93 research outputs found

    Оформлення курсових, дипломних і магістерських робіт

    Get PDF
    Описані вимоги до оформлення курсових, дипломних і магістерських робітЗміст : ВСТУП 1 ; 1. СТРУКТУРА РОБІТ 6 ; 2. ОФОРМЛЕННЯ РОБІТ 9 ; 2.1. Загальні вимоги до тексту 9 ; 2.2. Титульна сторінка 11 ; 2.3. Рубрикація 12 ; 2.3.1. Класична система рубрикації 12 ; 2.3.2. Рубрикація науково-технічної літератури 14 ; 2.4. Зміст 15 ; 2.5. Посилання на літературу в тексті 15 ; 2.6. Ілюстрації 18 ; 2.7. Таблиці 20 ; 2.8. Формули 21 ; 2.9. Список літератури 22 ; 2.9.1. Елементи бібліографічного запису документа 22 ; 2.9.2. Бібліографічні описи книг 31 ; 2.9.3. Бібліографічний опис частини книги і статті у збірнику або періодичному виданні 31 ; 2.9.4. Бібліографічний опис рукописів і науково-технічних документів 35 ; 2.10. Оформлення додатків 38 ; ДОДАТКИ 39 ; Додаток 1. Зразки оформлення титульних сторінок 39 ; Додаток 2. Зразок оформлення змісту дипломної роботи з використанням рубрикації науково-технічної літератури 43 ; Додаток 3. Зразок оформлення змісту дипломної роботи з використанням класичної рубрикації 44 ; Додаток 4. Зразки оформлення ілюстративного матеріалу 45 ; Додаток 5. Приклади оформлення таблиць 48 ; Додаток 6. Вимоги до оформлення курсових, дипломних і магістерських робіт 49

    Курсова та кваліфікаційні роботи ОКР "бакалавр", "спеціаліст", "магістр" : методичні рекомендації до написання та оформлення

    Get PDF
    Наведено основні вимоги до написання курсових і кваліфікаційних робіт, викладені послідовні етапи їх підготовки, оформлення та процедуру захисту. Подана орієнтовна тематика курсових і випускних робіт, які виконуються студентами, що спеціалізуються на кафедрі ботаніки біологічного факультету СНУ імені Лесі Українки. Для студентів кафедри ботаніки біологічного факультету, викладачів

    Animal models of major depressive disorder and the implications for drug discovery and development

    Full text link
    Introduction: Depression is a highly debilitating psychiatric disorder that affects the global population and causes severe disabilities and suicide. Depression pathogenesis remains poorly understood, and the disorder is often treatment-resistant and recurrent, necessitating the development of novel therapies, models and concepts in this field. Areas covered: Animal models are indispensable for translational biological psychiatry, and markedly advance the study of depression. Novel approaches continuously emerge that may help untangle the disorder heterogeneity and unclear categories of disease classification systems. Some of these approaches include widening the spectrum of model species used for translational research, using a broader range of test paradigms, exploring new pathogenic pathways and biomarkers, and focusing more closely on processes beyond neural cells (e.g. glial, inflammatory and metabolic deficits). Expert opinion: Dividing the core symptoms into easily translatable, evolutionarily conserved phenotypes is an effective way to reevaluate current depression modeling. Conceptually novel approaches based on the endophenotype paradigm, cross-species trait genetics and ‘domain interplay concept’, as well as using a wider spectrum of model organisms and target systems will enhance experimental modeling of depression and antidepressant drug discovery. © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group

    Factors associated with diversity, quantity and zoonotic potential of ectoparasites on urban mice and voles

    Get PDF
    Wild rodents are important hosts for tick larvae but co-infestations with other mites and insects are largely neglected. Small rodents were trapped at four study sites in Berlin, Germany, to quantify their ectoparasite diversity. Host-specific, spatial and temporal occurrence of ectoparasites was determined to assess their influence on direct and indirect zoonotic risk due to mice and voles in an urban agglomeration. Rodent-associated arthropods were diverse, including 63 species observed on six host species with an overall prevalence of 99%. The tick Ixodes ricinus was the most prevalent species, found on 56% of the rodents. The trapping location clearly affected the presence of different rodent species and, therefore, the occurrence of particular host-specific parasites. In Berlin, fewer temporary and periodic parasite species as well as non-parasitic species (fleas, chiggers and nidicolous Gamasina) were detected than reported from rural areas. In addition, abundance of parasites with low host-specificity (ticks, fleas and chiggers) apparently decreased with increasing landscape fragmentation associated with a gradient of urbanisation. In contrast, stationary ectoparasites, closely adapted to the rodent host, such as the fur mites Myobiidae and Listrophoridae, were most abundant at the two urban sites. A direct zoonotic risk of infection for people may only be posed by Nosopsyllus fasciatus fleas, which were prevalent even in the city centre. More importantly, peridomestic rodents clearly supported the life cycle of ticks in the city as hosts for their subadult stages. In addition to trapping location, season, host species, body condition and host sex, infestation with fleas, gamasid Laelapidae mites and prostigmatic Myobiidae mites were associated with significantly altered abundance of I. ricinus larvae on mice and voles. Whether this is caused by predation, grooming behaviour or interaction with the host immune system is unclear. The present study constitutes a basis to identify interactions and vector function of rodent-associated arthropods and their potential impact on zoonotic diseases

    Imaging Long-Term Fate of Intramyocardially Implanted Mesenchymal Stem Cells in a Porcine Myocardial Infarction Model

    Get PDF
    The long-term fate of stem cells after intramyocardial delivery is unknown. We used noninvasive, repetitive PET/CT imaging with [18F]FEAU to monitor the long-term (up to 5 months) spatial-temporal dynamics of MSCs retrovirally transduced with the sr39HSV1-tk gene (sr39HSV1-tk-MSC) and implanted intramyocardially in pigs with induced acute myocardial infarction. Repetitive [18F]FEAU PET/CT revealed a biphasic pattern of sr39HSV1-tk-MSC dynamics; cell proliferation peaked at 33–35 days after injection, in periinfarct regions and the major cardiac lymphatic vessels and lymph nodes. The sr39HSV1-tk-MSC–associated [18F]FEAU signals gradually decreased thereafter. Cardiac lymphography studies using PG-Gd-NIRF813 contrast for MRI and near-infrared fluorescence imaging showed rapid clearance of the contrast from the site of intramyocardial injection through the subepicardial lymphatic network into the lymphatic vessels and periaortic lymph nodes. Immunohistochemical analysis of cardiac tissue obtained at 35 and 150 days demonstrated several types of sr39HSV1-tk expressing cells, including fibro-myoblasts, lymphovascular cells, and microvascular and arterial endothelium. In summary, this study demonstrated the feasibility and sensitivity of [18F]FEAU PET/CT imaging for long-term, in-vivo monitoring (up to 5 months) of the fate of intramyocardially injected sr39HSV1-tk-MSC cells. Intramyocardially transplanted MSCs appear to integrate into the lymphatic endothelium and may help improve myocardial lymphatic system function after MI

    Cross-species Analyses of Intra-species Behavioral Differences in Mammals and Fish

    Get PDF
    Multiple species display robust behavioral variance among individuals due to different genetic, genomic, epigenetic, neuroplasticity and environmental factors. Behavioral individuality has been extensively studied in various animal models, including rodents and other mammals. Fish, such as zebrafish (Danio rerio), have recently emerged as powerful aquatic model organisms with overt individual differences in behavioral, nociceptive and other CNS traits. Here, we evaluate individual behavioral differences in mammals and fish, emphasizing the importance of cross-species analyses of intraspecies variance in experimental models of normal and pathological CNS functions. © 2019 IBROAVK laboratory is supported by the Southwest University (Chongqing, China) Zebrafish Platform construction funds. This research is supported by the Russian Science Foundation grant 19-15-00053 . KAD is supported by the Russian Foundation for Basic Research ( RFBR) grant 18-34-00996 , Fellowship of the President of Russia and Special Rector’s Fellowship for SPSU PhD Students. DBR receives the CNPq research productivity grant (305051/2018-0), and his work is also supported by the PROEX/CAPES fellowhip grant 23038.004173/2019-93 (Brazil). MP receives funding from the British Academy (UK) . BDF is supported by a CAPES Foundation studentship (Brazil). FC is supported by the Father’s Foundation and the Fast Data Sharing-2036 programs. AVK is the Chair of the International Zebrafish Neuroscience Research Consortium (ZNRC) Special 2018-2019 Task Force that coordinated this multi-laboratory collaborative project

    Lichen indication of air quality in the outskirts of sulphur mining factory with the help of indexes of atmospheric pollution

    Get PDF
    During the lichen indication investigation of air quality in the outskirts of the Yavoriv state mining-chemical factory „Sirka” in the Lviv region the mapping of the polluted territory with according to Index of Atmospheric Purity (IAP) and Improved Index of Atmospheric Purity (IAP18) was made. It was discovered 81 species of epiphytic lichens, for which the meanings of the Ecological Index (Qi) are calculated and reported for 28 widespread species. At the investigated territory 4 isotoxic lichen zones are established. Their position is determined by the main springs of pollution: „Sirka” factory and highways. These sources of pollution also influence the distribution of the indicatory species

    Lichens of genus Cladonia Hill. ex P. Browne in Ukrainian Roztochya. 1. Sections Cocciferae (Del.) Vain and Ochroleucae Fr.

    No full text
    Data on 9 lichen species of the genus Cladonia Hill. ex P. Browne, sections Cocciferae (Del.) Vain. and Ochroleucae Fr. are provided for Roztochya region on the basis of the own field observations and thd cited publicationns. Among them, 6 species occur in the Ukrainian part of Roztochya. Data on 4 species, Cladonia digitata (L.) Hoffm., C. deformis (L.) Hoffm., C. pleurota (Flörke) Schaer., C. sulphurina (Michx.) Fr., and 1 subspecies, Cladonia macilenta Hoffm. ssp. floerkeana (Fr.) V. Wirthe are reported for the first time for this territory. Ecological, coenotic and geographical features of the cited species are discussed. Plats communities in which investigated lichens occur or may be discovered later are subjected to syntaxonomic analysis
    corecore