Investigation of 4th Grade Students' Geometric Thinking Levels and Success Scores in Terms of Different Variables

The aim of this study is to investigate the 4th grade students' geometric thinking levels and achievement scores in terms of some demographic variables by using the Geometric Thinking Level Test. The data has been collected with 429 elementary school students at 10 elementary schools in Amasya employing the Geometric Thinking Level Test. The collected data has been analyzed by SPSS22 program. Based on analyzing the collected data, it is found that 4th grade students' geometric thinking level is low. Furthermore, participant students' geometric thinking success score has been examined. As a result; even though gender, parents' education level, parents' occupation, and using computer at home are statistically significant, whether or not getting pre-elementary education is not statistically significant on students' geometric thinking success score

Effect of Low-flow Anesthesia Education on Knowledge, Attitude and Behavior of the Anesthesia Team

AbstractThe aim of this study was to evaluate the effect of education on the knowledge, attitude and behavior of anesthesiology staff and residents towards low-flow anesthesia. The staff and residents in the Department of Anesthesia and Reanimation, Zonguldak Karaelmas University were given theoretical and practical training in delivering low-flow anesthesia. To evaluate their attitudes and behaviors toward low-flow anesthesia, we collected data during the 6 months before training, during the first 3 months after training, and at 4–6 months after training. Anesthesia follow-up records, operation time, volatile anesthetic agent used, and the amount (in liters) of fresh gas low mid-anesthesia were recorded in all three stages. A total of 3,158 patients received general anesthesia and inhalation anesthesia was used in 3,115 of these patients. Our study group consisted of 2,752 patients who had no absolute or relative contraindications to low-flow anesthesia. While the mean fresh gas flow was 4.00 ± 0.00 L/min before training, this level dropped to 2.98 L/min in the first 3 months after training, and to 3.26 L/min in the following 3 months. The mean fresh gas flow was significantly lower at the two post-training assessments than before training (p < 0.05). In conclusion, low-flow anesthesia may be used more frequently if educational seminars are provided to anesthetists. The use of low-flow anesthesia may increase further by allocating more time to this technique in anesthesia training programs provided at regular intervals

Crimean-Congo Hemorrhagic Fever in Turkey

Nineteen cases of suspected Crimean-Congo hemorrhagic fever reported from Turkey

Pathophysiological impact of targeting the ROS-p53 axis

The goal of this PhD thesis was to define the importance of the interplay between reactive oxygen species (ROS) and their activation of the tumor suppressor p53 in development and disease. We addressed this question using molecular biology and biochemical techniques together with mouse genetics and bioinformatics. We have made two important discoveries: First, we show that antioxidant supplementation accelerates lung cancer progression in mice and the growth of human lung cancer cell lines. By reducing the levels of ROS and DNA damage, antioxidants deactivate the p53 protein and help cancer cells to evade growth arrest. Second, we show that the transcription factor zinc finger protein 148 (Zfp148) is a potent suppressor of p53 activation under oxidative conditions. During lung development, suppression of p53 prevents growth arrest of pulmonary cells and permits prenatal lung maturation. However, in the ApcMin/+ model of colorectal cancer and in the Apoe–/– model of atherosclerosis, suppression of p53 promotes tumor development and atherosclerosis, respectively. Thus Zfp148 suppression of p53 plays important roles in both physiological and pathological contexts. We conclude that: 1) Antioxidant supplementation may stimulate the growth and progression of undiagnosed lung tumors and should be used with caution. The risk of developing lung cancer in patients with chronic obstructive pulmonary disease (COPD) who take the antioxidant acetylcysteine to break down mucus should be carefully evaluated. 2) Therapeutic targeting of Zfp148 may have beneficial effects in cancer and atherosclerosis by increasing p53 activity

Cellular Redox Homeostasis

Cellular redox homeostasis is an essential and dynamic process that ensures the balance between reducing and oxidizing reactions within cells and regulates a plethora of biological responses and events. The study of these biochemical reactions has proven difficult over time, but recent technical and methodological developments have contributed to the rapid growth of the redox field and to our understanding of its importance in biology. The aim of this short review is to give the reader an overall understanding of redox regulation in the areas of cellular signaling, development, and disease, as well as to introduce some recent discoveries in those fields

Anesthesia in a patient with Stiff Person Syndrome

Stiff Person Syndrome (SPS), typified by rigidity in muscles of the torso and extremities and painful episodic spasms, is a rare autoimmune-based neurological disease. Here we present the successful endotracheal intubation and application of TIVA without muscle relaxants on an SPS patient

Anesthesia in a patient with Stiff Person Syndrome

Abstract Stiff Person Syndrome (SPS), typified by rigidity in muscles of the torso and extremities and painful episodic spasms, is a rare autoimmune-based neurological disease. Here we present the successful endotracheal intubation and application of TIVA without muscle relaxants on an SPS patient. A 46 years old male patient was operated with ASA-II physical status because of lumber vertebral compression fracture. After induction of anesthesia using lidocaine, propofol and remifentanil tracheal intubation was completed easily without neuromuscular blockage. Anesthesia was maintained with propofol, remifentanil and O2/air mixture. After a problem-free intraoperative period the patient was extubated and seven days later was discharged walking with aid. Though the mechanism is not clear neuromuscular blockers and volatile anesthetics may cause prolonged hypotonia in patients with SPS. We think the TIVA technique, a general anesthetic practice which does not require neuromuscular blockage, is suitable for these patients

Anesthesia in a patient with Stiff Person Syndrome

Abstract Stiff Person Syndrome (SPS), typified by rigidity in muscles of the torso and extremities and painful episodic spasms, is a rare autoimmune-based neurological disease. Here we present the successful endotracheal intubation and application of TIVA without muscle relaxants on an SPS patient. A 46 years old male patient was operated with ASA-II physical status because of lumber vertebral compression fracture. After induction of anesthesia using lidocaine, propofol and remifentanil tracheal intubation was completed easily without neuromuscular blockage. Anesthesia was maintained with propofol, remifentanil and O2/air mixture. After a problem-free intraoperative period the patient was extubated and seven days later was discharged walking with aid. Though the mechanism is not clear neuromuscular blockers and volatile anesthetics may cause prolonged hypotonia in patients with SPS. We think the TIVA technique, a general anesthetic practice which does not require neuromuscular blockage, is suitable for these patients