Deepening subwavelength acoustic resonance via metamaterials with universal broadband elliptical microstructure

Slow sound is a frequently exploited phenomenon that metamaterials can induce in order to permit wave energy compression, redirection, imaging, sound absorption, and other special functionalities. Generally, however, such slow sound structures have a poor impedance match to air, particularly at low frequencies and consequently exhibit strong transmission only in narrow frequency ranges. This therefore strongly restricts their application in wave manipulation devices. In this work, we design a slow sound medium that halves the effective speed of sound in air over a wide range of low frequencies (hence our referral to the microstructure as “broadband”), whilst simultaneously maintaining a near impedance match to air. This is achieved with a rectangular array of acoustically rigid cylinders of elliptical cross section, a microstructure that is motivated by combining transformation acoustics with homogenization. Microstructural parameters are optimized in order to provide the required anisotropic material properties as well as near impedance matching. We then employ this microstructure in order to halve the size of a quarter-wavelength resonator (QWR) or equivalently to halve the resonant frequency of a QWR of a given size. This provides significant space savings in the context of low-frequency tonal noise attenuation in confined environments where the absorbing material is adjacent to the region in which sound propagates, such as in a duct. We employ the term “universal” since we envisage that this microstructure may be employed in a number of diverse applications involving sound manipulation.EPSRC Grant EP/K033208/I and EP/R014604/

International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci

The risk of posttraumatic stress disorder (PTSD) following trauma is heritable, but robust common variants have yet to be identified. In a multi-ethnic cohort including over 30,000 PTSD cases and 170,000 controls we conduct a genome-wide association study of PTSD. We demonstrate SNP-based heritability estimates of 5–20%, varying by sex. Three genome-wide significant loci are identified, 2 in European and 1 in African-ancestry analyses. Analyses stratified by sex implicate 3 additional loci in men. Along with other novel genes and non-coding RNAs, a Parkinson’s disease gene involved in dopamine regulation, PARK2, is associated with PTSD. Finally, we demonstrate that polygenic risk for PTSD is significantly predictive of re-experiencing symptoms in the Million Veteran Program dataset, although specific loci did not replicate. These results demonstrate the role of genetic variation in the biology of risk for PTSD and highlight the necessity of conducting sex-stratified analyses and expanding GWAS beyond European ancestry populations. © 2019, This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply

Ethnic and mouse strain differences in central corneal thickness and association with pigmentation phenotype

The cornea is a transparent structure that permits the refraction of light into the eye. Evidence from a range of studies indicates that central corneal thickness (CCT) is strongly genetically determined. Support for a genetic component comes from data showing significant variation in CCT between different human ethnic groups. Interestingly, these studies also appear to show that skin pigmentation may influence CCT. To validate these observations, we undertook the first analysis of CCT in an oculocutaneous albinism (OCA) and Ugandan cohort, populations with distinct skin pigmentation phenotypes. There was a significant difference in the mean CCT of the OCA, Ugandan and Australian-Caucasian cohorts (Ugandan: 517.3±37 µm; Caucasian: 539.7±32.8 µm, OCA: 563.3±37.2 µm; p<0.001). A meta-analysis of 53 studies investigating the CCT of different ethnic groups was then performed and demonstrated that darker skin pigmentation is associated with a thinner CCT (p<0.001). To further verify these observations, we measured CCT in 13 different inbred mouse strains and found a significant difference between the albino and pigmented strains (p = 0.008). Specific mutations within the melanin synthesis pathway were then investigated in mice for an association with CCT. Significant differences between mutant and wild type strains were seen with the nonagouti (p<0.001), myosin VA (p<0.001), tyrosinase (p = 0.025) and tyrosinase related protein (p = 0.001) genes. These findings provide support for our hypothesis that pigmentation is associated with CCT and identifies pigment-related genes as candidates for developmental determination of a non-pigmented structure.David P. Dimasi, Alex W. Hewitt, Kenneth Kagame, Sam Ruvama, Ludovica Tindyebwa, Bastien Llamas, Kirsty A. Kirk, Paul Mitchell, Kathryn P. Burdon and Jamie E. Crai

Deepening subwavelength acoustic resonance via metamaterials with universal broadband elliptical microstructure

© 2018 Author(s). Slow sound is a frequently exploited phenomenon that metamaterials can induce in order to permit wave energy compression, redirection, imaging, sound absorption, and other special functionalities. Generally, however, such slow sound structures have a poor impedance match to air, particularly at low frequencies and consequently exhibit strong transmission only in narrow frequency ranges. This therefore strongly restricts their application in wave manipulation devices. In this work, we design a slow sound medium that halves the effective speed of sound in air over a wide range of low frequencies (hence our referral to the microstructure as "broadband"), whilst simultaneously maintaining a near impedance match to air. This is achieved with a rectangular array of acoustically rigid cylinders of elliptical cross section, a microstructure that is motivated by combining transformation acoustics with homogenization. Microstructural parameters are optimized in order to provide the required anisotropic material properties as well as near impedance matching. We then employ this microstructure in order to halve the size of a quarter-wavelength resonator (QWR) or equivalently to halve the resonant frequency of a QWR of a given size. This provides significant space savings in the context of low-frequency tonal noise attenuation in confined environments where the absorbing material is adjacent to the region in which sound propagates, such as in a duct. We employ the term "universal" since we envisage that this microstructure may be employed in a number of diverse applications involving sound manipulation.EPSRC Grant EP/K033208/I and EP/R014604/

DRD2 C957T polymorphism is associated with improved 6-month verbal learning following traumatic brain injury

Traumatic brain injury (TBI) often leads to heterogeneous clinical outcomes, which may be influenced by genetic variation. A single-nucleotide polymorphism (SNP) in the dopamine D2 receptor (DRD2) may influence cognitive deficits following TBI. However, part of the association with DRD2 has been attributed to genetic variability within the adjacent ankyrin repeat and kinase domain containing 1 protein (ANKK1). Here, we utilize the Transforming Research and Clinical Knowledge in Traumatic Brain Injury Pilot (TRACK-TBI Pilot) study to investigate whether a novel DRD2 C957T polymorphism (rs6277) influences outcome on a cognitive battery at 6 months following TBI-California Verbal Learning Test (CVLT-II), Wechsler Adult Intelligence Test Processing Speed Index Composite Score (WAIS-PSI), and Trail Making Test (TMT). Results in 128 Caucasian subjects show that the rs6277 T-allele associates with better verbal learning and recall on CVLT-II Trials 1-5 (T-allele carrier 52.8 ± 1.3 points, C/C 47.9 ± 1.7 points; mean increase 4.9 points, 95% confidence interval [0.9 to 8.8]; p = 0.018), Short-Delay Free Recall (T-carrier 10.9 ± 0.4 points, C/C 9.7 ± 0.5 points; mean increase 1.2 points [0.1 to 2.5]; p = 0.046), and Long-Delay Free Recall (T-carrier 11.5 ± 0.4 points, C/C 10.2 ± 0.5 points; mean increase 1.3 points [0.1 to 2.5]; p = 0.041) after adjusting for age, education years, Glasgow Coma Scale, presence of acute intracranial pathology on head computed tomography scan, and genotype of the ANKK1 SNP rs1800497 using multivariable regression. No association was found between DRD2 C947T and non-verbal processing speed (WAIS-PSI) or mental flexibility (TMT) at 6 months. Hence, DRD2 C947T (rs6277) may be associated with better performance on select cognitive domains independent of ANKK1 following TBI

Corrosion Protection of Metal Alloys by Laser Cladding

This chapter looks at laser cladding (LC) processes to improve the corrosion resistance of metallic alloys. A detailed literature survey has shown that LC is a cost-effective method for protecting high-value components from corrosion and erosion attacks