Supply Chain Strategy and Labor Partnership as a National Priority in the Economic Development of Russia

Abstract— Global competition has intensified geographic repositioning of supply chain activities with implications for the economic prosperity of specific regions and geographies affected by such shift. The article reflects the results of studies based on an interdisciplinary approach to the economic development by supply chain strategy and labor partnership. The work is aimed at clarifying the concept of supply chain management and labor partnership as an economic category. Therefore, this concept has been studied through the synthesis of jurisprudence, conflict management, sociology and political science, which allows to identify the economic and microeconomic substances of this phenomenon. The former is considered through the labor market trends and conditions, and quantified in derived parameters of supply chain and social-labor relations depending on it. The latter, as a specific type of management, is formed at the intersection of entrepreneurial, systemic management under limited conditions for self-management model implementation, typical for modern transition to the information, digital economy. Thus, a model of supply chain strategy and labor partnership has been developed as a microeconomic category, implying the impact characteristic of such management tools as investments in human capital, development of corporate culture, adequacy of compensation policies and supply chain responsibility tools, on social capital, considered as a synergistic amount of company’s human capital realized to the full. Additionally, a set of indicators developed in the course of research, and their dynamics can be used to monitor general trends in supply chain and labor partnership as an economic category. Our findings allow expanding the field of research and providing a scientific background for practical tools to improve economic relations

Wind Accretion and State Transitions in Cygnus X-1

We present the results of a spectroscopic monitoring program (from 1998 to 2002) of the H-alpha emission strength in HDE 226868, the optical counterpart of the black hole binary, Cyg X-1. The H-alpha profiles consist of (1) a P Cygni component associated with the wind of the supergiant, (2) emission components that attain high velocity at the conjunctions and that probably form in enhanced outflows both towards and away from the black hole, and (3) an emission component that moves in anti-phase with the supergiant's motion. We argue that the third component forms in accreted gas near the black hole, and the radial velocity curve of the emission is consistent with a mass ratio of M_X / M_opt = 0.36 +/- 0.05. We find that there is a general anti-correlation between the H-alpha emission strength and X-ray flux in the sense that when the H-alpha emission is strong (W_\lambda < -0.5 Angstroms) the X-ray flux is weaker and the spectrum harder. On the other hand, there is no correlation between H-alpha emission strength and X-ray flux when H-alpha is weak. During the low/hard X-ray state, the strong wind is fast and the accretion rate is relatively low, while in the high/soft state the weaker, highly ionized wind attains only a moderate velocity and the accretion rate increases. We argue that the X-ray transitions from the normal low/hard to the rare high/soft state are triggered by episodes of decreased mass loss rate in the supergiant donor star.Comment: 45 pages, 16 figures, ApJ, in pres

Self-assembly of Gd³⁺-bound keplerate polyanions into nanoparticles as a route for the synthesis of positive MRI contrast agents. Impact of the structure on the magnetic relaxivity

© The Royal Society of Chemistry. The present work introduces Gd3+ complexes with giant keplerate polyanions as a promising basis for MRI contrast agents. The impact of Gd3+ binding with different building blocks of keplerates on the magnetic relaxivity of the complexes is revealed by comparative study of the keplerates [{Mo6O21}12{Mo2O4(OAc)}30]42−, [{Mo6O21}12{Mo2O4(HPO4)}30]72−, and [{Mo6O21}12{Mo2O2S2(OAc)}30]42−. Unprecedentedly high longitudinal and transverse relaxivity values (up to 250 and 300 mM−1 s−1 correspondingly) are achieved for the keplerates possessing edl{Mo2O4(OAc)} and {Mo2O4(HPO42−)} moieties under their 1 : 1 complex formation with Gd3+. The transformation of the external pores from Mo9O9 to Mo9O6S3 in the {Mo2O2S2(OAc)}-keplerate and an increase in the Gd3+-to-keplerate ratio are the factors that decrease the relaxivity. The rapid degradation of the free keplerates in aqueous solutions restricts the use of the Gd3+-bound keplerates with 1 : 1 stoichiometry as MRI contrast agents. In this work, the optimized stoichiometry of the complexes, their self-assembly into ultra-small nanoparticles and their hydrophilic coating by a triblock copolymer are highlighted as tools for increasing both the colloid and chemical stability of the keplerate complexes. Optimal keplerate compositions have been identified to achieve a compromise of low cytotoxicity and high stability; these Gd3+-bound keplerates exhibit longitudinal and transverse relaxivity values (95 and 114 mM−1 s−1, respectively), well within the region of interest for MRI techniques

Nanoscale hydrophilic colloids with high relaxivity and low cytotoxicity based on Gd(III) complexes with Keplerate polyanions

© The Royal Society of Chemistry and the Centre National de la Recherche Scientifique. The work introduces for the first time Mo-132-type Keplerates (Kp) and Gd 3+ ions as a basis for the one-pot synthesis of aqueous colloids with high longitudinal relaxivity (r 1 = 96.4 mM -1 s -1 at 20 MHz). The hydrophilic coating of small (3-5 nm) Gd x (Kp) y -based cores provides their colloid stabilization, protection from degradation and low cytotoxicity

Nontoxic antimicrobial micellar systems based on mono- and di-cationic Dabco-surfactants and furazolidone: Structure-solubilization properties relationships

Supplementary data to this article can be found online at https://doi.org/10.1016/j.molliq.2019.112062.Self-assembly and solubilization properties of amphiphilic mono- and bisquaternized derivatives of 1,4-diazabicyclo[2.2.2]octane (mono-CS-n and di-CS-n, where CS cationic surfactant, n=12, 14, 16, 18) was investigated by nuclear magnetic resonance with magnetic field pulse gradient. The influence of Dabco-surfactant structure (head group and length of alkyl chains) on critical micelle concentration and aggregation number of micelles was studied. The CMC of mono-CS-n are lower than CMC of di-CS-n. The aggregation numbers of mono-CS-n micelles are higher than for di-CS-n micelles. The solubilization capacity of mono-CS-n is higher than di-CS-n. The solubilization capacity of mono-CS-16 is 2.5 times higher than CTAB in the case of Orange OT as a solute, and it is close to CTAB in the case of Sudan I. The solubility of a poorly water-soluble antibacterial drug furazolidone was improved by micellar solubilization based on mono- and di-Dabco-surfactants. Mono-CS-n is the best solubilizing agents toward furazolidone. The use of mixed composition mono-Dabco-16-furazolidone provides a significant increase in antimicrobial activity (2 times against bacteria and 8 times against fungi) and reduces 2 times the dose of each of the components in combination formulation and causes <2% haemolysis of human red blood cells at the active dose.The report study was funded by Russian Foundation for Basic Research according to the research project № 18-43-160015. The authors gratefully acknowledge the CSF-SAC FRC KSC RAS.info:eu-repo/semantics/publishedVersio

Diffusion of Alexa Fluor 488-Conjugated Dendrimers in Rat Aortic Tissue

In this study, the distribution of labeled dendrimers in native and aneurysmal rat aortic tissue was examined. Adult male rats underwent infrarenal aorta perfusion with generation 5 (G5) acetylated Alexa Fluor 488-conjugated dendrimers for varying lengths of time. In a second set of experiments, rats underwent aortic elastase perfusion followed by aortic dendrimer perfusion 7 days later. Aortic diameters were measured prior to and postelastase perfusion, and again on the day of harvest. Aortas were harvested 0, 12, or 24 h postperfusion, fixed, and mounted. Native aortas were harvested and viewed as negative controls. Aortic cross-sections were viewed and imaged using confocal microscopy. Dendrimers were quantified (counts high-powered field). Results were evaluated by repeated measures ANOVA and Student's t -test. We found that in native aortas, dendrimers penetrated the aortic wall in all groups. For all perfusion times, fewer dendrimers were present as time between dendrimer perfusion and aortic harvest increased. Longer perfusion times resulted in increased diffusion of dendrimers throughout the aortic wall. By 24 h, the majority of the dendrimers were through the wall. Dendrimers in aneurysmal aortas, on day 0 postdendrimer perfusion, diffused farther into the aortic wall than controls. In conclusion, this study documents labeled dendrimers delivered intra-arterially to native rat aortas in vivo , and the temporal diffusion of these molecules within the aortic wall. Increasing perfusion time and length of time prior to harvest resulted in continued dendrimer diffusion into the aortic wall. These preliminary data provide a novel mechanism whereby local inhibitory therapy may be delivered locally to aortic tissue.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72448/1/annals.1383.004.pd

On the Change of the Inner Boundary of an Optically Thick Accretion Disk around White Dwarfs Using the Dwarf Nova SS Cyg as an Example

We present the results of our studies of the aperiodic optical flux variability for SS Cyg, an accreting binary systemwith a white dwarf. The main set of observational data presented here was obtained with the ANDOR/iXon DU-888 photometer mounted on the RTT-150 telescope, which allowed a record(for CCD photometers) time resolution up to 8 ms to be achieved. The power spectra of the source's flux variability have revealed that the aperiodic variability contains information about the inner boundary of the optically thick flow in the binary system. We show that the inner boundary of the optically thick accretion disk comes close to the white dwarf surface at the maximum of the source's bolometric light curve, i.e., at the peak of the instantaneous accretion rate onto the white dwarf, while the optically thick accretion disk is truncated at distances 8.5e9 cm ~10 R_{WD} in the low state. We suggest that the location of the inner boundary of the accretion disk in the binary can be traced by studying the parameters of the power spectra for accreting white dwarfs. In particular, this allows the mass of the accreting object to be estimated.Comment: 9 pages, 7 figures, Published in Astronomy Letter

The study of different methods of teaching the differential diagnostics of essential resistant and pseudoresistant arterial hypertension for residents on speciality “General practice – family medicine”

Мета роботи – оцінити ефективність засвоєння лікарями-інтернами удосконаленої нами методики диференційної діагностики есенціальної РАГ та ПРАГ у порівнянні з загальноприйнятою методикою. Основна частина. У дослідження було включено 120 пацієнтів (чоловіків – 68 (56,7 %); жінок – 52 (43,3 %); середній вік – (55±8,8) року) з гіпертонічною хворобою. Всі пацієнти мали вихідний рівень артеріального тиску (АТ) вище за 140/90 мм рт. ст. при прийомі 3-х та більше антигіпертензивних препаратів (АГП), один із яких діуретик. Лікарі-інтерни першого року навчання були розподілені на дві групи: І група – контрольна (30 інтернів) – опрацьовувала традиційну методику диференційної діагностики есенціальної РАГ та ПРАГ; ІІ група (30 інтернів) – навчалась нової методики диференційної діагностики есенціальної РАГ та ПРАГ. Строки проведення диференційної діагностики РАГ та ПРАГ запропонованою нами методикою склали (3,9±2,6) дня, у порівнянні з традиційною методикою – (16,4±6,8) дня (p<0,01). Впровадження запропонованої методики дозволило лікарям-інтернам основної групи краще орієнтуватись у причинах вторинних форм РАГ – 25 ((83,3±6,8) %), у порівнянні з контрольною групою – 14 ((46,7±9,1) %) інтернів (p<0,01). Внаслідок проведеної роботи збільшилась кількість інтернів, які опанували методику диференційної діагностики РАГ та ПРАГ, з 12 ((40,0±8,9) %) до 24 ((80,0±7,3) %) в основній групі (p<0,001), та з 14 ((46,7±9,1) %) до 18 ((60,0±8,9) %) інтернів контрольної групи (p>0,5). Висновок. Удосконалена нами методика викладання знань і навичок диференційної діагностики есенціальної РАГ і ПРАГ дозволяє значно скоротити строки її проведення та достовірно покращити засвоєння знань і практичних навичок у лікарівінтернів зі спеціальності “Загальна практика – сімейна медицина”. Ключові слова:The aim of the work – to evaluate the effectiveness of mastering residents improved by us method of differential diagnostics of essential resistant arterial hypertension (RAH) and pseudo-resistant arterial hypertension (PRAH) in comparison with conventional procedures. The main body. The study included 120 patients (men – 68 (56.7 %); women – 52 (43.3 %); average age 55±8.8 years) with a stable course of hypertension. All patients had a baseline blood pressure (BP) above 140/90 mm hg while receiving 3 or more antihypertensive drugs, one of which was a diuretic. The first year residents of training were divided into two groups: group I – control (30 residents) – processed the conventional method of differential diagnosis of RAH and PRAH; group II (30 residents) – studied new method of differential diagnosis of RAH and PRAH. The time period for differential diagnostics of RAH and PRAH by our methodology averaged 3.9±2.6 days, comparing to traditional methodology – 16.4±6.8 days, (p<0.01). Introduction of new methodology allowed the residents of basic group to be better oriented in reasons of secondary forms of RAH – 25 (83.3±6.8 %) residents, comparing to the control group – 14 (46.7±9.1 %) residents, (p<0.01). This work allowed increasing the knowledge about methods of differential diagnostics RAH and PRAH in the basic group of residents from 12 (40.0±8.9 %) to 24 (80.0±7.3 %), (p0.5). Conclusion. Advanced by us methods of teaching knowledge and skills of differential diagnostics of RAH and PRAH, signifcantly reduces its time and reliably improve the assimilation of knowledge and practical skills of medical interns in specialty «General Practice – Family Medicine»

Survey of Period Variations of Superhumps in SU UMa-Type Dwarf Novae. VIII: The Eighth Year (2015-2016)

Continuing the project described by Kato et al. (2009, arXiv:0905.1757), we collected times of superhump maxima for 128 SU UMa-type dwarf novae observed mainly during the 2015-2016 season and characterized these objects. The data have improved the distribution of orbital periods, the relation between the orbital period and the variation of superhumps, the relation between period variations and the rebrightening type in WZ Sge-type objects. Coupled with new measurements of mass ratios using growing stages of superhumps, we now have a clearer and statistically greatly improved evolutionary path near the terminal stage of evolution of cataclysmic variables. Three objects (V452 Cas, KK Tel, ASASSN-15cl) appear to have slowly growing superhumps, which is proposed to reflect the slow growth of the 3:1 resonance near the stability border. ASASSN-15sl, ASASSN-15ux, SDSS J074859.55+312512.6 and CRTS J200331.3-284941 are newly identified eclipsing SU UMa-type (or WZ Sge-type) dwarf novae. ASASSN-15cy has a short (~0.050 d) superhump period and appears to belong to EI Psc-type objects with compact secondaries having an evolved core. ASASSN-15gn, ASASSN-15hn, ASASSN-15kh and ASASSN-16bu are candidate period bouncers with superhump periods longer than 0.06 d. We have newly obtained superhump periods for 79 objects and 13 orbital periods, including periods from early superhumps. In order that the future observations will be more astrophysically beneficial and rewarding to observers, we propose guidelines how to organize observations of various superoutbursts.Comment: 123 pages, 162 figures, 119 tables, accepted for publication in PASJ (including supplementary information