»ΡƒΡ€ΠΎΠ½ΠΎΠ²Ρƒ кислоту Π΄ΠΎ 6-7 Π³/Π» ΡƒΠΏΡ€ΠΎΠ΄ΠΎΠ²ΠΆ 120 Π³ΠΎΠ΄. Π’Π°ΠΊΠΎΠΆ ΡƒΡ‡Π΅Π½Ρ–ΡΡ‚Π²ΠΎΡ€ΡŽΡŽΡ‚ΡŒ Π½ΠΎΠ²Ρ– Π³Π΅Π½Π΅Ρ‚ΠΈΡ‡Π½ΠΎ ΠΌΠΎΠ΄ΠΈΡ„Ρ–ΠΊΠΎΠ²Π°Π½Ρ– ΡˆΡ‚Π°ΠΌΠΈ Lactococcus lactis, Corynebacterium glutamicum, Escherichia coli, Pichia pastoris. ΠΠ°ΠΉΠ±Ρ–Π»ΡŒΡˆΠΈΠΉ Π²ΠΈΡ…Ρ–Π΄ Π³Ρ–Π°Π»ΡƒΡ€ΠΎΠ½ΠΎΠ²ΠΎΡ— кислоти ΡΠΏΠΎΡΡ‚Π΅Ρ€Ρ–Π³Π°Ρ”Ρ‚ΡŒΡΡ ΠΏΡ€ΠΈ ΠΊΡƒΠ»ΡŒΡ‚ΠΈΠ²ΡƒΠ²Π°Π½Π½Ρ– C. glutamicum (8,3 Π³/Π» ΡƒΠΏΡ€ΠΎΠ΄ΠΎΠ²ΠΆ 48 Π³ΠΎΠ΄). ΠŸΠΎΡˆΡƒΠΊ Π½ΠΎΠ²ΠΈΡ… ΡˆΡ‚Π°ΠΌΡ–Π² Ρ” Π°ΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½ΠΈΠΌ Ρ‰Π΅ ΠΉ Ρ‚ΠΎΠΌΡƒ, Ρ‰ΠΎ Π³Ρ–Π°Π»ΡƒΡ€ΠΎΠ½ΠΎΠ²Π° кислота завдяки своїй ΡƒΠ½Ρ–ΠΊΠ°Π»ΡŒΠ½Ρ–ΠΉ біосумісності Ρ‚Π° в’язкопруТним властивостям Ρ” Π΄ΡƒΠΆΠ΅ ваТливою складовою Π»Ρ–ΠΊΠ°Ρ€ΡΡŒΠΊΠΈΡ… ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚Ρ–Π², які Π·Π°ΡΡ‚ΠΎΡΠΎΠ²ΡƒΡŽΡ‚ΡŒΡΡ Π² ΠΌΠ΅Π΄ΠΈΡ†ΠΈΠ½Ρ–, космСтології Ρ‚Π° Π²Π΅Ρ‚Π΅Ρ€ΠΈΠ½Π°Ρ€Ρ–Ρ—.Висновки. НСобхідно ΠΏΡ€ΠΎΠ²ΠΎΠ΄ΠΈΡ‚ΠΈ ΠΏΠΎΡˆΡƒΠΊ Π½ΠΎΠ²ΠΈΡ… ΠΏΡ€ΠΎΠ΄ΡƒΡ†Π΅Π½Ρ‚Ρ–Π² Π³Ρ–Π°Π»ΡƒΡ€ΠΎΠ½ΠΎΠ²ΠΎΡ— кислоти Ρ‚Π° ΠΏΡ€ΠΎΠ΄ΠΎΠ²ΠΆΡƒΠ²Π°Ρ‚ΠΈ Ρ€Ρ–Π·Π½Ρ– маніпуляції Π· Ρ–ΡΠ½ΡƒΡŽΡ‡ΠΈΠΌΠΈ Ρ‚Π° Π³Π΅Π½Π΅Ρ‚ΠΈΡ‡Π½ΠΎ-ΠΌΠΎΠ΄ΠΈΡ„Ρ–ΠΊΠΎΠ²Π°Π½ΠΈΠΌΠΈ ΡˆΡ‚Π°ΠΌΠ°ΠΌΠΈ, ΠΎΡΠΊΡ–Π»ΡŒΠΊΠΈ ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚ΠΈ Π½Π° Ρ—Ρ— основі ΠΊΠΎΡ€ΠΈΡΡ‚ΡƒΡŽΡ‚ΡŒΡΡ Π½Π°Π΄Π·Π²ΠΈΡ‡Π°ΠΉΠ½ΠΎ Π²Π΅Π»ΠΈΠΊΠΈΠΌ ΠΏΠΎΠΏΠΈΡ‚ΠΎΠΌ Π½Π° Ρ€ΠΈΠ½ΠΊΡƒ Ρ„Π°Ρ€ΠΌΠ°Ρ†Π΅Π²Ρ‚ΠΈΡ‡Π½ΠΈΡ… ΠΏΡ€Π΅ΠΏΠ°Ρ€Π°Ρ‚Ρ–Π² Ρ‚Π° космСтологічних засобів

    Ξ±-aminophosphonates and imines on the basis of citral, citronellal, and (-)-myrtenal

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    The Kabachnik-Fields reaction of citral with dialkyl phosphites in the presence alkyl amines; the imine formation reaction of E,Z-citral, R,S-citronellal, and (R)-(-)-myrtenal with primary amines; and Pudovik reactions of prenyl imines obtained with dialkyl phosphites or with O,O-dialkyl trimethylsilylphosphites were studied. On the basis of these studies, new unsaturated prenyl imines and Ξ±-aminophosphonates were prepared. Copyright Β© Taylor & Francis Group, LLC

    Features of a course of initial caries of teeth at children of Omsk at various activity of pathological process

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    Stomatologic health of the population of Russia worsens. Active prevention of stomatologic diseases, especially sharply this problem is necessary costs at children s age. In due time held preventive events at a stage of a mineralization of enamel are most effective and promote preservation and strengthening of stomatologic health. Detailed epidemiological researches are necessary for carrying out prevention taking into account regional features.БтоматологичСскоС Π·Π΄ΠΎΡ€ΠΎΠ²ΡŒΠ΅ насСлСния России ΡƒΡ…ΡƒΠ΄ΡˆΠ°Π΅Ρ‚ΡΡ. НСобходима активная ΠΏΡ€ΠΎΡ„ΠΈΠ»Π°ΠΊΡ‚ΠΈΠΊΠ° стоматологичСских Π·Π°Π±ΠΎΠ»Π΅Π²Π°Π½ΠΈΠΉ, особСнно остро данная ΠΏΡ€ΠΎΠ±Π»Π΅ΠΌΠ° стоит Π² дСтском возрастС. Π‘Π²ΠΎΠ΅Π²Ρ€Π΅ΠΌΠ΅Π½Π½ΠΎ ΠΏΡ€ΠΎΠ²Π΅Π΄Π΅Π½Π½Ρ‹Π΅ профилактичСскиС мСроприятия Π½Π° этапС ΠΌΠΈΠ½Π΅Ρ€Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ эмали Π½Π°ΠΈΠ±ΠΎΠ»Π΅Π΅ эффСктивны ΠΈ ΡΠΏΠΎΡΠΎΠ±ΡΡ‚Π²ΡƒΡŽΡ‚ ΡΠΎΡ…Ρ€Π°Π½Π΅Π½ΠΈΡŽ ΠΈ ΡƒΠΊΡ€Π΅ΠΏΠ»Π΅Π½ΠΈΡŽ стоматологичСского Π·Π΄ΠΎΡ€ΠΎΠ²ΡŒΡ. Для провСдСния ΠΏΡ€ΠΎΡ„ΠΈΠ»Π°ΠΊΡ‚ΠΈΠΊΠΈ Π½Π΅ΠΎΠ±Ρ…ΠΎΠ΄ΠΈΠΌΡ‹ ΠΏΠΎΠ΄Ρ€ΠΎΠ±Π½Ρ‹Π΅ эпидСмиологичСскиС исслСдования с ΡƒΡ‡Π΅Ρ‚ΠΎΠΌ Ρ€Π΅Π³ΠΈΠΎΠ½Π°Π»ΡŒΠ½Ρ‹Ρ… особСнностСй

    Language indigenization in terms of language contacts (based on the Nigerian English variant)

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    The purpose of the article is to identify the specifics of the English language Indigenization procedure on the territory of Nigeria, one of the largest countries in West Africa. The research work has the complex system to analyze the cultural and linguistic processes, which are manifested in the study under the influence of cultural factors and its influence on the language functioning. The practical work part is based on the analysis of the language thematic groups "National food" and "National clothes" presenting the specific features of Nigerian English. The results show, Nigerian English has a wide range of words denoting local realities and reflecting the adaptation of the English language to the Nigerian culture peculiarities, which are the process of indigenizatio
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