1,541 research outputs found
Emergency liquidity provision to public banks: rules versus discretion
This paper analyzes a government's incentives to provide financial assistance to a public bank which is hit by a liquidity shock. We show that discretionary decisions about emergency liquidity assistance result in either excessively small or excessively large liquidity injections in a wide variety of circumstances. Also, adding a lender of last resort does not generally ensure a socially optimal policy. However, optimal rules exist that align the preferences of the government and/or a lender of last resort with social preferences by either subsidizing or taxing liquidity aid
Statistical analysis of coherent structures in transitional pipe flow
Numerical and experimental studies of transitional pipe flow have shown the
prevalence of coherent flow structures that are dominated by downstream
vortices. They attract special attention because they contribute predominantly
to the increase of the Reynolds stresses in turbulent flow. In the present
study we introduce a convenient detector for these coherent states, calculate
the fraction of time the structures appear in the flow, and present a Markov
model for the transition between the structures. The fraction of states that
show vortical structures exceeds 24% for a Reynolds number of about Re=2200,
and it decreases to about 20% for Re=2500. The Markov model for the transition
between these states is in good agreement with the observed fraction of states,
and in reasonable agreement with the prediction for their persistence. It
provides insight into dominant qualitative changes of the flow when increasing
the Reynolds number.Comment: 11 pages, 26 (sub)figure
Understanding Gentzen and Frege Systems for QBF
Recently Beyersdorff, Bonacina, and Chew [10] introduced a natural class of Frege systems for quantified Boolean formulas (QBF) and showed strong lower bounds for restricted versions of these systems. Here we provide a comprehensive analysis of the new extended Frege system from [10], denoted EF + ∀red, which is a natural extension of classical extended Frege EF. Our main results are the following: Firstly, we prove that the standard Gentzen-style system G*1 p-simulates EF + ∀red and that G*1 is strictly stronger under standard complexity-theoretic hardness assumptions.
Secondly, we show a correspondence of EF + ∀red to bounded arithmetic: EF + ∀red can be seen as the non-uniform propositional version of intuitionistic S12. Specifically, intuitionistic S12 proofs of arbitrary statements in prenex form translate to polynomial-size EF + ∀red proofs, and EF + ∀red is in a sense the weakest system with this property. Finally, we show that unconditional lower bounds for EF + ∀red would imply either a major breakthrough in circuit complexity or in classical proof complexity, and in fact the converse implications hold as well. Therefore, the system EF + ∀red naturally unites the central problems from circuit and proof complexity.
Technically, our results rest on a formalised strategy extraction theorem for EF + ∀red akin to witnessing in intuitionistic S12 and a normal form for EF + ∀red proofs
Atomic Hydrogen Properties of AGN Host Galaxies: HI in 16 NUclei of GAlaxies (NUGA) Sources
We present a comprehensive spectroscopic imaging survey of the distribution
and kinematics of atomic hydrogen (HI) in 16 nearby spiral galaxies hosting low
luminosity AGN, observed with high spectral and spatial resolution (resolution:
~20 arcsec, 5 km/s) using the NRAO Very Large Array (VLA). The sample contains
a range of nuclear types, ranging from Seyfert to star-forming nuclei and was
originally selected for the NUclei of GAlaxies project (NUGA) - a spectrally
and spatially resolved interferometric survey of gas dynamics in nearby
galaxies designed to identify the fueling mechanisms of AGN and the relation to
host galaxy evolution. Here we investigate the relationship between the HI
properties of these galaxies, their environment, their stellar distribution and
their AGN type. The large-scale HI morphology of each galaxy is classified as
ringed, spiral, or centrally concentrated; comparison of the resulting
morphological classification with AGN type reveals that ring structures are
significantly more common in LINER than in Seyfert host galaxies, suggesting a
time evolution of the AGN activity together with the redistribution of the
neutral gas. Dynamically disturbed HI disks are also more prevalent in LINER
host galaxies than in Seyfert host galaxies. While several galaxies are
surrounded by companions (some with associated HI emission), there is no
correlation between the presence of companions and the AGN type
(Seyfert/LINER).Comment: 54 pages, 7 figures, accepted for publication in AJ. The
full-resolution version is available at
http://www.mpia.de/homes/haan/research.htm
Nonlinear Magneto-Optics of Fe Monolayers from first principles: Structural dependence and spin-orbit coupling strength
We calculate the nonlinear magneto-optical response of free-standing fcc
(001), (110) and (111) oriented Fe monolayers. The bandstructures are
determined from first principles using a full-potential LAPW method with the
additional implementation of spin-orbit coupling. The variation of the
spin-orbit coupling strength and the nonlinear magneto-optical spectra upon
layer orientation are investigated. We find characteristic differences which
indicate an enhanced sensitivity of nonlinear magneto-optics to surface
orientation and variation of the in-plane lattice constants. In particular the
crossover from onedimensional stripe structures to twodimensional films of
(111) layers exhibits a clean signature in the nonlinear Kerr-spectra and
demonstrates the versatility of nonlinear magneto-optics as a tool for in situ
thin-film analysis.Comment: 28 pages, RevTeX, psfig, submitted to PR
Replication of an empirical approach to delineate the heterogeneity of chronic unexplained fatigue
<p>Abstract</p> <p>Background</p> <p>Chronic fatigue syndrome (CFS) is defined by self-reported symptoms. There are no diagnostic signs or laboratory markers, and the pathophysiology remains inchoate. In part, difficulties identifying and replicating biomarkers and elucidating the pathophysiology reflect the heterogeneous nature of the syndromic illness CFS. We conducted this analysis of people from defined metropolitan, urban, and rural populations to replicate our earlier empirical delineation of medically unexplained chronic fatigue and CFS into discrete endophenotypes. Both the earlier and current analyses utilized quantitative measures of functional impairment and symptoms as well as laboratory data. This study and the earlier one enrolled participants from defined populations and measured the internal milieu, which differentiates them from studies of clinic referrals that examine only clinical phenotypes.</p> <p>Methods</p> <p>This analysis evaluated 386 women identified in a population-based survey of chronic fatigue and unwellness in metropolitan, urban, and rural populations of the state of Georgia, USA. We used variables previously demonstrated to effectively delineate endophenotypes in an attempt to replicate identification of these endophenotypes. Latent class analyses were used to derive the classes, and these were compared and contrasted to those described in the previous study based in Wichita, Kansas.</p> <p>Results</p> <p>We identified five classes in the best fit analysis. Participants in Class 1 (25%) were polysymptomatic, with sleep problems and depressed mood. Class 2 (24%) was also polysymptomatic, with insomnia and depression, but participants were also obese with associated metabolic strain. Class 3 (20%) had more selective symptoms but was equally obese with metabolic strain. Class 4 (20%) and Class 5 (11%) consisted of nonfatigued, less symptomatic individuals, Class 4 being older and Class 5 younger. The classes were generally validated by independent variables. People with CFS fell equally into Classes 1 and 2. Similarities to the Wichita findings included the same four main defining variables of obesity, sleep problems, depression, and the multiplicity of symptoms. Four out of five classes were similar across both studies.</p> <p>Conclusion</p> <p>These data support the hypothesis that chronic medically unexplained fatigue is heterogeneous and can be delineated into discrete endophenotypes that can be replicated. The data do not support the current perception that CFS represents a unique homogeneous disease and suggests broader criteria may be more explanatory. This replication suggests that delineation of endophenotypes of CFS and associated ill health may be necessary in order to better understand etiology and provide more patient-focused treatments.</p
Development of a prototype superconducting radio-frequency cavity for conduction-cooled accelerators
The higher efficiency of superconducting radio-frequency (SRF) cavities
compared to normal-conducting ones enables the development of high-energy
continuous-wave linear accelerators (linacs). Recent progress in the
development of high-quality NbSn film coatings along with the availability
of cryocoolers with high cooling capacity at 4 K makes it feasible to operate
SRF cavities cooled by thermal conduction at relevant accelerating gradients
for use in accelerators. A possible use of conduction-cooled SRF linacs is for
environmental applications, requiring electron beams with energy of
MeV and 1 MW of power. We have designed a 915 MHz SRF linac for such an
application and developed a prototype single-cell cavity to prove the proposed
design by operating it with cryocoolers at the accelerating gradient required
for 1 MeV energy gain. The cavity has a m thick NbSn film on
the inner surface, deposited on a mm thick bulk Nb substrate and a bulk
mm thick Cu outer shell with three Cu attachment tabs. The cavity was
tested up to a peak surface magnetic field of 53 mT in liquid He at 4.3 K. A
horizontal test cryostat was designed and built to test the cavity cooled with
three Gifford-McMahon cryocoolers. The rf tests of the conduction-cooled
cavity, performed at General Atomics, achieved a peak surface magnetic field of
50 mT and stable operation was possible with up to 18.5 W of rf heat load. The
peak frequency shift due to microphonics was 23 Hz. These results represent the
highest peak surface magnetic field achieved in a conduction-cooled SRF cavity
to date and meet the requirements for a 1 MeV energy gain
Toward Automatic Label-Free Whispering Gallery Modes Biodetection with a Quantum Dot-Coated Microsphere Population
We explore a new calibration-free approach to biodetection based on whispering gallery modes (WGMs) without a reference measure and relative shifts. Thus, the requirement to keep track of the sensor position is removed, and a freely moving population of fluorophore-doped polystyrene microspheres can now fulfill this role of sensing resonator. Breaking free from fixed surface-based biosensing promotes adhesion between the microsphere sensors and the analytes since both can now be thoroughly mixed. The 70-nm-wide spectrum of green fluorescent microbeads allows us to monitor over 20 WGMs simultaneously without needing evanescent light coupling into the microspheres, hence enabling remote sensing. Since the exact radius of each microsphere is unknown a priori, it requires algorithmic analyses to obtain a reliable result for the refractive index of a solution. We first test our approach with different solutions of alcohol in water obtaining 3 × 10−4 precision on the refractive index at lower concentrations. Then, the solutions of bacterial spores in water yield clear evidence of biodetection in the statistical analysis of WGMs from 50 microspheres. To extend the fluorescence spectral range of our WGM sensors, we present preliminary results on coating microspheres with CdSe/ZnS quantum dots
The host metabolite D-serine contributes to bacterial niche specificity through gene selection
Escherichia coli comprise a diverse array of both commensals and niche-specific pathotypes. The ability to cause disease results from both carriage of specific virulence factors and regulatory control of these via environmental stimuli. Moreover, host metabolites further refine the response of bacteria to their environment and can dramatically affect the outcome of the host–pathogen interaction. Here, we demonstrate that the host metabolite, D-serine, selectively affects gene expression in E. coli O157:H7. Transcriptomic profiling showed exposure to D-serine results in activation of the SOS response and suppresses expression of the Type 3 Secretion System (T3SS) used to attach to host cells. We also show that concurrent carriage of both the D-serine tolerance locus (dsdCXA) and the locus of enterocyte effacement pathogenicity island encoding a T3SS is extremely rare, a genotype that we attribute to an ‘evolutionary incompatibility’ between the two loci. This study demonstrates the importance of co-operation between both core and pathogenic genetic elements in defining niche specificity
Resistance to Mucosal Lysozyme Compensates for the Fitness Deficit of Peptidoglycan Modifications by Streptococcus pneumoniae
The abundance of lysozyme on mucosal surfaces suggests that successful colonizers must be able to evade its antimicrobial effects. Lysozyme has a muramidase activity that hydrolyzes bacterial peptidoglycan and a non-muramidase activity attributable to its function as a cationic antimicrobial peptide. Two enzymes (PgdA, a N-acetylglucosamine deacetylase, and Adr, an O-acetyl transferase) that modify different sites on the peptidoglycan of Streptococcus pneumoniae have been implicated in its resistance to lysozyme in vitro. Here we show that the antimicrobial effect of human lysozyme is due to its muramidase activity and that both peptidoglycan modifications are required for full resistance by pneumococci. To examine the contribution of lysozyme and peptidoglycan modifications during colonization of the upper respiratory tract, competition experiments were performed with wild-type and pgdAadr mutant pneumococci in lysozyme M-sufficient (LysM+/+) and -deficient (LysM−/−) mice. The wild-type strain out-competed the double mutant in LysM+/+, but not LysM−/− mice, indicating the importance of resistance to the muramidase activity of lysozyme during mucosal colonization. In contrast, strains containing single mutations in either pgdA or adr prevailed over the wild-type strain in both LysM+/+ and LysM−/− mice. Our findings demonstrate that individual peptidoglycan modifications diminish fitness during colonization. The competitive advantage of wild-type pneumococci in LysM+/+ but not LysM−/− mice suggests that the combination of peptidoglycan modifications reduces overall fitness, but that this is outweighed by the benefits of resistance to the peptidoglycan degrading activity of lysozyme
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